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The phosphorylation of serine 209 of eukaryotic translation initiation factor 4E (eIF4E) by mitogen-activated protein kinase-interacting kinase (MNK) is closely related to the process of translation initiation of tumor-related mRNA, and this process plays an important role in tumor occurrence and metastasis. Since MNK has gradually become an important antitumor target, the development of MNK small-molecule inhibitors has attracted the attention of researchers in recent years. Therefore, we reviewed the research progress of MNK small-molecule inhibitors by summarizing the structure and signal transduction mechanism of MNK.

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有丝分裂原激活的蛋白激酶作用激酶（MNK）对真核细胞翻译起始因子4E（eIF4E）209位丝氨酸的磷酸化作用与肿瘤相关mRNA的翻译起始过程密切相关，在肿瘤的发生、转移等过程中具有重要作用，MNK已经逐渐成为抗肿瘤的重要靶标。近年来MNK小分子抑制剂的开发已受到了研究人员的关注，因此本文在总结MNK的结构和信号转导机制的基础上，对MNK小分子抑制剂的研究进展进行综述。

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曾扬杰，男，硕士研究生，研究方向：抗肿瘤小分子药物研究。E-mail: cengyangjie@163.com。

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曾扬杰，男，硕士研究生，研究方向：抗肿瘤小分子药物研究。E-mail: cengyangjie@163.com。

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