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Article(id=1236334086747386467, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236334083500995077, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1677427200000, acceptedDateStr=2023-02-27, onlineDate=1772694616256, onlineDateStr=2026-03-05, pubDate=1690646400000, pubDateStr=2023-07-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772694616256, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772694616256, creator=13701087609, updateTime=1772694616256, updator=13701087609, issue=Issue{id=1236334083500995077, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='14', pageStart='1385', pageEnd='1488', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=0, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772694615483, creator=13701087609, updateTime=1772696065206, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236340164130295845, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236334083500995077, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236340164130295846, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236334083500995077, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1417, endPage=1422, ext={EN=ArticleExt(id=1236334086994850412, articleId=1236334086747386467, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Research progress in flavor correction and mask technology for traditional Chinese medicine oral liquids for children, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Taste masking is one of the key issues to improve drug compliance in children during the development of oral liquid preparations of traditional Chinese medicine (TCM). Because different families of TCM contain different odors, and TCMs are generally used as compound preparations in clinical practice, the taste usually presents a complex blend phenomenon. At present, the main methods to improve the taste of TCM oral liquids are medicinal materials processing, pre-treatment, preparation technology modification, adding auxiliary materials and so on. but the masking effect and application range of various masking methods are different. In practical application, the masking methods should be selected according to the drug type, dosage form and equipment needs. This paper summarizes the classification, application and new taste masking technology of TCM oral liquid preparations for children by sorting and analyzing relevant journals and patents, so as to provide reference for the research on this kind of pharmaceutical preparations.

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儿童中药口服液体制剂研发过程中矫掩味是提高儿童用药顺应性的关键问题之一。由于不同科属的中药含有不同的气味，且临床上中药制剂一般都以复方配伍，所以味道口感通常呈现出复杂交融的现象。目前改善中药口服液口感主要在炮制、前处理、工艺、添加辅料等方面进行矫掩味处理，但是各种矫掩味方法的效果和适用范围不同，在实际运用中也应根据药物的类型、剂型和设备需要来选择方法。本文通过对相关期刊文献和专利等整理和分析，对儿童中药口服液体制剂矫掩味辅料的分类、应用以及新型掩味技术进展等进行归纳总结，以期对儿童中药口服液体制剂的矫掩味研究提供参考。

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郑稳生，男，教授，博士生导师，主要从事中、西药物新制剂及新释药系统关键技术研究。联系电话：(010)63165233，E-mail: 。
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马思文，女，硕士研究生，主要从事新药研发与生产工作。E-mail: 。

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马思文，女，硕士研究生，主要从事新药研发与生产工作。E-mail: 。

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马思文，女，硕士研究生，主要从事新药研发与生产工作。E-mail: 。

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儿童中药口服液体矫掩味技术研究进展
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马思文 1, 2 , 孟雅 1 , 车宏伟 1 , 金立群 3 , 何淑旺 4 , 王辉 2 , 谭晓川 1 , 张宇佳 1 , 焦杨 2 , 郑稳生 1
中国新药杂志 | 重大新药创制专项巡礼 2023,32(14): 1417-1422
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中国新药杂志 | 重大新药创制专项巡礼 2023, 32(14): 1417-1422
儿童中药口服液体矫掩味技术研究进展
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马思文1, 2 , 孟雅1, 车宏伟1, 金立群3, 何淑旺4, 王辉2, 谭晓川1, 张宇佳1, 焦杨2, 郑稳生1
作者信息
  • 1北京协和医学院中国医学科学院药物研究所/药物传输技术及新型制剂北京市重点实验室，北京 100050
  • 2广西医科大学，南宁 530021
  • 3吉林华康药业股份有限公司，敦化 133722
  • 4山东达因海洋生物制药有限公司，荣成 264300

    • 马思文，女，硕士研究生，主要从事新药研发与生产工作。E-mail: 。

通讯作者:

郑稳生，男，教授，博士生导师，主要从事中、西药物新制剂及新释药系统关键技术研究。联系电话：(010)63165233，E-mail: 。
Research progress in flavor correction and mask technology for traditional Chinese medicine oral liquids for children
Si-wen MA1, 2 , Ya MENG1, Hong-wei CHE1, Li-qun JIN3, Shu-wang HE4, Hui WANG2, Xiao-chuan TAN1, Yu-jia ZHANG1, Yang JIAO2, Wen-sheng ZHENG1
Affiliations
  • 1Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College/Beijing City Key Laboratory of Drug Delivery Technology and Novel Formulation, Beijing 100050, China
  • 2Guangxi Medical University, Nanning 530021, China
  • 3Jilin Huakang Pharmaceutical Co., Ltd., Dunhua 133722, China
  • 4Shandong Dayin MarineBiopharmaceutical Co., Ltd., Rongcheng 264300, China
出版时间: 2023-07-30
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摘要
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儿童中药口服液体制剂研发过程中矫掩味是提高儿童用药顺应性的关键问题之一。由于不同科属的中药含有不同的气味，且临床上中药制剂一般都以复方配伍，所以味道口感通常呈现出复杂交融的现象。目前改善中药口服液口感主要在炮制、前处理、工艺、添加辅料等方面进行矫掩味处理，但是各种矫掩味方法的效果和适用范围不同，在实际运用中也应根据药物的类型、剂型和设备需要来选择方法。本文通过对相关期刊文献和专利等整理和分析，对儿童中药口服液体制剂矫掩味辅料的分类、应用以及新型掩味技术进展等进行归纳总结，以期对儿童中药口服液体制剂的矫掩味研究提供参考。

中药  /  口服液体制剂  /  儿童药物  /  矫味剂  /  掩味技术

Taste masking is one of the key issues to improve drug compliance in children during the development of oral liquid preparations of traditional Chinese medicine (TCM). Because different families of TCM contain different odors, and TCMs are generally used as compound preparations in clinical practice, the taste usually presents a complex blend phenomenon. At present, the main methods to improve the taste of TCM oral liquids are medicinal materials processing, pre-treatment, preparation technology modification, adding auxiliary materials and so on. but the masking effect and application range of various masking methods are different. In practical application, the masking methods should be selected according to the drug type, dosage form and equipment needs. This paper summarizes the classification, application and new taste masking technology of TCM oral liquid preparations for children by sorting and analyzing relevant journals and patents, so as to provide reference for the research on this kind of pharmaceutical preparations.

traditional Chinese medicine  /  oral liquid preparations  /  medicines for children  /  taste masking agent  /  taste masking technology
马思文, 孟雅, 车宏伟, 金立群, 何淑旺, 王辉, 谭晓川, 张宇佳, 焦杨, 郑稳生. 儿童中药口服液体矫掩味技术研究进展. 中国新药杂志, 2023 , 32 (14) : 1417 -1422 .
Si-wen MA, Ya MENG, Hong-wei CHE, Li-qun JIN, Shu-wang HE, Hui WANG, Xiao-chuan TAN, Yu-jia ZHANG, Yang JIAO, Wen-sheng ZHENG. Research progress in flavor correction and mask technology for traditional Chinese medicine oral liquids for children[J]. Chinese Journal of New Drugs, 2023 , 32 (14) : 1417 -1422 .
基金
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  • 国家重大新药创制科技重大专项资助项目：儿童用药品种及关键技术研发疏清口服液临床前研究(2018ZX09721003-009-003)
  • 中国医学科学院医学与健康科技创新工程基金资助项目(2021-I2M-1-028)
2023年第32卷第14期
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  • 首发时间：2026-03-05
  • 出版时间：2023-07-30
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  • 录用日期：2023-02-27
基金
国家重大新药创制科技重大专项资助项目：儿童用药品种及关键技术研发疏清口服液临床前研究(2018ZX09721003-009-003)
中国医学科学院医学与健康科技创新工程基金资助项目(2021-I2M-1-028)
作者信息
    1北京协和医学院中国医学科学院药物研究所/药物传输技术及新型制剂北京市重点实验室，北京 100050
    2广西医科大学，南宁 530021
    3吉林华康药业股份有限公司，敦化 133722
    4山东达因海洋生物制药有限公司，荣成 264300

通讯作者:

郑稳生，男，教授，博士生导师，主要从事中、西药物新制剂及新释药系统关键技术研究。联系电话：(010)63165233，E-mail: 。
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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