Article(id=1236331740776690662, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236331736221676464, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1701964800000, acceptedDateStr=2023-12-08, onlineDate=1772694056933, onlineDateStr=2026-03-05, pubDate=1699977600000, pubDateStr=2023-11-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772694056933, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772694056933, creator=13701087609, updateTime=1772694056933, updator=13701087609, issue=Issue{id=1236331736221676464, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='21', pageStart='2121', pageEnd='2224', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772694055848, creator=13701087609, updateTime=1772696903836, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236343681607856366, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236331736221676464, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236343681607856367, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236331736221676464, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=2184, endPage=2190, ext={EN=ArticleExt(id=1236331740978017262, articleId=1236331740776690662, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Screening of differential quality markers of Poria from different regions by characteristic fingerprints and chemical pattern recognition, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: The chemical pattern recognition technology was used to analyze the HPLC characteristic fingerprints data of Poria, screen the differential quality markers and perform quantitative analysis, so as to provide scientific basis for quality evaluation of Poria.
Methods: Welch Ultimate Plus C18 chromatographic column (250 mm×4.6 mm, 5 μm) was used. Acetonitrile (containing 0.2% tetrahydrofuran)-0.1% phosphoric acid aqueous solution with gradient elution was used as mobile phase. The fingerprint of Poria was established with detection wavelength set at 222 nm, flow rate at 1 mL·min-1, column temperature at 30 ℃, injection volume at 10 μL. The differential quality markers were identified by similarity analysis, principal component analysis (PCA), cluster analysis (CA) and orthogonal partial least squares-discriminant analysis (OPLS-DA). The quantitative research was carried out in accordance with the requirements of "Guidelines for Validation of Analytical Methods" in Chinese Pharmacopoeia.
Results: The similarity of 15 batches of Poria was between 0.935~0.998. Eight common peaks were calibrated and 6 were identified; The samples were classified according to the origins from PAC results, which is consistent with CA result. Pachymic acid was screened as the differential quality marker of Poria by OPLS-DA. The established method for the determination of pachymic acid was stable, reliable, durable, which meets the requirements of the Pharmacopoeia.
Conclusion: The methods of characteristic fingerprint combined with chemical pattern recognition technology can effectively screen the differential quality marker of Poria from different regions, providing a reference for the establishment of quality standards for Poria.
, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Peng-hui LI, Hui-ling LONG, Yuan CAI, Nian-chun GONG, Ze-heng ZHANG, Xin LIAO, Yan-mei PENG), CN=ArticleExt(id=1236331741217092604, articleId=1236331740776690662, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=特征图谱结合化学模式识别筛选不同产地茯苓药材差异质量标志物, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的： 利用化学模式识别技术，对茯苓药材HPLC特征图谱数据进行分析，筛选差异质量标志物并建立定量分析策略，为茯苓质量标准研究提供科学依据。
方法： 采用Welch Ultimate Plus C18色谱柱（250 mm×4.6 mm，5 μm），流动相为乙腈（含0.2%四氢呋喃）-0.1%磷酸水溶液，梯度洗脱，检测波长222 nm，体积流量1 mL·min-1，柱温30 ℃，进样量10 μL，建立茯苓药材特征图谱。运用相似度分析、主成分分析（principal component analysis, PCA）、聚类分析（cluster analysis, CA）和正交偏最小二乘-判别分析（orthogonal partial least squares discrimination analysis, OPLS-DA）等模式识别方法，筛选不同产地茯苓的差异质量标志物，并按照《中华人民共和国药典》中“分析方法验证指导原则”的要求，进行定量研究。
结果： 15批茯苓药材的相似度在0.935~0.998，共标定8个共有峰，指认出6个色谱峰；PCA结果显示样品按产地呈现聚类趋势，CA结果与PCA一致，通过OPLS-DA筛选茯苓酸作为差异质量标志物；建立的茯苓酸含量测定方法稳定、可靠且耐用性良好，符合药典要求。
结论： 通过特征图谱结合化学模式识别技术的分析策略，可快速有效地筛选不同产地茯苓药材的差异质量标志物，为茯苓药材质量标准的建立提供参考。
, correspAuthors=null, authorNote=null, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=nEzsoS1XsckcE1K5ocA9bw==, magXml=o2VLq492payanTMXTICT6g==, pdfUrl=null, pdf=H6xAonID0VyMzDFxq3Ywkw==, pdfFileSize=5963600, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=6n1fPwsCzaFiKm+JWdW/gw==, mapNumber=null, authorCompany=null, fund=null, authors=
, authorsList=李鹏辉, 龙慧玲, 蔡媛, 龚年春, 章泽恒, 廖鑫, 彭艳梅)}, authors=[Author(id=1236331741753962524, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=784113726@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236331741837848610, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, authorId=1236331741753962524, language=EN, stringName=Peng-hui LI, firstName=Peng-hui, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1Hunan Academy of Traditional Chinese Medicine, Changsha 410006, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236331741904957480, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, authorId=1236331741753962524, language=CN, stringName=李鹏辉, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1湖南省中医药研究院，长沙 410006, bio={"content":"
李鹏辉，男，助理研究员，主要从事中药制剂和中药质量控制研究。E-mail: 784113726@qq.com。
"}, bioImg=null, bioContent=
李鹏辉，男，助理研究员，主要从事中药制剂和中药质量控制研究。E-mail: 784113726@qq.com。
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236331741443584005, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, xref=1, ext=[AuthorCompanyExt(id=1236331741456166919, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, companyId=1236331741443584005, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1Hunan Academy of Traditional Chinese Medicine, Changsha 410006, China), AuthorCompanyExt(id=1236331741460361225, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, companyId=1236331741443584005, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1湖南省中医药研究院，长沙 410006)])]), Author(id=1236331741980454959, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=25352830@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236331742064341048, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, authorId=1236331741980454959, language=EN, stringName=Hui-ling LONG, firstName=Hui-ling, middleName=null, lastName=LONG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2Hunan Center for Drug Evaluation and ADR Monitoring, Changsha 410209, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236331742152421436, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, authorId=1236331741980454959, language=CN, stringName=龙慧玲, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2湖南省药品审评与不良反应监测中心，长沙 410209, bio={"content":"
龙慧玲，女，高级工程师，主要从事药品医疗器械化妆品技术审评。E-mail: 25352830@qq.com。
"}, bioImg=null, bioContent=
龙慧玲，女，高级工程师，主要从事药品医疗器械化妆品技术审评。E-mail: 25352830@qq.com。
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236331741623939089, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, xref=2, ext=[AuthorCompanyExt(id=1236331741632327698, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, companyId=1236331741623939089, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2Hunan Center for Drug Evaluation and ADR Monitoring, Changsha 410209, China), AuthorCompanyExt(id=1236331741640716308, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, companyId=1236331741623939089, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2湖南省药品审评与不良反应监测中心，长沙 410209)])]), Author(id=1236331742357942339, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236331742466994254, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, authorId=1236331742357942339, language=EN, stringName=Yuan CAI, firstName=Yuan, middleName=null, lastName=CAI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1Hunan Academy of Traditional Chinese Medicine, Changsha 410006, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236331742601211988, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, authorId=1236331742357942339, language=CN, stringName=蔡媛, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1湖南省中医药研究院，长沙 410006, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236331741443584005, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, xref=1, ext=[AuthorCompanyExt(id=1236331741456166919, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, companyId=1236331741443584005, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1Hunan Academy of Traditional Chinese Medicine, Changsha 410006, China), AuthorCompanyExt(id=1236331741460361225, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, companyId=1236331741443584005, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1湖南省中医药研究院，长沙 410006)])]), Author(id=1236331742701875293, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236331742802538596, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, authorId=1236331742701875293, language=EN, stringName=Nian-chun GONG, firstName=Nian-chun, middleName=null, lastName=GONG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1Hunan Academy of Traditional Chinese Medicine, Changsha 410006, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236331742907396206, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, authorId=1236331742701875293, language=CN, stringName=龚年春, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1湖南省中医药研究院，长沙 410006, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236331741443584005, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, xref=1, ext=[AuthorCompanyExt(id=1236331741456166919, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, companyId=1236331741443584005, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1Hunan Academy of Traditional Chinese Medicine, Changsha 410006, China), AuthorCompanyExt(id=1236331741460361225, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, companyId=1236331741443584005, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1湖南省中医药研究院，长沙 410006)])]), Author(id=1236331743029031031, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236331743117111424, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, authorId=1236331743029031031, language=EN, stringName=Ze-heng ZHANG, firstName=Ze-heng, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2Hunan Center for Drug Evaluation and ADR Monitoring, Changsha 410209, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236331743205191815, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, authorId=1236331743029031031, language=CN, stringName=章泽恒, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2湖南省药品审评与不良反应监测中心，长沙 410209, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236331741623939089, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, xref=2, ext=[AuthorCompanyExt(id=1236331741632327698, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, companyId=1236331741623939089, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2Hunan Center for Drug Evaluation and ADR Monitoring, Changsha 410209, China), AuthorCompanyExt(id=1236331741640716308, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, companyId=1236331741623939089, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2湖南省药品审评与不良反应监测中心，长沙 410209)])]), Author(id=1236331743318438025, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236331743444267152, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, authorId=1236331743318438025, language=EN, stringName=Xin LIAO, firstName=Xin, middleName=null, lastName=LIAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1Hunan Academy of Traditional Chinese Medicine, Changsha 410006, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236331743532347541, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, authorId=1236331743318438025, language=CN, stringName=廖鑫, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1湖南省中医药研究院，长沙 410006, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236331741443584005, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, xref=1, ext=[AuthorCompanyExt(id=1236331741456166919, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, companyId=1236331741443584005, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1Hunan Academy of Traditional Chinese Medicine, Changsha 410006, China), AuthorCompanyExt(id=1236331741460361225, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, companyId=1236331741443584005, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1湖南省中医药研究院，长沙 410006)])]), Author(id=1236331743649788060, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=271853145@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236331743746257056, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, authorId=1236331743649788060, language=EN, stringName=Yan-mei PENG, firstName=Yan-mei, middleName=null, lastName=PENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1Hunan Academy of Traditional Chinese Medicine, Changsha 410006, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236331743838531750, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, authorId=1236331743649788060, language=CN, stringName=彭艳梅, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1湖南省中医药研究院，长沙 410006, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236331741443584005, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, xref=1, ext=[AuthorCompanyExt(id=1236331741456166919, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, companyId=1236331741443584005, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1Hunan Academy of Traditional Chinese Medicine, Changsha 410006, China), AuthorCompanyExt(id=1236331741460361225, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, companyId=1236331741443584005, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1湖南省中医药研究院，长沙 410006)])])], keywords=[Keyword(id=1236331743947583660, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, language=EN, orderNo=1, keyword=
Poria cocos), Keyword(id=1236331744056635569, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, language=EN, orderNo=2, keyword=characteristic fingerprint), Keyword(id=1236331744161493173, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, language=EN, orderNo=3, keyword=chemical pattern recognition), Keyword(id=1236331744228602040, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, language=EN, orderNo=4, keyword=differential quality marker), Keyword(id=1236331744316682426, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, language=EN, orderNo=5, keyword=pachymic acid), Keyword(id=1236331744413151422, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, language=CN, orderNo=1, keyword=茯苓), Keyword(id=1236331744471871680, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, language=CN, orderNo=2, keyword=特征图谱), Keyword(id=1236331744543174851, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, language=CN, orderNo=3, keyword=化学模式识别), Keyword(id=1236331744614478022, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, language=CN, orderNo=4, keyword=差异质量标志物), Keyword(id=1236331744710947017, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, language=CN, orderNo=5, keyword=茯苓酸)], refs=null, funds=[Fund(id=1236331744807416012, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, awardId=2021SK2007, language=CN, fundingSource=湖南省重点研发计划(2021SK2007), fundOrder=null, country=null), Fund(id=1236331744878719182, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, awardId=2021098; A2023005; C2023011, language=CN, fundingSource=湖南省中医药科研计划项目(2021098; A2023005; C2023011), fundOrder=null, country=null), Fund(id=1236331744958410961, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, awardId=2021JJ80050; 2021JJ80048; 2022JJ80075, language=CN, fundingSource=湖南省自然科学基金科药联合基金资助项目(2021JJ80050; 2021JJ80048; 2022JJ80075), fundOrder=null, country=null), Fund(id=1236331745046491345, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, awardId=kq2202359, language=CN, fundingSource=长沙市自然科学基金(kq2202359), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1236331741443584005, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, xref=1, ext=[AuthorCompanyExt(id=1236331741456166919, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, companyId=1236331741443584005, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1Hunan Academy of Traditional Chinese Medicine, Changsha 410006, China), AuthorCompanyExt(id=1236331741460361225, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, companyId=1236331741443584005, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1湖南省中医药研究院，长沙 410006)]), AuthorCompany(id=1236331741623939089, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, xref=2, ext=[AuthorCompanyExt(id=1236331741632327698, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, companyId=1236331741623939089, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2Hunan Center for Drug Evaluation and ADR Monitoring, Changsha 410209, China), AuthorCompanyExt(id=1236331741640716308, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236331740776690662, companyId=1236331741623939089, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2湖南省药品审评与不良反应监测中心，长沙 410209)])], figs=null, attaches=null, journal=Journal(id=1235980159023624194, delFlag=0, nameCn=中国新药杂志, nameEn=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, issn=1003-3734, eissn=null, cn=11-2850/R, coden=ZXZHA6, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of New Drugs, journalRemark=null, publicationField=null, createdTime=1772610233314, updatedTime=1772610649152, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=C, firstLetterEn=C, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=ohPEEN//Vz1tDT3ZBNTp4Q==, picEn=f9WK9bvTM4guTmS/iGhOMg==, jcr=null, cjcr=null, exts=[JournalExt(id=1235981903275290962, language=CN, name=中国新药杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1772610649174, updatedTime=1772610649174, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1235981903338205523, language=EN, name=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1772610649189, updatedTime=1772610649189, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1235980733773295621, websiteList=[Website(id=1235982099191222761, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/CN, language=CN, createTime=1772610695884, createBy=18614031015, updateTime=1772610860397, updateBy=18614031015, name=中国新药杂志-中文, tplId=1146099689490845704, title=中国新药杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983918629966444, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=articleTextType, value=kx, createTime=1772611129672, updateTime=1772611129672, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918604800617, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=banner, value=null, createTime=1772611129666, updateTime=1772611129666, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918655132271, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=grayFlag, value=0, createTime=1772611129678, updateTime=1772611129678, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918596412008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611129664, updateTime=1772611129664, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918667715185, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=minRunFlag, value=0, createTime=1772611129681, updateTime=1772611129681, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918617383531, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic, createTime=1772611129669, updateTime=1772611129669, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918659326576, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=silenceFlag, value=0, createTime=1772611129679, updateTime=1772611129679, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918613189226, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1772611129668, updateTime=1772611129668, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918634160749, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeColor, value=null, createTime=1772611129673, updateTime=1772611129673, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918646743662, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeStyle, value=null, createTime=1772611129676, updateTime=1772611129676, creator=18614031015, updator=18614031015)]), Website(id=1235982099270914542, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/EN, language=EN, createTime=1772610695903, createBy=18614031015, updateTime=1772610875891, updateBy=18614031015, name=中国新药杂志-英文, tplId=1146101810881728533, title=Chinese Journal of New Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983955829248630, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=articleTextType, value=kx, createTime=1772611138541, updateTime=1772611138541, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955804082803, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=banner, value=null, createTime=1772611138535, updateTime=1772611138535, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955854414457, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=grayFlag, value=0, createTime=1772611138547, updateTime=1772611138547, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955795694194, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611138533, updateTime=1772611138533, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955866997371, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=minRunFlag, value=0, createTime=1772611138550, updateTime=1772611138550, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955820860021, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic, createTime=1772611138539, updateTime=1772611138539, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955862803066, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=silenceFlag, value=0, createTime=1772611138549, updateTime=1772611138549, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955812471412, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1772611138537, updateTime=1772611138537, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955837637239, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeColor, value=null, createTime=1772611138543, updateTime=1772611138543, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955846025848, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeStyle, value=null, createTime=1772611138545, updateTime=1772611138545, creator=18614031015, updator=18614031015)])], journalTitle=中国新药杂志, weixinUrl=null, journalUrl=http://www.newdrug.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of New Drugs, journalPhotoCn=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPhotoEn=f9WK9bvTM4guTmS/iGhOMg==, journalFirstLetter=C, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/Y2023/V32/I21/2184, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/Y2023/V32/I21/2184, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/PDF/Y2023/V32/I21/2184, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/PDF/Y2023/V32/I21/2184, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)
全屏
文章导航
PDF下载
33
12
关闭全屏
北京市海淀区学院南路86号
010-62199257
qkjq@cast.org.cn
