Article(id=1236342824682189695, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236342820131361209, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1673193600000, acceptedDateStr=2023-01-09, onlineDate=1772696699542, onlineDateStr=2026-03-05, pubDate=1677513600000, pubDateStr=2023-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772696699542, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772696699542, creator=13701087609, updateTime=1772696699542, updator=13701087609, issue=Issue{id=1236342820131361209, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='4', pageStart='329', pageEnd='440', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772696698458, creator=13701087609, updateTime=1772696766437, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236343105318875204, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236342820131361209, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236343105318875205, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236342820131361209, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=379, endPage=385, ext={EN=ArticleExt(id=1236342824946430848, articleId=1236342824682189695, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Meta-analysis of the efficacy and safety of ginkgo biloba preparations for treating depression, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To systematically evaluate the efficacy and safety of ginkgo biloba preparation combined with western medicines in the treatment of depression.
Methods: Randomized controlled trials (RCTs) were electronically retrieved from CNKI, Wanfang Data, VIP, CBM, Pubmed and Cochrane Library according to the preset inclusion criteria and exclusion criteria. A total of 242 articles were retrieved. Through reading topics, abstracts, and full texts, 12 articles that met the inclusion and exclusion criteria were finally included for the analysis. The data extraction and Meta-analysis were conducted by using RevMan 5.3 software.
Results: The clinical efficacy of ginkgo biloba preparation combined with western medicines in the treatment of depression was superior to the western medicine routine treatment group, OR=2.48, 95%CI (1.77, 3.45), P<0.000 01. At the same time, the combined application of Ginkgo biloba extract could reduce the HAMD scale score and improve depressive symptoms, MD=-3.22, 95%CI (-4.25, -2.19), P<0.000 01.
Conclusion: Compared with the western medicine routine treatment group, the ginkgo biloba preparation treatment can improve depressive symptoms, lower the HAMD score, and reduce the adverse reactions of western medicines.
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目的： 系统评价银杏叶制剂联合西药治疗抑郁症的有效性及安全性。
方法： 通过计算机检索CNKI，CBM，Pubmed等6个数据库，收集公开发表的与银杏叶制剂治疗抑郁症相关的随机对照试验研究，共检索到文献242篇，最终筛选到符合纳入及排除标准的文献共12篇。然后应用Revman 5.3软件对银杏叶制剂联合西药治疗抑郁症有效性及安全性进行Meta分析。
结果： Meta分析结果显示，银杏叶制剂联合西药治疗抑郁的临床疗效方面优于西药常规治疗组，OR=2.48，95%CI（1.77，3.45），P<0.000 01。同时，联合应用银杏叶制剂可降低HAMD量表评分，改善抑郁症状，MD=-3.22，95%CI（-4.25，-2.19），P<0.000 01。
结论： 银杏叶制剂治疗组与西药常规治疗组比较，可提高治疗抑郁的临床疗效，改善抑郁症状，降低HAMD评分，并可降低西药的不良反应。
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, authorsList=高洪阳, 陆芳, 赵阳, 李庆娜, 曹唯仪, 孙明月)}, authors=[Author(id=1236342825596547976, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236342824682189695, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=18810320399@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236342825705599883, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236342824682189695, authorId=1236342825596547976, language=EN, stringName=Hong-yang GAO, firstName=Hong-yang, middleName=null, lastName=GAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100091, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236342825776903053, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236342824682189695, authorId=1236342825596547976, language=CN, stringName=高洪阳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=中国中医科学院西苑医院，北京 100091, bio={"content":"
高洪阳，男，硕士，主治医师，主要从事中药临床药理研究。E-mail: 18810320399@163.com。
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高洪阳，男，硕士，主治医师，主要从事中药临床药理研究。E-mail: 18810320399@163.com。
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