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Oliceridine is a G-protein-biased μ-opioid receptor agonist. It was approved by the U.S. FDA for the treatment of moderate to severe acute pain in adults by intravenous injection on August 7, 2020. Clinical studies have shown that oliceridine has a favorable analgesic efficacy which is noninferior than morphine with a lower risk of opioid-related adverse events than conventional opioids at the same time. This review focuses on the mechanism of action, pharmacokinetics, pharmacodynamics, clinical studies and safety evaluation of oliceridine．

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oliceridine是一种对G蛋白通路具有偏向性的新型阿片μ受体激动剂。2020年8月7日，美国FDA批准oliceridine用于静脉注射治疗成人中重度急性疼痛。临床研究显示，oliceridine有不劣于吗啡的良好镇痛功效，同时降低了传统阿片类药物不良反应（opioid-related adverse events, ORAEs）的发生风险。现对oliceridine的作用机制、药动学、药效学、临床研究、安全性评价等进行概述。

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吴禧敏，女，硕士研究生，研究方向：医院药学。E-mail: wuximin246@163.com。

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吴禧敏，女，硕士研究生，研究方向：医院药学。E-mail: wuximin246@163.com。

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