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Oil APIs for injection extracted from animals and plants mainly used in fat emulsions. Based on the requirements of relevant regulations, guidelines, and review experience in recent years, this paper expounds some considerations on the study of oil APIs for injection extracted from animals and plants, including starting materials and process control, impurity control, validation of virus inactivation/removal process, quality research, etc, in order to provide some references for future research.

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供注射用动植物提取油类原料药主要应用于脂肪乳类制剂。现结合相关法规、指导原则的要求以及近年的审评经验,阐述供注射用动植物提取油类原料药研究的一些考虑,包括起始原料及过程控制、杂质控制、病毒灭活/去除工艺验证、质量研究等,旨在为后续研发提供参考。

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白玉,女,博士研究生,高级审评员,主要从事药品审评工作。E-mail:
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刘丹杏,女,审评员,主要从事化学药品审评工作。E-mail:

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刘丹杏,女,审评员,主要从事化学药品审评工作。E-mail:

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供注射用动植物提取油类原料药研究的考虑
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刘丹杏 , 安珍珍 , 吴小飞 , 王宏亮 , 白玉
中国新药杂志 | 新药注册与审评技术 2023,32(18): 1828-1831
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中国新药杂志 | 新药注册与审评技术 2023, 32(18): 1828-1831
供注射用动植物提取油类原料药研究的考虑
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刘丹杏 , 安珍珍, 吴小飞, 王宏亮, 白玉
作者信息
  • 国家药品监督管理局药品审评中心,北京 100022
  • 刘丹杏,女,审评员,主要从事化学药品审评工作。E-mail:

通讯作者:

白玉,女,博士研究生,高级审评员,主要从事药品审评工作。E-mail:
Considerations on the study of oil APIs for injection extracted from animals and plants
Dan-xing LIU , Zhen-zhen AN, Xiao-fei WU, Hong-liang WANG, Yu BAI
Affiliations
  • Center for Drug Evaluation, National Medical Products Administration, Beijing 100022, China
出版时间: 2023-09-30
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供注射用动植物提取油类原料药主要应用于脂肪乳类制剂。现结合相关法规、指导原则的要求以及近年的审评经验,阐述供注射用动植物提取油类原料药研究的一些考虑,包括起始原料及过程控制、杂质控制、病毒灭活/去除工艺验证、质量研究等,旨在为后续研发提供参考。

供注射用动植物提取油类原料药  /  药学研发  /  过程控制

Oil APIs for injection extracted from animals and plants mainly used in fat emulsions. Based on the requirements of relevant regulations, guidelines, and review experience in recent years, this paper expounds some considerations on the study of oil APIs for injection extracted from animals and plants, including starting materials and process control, impurity control, validation of virus inactivation/removal process, quality research, etc, in order to provide some references for future research.

oil APIs for injection extracted from animals and plants  /  pharmaceutical research  /  process control
刘丹杏, 安珍珍, 吴小飞, 王宏亮, 白玉. 供注射用动植物提取油类原料药研究的考虑. 中国新药杂志, 2023 , 32 (18) : 1828 -1831 .
Dan-xing LIU, Zhen-zhen AN, Xiao-fei WU, Hong-liang WANG, Yu BAI. Considerations on the study of oil APIs for injection extracted from animals and plants[J]. Chinese Journal of New Drugs, 2023 , 32 (18) : 1828 -1831 .
2023年第32卷第18期
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  • 首发时间:2026-03-05
  • 出版时间:2023-09-30
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  • 录用日期:2023-04-25
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作者信息
    国家药品监督管理局药品审评中心,北京 100022

通讯作者:

白玉,女,博士研究生,高级审评员,主要从事药品审评工作。E-mail:
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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