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This article reviewed the reports of adverse reactions of 17 weight-loss drugs approved by the FDA since 1887 during the clinical trials and after their marketing, including six that are still on the market and 11 that have been withdrawn due to valvular heart disease, suicidal tendencies, cancer risk, or other reasons. Weight-loss drugs can reduce weight and bring metabolic benefits in obese patients, but also cause various side effects, including psychonervous system adverse reactions, cancer risk, cardiotoxicity, liver damage, pancreatic toxicity, renal toxicity, digestive tract side effects, etc. Drugs with severe side effects will receive a black box warning from the FDA, and drugs with fatal side effects will be ordered to withdraw from the market. In addition to summarizing the side effects of weight-loss drugs, this article put forward some in-depth considerations on their safety, in order to provide reference for pharmaceutical companies to develop weight-loss drugs, clinicians and patients to use weight-loss drugs correctly and protect people's lives and health.

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本文综述了1887年至今获得美国FDA批准上市的17种减肥药在临床试验期间及上市后的相关不良反应，包括仍在市的6种以及因瓣膜性心脏病、自杀倾向、致癌风险等原因遭撤市的11种减肥药。减肥药在降低肥胖患者体重以及代谢获益的同时也会引发各种不良反应，包括精神神经系统不良反应、致癌风险、心脏毒性、肝损伤、胰腺毒性、肾毒性、消化道不良反应等诸多不良反应；其中，美国FDA会对严重不良反应进行黑框警告，而具有致命性的严重不良反应药物则被勒令撤市。本文在归纳减肥药不良反应的同时对其安全性进行深度思考，以期为减肥药的研发及临床医生与患者正确使用减肥药提供相关参考，保护人民生命健康。

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周围，女，助理研究员，主要从事药理毒理专业审评工作。联系电话：(010)88096591，E-mail: zhouw@cde.org.cn。

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周围，女，助理研究员，主要从事药理毒理专业审评工作。联系电话：(010)88096591，E-mail: zhouw@cde.org.cn。

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