Article(id=1236335231058374925, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236335227262529633, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1671984000000, acceptedDateStr=2022-12-26, onlineDate=1772694889081, onlineDateStr=2026-03-05, pubDate=1696003200000, pubDateStr=2023-09-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772694889081, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772694889081, creator=13701087609, updateTime=1772694889081, updator=13701087609, issue=Issue{id=1236335227262529633, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='18', pageStart='1801', pageEnd='1904', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772694888176, creator=13701087609, updateTime=1772694973637, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236335585770656362, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236335227262529633, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236335585770656363, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236335227262529633, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1858, endPage=1865, ext={EN=ArticleExt(id=1236335231331004695, articleId=1236335231058374925, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=An updated review on dosage regimen and therapeutic drug monitoring of caffeine for treating apnea of prematurity, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Caffeine is the drug of choice for the treatment of apnea of prematurity. Although it has been used abroad for nearly 50 years, it has only begun to be widely used in China in recent years. There is still no consensus on the timing of caffeine initiation and discontinuation at home and abroad up to now. The efficacy and safety of caffeine under the standard-dose regimen have been confirmed, but the apnea symptoms of some preterm infants are still poorly controlled. The high-dose regimen is more effective, but the potential adverse effects are still worrisome. In addition, the necessity for the therapeutic drug monitoring of caffeine remains debatable since the effective blood concentration range is still controversial. Therefore, the pharmacokinetic characteristics of caffeine in premature infants, as well as the efficacy, safety, and effective blood concentration range under different dosage regimens were summarized. Of note, the research progress of the therapeutic drug monitoring and dose regimen optimization of caffeine were also discussed.

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咖啡因是治疗早产儿呼吸暂停的首选药物，尽管已在国外应用了近50年，但近些年才开始在国内广泛使用。目前国内外对于咖啡因的用药时机和停药时间仍未达成共识。咖啡因在标准剂量方案下的疗效与安全性均已被证实，但对部分早产儿的呼吸暂停症状控制不佳。高剂量方案对早产儿呼吸暂停更有效，但潜在的不良反应同样令人担忧。此外，由于有效血药浓度范围还存在争议，对咖啡因进行治疗药物监测的必要性仍值得讨论。为此，本文总结了咖啡因在早产儿中的药动学特征及不同给药方案下的疗效、安全性和有效血药浓度范围，并对咖啡因的治疗药物监测与给药方案优化相关研究进展进行综述。

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代浩然，男，硕士研究生，主要从事临床药理学研究。联系电话：(025)83117210，E-mail: daihaoran1212@foxmail.com。

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代浩然，男，硕士研究生，主要从事临床药理学研究。联系电话：(025)83117210，E-mail: daihaoran1212@foxmail.com。

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