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Article(id=1236331824604049731, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236331822909550881, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1673193600000, acceptedDateStr=2023-01-09, onlineDate=1772694076919, onlineDateStr=2026-03-05, pubDate=1701273600000, pubDateStr=2023-11-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772694076919, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772694076919, creator=13701087609, updateTime=1772694076919, updator=13701087609, issue=Issue{id=1236331822909550881, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='22', pageStart='2225', pageEnd='2328', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772694076516, creator=13701087609, updateTime=1772696919965, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236343749253591892, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236331822909550881, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236343749253591893, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236331822909550881, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=2324, endPage=2328, ext={EN=ArticleExt(id=1236331824889262419, articleId=1236331824604049731, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Retrospective analysis of 208 nephrology patients in the treatment of roxadustat, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To analyze the characteristics of roxadustat utilization in our hospital's renal division, promote rational use of roxadustat, and provide evidence for a post-marketing study.

Methods:

A retrospective study was conducted. The clinical data of hospitalized patients treated with roxadustat from July 1st, 2021, to June 30th, 2022, in the renal division of our hospital were collected and analyzed.

Results:

A total of 208 medical records were included. Twenty-two (10.6%) acute kidney injury patients with anemia without the diagnosis of chronic kidney disease were treated with roxadustat. The average single dose of dialysis patients was significantly higher than that of non-dialysis patients (77.85 vs 67.37 mg, P=0.03). Sixty-three patients (30.3%) received statins, and 27 (13.0%) received sevelamer. There was significant difference between hemoglobin levels at baseline and discharge (84.80 vs 89.43 g·L-1, P=0.007). No adverse events occurred in any patient.

Conclusion:

The tolerability and safety were good in anemia patients in the renal division who were treated with roxadustat. However, there existed a few problems, such as off-label drug use, subtherapeutic dosage and drug-drug interactions. It is necessary to strengthen the intervention of clinical pharmacists and promote the rational use of roxadustat.

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目的：

分析罗沙司他在我院肾内科的应用特点，为促进药物合理应用和药物上市后研究提供参考。

方法：

采用回顾性分析方法，调取我院肾内科2021年7月1日—2022年6月30日应用罗沙司他住院患者临床资料，分析药物使用情况。

结果：

共纳入208份使用了罗沙司他的患者病历，其中急性肾损伤伴贫血（无慢性肾脏病诊断）的患者22例（10.6%），透析患者平均单次剂量显著高于非透析患者（77.85 vs 67.37 mg，P=0.03），63例（30.3%）合并他汀类降脂药，27例（13.0%）合并司维拉姆，患者入院和出院血红蛋白（Hb）水平存在显著性差异（84.80 vs 89.43 g·L-1，P=0.007），所有患者未发生不良事件。

结论：

肾内科患者使用罗沙司他治疗贫血效果显著、耐受性良好，但少数仍存在超说明书用药、用药剂量偏低、合并相互作用药物等问题。临床药师应积极开展药物利用评价以促进罗沙司他的合理使用。

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崔一民，男，主任药师，教授，博士生导师，研究方向：临床药理和临床药学。联系电话：(010)66155258，E-mail: 。
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种姗，女，在读硕士研究生，主要从事临床药学的相关研究。E-mail: 。

谢秋芬，女，主管药师，硕士研究生，主要从事临床药学的相关研究。E-mail: 。

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谢秋芬，女，主管药师，硕士研究生，主要从事临床药学的相关研究。E-mail: 。

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208例肾内科患者应用罗沙司他的回顾性分析
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种姗 1, 2 , 谢秋芬 1 , 马甜甜 3 , 向倩 1 , 周颖 1 , 崔一民 1, 2, 4
中国新药杂志 | 药物安全与合理应用 2023,32(22): 2324-2328
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中国新药杂志 | 药物安全与合理应用 2023, 32(22): 2324-2328
208例肾内科患者应用罗沙司他的回顾性分析
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种姗1, 2 , 谢秋芬1 , 马甜甜3, 向倩1, 周颖1, 崔一民1, 2, 4
作者信息
  • 1北京大学第一医院药学部，北京 100034
  • 2北京大学药学院药事管理与临床药学系，北京 100191
  • 3北京大学第一医院肾内科，北京 100034
  • 4北京大学第一医院临床药理研究所，北京 100191

    • 种姗，女，在读硕士研究生，主要从事临床药学的相关研究。E-mail: 。

    谢秋芬，女，主管药师，硕士研究生，主要从事临床药学的相关研究。E-mail: 。

通讯作者:

崔一民，男，主任药师，教授，博士生导师，研究方向：临床药理和临床药学。联系电话：(010)66155258，E-mail: 。
Retrospective analysis of 208 nephrology patients in the treatment of roxadustat
Shan CHONG1, 2 , Qiu-fen XIE1 , Tian-tian MA3, Qian XIANG1, Ying ZHOU1, Yi-min CUI1, 2, 4
Affiliations
  • 1Department of Pharmacy, Peking University First Hospital, Beijing 100034, China
  • 2Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
  • 3Renal Division of Peking University First Hospital, Beijing 100034, China
  • 4Institute of Clinical Pharmacology, Peking University First Hospital, Beijing 100191, China
出版时间: 2023-11-30
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摘要
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目的：

分析罗沙司他在我院肾内科的应用特点，为促进药物合理应用和药物上市后研究提供参考。

方法：

采用回顾性分析方法，调取我院肾内科2021年7月1日—2022年6月30日应用罗沙司他住院患者临床资料，分析药物使用情况。

结果：

共纳入208份使用了罗沙司他的患者病历，其中急性肾损伤伴贫血（无慢性肾脏病诊断）的患者22例（10.6%），透析患者平均单次剂量显著高于非透析患者（77.85 vs 67.37 mg，P=0.03），63例（30.3%）合并他汀类降脂药，27例（13.0%）合并司维拉姆，患者入院和出院血红蛋白（Hb）水平存在显著性差异（84.80 vs 89.43 g·L-1，P=0.007），所有患者未发生不良事件。

结论：

肾内科患者使用罗沙司他治疗贫血效果显著、耐受性良好，但少数仍存在超说明书用药、用药剂量偏低、合并相互作用药物等问题。临床药师应积极开展药物利用评价以促进罗沙司他的合理使用。

罗沙司他  /  慢性肾脏病  /  贫血  /  合理用药
Objective:

To analyze the characteristics of roxadustat utilization in our hospital's renal division, promote rational use of roxadustat, and provide evidence for a post-marketing study.

Methods:

A retrospective study was conducted. The clinical data of hospitalized patients treated with roxadustat from July 1st, 2021, to June 30th, 2022, in the renal division of our hospital were collected and analyzed.

Results:

A total of 208 medical records were included. Twenty-two (10.6%) acute kidney injury patients with anemia without the diagnosis of chronic kidney disease were treated with roxadustat. The average single dose of dialysis patients was significantly higher than that of non-dialysis patients (77.85 vs 67.37 mg, P=0.03). Sixty-three patients (30.3%) received statins, and 27 (13.0%) received sevelamer. There was significant difference between hemoglobin levels at baseline and discharge (84.80 vs 89.43 g·L-1, P=0.007). No adverse events occurred in any patient.

Conclusion:

The tolerability and safety were good in anemia patients in the renal division who were treated with roxadustat. However, there existed a few problems, such as off-label drug use, subtherapeutic dosage and drug-drug interactions. It is necessary to strengthen the intervention of clinical pharmacists and promote the rational use of roxadustat.

roxadustat  /  chronic kidney disease  /  anemia  /  rational drug use
种姗, 谢秋芬, 马甜甜, 向倩, 周颖, 崔一民. 208例肾内科患者应用罗沙司他的回顾性分析. 中国新药杂志, 2023 , 32 (22) : 2324 -2328 .
Shan CHONG, Qiu-fen XIE, Tian-tian MA, Qian XIANG, Ying ZHOU, Yi-min CUI. Retrospective analysis of 208 nephrology patients in the treatment of roxadustat[J]. Chinese Journal of New Drugs, 2023 , 32 (22) : 2324 -2328 .
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  • 中央高水平医院临床科研业务费资助项目（北京大学第一医院科研种子基金项目(2022SF83)
2023年第32卷第22期
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  • 首发时间：2026-03-05
  • 出版时间：2023-11-30
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  • 录用日期：2023-01-09
基金
中央高水平医院临床科研业务费资助项目（北京大学第一医院科研种子基金项目(2022SF83)
作者信息
    1北京大学第一医院药学部，北京 100034
    2北京大学药学院药事管理与临床药学系，北京 100191
    3北京大学第一医院肾内科，北京 100034
    4北京大学第一医院临床药理研究所，北京 100191

通讯作者:

崔一民，男，主任药师，教授，博士生导师，研究方向：临床药理和临床药学。联系电话：(010)66155258，E-mail: 。
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https://castjournals.cast.org.cn/joweb/zgxyzz/CN/1236331824604049731
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2种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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