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Ergosterol peroxide, a derivative of ergosterol, is widely found in a variety of medicinal fungi and plants and has various biological activities because of its 5α, 8α-peroxide bridge structure, such as anti-tumor, anti-virus, immune regulation, bacteriostasis and anti-inflammation. It is worth noting that the anti-tumor activity of ergosterol peroxide is significantly higher than ergosterol. At present, the preparation processes of ergosterol peroxide mainly include biological extraction and chemical synthesis. Biological extraction fails to acquire a large amount of ergosterol peroxide because of its low content in natural resources. However, chemical synthesis is convenient, and may realizes the industrialization of ergosterol peroxide. Here, the progress in study on biological activities and preparation of ergosterol peroxide was reviewed to provide direction for its application.

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麦角甾醇过氧化物是麦角甾醇的衍生物，广泛存在于多种药用真菌及植物中，因含5α，8α-过氧化物桥结构而具有多种不同的生物活性，如抗肿瘤、抗病毒、免疫调节、抑菌等，并且其抗肿瘤活性显著高于麦角甾醇。目前，麦角甾醇过氧化物的制备主要有生物提取及化学合成2种方法。但因麦角甾醇过氧化物在天然资源中的含量较低，所以生物提取无法大量获取目标产物；化学合成的简单快速，使麦角甾醇过氧化物有望实现产业化。本文对麦角甾醇过氧化物生物活性及制备进展进行综述，为麦角甾醇过氧化物的应用提供指导。

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刘鹏，男，博士研究生，主要从事生物化学与分子生物学研究。E-mail: lp54@stu.xju.edu.cn。

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刘鹏，男，博士研究生，主要从事生物化学与分子生物学研究。E-mail: lp54@stu.xju.edu.cn。

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