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Natural medicines are becoming more and more popular in clinical applications because of their remarkable efficacy with few side effects. Natural pharmaceutical compounds have been shown to be effective against many human diseases, especially cancer. Sulforaphane (1-isothiocyanate-4-(methylsulfonyl) butane) is a natural drug, which widely exists in cruciferous plants and is abundant in broccoli, Chinese kale, broccoli and other vegetables. There is growing evidence that sulforaphane is effective in the prevention and treatment of various cancers, including prostate, breast, colon, skin, bladder and oral cancers. In addition, researchers have found that sulforaphane is highly effective in fighting neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and multiple sclerosis. Moreover, sulforaphane has great potential in preventing oxidative stress, anti-inflammation and anti-fatigue. In this paper, the biological activity and mechanism of sulforaphane are reviewed, and the bioavailability and toxicity of sulforaphane are discussed.

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天然药物疗效显著、不良反应较小，已被证明对包括癌症在内的多种人类疾病有效，在临床应用中越来越广泛。莱菔硫烷［1-异硫氰酸基-4-（甲基亚磺酰基）丁烷］是一种广泛存在于十字花科植物中的天然药物，在西兰花、芥蓝、花椰菜等蔬菜中含量丰富。目前，越来越多的证据表明莱菔硫烷不仅能有效预防和治疗各种癌症，如前列腺癌、乳腺癌、结肠癌、皮肤癌、膀胱癌和口腔癌等，而且在对抗阿尔茨海默病、帕金森病和多发性硬化症等神经退行性疾病方面有很好的疗效。此外，莱菔硫烷在预防氧化应激、抗炎、抗疲劳等方面也具有很大的潜力。本文就莱菔硫烷的生物活性和作用机制进行综述，并对莱菔硫烷的成药特性和毒性进行探讨。

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彭鹤松，男，硕士研究生，研究方向：中药材药效物质基础以及质量标准控制。E-mail: penghesong1996@163.com。

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彭鹤松，男，硕士研究生，研究方向：中药材药效物质基础以及质量标准控制。E-mail: penghesong1996@163.com。

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