Article(id=1236331824423694650, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236331822909550881, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1696867200000, acceptedDateStr=2023-10-10, onlineDate=1772694076877, onlineDateStr=2026-03-05, pubDate=1701273600000, pubDateStr=2023-11-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772694076877, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772694076877, creator=13701087609, updateTime=1772694076877, updator=13701087609, issue=Issue{id=1236331822909550881, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='22', pageStart='2225', pageEnd='2328', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772694076516, creator=13701087609, updateTime=1772696919965, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236343749253591892, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236331822909550881, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236343749253591893, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236331822909550881, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=2240, endPage=2245, ext={EN=ArticleExt(id=1236331824696324425, articleId=1236331824423694650, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=An overview of phosphodiesterase 4 inhibitors in the treatment of rheumatic autoimmune diseases, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To review the application and recent research progress of phosphodiesterase 4 (PDE4) inhibitors in rheumatic autoimmune diseases.
Methods: Through a review of recent relevant literature and guidelines, we explored the latest research progress of PDE4 inhibitors in rheumatic autoimmune diseases such as psoriatic arthritis, Behçet's syndrome, rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, and systemic sclerosis, focusing on their clinical efficacy, safety, and mechanisms of action.
Results: PDE4 inhibitors demonstrated significant clinical efficacy in rheumatic autoimmune diseases, often accompanied by manageable adverse reactions like nausea and diarrhea.
Conclusion: PDE4 inhibitors are safe and effective drugs for treating rheumatic autoimmune illnesses and can improve the quality of life. They hold promising prospects for clinical applications.
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目的： 综述磷酸二酯酶4（phosphodiesterase 4, PDE4）抑制剂在风湿免疫性疾病中的应用及其最新研究进展。
方法： 通过对近年来的相关文献和指南进行综述，探讨PDE4抑制剂在风湿免疫性疾病如银屑病关节炎、白塞综合征、类风湿关节炎、系统性红斑狼疮、强直性脊柱炎、系统性硬化症的临床疗效、安全性以及作用机制等方面的研究进展。
结果： PDE4抑制剂在风湿免疫性疾病中具有显著的临床疗效，常伴随可耐受的恶心、腹泻等不良反应。
结论： PDE4抑制剂是一类安全、有效的药物，在控制风湿免疫性疾病病情和改善生活质量方面发挥了重要作用，具有良好的临床应用前景。
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刘烨玲，女，博士研究生，研究方向：风湿免疫性疾病机制研究。E-mail: ylliu@student.pumc.edu.cn。
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刘烨玲，女，博士研究生，研究方向：风湿免疫性疾病机制研究。E-mail: ylliu@student.pumc.edu.cn。
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