Article(id=1236342825994998430, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236342820131361209, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1669046400000, acceptedDateStr=2022-11-22, onlineDate=1772696699856, onlineDateStr=2026-03-05, pubDate=1677513600000, pubDateStr=2023-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772696699856, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772696699856, creator=13701087609, updateTime=1772696699856, updator=13701087609, issue=Issue{id=1236342820131361209, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='4', pageStart='329', pageEnd='440', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772696698458, creator=13701087609, updateTime=1772696766437, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236343105318875204, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236342820131361209, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236343105318875205, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236342820131361209, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=372, endPage=378, ext={EN=ArticleExt(id=1236342826288599726, articleId=1236342825994998430, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Mechanism of Polygonatum in the prevention and treatment of Alzheimer's disease based on network pharmacology, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To explore the main active components, potential targets and mechanisms of Polygonatum in the treatment of Alzheimer's disease (AD) by using network pharmacological techniques and methods.
Methods: The active components of Polygonatum were screened in TCMSP. AD-related targets were retrieved from GeneCards database, TTD database and DrugBank database. Cytoscape 3.7.2 software was used to establish the "yellow essence-component-target" network, which was imported into STRING database to obtain the target PPI network. Key genes were screened using "CytoHubba" function, and GO biological process and KEGG pathway enrichment analysis were performed.
Results: β-Sitosterol, baicalin, diosgenin and other active components in Polygonatum may exert an effect of prevention and treatment of AD through AKT1, CASP3, TP53, VEGFA, HIF1, mTOR and other key gene targets to regulate neurodegenerative pathways, including various diseases, PI3K-Akt signaling pathway, MAPK signaling pathway, and apoptosis signaling pathway.
Conclusion: Polygonatum may regulate and integrate multi-components, multi-targets and multi-pathways to achieve prevention and treatment of AD.
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目的： 利用网络药理学技术与方法，探讨黄精治疗阿尔茨海默病（AD）的主要活性成分、潜在作用靶点和机制。
方法： 借助中药系统药理学数据库与分析平台（TCMSP） 筛选黄精的有效成分，通过GeneCards数据库、TTD数据库、DrugBank数据库中检索AD相关疾病靶点。运用Cytoscape 3.7.2软件建立“黄精-成分-靶点”网络，导入STRING数据库获取靶点PPI网络，并通过“CytoHubba”功能筛选关键基因，并进行GO生物进程及KEGG通路富集分析。
结果： 黄精中β-谷甾醇、黄芩甙元、薯蓣皂苷元有效成分份可能通过AKT1，CASP3，TP53，VEGFA，HIF1，mTOR等关键基因靶点调控神经退行性变途径-多种疾病、PI3K-Akt信号通路、MAPK信号通路、细胞凋亡信号等通路发挥防治AD的作用。
结论： 黄精可能通过多成分、多靶点和多途径整合调节防治AD。
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高蕊，女，博士，教授，主任医师，研究方向：中药临床药理及中医内科内分泌。联系电话：(010)62835651，E-mail:
ruigao@126.com。
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马唯，男，博士研究生，研究方向：内分泌及代谢相关疾病。联系电话：(010)62835651，E-mail: 15811096320@163.com。
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马唯，男，博士研究生，研究方向：内分泌及代谢相关疾病。联系电话：(010)62835651，E-mail: 15811096320@163.com。
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