Article(id=1236335228847976575, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236335227262529633, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1667404800000, acceptedDateStr=2022-11-03, onlineDate=1772694888554, onlineDateStr=2026-03-05, pubDate=1696003200000, pubDateStr=2023-09-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772694888554, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772694888554, creator=13701087609, updateTime=1772694888554, updator=13701087609, issue=Issue{id=1236335227262529633, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='18', pageStart='1801', pageEnd='1904', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772694888176, creator=13701087609, updateTime=1772694973637, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236335585770656362, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236335227262529633, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236335585770656363, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236335227262529633, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1850, endPage=1857, ext={EN=ArticleExt(id=1236335229045108874, articleId=1236335228847976575, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Research progress in application of low toxic fumagillin in medicine field, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Fumagillin is a natural insoluble antibiotic isolated and purified from the liquid fermentation medium of Aspergillus fumigatus. Fumagillin and its derivatives have been found to have a variety of biological activities such as anti-tumor, anti-obesity and anti-microsporidiosis, so they are widely used in the field of medicine. The molecular structure properties, biological activity, application and mechanism of action of fumagillin and its several common derivatives based on C6 site modification, such as fumagillin B, TNP-470, CKD-732 and PPI-2458 are reviewed in this article, and the separation and purification process, activity research and application prospect are prospected in order to provide reference for the further application of low toxic fumagillin and its derivatives in clinical practice and research.

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烟曲霉素是从烟曲霉菌的液体发酵培养液中分离纯化得到的一种天然不溶于水的抗生素。烟曲霉素及其衍生物具有抗肿瘤、抗肥胖和治疗微孢子虫病等多种生物活性，被广泛应用于医药领域。本文主要综述了烟曲霉素及其基于C6位结构修饰的几种常见衍生物Fumagillin B，TNP-470，CKD-732及PPI-2458的分子结构性质、生物活性、应用及作用机制等，并对其分离纯化工艺、活性研究和应用前景进行了展望，以期为低毒性烟曲霉素类药物在医药治疗和临床研究领域的进一步应用提供参考。

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王彬，男，硕士研究生，主要从事天然药物生物技术。E-mail: 1095344707@qq.com。

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王彬，男，硕士研究生，主要从事天然药物生物技术。E-mail: 1095344707@qq.com。

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