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Article(id=1236331826587947159, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236331822909550881, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1696608000000, acceptedDateStr=2023-10-07, onlineDate=1772694077392, onlineDateStr=2026-03-05, pubDate=1701273600000, pubDateStr=2023-11-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772694077392, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772694077392, creator=13701087609, updateTime=1772694077392, updator=13701087609, issue=Issue{id=1236331822909550881, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='22', pageStart='2225', pageEnd='2328', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772694076516, creator=13701087609, updateTime=1772696919965, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236343749253591892, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236331822909550881, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236343749253591893, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236331822909550881, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=2257, endPage=2263, ext={EN=ArticleExt(id=1236331826814439585, articleId=1236331826587947159, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=A retrospective study of rituximab for treatment of lupus mesenteric vasculitis and improvement of intestinal damage, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To analyze the clinical efficacy of rituximab by comparing the changes of clinical manifestations, immunological features, imaging tests and human lipopolysaccharids-binding protein (LBP) before and after rituximab treatment in patients with lupus mesenteric vasculitis (LMV).

Methods:

A total of 10 patients diagnosed with secondary LMV of systemic lupus erythematosus (SLE) in the Department of Rheumatology and Immunology of Peking University People's Hospital from January 2011 to May 2023 who were treated with rituximab were enrolled. Their clinical characteristics, laboratory results, efficacy and prognosis data were analyzed, and the level of intestinal injury marker LBP before and after treatment was analyzed.

Results:

The clinical symptoms of 10 LMV patients were significantly improved after rituximab treatment, abdominal pain lessened or disappeared (P=0.003), gastrointestinal wall thickening and edema alleviated or disappeared (P=0.000), intestinal obstruction/perforation relieved (P=0.025), IgG declined (P=0.032), complement 3 rebounded (P=0.047), the percentage of B lymphocytes decreased (P=0.022), and SLEDAI scores decreased (P=0.005). LMV remission rate was 100%, while the recurrence rate was 10%. LBP concentration decreased significantly after rituximab treatment [(8.94±6.37) μg·mL-1 vs (2.89±3.21) μg·mL-1, P=0.04].

Conclusion:

Rituximab combined with glucocorticoid therapy can effectively improve serum immunological features, imaging tests and intestinal damage in patients with lupus mesenteric vasculitis, and has good clinical effect. Human lipopolysaccharide-binding protein is expected to be an index for evaluating and monitoring intestinal injury in lupus mesenteric vasculitis.

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目的：

通过比较利妥昔单抗治疗狼疮肠系膜血管炎（LMV）患者前后的临床表现、免疫指标、影像学以及人脂多糖结合蛋白（LBP）的变化，分析该治疗的临床有效性以及对肠道损伤的缓解作用。

方法：

回顾性分析2011年1月至2023年5月在北京大学人民医院风湿免疫科诊断为系统性红斑狼疮（SLE）继发LMV并使用利妥昔单抗治疗的患者共10例，分析其临床特点、实验室检查结果、疗效及预后，并且测定治疗前后的肠道损伤标志物LBP水平。

结果：

10例LMV患者经利妥昔单抗治疗后，临床症状明显改善，腹痛减轻或消失（P=0.003），胃肠壁增厚水肿减轻或消失（P=0.000），肠梗阻/肠穿孔解除（P=0.025），IgG降低（P=0.032），补体C3回升（P=0.047），B淋巴细胞百分比下降（P=0.022），SLEDAI评分下降（P=0.005），LMV缓解率100%，复发率10%。利妥昔单抗治疗后LBP浓度显著下降［（8.94±6.37） μg·mL-1 vs （2.89±3.21） μg·mL-1，P=0.04］。

结论：

利妥昔单抗联合糖皮质激素治疗可有效改善狼疮肠系膜血管炎患者血清免疫学指标、影像学及肠道损伤，具有良好的临床疗效，LBP有望成为狼疮肠系膜血管炎肠道损伤的评估及监测指标。

, correspAuthors=null, authorNote=null, correspAuthorsNote=
金月波，女，博士研究生，主要从事系统性红斑狼疮、干燥综合征等自身免疫病发病机制与临床研究。联系电话：(010)88326452，E-mail: 。
何菁，女，博士生导师，教授，主任医师，主要从事系统性红斑狼疮、干燥综合征等自身免疫病发病机制与临床研究。联系电话：(010)88326452，E-mail: 。
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共同第一作者

王蓓，女，主治医师，主要从事风湿免疫病临床研究。联系电话：(0855)8218256，E-mail: 。

程功，男，博士研究生，主要从事风湿免疫病临床研究。联系电话：(010)88326452，E-mail: 。

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王蓓，女，主治医师，主要从事风湿免疫病临床研究。联系电话：(0855)8218256，E-mail: 。

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王蓓，女，主治医师，主要从事风湿免疫病临床研究。联系电话：(0855)8218256，E-mail: 。

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程功，男，博士研究生，主要从事风湿免疫病临床研究。联系电话：(010)88326452，E-mail: 。

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程功，男，博士研究生，主要从事风湿免疫病临床研究。联系电话：(010)88326452，E-mail: 。

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利妥昔单抗治疗狼疮肠系膜血管炎并改善肠道损伤的回顾性研究
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王蓓 1, 2 , 程功 1 , 李浩 1 , 王乃迪 1 , 赵亚云 1, 3 , 冯瑞玲 1 , 金月波 1 , 何菁 1
中国新药杂志 | 风湿免疫疾病药物治疗专题 2023,32(22): 2257-2263
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中国新药杂志 | 风湿免疫疾病药物治疗专题 2023, 32(22): 2257-2263
利妥昔单抗治疗狼疮肠系膜血管炎并改善肠道损伤的回顾性研究
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王蓓1, 2 , 程功1 , 李浩1, 王乃迪1, 赵亚云1, 3, 冯瑞玲1, 金月波1 , 何菁1
作者信息
  • 1北京大学人民医院风湿免疫科，北京 100044
  • 2贵州省黔东南州人民医院风湿免疫科，凯里 556000
  • 3河北省中医院风湿病科，石家庄 050000

    • 王蓓，女，主治医师，主要从事风湿免疫病临床研究。联系电话：(0855)8218256，E-mail: 。

    程功，男，博士研究生，主要从事风湿免疫病临床研究。联系电话：(010)88326452，E-mail: 。

通讯作者:

金月波，女，博士研究生，主要从事系统性红斑狼疮、干燥综合征等自身免疫病发病机制与临床研究。联系电话：(010)88326452，E-mail: 。
何菁，女，博士生导师，教授，主任医师，主要从事系统性红斑狼疮、干燥综合征等自身免疫病发病机制与临床研究。联系电话：(010)88326452，E-mail: 。
A retrospective study of rituximab for treatment of lupus mesenteric vasculitis and improvement of intestinal damage
Bei WANG1, 2 , Gong CHENG1 , Hao LI1, Nai-di WANG1, Ya-yun ZHAO1, 3, Rui-ling FENG1, Yue-bo JIN1 , Jing HE1
Affiliations
  • 1Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China
  • 2Department of Rheumatology and Immunology, Qiandongnan People's Hospital, Guizhou Province, Kaili 556000, China
  • 3Department of Rheumatology, Hebei Hospital of Traditional Chinese Medicine, Shijiazhuang 050000, China
出版时间: 2023-11-30
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摘要
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目的：

通过比较利妥昔单抗治疗狼疮肠系膜血管炎（LMV）患者前后的临床表现、免疫指标、影像学以及人脂多糖结合蛋白（LBP）的变化，分析该治疗的临床有效性以及对肠道损伤的缓解作用。

方法：

回顾性分析2011年1月至2023年5月在北京大学人民医院风湿免疫科诊断为系统性红斑狼疮（SLE）继发LMV并使用利妥昔单抗治疗的患者共10例，分析其临床特点、实验室检查结果、疗效及预后，并且测定治疗前后的肠道损伤标志物LBP水平。

结果：

10例LMV患者经利妥昔单抗治疗后，临床症状明显改善，腹痛减轻或消失（P=0.003），胃肠壁增厚水肿减轻或消失（P=0.000），肠梗阻/肠穿孔解除（P=0.025），IgG降低（P=0.032），补体C3回升（P=0.047），B淋巴细胞百分比下降（P=0.022），SLEDAI评分下降（P=0.005），LMV缓解率100%，复发率10%。利妥昔单抗治疗后LBP浓度显著下降［（8.94±6.37） μg·mL-1 vs （2.89±3.21） μg·mL-1，P=0.04］。

结论：

利妥昔单抗联合糖皮质激素治疗可有效改善狼疮肠系膜血管炎患者血清免疫学指标、影像学及肠道损伤，具有良好的临床疗效，LBP有望成为狼疮肠系膜血管炎肠道损伤的评估及监测指标。

利妥昔单抗  /  狼疮肠系膜血管炎  /  肠道损伤  /  人脂多糖结合蛋白
Objective:

To analyze the clinical efficacy of rituximab by comparing the changes of clinical manifestations, immunological features, imaging tests and human lipopolysaccharids-binding protein (LBP) before and after rituximab treatment in patients with lupus mesenteric vasculitis (LMV).

Methods:

A total of 10 patients diagnosed with secondary LMV of systemic lupus erythematosus (SLE) in the Department of Rheumatology and Immunology of Peking University People's Hospital from January 2011 to May 2023 who were treated with rituximab were enrolled. Their clinical characteristics, laboratory results, efficacy and prognosis data were analyzed, and the level of intestinal injury marker LBP before and after treatment was analyzed.

Results:

The clinical symptoms of 10 LMV patients were significantly improved after rituximab treatment, abdominal pain lessened or disappeared (P=0.003), gastrointestinal wall thickening and edema alleviated or disappeared (P=0.000), intestinal obstruction/perforation relieved (P=0.025), IgG declined (P=0.032), complement 3 rebounded (P=0.047), the percentage of B lymphocytes decreased (P=0.022), and SLEDAI scores decreased (P=0.005). LMV remission rate was 100%, while the recurrence rate was 10%. LBP concentration decreased significantly after rituximab treatment [(8.94±6.37) μg·mL-1 vs (2.89±3.21) μg·mL-1, P=0.04].

Conclusion:

Rituximab combined with glucocorticoid therapy can effectively improve serum immunological features, imaging tests and intestinal damage in patients with lupus mesenteric vasculitis, and has good clinical effect. Human lipopolysaccharide-binding protein is expected to be an index for evaluating and monitoring intestinal injury in lupus mesenteric vasculitis.

rituximab  /  lupus mesenteric vasculitis  /  intestinal injury  /  human lipopolysaccharide binding protein
王蓓, 程功, 李浩, 王乃迪, 赵亚云, 冯瑞玲, 金月波, 何菁. 利妥昔单抗治疗狼疮肠系膜血管炎并改善肠道损伤的回顾性研究. 中国新药杂志, 2023 , 32 (22) : 2257 -2263 .
Bei WANG, Gong CHENG, Hao LI, Nai-di WANG, Ya-yun ZHAO, Rui-ling FENG, Yue-bo JIN, Jing HE. A retrospective study of rituximab for treatment of lupus mesenteric vasculitis and improvement of intestinal damage[J]. Chinese Journal of New Drugs, 2023 , 32 (22) : 2257 -2263 .
基金
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  • 国家重点研发计划“政府间国际科技创新合作”(2022YFE0131700)
  • 国家自然科学基金面上项目(82071813)
  • 北京大学人民医院研究与发展基金(RDZH2022-03)
  • 河北省中医药管理局科研计划项目(2021039)
2023年第32卷第22期
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  • 首发时间：2026-03-05
  • 出版时间：2023-11-30
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  • 录用日期：2023-10-07
基金
国家重点研发计划“政府间国际科技创新合作”(2022YFE0131700)
国家自然科学基金面上项目(82071813)
北京大学人民医院研究与发展基金(RDZH2022-03)
河北省中医药管理局科研计划项目(2021039)
作者信息
    1北京大学人民医院风湿免疫科，北京 100044
    2贵州省黔东南州人民医院风湿免疫科，凯里 556000
    3河北省中医院风湿病科，石家庄 050000

通讯作者:

金月波，女，博士研究生，主要从事系统性红斑狼疮、干燥综合征等自身免疫病发病机制与临床研究。联系电话：(010)88326452，E-mail: 。
何菁，女，博士生导师，教授，主任医师，主要从事系统性红斑狼疮、干燥综合征等自身免疫病发病机制与临床研究。联系电话：(010)88326452，E-mail: 。
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species		 占总种数比例
Percentage of
total species (%)		 属
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species		 占总种数比例
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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