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Sodium-glucose cotransporter 2 inhibitor (SGLT2i) is a novel anti-diabetes drug with a unique mechanism of action through inhibiting renal glucose re-absorption and increasing uric glucose excretion. Several studies have shown that the use of SGLT2i can reduce the risk of adverse cardiovascular events and improve outcomes in patients with type 2 diabetes mellitus at high cardiovascular risk or even heart failure. This review summarizes the protective mechanisms, evidence-based medical evidence and drug use progress and discusses the clinical use of SGLT2i in cardiovascular field.

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钠-葡萄糖共转运蛋白2抑制剂（sodium-glucose cotransporter 2 inhibitor, SGLT2i）是一类新型口服降糖药物，其作用机制是抑制近端肾小管钠-葡萄糖重吸收，促进尿糖排泄，从而降低血糖浓度。多项研究表明SGLT2i的使用可以降低心血管不良事件发生的风险，改善T2DM合并心血管风险高危甚至心力衰竭患者的预后。本文通过对SGLT2i心血管系统的保护机制、循证医学证据和药物使用进展进行综述，探讨SGLT2i在心血管领域的临床应用。

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舒冰，女，硕士，副主任药师，研究方向：临床药学。联系电话：(0551)62283379，E-mail: ahslyysb@163.com。

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舒冰，女，硕士，副主任药师，研究方向：临床药学。联系电话：(0551)62283379，E-mail: ahslyysb@163.com。

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