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Charged aerosol detector (CAD) is a new universal liquid chromatography detector rapidly developed in recent years. It has the advantages of high sensitivity, broad linear range, the signal response consistency independent of chemical structures, as well as the feature of simple operation. It is especially suitable for detecting substances without ultraviolet absorption. This paper briefly summarizes the working principle and detection characteristics of CAD detector and its application in the analysis fields of traditional Chinese medicine and natural products, chemical drugs, sugars, biochemical drugs, pharmaceutic adjuvant and surfactants, so as to provide reference for its better application in the liquid chromatographic analysis.

, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Xue-song WU, Yong-sheng LEI, Mu-jun ZHANG, Wei CHEN, Yi PAN, Hua CHEN), CN=ArticleExt(id=1236342824451494469, articleId=1236342823927206444, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=电喷雾检测器的工作特点及其在药物分析中的应用进展, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

电喷雾检测器（CAD）是近年来发展迅速的新型通用型液相色谱检测器，具有灵敏度高、线性范围宽、不依赖于化学结构的响应一致性和操作简便等优势，尤其适用于无紫外吸收物质的检测。本文简要综述了CAD检测器的工作原理、检测特点及其在中药及天然产物、化学药物、糖类物质、生化药物、药用辅料及表面活性剂等分析领域的应用，为其更好地应用于液相色谱分析检测提供参考。

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吴雪松，男，硕士，研究方向：药物质量分析研究。E-mail: wuxuesong@tipr.com.cn。

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吴雪松，男，硕士，研究方向：药物质量分析研究。E-mail: wuxuesong@tipr.com.cn。

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