Article(id=1236331739501622218, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236331736221676464, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1679846400000, acceptedDateStr=2023-03-27, onlineDate=1772694056629, onlineDateStr=2026-03-05, pubDate=1699977600000, pubDateStr=2023-11-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772694056629, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772694056629, creator=13701087609, updateTime=1772694056629, updator=13701087609, issue=Issue{id=1236331736221676464, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='21', pageStart='2121', pageEnd='2224', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772694055848, creator=13701087609, updateTime=1772696903836, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236343681607856366, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236331736221676464, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236343681607856367, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236331736221676464, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=2164, endPage=2172, ext={EN=ArticleExt(id=1236331739728114635, articleId=1236331739501622218, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Research progress on the mechanism of salt-induced kinases (SIKs) in central nervous system diseases, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Salt-inducible kinases (SIKs) belong to the AMP-activated protein kinase (AMPK) family, which mainly regulates the cytosolic-cytoplasmic distribution of cAMP-response element binding protein transcriptional coactivators (CRTCs). They exert regulatory effect on the synthesis of CRTC-CREB complexes, which indirectly affect the transcription and expression of CREB target genes and various physiological processes, such as energy metabolism, cell cycle progression and apoptosis. Previous researches related to SIKs have focused on peripheral system diseases, including tumors, hypertension and gluconeogenesis. In recent years, increasing studies have begun to explore the link between SIKs and central nervous system diseases with abnormal levels of SIKs present in diseases such as depression, sleep disturbance, epilepsy and Alzheimer's disease. It suggests that dysregulation of SIKs signaling is involved in the pathological processes of these diseases and has the potential to become new therapeutic targets in these diseases. This article reviews the role and regulatory mechanisms of SIKs in depression, sleep disturbance and other neurological diseases.

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盐诱导激酶（salt-inducible kinases, SIKs）属于腺苷酸活化激酶（AMP-activated protein kinase, AMPK）家族，主要调控环磷酸苷效应元件结合蛋白（cAMP-response element binding protein, CREB）转录共激活因子（CREB-regulated transcription coactivators, CRTCs）的胞核-胞质分布，对CRTC-CREB复合物的合成起到调节作用，从而间接影响CREB目的基因的转录与表达，影响多种生理过程，例如能量代谢、细胞周期进程和细胞凋亡。过去对SIKs的相关研究主要集中在外周系统疾病，包括肿瘤、高血压和糖异生等。近年来越来越多的研究开始探索SIKs和中枢神经系统疾病的关联性，如抑郁症、睡眠障碍、癫痫和阿尔茨海默病等都存在SIKs水平异常的情况，这提示SIKs信号失调参与这些疾病的病理过程，SIKs具有成为此类疾病新治疗靶点的潜力。本文就SIKs在抑郁症、睡眠障碍及其他神经系统疾病中的作用和调控机制进行综述。

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任廷婷，女，硕士研究生，研究方向：中药神经药理。E-mail: 704418375@qq.com。

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任廷婷，女，硕士研究生，研究方向：中药神经药理。E-mail: 704418375@qq.com。

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