Article(id=1236342825227449217, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236342820131361209, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1658073600000, acceptedDateStr=2022-07-18, onlineDate=1772696699672, onlineDateStr=2026-03-05, pubDate=1677513600000, pubDateStr=2023-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772696699672, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772696699672, creator=13701087609, updateTime=1772696699672, updator=13701087609, issue=Issue{id=1236342820131361209, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='4', pageStart='329', pageEnd='440', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772696698458, creator=13701087609, updateTime=1772696766437, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236343105318875204, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236342820131361209, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236343105318875205, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236342820131361209, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=410, endPage=419, ext={EN=ArticleExt(id=1236342825479107459, articleId=1236342825227449217, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Chemical constituents and pharmacological effects of Astragali Radix and predictive analysis on quality markers, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Huangqi (Astragali Radix) is the dry root of Mongol Milkvetch (Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao) and Membranous Milkvetch (Astragalus membranaceus (Fisch.) Bge.), which is a major medicinal material in Gansu Province. It mainly contains Astragali Radix polysaccharides, flavonoids, saponins, alkaloids, amino acids, trace elements, organic acids and other chemical components. The pharmacological effects of Huangqi mainly focus on improving immunity, anti-oxidation, anti-tumor, protecting cardiovascular, promoting body metabolism, lowering blood sugar, diuresis and decreasing swelling. Based on literature retrieval, the distribution of resources, chemical components and pharmacological effects of Astragalus are reviewed and summarized. The quality markers (Q-Marker) of Astragali Radix are predicted based on traditional medicinal properties, efficacy, chemical components and different compatibility. The chemical components of Astragali Radix polysaccharide, ononin, calycosin, formononetin, astragaloside Ⅰ, astragaloside Ⅱ, and astragaloside Ⅳ were predicted by the analysis, providing a scientific basis for the quality control of Astragali Radix.

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黄芪是蒙古黄芪［Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao］和膜荚黄芪［Astragalus membranaceus (Fisch.) Bge.］的干燥根，为甘肃大宗药材，其主要化学成分有多糖、黄酮、皂苷、生物碱、氨基酸、微量元素及有机酸等。其药理作用主要集中在提高免疫力、抗氧化、抗肿瘤、保护心血管、促进机体代谢、降血糖、利尿消肿等方面。本文通过文献检索，对黄芪资源分布、化学成分和药理作用进行梳理总结，围绕传统药性、功效、化学成分和不同配伍等方面对黄芪质量标志物（quality marker, Q-Marker）进行了预测分析，最终预测了黄芪多糖、芒柄花苷、毛蕊异黄酮、芒柄花素、黄芪皂苷Ⅰ和Ⅱ、黄芪甲苷等中药成分，为黄芪质量控制提供科学依据。

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张柂儇，女，硕士研究生，主要从事中药药理毒理与产品开发研究。E-mail: 2510524988@qq.com。

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张柂儇，女，硕士研究生，主要从事中药药理毒理与产品开发研究。E-mail: 2510524988@qq.com。

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