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Infection is a great challenge that threatens human health today. The immune system consists of cells, tissues, and molecules in the body that work together to protect against foreign pathogens, such as infections, to maintain health. Infection triggers an immune response, but dysfunction of T cells, B cells and NK cells has the potential to predispose patients to infection and reduce the clearance or suppression of pathogenic microorganisms. Since interleukin-2 (IL-2) has been shown to stimulate and up-regulate the function and number of CD₄⁺ T cells and CD₈⁺ T cells, it has been widely reported that IL-2 can increase anti-infective function and clinical efficacy in the treatment of a variety of chronic infectious diseases. This article reviews the possible mechanism of IL-2 in infection immunity and related clinical trials, aiming to provide a reference for the prevention and treatment of chronic infectious diseases with low dose of IL-2.

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感染是当前威胁人类健康的一大挑战。免疫系统是人体内的一组复杂的细胞、组织和分子，协同作用来对抗外来病原体，例如感染，从而保持身体健康。感染会引起免疫应答，然而免疫应答减弱如T细胞、B细胞和NK细胞等的功能障碍可能会使患者容易感染，降低对病原微生物的清除或者抑制。由于白细胞介素-2（IL-2）被证明可以刺激并上调CD₄⁺ T细胞、CD₈⁺ T细胞功能和数量，因此其增加抗感染功能的机制和临床上治疗多种慢性感染性疾病的疗效被广泛报道。本文对IL-2在感染免疫中发挥的可能机制以及临床试验进行综述，以期为低剂量IL-2在慢性感染性疾病中的预防和治疗提供可借鉴的思路。

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朱颜，女，在读博士生，主要从事风湿免疫学研究。E-mail: 1810301248@pku.edu.cn。

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朱颜，女，在读博士生，主要从事风湿免疫学研究。E-mail: 1810301248@pku.edu.cn。

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