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Omadacycline is a new broad-spectrum antibiotic with excellent pharmacokinetic characteristics and few adverse reactions. It can be used orally or intravenously once daily. Omadacycline is effective against a variety of pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), extended-spectrum beta-lactamase-producing gram-negative bacteria, atypical pathogens, etc. Omadacycline has been approved for the treatment of community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSI) in adults. Through literature review, this paper focused on the pharmacokinetics/pharmacodynamics (PK/PD) characteristics of omadacycline in special patients in recent research, in order to provide reference for clinical medication.

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奥马环素是一种新型的广谱抗生素，其药动学参数优良、不良反应少，可采用每日单剂量口服或静脉用药。奥马环素对多种病原体有效，如耐甲氧西林金黄色葡萄球菌、耐万古霉素肠球菌、产超广谱β-内酰胺酶革兰阴性菌、非典型病原体等。奥马环素已被批准用于治疗成人的社区获得性细菌性肺炎（community-acquired bacterial pneumonia, CABP）以及急性细菌性皮肤和皮肤结构感染（acute bacterial skin and skin structure infections, ABSSSI）。本研究通过查阅文献资料，重点对近期研究进展中的特殊患者进行奥马环素治疗后的药动学/药效学（pharmacokinetics/pharmacodynamics, PK/PD）特点进行综述，以期为临床用药提供参考。

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陈明毅，女，硕士，主管药师，研究方向：临床药学。联系电话：(020)87755766，E-mail: chenmy98@mail.sysu.edu.cn。

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陈明毅，女，硕士，主管药师，研究方向：临床药学。联系电话：(020)87755766，E-mail: chenmy98@mail.sysu.edu.cn。

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