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Roflumilast is a selective phosphodiesterase-4 inhibitor. Roflumilast 0.3% cream was approved by the U.S. FDA on July 29, 2022 (trade name Zoryve) for the treatment of plaque psoriasis in patients of 12 years or older, including intertriginous areas. Unlike other topical medicines, roflumilast has a higher safety profile, it is non-irritating to the skin, can be used continuously in long-term, and does not thin the skin. This article reviews its mechanism of action, pharmacokinetics, safety, clinical efficacy and precautions for use.

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罗氟司特（roflumilast）是一种选择性的磷酸二酯酶-4（phosphodiesterase-4, PDE-4）抑制剂。2022年7月29日，罗氟司特0.3%乳膏获得美国FDA批准上市（商品名：Zoryve），用于治疗12岁及以上患者的斑块型银屑病，包括皮肤皱襞区域的间擦性银屑病。与其他外用药物不同，罗氟司特具有更高安全性，且对皮肤无刺激性，可以连续、长期地使用，不会使皮肤变薄。本文对其作用机制、药动学、安全性、临床疗效和使用注意事项进行综述。

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王茜茜，女，硕士研究生，研究方向：小分子药物的设计与合成。E-mail: 3321010336@stu.cpu.edu.cn。

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王茜茜，女，硕士研究生，研究方向：小分子药物的设计与合成。E-mail: 3321010336@stu.cpu.edu.cn。

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