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Lazertinib is a highly effective, oral and irreversible third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (EGFR-TKI). On January 18, 2021, the Korea Ministry of Food and Drug Safety (MFDS) first approved lazertinib for the treatment of patients with EGFR T790M mutation-positive locally advanced or metastatic non-small cell lung cancer, who previously received EGFR-TKI treatment. This article introduces lazertinib's mechanism of action, pharmacokinetics, pharmacodynamics, clinical research, safety evaluation, etc.

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拉泽替尼是一款高效、口服、不可逆的第3代表皮生长因子受体（EGFR）酪氨酸激酶抑制剂（EGFR-TKI），2021年1月18日，韩国食品药品安全处（MFDS）首次批准拉泽替尼用于治疗先前接受过EGFR-TKI治疗的EGFR T790M突变阳性局部晚期或转移性非小细胞肺癌患者。本文就其作用机制、药动学、药效学、临床研究、安全性评价等方面信息进行介绍。

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黄璐，男，高级工程师，主要从事药品与医疗器械开发以及生物医药知识产权工作。E-mail: 47153437@qq.com。

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黄璐，男，高级工程师，主要从事药品与医疗器械开发以及生物医药知识产权工作。E-mail: 47153437@qq.com。

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