首页 期刊 论文 学科刊群 资讯 加盟 关于
EN
image
Article(id=1236344970647490854, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236344966058931117, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1658764800000, acceptedDateStr=2022-07-26, onlineDate=1772697211181, onlineDateStr=2026-03-05, pubDate=1678809600000, pubDateStr=2023-03-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772697211181, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772697211181, creator=13701087609, updateTime=1772697211181, updator=13701087609, issue=Issue{id=1236344966058931117, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='5', pageStart='441', pageEnd='552', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772697210087, creator=13701087609, updateTime=1772697640190, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236346770087793082, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236344966058931117, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236346770087793083, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236344966058931117, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=522, endPage=530, ext={EN=ArticleExt(id=1236344970941092149, articleId=1236344970647490854, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Pharmacokinetics of two components of Jinzhen oral liquid in rats, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To evaluate the pharmacokinetic characteristics of Jinzhen oral liquid and compare the difference of the absorption and metabolism after single and multiple administrations in rats.

Methods:

An ultra-high performance liquid chromatography coupled to triple-stage quadrupole mass spectrometer (UPLC-TSQ-MS) was applied to established the method for simultaneous determination of baicalin and wogonoside in rat plasma. Healthy rats were administered a single dose (3.228, 6.456, and 12.912 g·kg-1) and multiple dose (6.456 g·kg-1) of Jinzhen oral liquid (crude drug) by oral gavage. The content of target components in plasma at different time points was determined, and the pharmacokinetic parameters were calculated using the non-compartmental model.

Results:

The two components in the plasma sample have good linear relation (r>0.99). RSDs of their extraction recovery rate and matrix effect are both <15%, the intra- and inter-batch precision and accuracy, and stability meet the requirements of biological sample analysis. After single administration of Jinzhen oral liquid, the areas under the concentration-time curve AUC(0-t) of baicalin and wogonoside show a good positive correlation with dose (R2>0.9), and their t1/2z and CLz/F have no significant difference at different doses. Compared with a single administration, their absorption and metabolism process are basically the same, and their AUC(0-t) and t1/2z have no significant difference after multiple administration.

Conclusion:

A stable and reliable UPLC-TSQ-MS quantitative method for baicalin and wogonoside was established. And two components of Jinzhen oral liquid show linear dynamics characteristics in rats between 3.228 and 12.912 g·kg-1 (crude drug), and there is no accumulation after multiple administrations, revealing the rationality of the clinical dosage of the preparation.

, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Xia GAO, Shan-li WANG, Jia-jia WANG, Hui-fang GAO, Meng-yu QIAN, Xiao-yu TONG, Xia-lin CHEN, Quan-chang ZHANG, Liang CAO, Zhen-zhong WANG, Wei XIAO), CN=ArticleExt(id=1236344971201139015, articleId=1236344970647490854, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=金振口服液的2种成分在大鼠体内的药动学, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的：

评估金振口服液单次和多次服用后药动学特征和吸收代谢差异。

方法：

运用超高效液相色谱-三重四级杆质谱联用（UPLC-TSQ-MS）技术，建立同时定量大鼠血浆中黄芩苷和汉黄芩苷的分析方法。将健康大鼠分别按3.228，6.456，12.912 g生药量·kg-1单次灌胃（ig）和按6.456 g生药量·kg-1多次ig金振口服液，测定不同时间血浆中待测成分含量，运用非房室模型计算药动学参数。

结果：

血浆样品中2种成分的线性关系良好（r>0.995），提取回收率和基质效应的RSD均<15%，批内、批间的精密度和准确度以及稳定性均符合生物样品分析要求。大鼠单次给药后，黄芩苷和汉黄芩苷的AUC0-t均与剂量呈良好的正相关性，且不同剂量下t1/2z和清除率（CLz/F）无显著变化；与单次给药相比，多次给药后大鼠的吸收代谢过程基本相同、AUC0-t和t1/2z差异无统计学意义。

结论：

本研究建立了稳定可靠的黄芩苷和汉黄芩苷UPLC-TSQ-MS定量方法，在3.228~12.912 g生药量·kg-1范围内金振口服液中2种成分在体内呈现线性动力学的特征，多次给药后无蓄积现象，揭示该制剂临床剂量的合理性。

, correspAuthors=null, authorNote=null, correspAuthorsNote=
肖伟，男，博士生导师，院士，主要从事中药新剂型的研究与开发。联系电话：(0518)81522367，E-mail: 。
, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=CrpLAjTlrv7UFo2ghW/6WA==, magXml=j980p2eGGwdgbrJ8VHWU2A==, pdfUrl=null, pdf=MLek2f+HjipcQgZ+96qMMg==, pdfFileSize=5698776, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=URqcUzbrZwJrKVJtaTN5wQ==, mapNumber=null, authorCompany=null, fund=null, authors=

高霞，女，硕士，主要从事药物分析、药动学研究。E-mail: 。

, authorsList=高霞, 王善丽, 王佳佳, 高惠芳, 钱梦雨, 童孝宇, 陈夏霖, 张全昌, 曹亮, 王振中, 肖伟)}, authors=[Author(id=1236344971641540960, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=gaoxia0218@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236344971725427046, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344971641540960, language=EN, stringName=Xia GAO, firstName=Xia, middleName=null, lastName=GAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236344971834478958, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344971641540960, language=CN, stringName=高霞, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1江苏康缘药业股份有限公司，连云港 222001
2中药制药过程新技术国家重点实验室，连云港 222001, bio={"content":"

高霞，女，硕士，主要从事药物分析、药动学研究。E-mail: 。

"}, bioImg=null, bioContent=

高霞，女，硕士，主要从事药物分析、药动学研究。E-mail: 。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236344971385688398, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=1, ext=[AuthorCompanyExt(id=1236344971389882703, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China), AuthorCompanyExt(id=1236344971398271312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1江苏康缘药业股份有限公司，连云港 222001)]), AuthorCompany(id=1236344971482157396, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=2, ext=[AuthorCompanyExt(id=1236344971486351701, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China), AuthorCompanyExt(id=1236344971494740311, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2中药制药过程新技术国家重点实验室，连云港 222001)])]), Author(id=1236344971922559345, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236344972010639733, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344971922559345, language=EN, stringName=Shan-li WANG, firstName=Shan-li, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, 3, address=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China
3China Pharmaceutical University, Nanjing 211199, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236344972094525818, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344971922559345, language=CN, stringName=王善丽, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, 3, address=1江苏康缘药业股份有限公司，连云港 222001
2中药制药过程新技术国家重点实验室，连云港 222001
3中国药科大学，南京 211199, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236344971385688398, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=1, ext=[AuthorCompanyExt(id=1236344971389882703, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China), AuthorCompanyExt(id=1236344971398271312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1江苏康缘药业股份有限公司，连云港 222001)]), AuthorCompany(id=1236344971482157396, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=2, ext=[AuthorCompanyExt(id=1236344971486351701, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China), AuthorCompanyExt(id=1236344971494740311, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2中药制药过程新技术国家重点实验室，连云港 222001)]), AuthorCompany(id=1236344971557654874, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=3, ext=[AuthorCompanyExt(id=1236344971561849178, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971557654874, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3China Pharmaceutical University, Nanjing 211199, China), AuthorCompanyExt(id=1236344971570237788, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971557654874, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3中国药科大学，南京 211199)])]), Author(id=1236344972178411901, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236344972325212547, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344972178411901, language=EN, stringName=Jia-jia WANG, firstName=Jia-jia, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236344972421681540, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344972178411901, language=CN, stringName=王佳佳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1江苏康缘药业股份有限公司，连云港 222001
2中药制药过程新技术国家重点实验室，连云港 222001, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236344971385688398, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=1, ext=[AuthorCompanyExt(id=1236344971389882703, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China), AuthorCompanyExt(id=1236344971398271312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1江苏康缘药业股份有限公司，连云港 222001)]), AuthorCompany(id=1236344971482157396, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=2, ext=[AuthorCompanyExt(id=1236344971486351701, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China), AuthorCompanyExt(id=1236344971494740311, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2中药制药过程新技术国家重点实验室，连云港 222001)])]), Author(id=1236344972497179017, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236344972610425232, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344972497179017, language=EN, stringName=Hui-fang GAO, firstName=Hui-fang, middleName=null, lastName=GAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236344972719477140, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344972497179017, language=CN, stringName=高惠芳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1江苏康缘药业股份有限公司，连云港 222001
2中药制药过程新技术国家重点实验室，连云港 222001, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236344971385688398, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=1, ext=[AuthorCompanyExt(id=1236344971389882703, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China), AuthorCompanyExt(id=1236344971398271312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1江苏康缘药业股份有限公司，连云港 222001)]), AuthorCompany(id=1236344971482157396, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=2, ext=[AuthorCompanyExt(id=1236344971486351701, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China), AuthorCompanyExt(id=1236344971494740311, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2中药制药过程新技术国家重点实验室，连云港 222001)])]), Author(id=1236344972794974616, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236344972883055004, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344972794974616, language=EN, stringName=Meng-yu QIAN, firstName=Meng-yu, middleName=null, lastName=QIAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236344972954358175, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344972794974616, language=CN, stringName=钱梦雨, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1江苏康缘药业股份有限公司，连云港 222001
2中药制药过程新技术国家重点实验室，连云港 222001, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236344971385688398, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=1, ext=[AuthorCompanyExt(id=1236344971389882703, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China), AuthorCompanyExt(id=1236344971398271312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1江苏康缘药业股份有限公司，连云港 222001)]), AuthorCompany(id=1236344971482157396, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=2, ext=[AuthorCompanyExt(id=1236344971486351701, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China), AuthorCompanyExt(id=1236344971494740311, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2中药制药过程新技术国家重点实验室，连云港 222001)])]), Author(id=1236344973071798693, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236344973164073389, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344973071798693, language=EN, stringName=Xiao-yu TONG, firstName=Xiao-yu, middleName=null, lastName=TONG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236344973243765170, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344973071798693, language=CN, stringName=童孝宇, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1江苏康缘药业股份有限公司，连云港 222001
2中药制药过程新技术国家重点实验室，连云港 222001, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236344971385688398, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=1, ext=[AuthorCompanyExt(id=1236344971389882703, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China), AuthorCompanyExt(id=1236344971398271312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1江苏康缘药业股份有限公司，连云港 222001)]), AuthorCompany(id=1236344971482157396, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=2, ext=[AuthorCompanyExt(id=1236344971486351701, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China), AuthorCompanyExt(id=1236344971494740311, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2中药制药过程新技术国家重点实验室，连云港 222001)])]), Author(id=1236344973323456946, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236344973424120248, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344973323456946, language=EN, stringName=Xia-lin CHEN, firstName=Xia-lin, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236344973499617722, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344973323456946, language=CN, stringName=陈夏霖, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1江苏康缘药业股份有限公司，连云港 222001
2中药制药过程新技术国家重点实验室，连云港 222001, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236344971385688398, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=1, ext=[AuthorCompanyExt(id=1236344971389882703, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China), AuthorCompanyExt(id=1236344971398271312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1江苏康缘药业股份有限公司，连云港 222001)]), AuthorCompany(id=1236344971482157396, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=2, ext=[AuthorCompanyExt(id=1236344971486351701, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China), AuthorCompanyExt(id=1236344971494740311, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2中药制药过程新技术国家重点实验室，连云港 222001)])]), Author(id=1236344973570920894, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236344973659001283, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344973570920894, language=EN, stringName=Quan-chang ZHANG, firstName=Quan-chang, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236344973738693064, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344973570920894, language=CN, stringName=张全昌, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1江苏康缘药业股份有限公司，连云港 222001
2中药制药过程新技术国家重点实验室，连云港 222001, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236344971385688398, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=1, ext=[AuthorCompanyExt(id=1236344971389882703, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China), AuthorCompanyExt(id=1236344971398271312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1江苏康缘药业股份有限公司，连云港 222001)]), AuthorCompany(id=1236344971482157396, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=2, ext=[AuthorCompanyExt(id=1236344971486351701, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China), AuthorCompanyExt(id=1236344971494740311, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2中药制药过程新技术国家重点实验室，连云港 222001)])]), Author(id=1236344973843550668, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, orderNo=8, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236344973923242449, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344973843550668, language=EN, stringName=Liang CAO, firstName=Liang, middleName=null, lastName=CAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236344974015517142, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344973843550668, language=CN, stringName=曹亮, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1江苏康缘药业股份有限公司，连云港 222001
2中药制药过程新技术国家重点实验室，连云港 222001, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236344971385688398, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=1, ext=[AuthorCompanyExt(id=1236344971389882703, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China), AuthorCompanyExt(id=1236344971398271312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1江苏康缘药业股份有限公司，连云港 222001)]), AuthorCompany(id=1236344971482157396, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=2, ext=[AuthorCompanyExt(id=1236344971486351701, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China), AuthorCompanyExt(id=1236344971494740311, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2中药制药过程新技术国家重点实验室，连云港 222001)])]), Author(id=1236344974124569050, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, orderNo=9, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236344974229426655, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344974124569050, language=EN, stringName=Zhen-zhong WANG, firstName=Zhen-zhong, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236344974296535520, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344974124569050, language=CN, stringName=王振中, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1江苏康缘药业股份有限公司，连云港 222001
2中药制药过程新技术国家重点实验室，连云港 222001, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236344971385688398, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=1, ext=[AuthorCompanyExt(id=1236344971389882703, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China), AuthorCompanyExt(id=1236344971398271312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1江苏康缘药业股份有限公司，连云港 222001)]), AuthorCompany(id=1236344971482157396, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=2, ext=[AuthorCompanyExt(id=1236344971486351701, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China), AuthorCompanyExt(id=1236344971494740311, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2中药制药过程新技术国家重点实验室，连云港 222001)])]), Author(id=1236344974355255778, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, orderNo=10, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=kanionlunwen@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236344974451724774, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344974355255778, language=EN, stringName=Wei XIAO, firstName=Wei, middleName=null, lastName=XIAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236344974535610857, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, authorId=1236344974355255778, language=CN, stringName=肖伟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1江苏康缘药业股份有限公司，连云港 222001
2中药制药过程新技术国家重点实验室，连云港 222001, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236344971385688398, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=1, ext=[AuthorCompanyExt(id=1236344971389882703, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China), AuthorCompanyExt(id=1236344971398271312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1江苏康缘药业股份有限公司，连云港 222001)]), AuthorCompany(id=1236344971482157396, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=2, ext=[AuthorCompanyExt(id=1236344971486351701, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China), AuthorCompanyExt(id=1236344971494740311, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2中药制药过程新技术国家重点实验室，连云港 222001)])])], keywords=[Keyword(id=1236344974611108331, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, language=EN, orderNo=1, keyword=Jinzhen oral liquid), Keyword(id=1236344974674022893, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, language=EN, orderNo=2, keyword=pharmacokinetics), Keyword(id=1236344974732743151, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, language=EN, orderNo=3, keyword=UPLC-TSQ-MS), Keyword(id=1236344974804046321, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, language=EN, orderNo=4, keyword=baicalin), Keyword(id=1236344974883738099, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, language=EN, orderNo=5, keyword=wogonin), Keyword(id=1236344974959235573, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, language=CN, orderNo=1, keyword=金振口服液), Keyword(id=1236344975026344439, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, language=CN, orderNo=2, keyword=药动学), Keyword(id=1236344975093453305, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, language=CN, orderNo=3, keyword=超高效液相色谱-三重四级杆质谱联用), Keyword(id=1236344975152173562, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, language=CN, orderNo=4, keyword=黄芩苷), Keyword(id=1236344975210893819, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, language=CN, orderNo=5, keyword=汉黄芩苷)], refs=null, funds=[Fund(id=1236344975286391292, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, awardId=null, language=CN, fundingSource=江苏省工信厅2020年度工业和信息产业转型升级专项资金项目：多组分中药研究关键技术, fundOrder=null, country=null)], companyList=[AuthorCompany(id=1236344971385688398, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=1, ext=[AuthorCompanyExt(id=1236344971389882703, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China), AuthorCompanyExt(id=1236344971398271312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971385688398, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1江苏康缘药业股份有限公司，连云港 222001)]), AuthorCompany(id=1236344971482157396, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=2, ext=[AuthorCompanyExt(id=1236344971486351701, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China), AuthorCompanyExt(id=1236344971494740311, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971482157396, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2中药制药过程新技术国家重点实验室，连云港 222001)]), AuthorCompany(id=1236344971557654874, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, xref=3, ext=[AuthorCompanyExt(id=1236344971561849178, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971557654874, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3China Pharmaceutical University, Nanjing 211199, China), AuthorCompanyExt(id=1236344971570237788, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236344970647490854, companyId=1236344971557654874, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3中国药科大学，南京 211199)])], figs=null, attaches=null, journal=Journal(id=1235980159023624194, delFlag=0, nameCn=中国新药杂志, nameEn=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, issn=1003-3734, eissn=null, cn=11-2850/R, coden=ZXZHA6, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of New Drugs, journalRemark=null, publicationField=null, createdTime=1772610233314, updatedTime=1772610649152, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=C, firstLetterEn=C, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=ohPEEN//Vz1tDT3ZBNTp4Q==, picEn=f9WK9bvTM4guTmS/iGhOMg==, jcr=null, cjcr=null, exts=[JournalExt(id=1235981903275290962, language=CN, name=中国新药杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1772610649174, updatedTime=1772610649174, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1235981903338205523, language=EN, name=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1772610649189, updatedTime=1772610649189, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1235980733773295621, websiteList=[Website(id=1235982099191222761, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/CN, language=CN, createTime=1772610695884, createBy=18614031015, updateTime=1772610860397, updateBy=18614031015, name=中国新药杂志-中文, tplId=1146099689490845704, title=中国新药杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983918629966444, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=articleTextType, value=kx, createTime=1772611129672, updateTime=1772611129672, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918604800617, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=banner, value=null, createTime=1772611129666, updateTime=1772611129666, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918655132271, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=grayFlag, value=0, createTime=1772611129678, updateTime=1772611129678, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918596412008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611129664, updateTime=1772611129664, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918667715185, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=minRunFlag, value=0, createTime=1772611129681, updateTime=1772611129681, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918617383531, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic, createTime=1772611129669, updateTime=1772611129669, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918659326576, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=silenceFlag, value=0, createTime=1772611129679, updateTime=1772611129679, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918613189226, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1772611129668, updateTime=1772611129668, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918634160749, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeColor, value=null, createTime=1772611129673, updateTime=1772611129673, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918646743662, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeStyle, value=null, createTime=1772611129676, updateTime=1772611129676, creator=18614031015, updator=18614031015)]), Website(id=1235982099270914542, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/EN, language=EN, createTime=1772610695903, createBy=18614031015, updateTime=1772610875891, updateBy=18614031015, name=中国新药杂志-英文, tplId=1146101810881728533, title=Chinese Journal of New Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983955829248630, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=articleTextType, value=kx, createTime=1772611138541, updateTime=1772611138541, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955804082803, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=banner, value=null, createTime=1772611138535, updateTime=1772611138535, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955854414457, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=grayFlag, value=0, createTime=1772611138547, updateTime=1772611138547, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955795694194, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611138533, updateTime=1772611138533, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955866997371, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=minRunFlag, value=0, createTime=1772611138550, updateTime=1772611138550, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955820860021, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic, createTime=1772611138539, updateTime=1772611138539, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955862803066, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=silenceFlag, value=0, createTime=1772611138549, updateTime=1772611138549, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955812471412, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1772611138537, updateTime=1772611138537, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955837637239, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeColor, value=null, createTime=1772611138543, updateTime=1772611138543, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955846025848, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeStyle, value=null, createTime=1772611138545, updateTime=1772611138545, creator=18614031015, updator=18614031015)])], journalTitle=中国新药杂志, weixinUrl=null, journalUrl=http://www.newdrug.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of New Drugs, journalPhotoCn=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPhotoEn=f9WK9bvTM4guTmS/iGhOMg==, journalFirstLetter=C, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/Y2023/V32/I5/522, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/Y2023/V32/I5/522, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/PDF/Y2023/V32/I5/522, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/PDF/Y2023/V32/I5/522, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)
收藏切换
金振口服液的2种成分在大鼠体内的药动学
收藏切换
PDF下载
高霞 1, 2 , 王善丽 1, 2, 3 , 王佳佳 1, 2 , 高惠芳 1, 2 , 钱梦雨 1, 2 , 童孝宇 1, 2 , 陈夏霖 1, 2 , 张全昌 1, 2 , 曹亮 1, 2 , 王振中 1, 2 , 肖伟 1, 2
中国新药杂志 | 实验研究 2023,32(5): 522-530
收起
收藏切换
中国新药杂志 | 实验研究 2023, 32(5): 522-530
金振口服液的2种成分在大鼠体内的药动学
全屏
高霞1, 2 , 王善丽1, 2, 3, 王佳佳1, 2, 高惠芳1, 2, 钱梦雨1, 2, 童孝宇1, 2, 陈夏霖1, 2, 张全昌1, 2, 曹亮1, 2, 王振中1, 2, 肖伟1, 2
作者信息
  • 1江苏康缘药业股份有限公司，连云港 222001
  • 2中药制药过程新技术国家重点实验室，连云港 222001
  • 3中国药科大学，南京 211199

    • 高霞，女，硕士，主要从事药物分析、药动学研究。E-mail: 。

通讯作者:

肖伟，男，博士生导师，院士，主要从事中药新剂型的研究与开发。联系电话：(0518)81522367，E-mail: 。
Pharmacokinetics of two components of Jinzhen oral liquid in rats
Xia GAO1, 2 , Shan-li WANG1, 2, 3, Jia-jia WANG1, 2, Hui-fang GAO1, 2, Meng-yu QIAN1, 2, Xiao-yu TONG1, 2, Xia-lin CHEN1, 2, Quan-chang ZHANG1, 2, Liang CAO1, 2, Zhen-zhong WANG1, 2, Wei XIAO1, 2
Affiliations
  • 1Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
  • 2State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China
  • 3China Pharmaceutical University, Nanjing 211199, China
出版时间: 2023-03-15
文章导航
收藏切换
摘要
收起
目的：

评估金振口服液单次和多次服用后药动学特征和吸收代谢差异。

方法：

运用超高效液相色谱-三重四级杆质谱联用（UPLC-TSQ-MS）技术，建立同时定量大鼠血浆中黄芩苷和汉黄芩苷的分析方法。将健康大鼠分别按3.228，6.456，12.912 g生药量·kg-1单次灌胃（ig）和按6.456 g生药量·kg-1多次ig金振口服液，测定不同时间血浆中待测成分含量，运用非房室模型计算药动学参数。

结果：

血浆样品中2种成分的线性关系良好（r>0.995），提取回收率和基质效应的RSD均<15%，批内、批间的精密度和准确度以及稳定性均符合生物样品分析要求。大鼠单次给药后，黄芩苷和汉黄芩苷的AUC0-t均与剂量呈良好的正相关性，且不同剂量下t1/2z和清除率（CLz/F）无显著变化；与单次给药相比，多次给药后大鼠的吸收代谢过程基本相同、AUC0-t和t1/2z差异无统计学意义。

结论：

本研究建立了稳定可靠的黄芩苷和汉黄芩苷UPLC-TSQ-MS定量方法，在3.228~12.912 g生药量·kg-1范围内金振口服液中2种成分在体内呈现线性动力学的特征，多次给药后无蓄积现象，揭示该制剂临床剂量的合理性。

金振口服液  /  药动学  /  超高效液相色谱-三重四级杆质谱联用  /  黄芩苷  /  汉黄芩苷
Objective:

To evaluate the pharmacokinetic characteristics of Jinzhen oral liquid and compare the difference of the absorption and metabolism after single and multiple administrations in rats.

Methods:

An ultra-high performance liquid chromatography coupled to triple-stage quadrupole mass spectrometer (UPLC-TSQ-MS) was applied to established the method for simultaneous determination of baicalin and wogonoside in rat plasma. Healthy rats were administered a single dose (3.228, 6.456, and 12.912 g·kg-1) and multiple dose (6.456 g·kg-1) of Jinzhen oral liquid (crude drug) by oral gavage. The content of target components in plasma at different time points was determined, and the pharmacokinetic parameters were calculated using the non-compartmental model.

Results:

The two components in the plasma sample have good linear relation (r>0.99). RSDs of their extraction recovery rate and matrix effect are both <15%, the intra- and inter-batch precision and accuracy, and stability meet the requirements of biological sample analysis. After single administration of Jinzhen oral liquid, the areas under the concentration-time curve AUC(0-t) of baicalin and wogonoside show a good positive correlation with dose (R2>0.9), and their t1/2z and CLz/F have no significant difference at different doses. Compared with a single administration, their absorption and metabolism process are basically the same, and their AUC(0-t) and t1/2z have no significant difference after multiple administration.

Conclusion:

A stable and reliable UPLC-TSQ-MS quantitative method for baicalin and wogonoside was established. And two components of Jinzhen oral liquid show linear dynamics characteristics in rats between 3.228 and 12.912 g·kg-1 (crude drug), and there is no accumulation after multiple administrations, revealing the rationality of the clinical dosage of the preparation.

Jinzhen oral liquid  /  pharmacokinetics  /  UPLC-TSQ-MS  /  baicalin  /  wogonin
高霞, 王善丽, 王佳佳, 高惠芳, 钱梦雨, 童孝宇, 陈夏霖, 张全昌, 曹亮, 王振中, 肖伟. 金振口服液的2种成分在大鼠体内的药动学. 中国新药杂志, 2023 , 32 (5) : 522 -530 .
Xia GAO, Shan-li WANG, Jia-jia WANG, Hui-fang GAO, Meng-yu QIAN, Xiao-yu TONG, Xia-lin CHEN, Quan-chang ZHANG, Liang CAO, Zhen-zhong WANG, Wei XIAO. Pharmacokinetics of two components of Jinzhen oral liquid in rats[J]. Chinese Journal of New Drugs, 2023 , 32 (5) : 522 -530 .
基金
收起
  • 江苏省工信厅2020年度工业和信息产业转型升级专项资金项目：多组分中药研究关键技术
2023年第32卷第5期
PDF下载
48
16
引用本文
BibTeX
文章信息
  • 首发时间：2026-03-05
  • 出版时间：2023-03-15
补充材料
相关文章
文章信息
作者
出版历史
  • 录用日期：2022-07-26
基金
江苏省工信厅2020年度工业和信息产业转型升级专项资金项目：多组分中药研究关键技术
作者信息
    1江苏康缘药业股份有限公司，连云港 222001
    2中药制药过程新技术国家重点实验室，连云港 222001
    3中国药科大学，南京 211199

通讯作者:

肖伟，男，博士生导师，院士，主要从事中药新剂型的研究与开发。联系电话：(0518)81522367，E-mail: 。
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/zgxyzz/CN/1236344970647490854
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
相关链接
论文
最新文章
热读文章
热点专题
内参
蓝皮书
产业发展报告
传播力报告
期刊分级目录
资讯
学术新闻
行业新闻
学术会议
行业会议
关于
关于我们
联系我们
北京市海淀区学院南路86号
100081
010-62199257
qkjq@cast.org.cn

中国科学技术协会版权所有 京ICP 备10216604号-4 海淀分局备案 1101084647
科技导报社主办 中国科协信息中心技术支持