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Nanocrystals possess the merits of high solubility, fast dissolution rate and high bioavailability with extremely small particle size, so they have been used in various formulations for oral, injectable, transdermal or mucosal delivery. Although injectable drug delivery is relatively reliable, the transport process of nanocrystals after injection is more complicated than that of solution. Based on literature research, this paper reviews the mechanisms of absorption, distribution, metabolism and excretion of injectable nanocrystals. Meanwhile, it also describes the factors affecting their processes in vivo, including the influence of physiological factors such as injection site, mononuclear phagocyte system, and formulation factors such as drug particle size and stabilizer. All of these provide a good foundation for further extensive application.

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纳米晶因为其粒径极小而具有溶解度高、溶出速度快、生物利用度高等优点，在口服、注射、经皮、黏膜给药等方面都有很好的应用。虽然注射给药相对比较可靠，但与溶液剂注射相比，纳米晶在体内的转运过程较为复杂。本文综述了注射给药纳米晶的吸收、分布、代谢和排泄的机制，并阐述影响其在体内各过程的因素，包括注射部位、单核吞噬细胞系统等生理因素和药物颗粒大小、稳定剂等制剂因素的影响，为其进一步广泛应用打下良好的基础。

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金鹤翔，女，硕士研究生，研究方向：药物新剂型与新技术。E-mail: 876833142@qq.com。

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金鹤翔，女，硕士研究生，研究方向：药物新剂型与新技术。E-mail: 876833142@qq.com。

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