Article(id=1236334169203200478, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236334167978472434, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1662998400000, acceptedDateStr=2022-09-13, onlineDate=1772694635916, onlineDateStr=2026-03-05, pubDate=1689350400000, pubDateStr=2023-07-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772694635916, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772694635916, creator=13701087609, updateTime=1772694635916, updator=13701087609, issue=Issue{id=1236334167978472434, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='13', pageStart='1281', pageEnd='1384', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=0, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772694635624, creator=13701087609, updateTime=1772696111905, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236340360004292707, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236334167978472434, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236340360004292708, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236334167978472434, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1285, endPage=1292, ext={EN=ArticleExt(id=1236334169467441631, articleId=1236334169203200478, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=The selection of comparators for health technology assessment: international experience and enlightenment, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

The health decision will be impacted by the selection of different comparators that influence the results of the comparative effectiveness and incremental cost-effectiveness analysis. With the application of health technology assessment in assistent of health decision-making, the selection of comparators has gradually received stakeholders' attention. Focusing on the comparators selection, this study systematically reviews the health technology assessment guidelines and comparator selection guidelines published by seven countries and regions including China Taiwan, Japan, the United Kingdom, Germany, Canada, Australia, the United States and international organizations based on a literature review. Meanwhile, taking the selection of comparators as an example in the health technology evaluation report of chimeric antigen receptor T-cell (CAR-T) immunotherapy therapies when applying for medical insurance access in different countries, the international experience is summarized from the selection process, criteria, methods, usage and other dimensions. To deal with the current issues discussed in this study, the decision-making departments and stakeholders need to determine the comparators before the beginning of the evaluation, establish a two-way communication and feedback mechanism, determine the selection criteria and methods based on different decision-making purposes and uses, and select flexible response options for special circumstances, so as to provide reference for optimizing the selection of comparators in drug value evaluation.

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选择不同的参照品会影响药品相对疗效评估及增量成本效果分析的结果，从而影响决策。随着卫生技术评估结果用于辅助决策，参照品的遴选逐渐受到业内关注。针对参照品遴选过程中讨论的焦点，本研究通过文献综述系统性回顾中国台湾地区、日本、英国、德国、加拿大、澳大利亚、美国等7个国家或地区及国际组织公布的卫生技术评估指南和参照品遴选指南，并以嵌合抗原受体T细胞（CAR-T）免疫疗法在不同国家或地区申请医保准入时，其卫生技术评估报告中参照药品的遴选为例，从遴选流程、标准、方法、用途等维度总结参照品遴选的国际经验。本研究认为针对当前讨论的问题，决策部门需要与利益相关方在评估开始前确定参照品，建立双向沟通反馈机制，基于不同的决策目的和用途确定遴选标准及方法，同时针对特殊情况选择灵活的应对方案，为优化药品价值评估中参照药品的遴选提供参考。

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艾丹丹，女，助理研究员，主要从事药物经济学评价与卫生技术评估研究。E-mail: cpuputi52@163.com。

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艾丹丹，女，助理研究员，主要从事药物经济学评价与卫生技术评估研究。E-mail: cpuputi52@163.com。

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