Article(id=1236335231804952900, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236335227262529633, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1678636800000, acceptedDateStr=2023-03-13, onlineDate=1772694889259, onlineDateStr=2026-03-05, pubDate=1696003200000, pubDateStr=2023-09-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772694889259, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772694889259, creator=13701087609, updateTime=1772694889259, updator=13701087609, issue=Issue{id=1236335227262529633, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='18', pageStart='1801', pageEnd='1904', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772694888176, creator=13701087609, updateTime=1772694973637, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236335585770656362, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236335227262529633, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236335585770656363, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236335227262529633, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1837, endPage=1842, ext={EN=ArticleExt(id=1236335232052416846, articleId=1236335231804952900, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Review of in vitro potency assays for CAR-T cell therapy products, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

As the use of cell therapy products such as chimeric antigen receptor T cells (CAR-T) is getting matured, there has been an increasing interest in the methods used to test the quality of cell therapy products. In vitro viability assay is an important method for evaluating the effectiveness of cell therapy products and is also widely used in the product release process because of its simplicity and rapidity. In this paper, we review the in vitro potency determination methods for cell therapy products such as CAR-T from the perspective of both effector cells and target cells.

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随着嵌合抗原受体T细胞（chimeric antigen receptor T cell, CAR-T）等细胞治疗产品的应用走向成熟，其产品质量的检测方法也日渐受到关注。体外活力是评价细胞治疗产品有效性的重要方法，体外效力测定方法也以其简单、快速的特点，在产品放行过程中被广泛采用。本文从效应细胞及靶细胞这2个角度对CAR-T等细胞治疗产品体外效力测定方法进行综述。

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王自强，男，副主任药师，研究方向：分子生物学。E-mail: ycwzq0219@126.com。

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王自强，男，副主任药师，研究方向：分子生物学。E-mail: ycwzq0219@126.com。

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