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Ionic liquids (ILs) are a class of salts that appear liquid form at or near room temperature. They are widely used in biomedicine, especially in transdermal drug delivery, because of their simple preparation process, high stability, good solubility and flexible structure. ILs can improve drug solubility, promote transdermal penetration, improve the efficacy of drugs, and solve the problems existing in the transdermal drug delivery. This article reviewed the classification, synthesis methods and its application in transdermal drug delivery. The IL-based transdermal preparation was also summarized, in order to provide reference for further research and development of ILs in transdermal drug delivery.

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离子液体(ionic liquids, ILs)是一类在室温或接近室温条件下呈液态的盐。由于其具有易于制备、稳定性好、溶解能力强和结构可调等优点,在生物医学特别是经皮给药方面得到了广泛的研究。ILs可以改善药物溶解度、促进药物经皮渗透、提高药物疗效、解决药物经皮递送存在的问题。本文综述了ILs的分类、合成方法以及ILs在经皮给药中的应用,并归纳了基于ILs的经皮给药制剂,以期为ILs在经皮给药中的深入研究和发展提供借鉴。

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袁海龙,男,研究员,博士生导师,主要从事中药新制剂、新剂型、新技术应用研究。联系电话:(010)66928505,E-mail:
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闫巧,女,硕士研究生,主要从事中药新制剂、新剂型、新技术应用研究。E-mail:

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离子液体在经皮给药系统中的应用研究进展
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闫巧 1, 2 , 李方琴 1 , 王芳 1 , 秦祉剑 1 , 杭凌宇 1 , 薛玉叶 1 , 袁海龙 1
中国新药杂志 | 综述 2023,32(20): 2073-2079
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中国新药杂志 | 综述 2023, 32(20): 2073-2079
离子液体在经皮给药系统中的应用研究进展
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闫巧1, 2 , 李方琴1, 王芳1, 秦祉剑1, 杭凌宇1, 薛玉叶1, 袁海龙1
作者信息
  • 1中国人民解放军空军特色医学中心药学部,北京 100142
  • 2成都中医药大学药学院,成都 611137
  • 闫巧,女,硕士研究生,主要从事中药新制剂、新剂型、新技术应用研究。E-mail:

通讯作者:

袁海龙,男,研究员,博士生导师,主要从事中药新制剂、新剂型、新技术应用研究。联系电话:(010)66928505,E-mail:
Research progress in the application of ionic liquids in transdermal drug delivery system
Qiao YAN1, 2 , Fang-qin LI1, Fang WANG1, Zhi-jian QIN1, Ling-yu HANG1, Yu-ye XUE1, Hai-long YUAN1
Affiliations
  • 1Department of Pharmacy, Air Force Medical Center, PLA, Beijing 100142, China
  • 2College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
出版时间: 2023-10-30
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离子液体(ionic liquids, ILs)是一类在室温或接近室温条件下呈液态的盐。由于其具有易于制备、稳定性好、溶解能力强和结构可调等优点,在生物医学特别是经皮给药方面得到了广泛的研究。ILs可以改善药物溶解度、促进药物经皮渗透、提高药物疗效、解决药物经皮递送存在的问题。本文综述了ILs的分类、合成方法以及ILs在经皮给药中的应用,并归纳了基于ILs的经皮给药制剂,以期为ILs在经皮给药中的深入研究和发展提供借鉴。

离子液体  /  经皮给药  /  促渗  /  溶解度  /  抗菌  /  给药剂型

Ionic liquids (ILs) are a class of salts that appear liquid form at or near room temperature. They are widely used in biomedicine, especially in transdermal drug delivery, because of their simple preparation process, high stability, good solubility and flexible structure. ILs can improve drug solubility, promote transdermal penetration, improve the efficacy of drugs, and solve the problems existing in the transdermal drug delivery. This article reviewed the classification, synthesis methods and its application in transdermal drug delivery. The IL-based transdermal preparation was also summarized, in order to provide reference for further research and development of ILs in transdermal drug delivery.

ionic liquids  /  transdermal drug delivery  /  permeation enhancer  /  solubility  /  antibacterial  /  dosage form
闫巧, 李方琴, 王芳, 秦祉剑, 杭凌宇, 薛玉叶, 袁海龙. 离子液体在经皮给药系统中的应用研究进展. 中国新药杂志, 2023 , 32 (20) : 2073 -2079 .
Qiao YAN, Fang-qin LI, Fang WANG, Zhi-jian QIN, Ling-yu HANG, Yu-ye XUE, Hai-long YUAN. Research progress in the application of ionic liquids in transdermal drug delivery system[J]. Chinese Journal of New Drugs, 2023 , 32 (20) : 2073 -2079 .
  • 国家自然科学基金资助项目(81873092; 82174074)
2023年第32卷第20期
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  • 首发时间:2026-03-05
  • 出版时间:2023-10-30
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  • 录用日期:2023-02-07
基金
国家自然科学基金资助项目(81873092; 82174074)
作者信息
    1中国人民解放军空军特色医学中心药学部,北京 100142
    2成都中医药大学药学院,成都 611137

通讯作者:

袁海龙,男,研究员,博士生导师,主要从事中药新制剂、新剂型、新技术应用研究。联系电话:(010)66928505,E-mail:
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2种不同金属材料的力学参数

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占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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