Article(id=1236330556087128364, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236330549866975405, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1688313600000, acceptedDateStr=2023-07-03, onlineDate=1772693774482, onlineDateStr=2026-03-05, pubDate=1697299200000, pubDateStr=2023-10-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772693774482, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772693774482, creator=13701087609, updateTime=1772693774482, updator=13701087609, issue=Issue{id=1236330549866975405, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='19', pageStart='1905', pageEnd='2008', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772693772998, creator=13701087609, updateTime=1772695059296, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236335945046348400, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236330549866975405, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236335945046348401, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236330549866975405, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1972, endPage=1978, ext={EN=ArticleExt(id=1236330556330398009, articleId=1236330556087128364, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Research and development of new vitiligo drugs: challenges and prospects, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Vitiligo is a kind of refractory depigmentation skin disease, which seriously affects the appearance and psychology of patients. At present, the pathogenesis of vitiligo includes heredity, oxidative stress, autoimmunity and environmental factors. The treatment includes systematic application of glucocorticoid, local application of glucocorticoid or calcineurin inhibitor, phototherapy and melanocyte transplantation. In this article, we reviewed the commonly used therapeutic drugs for vitiligo in the past and summarized the new progress of therapeutic drugs for the treatment of vitiligo. The emergence of new small-molecule targeted drugs, such as Janus kinase inhibitor baricitinib, has brought hope for vitiligo.

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白癜风是一种难治性色素脱失性皮肤病,严重影响患者的容貌与心理。目前白癜风的发病机制包括遗传、氧化应激、自身免疫、环境因素等,其治疗手段包括系统应用糖皮质激素、局部应用糖皮质激素或钙调磷酸酶抑制剂、光疗、黑素细胞移植手术等。在此,本文回顾了既往白癜风常用的治疗药物并总结白癜风治疗药物新进展,新的小分子靶向药物的出现如Janus活化激酶(JAK)抑制剂巴瑞替尼等给白癜风的治疗带来新希望。

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吴严,女,博士,教授,主任医师,主要从事激光美容相关研究。E-mail:
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马枞,女,博士研究生,主要从事色素性皮肤病及毛发相关研究。E-mail:

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马枞,女,博士研究生,主要从事色素性皮肤病及毛发相关研究。E-mail:

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马枞,女,博士研究生,主要从事色素性皮肤病及毛发相关研究。E-mail:

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白癜风新药研发的挑战与展望
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马枞 1 , 苑金平 2 , 高兴华 1 , 吴严 1
中国新药杂志 | 皮肤病新药研发与应用专题 2023,32(19): 1972-1978
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中国新药杂志 | 皮肤病新药研发与应用专题 2023, 32(19): 1972-1978
白癜风新药研发的挑战与展望
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马枞1 , 苑金平2, 高兴华1, 吴严1
作者信息
  • 1中国医科大学附属第一医院皮肤科,沈阳 110000
  • 2哈尔滨医科大学附属第二医院皮肤科,哈尔滨 150000
  • 马枞,女,博士研究生,主要从事色素性皮肤病及毛发相关研究。E-mail:

通讯作者:

吴严,女,博士,教授,主任医师,主要从事激光美容相关研究。E-mail:
Research and development of new vitiligo drugs: challenges and prospects
Cong MA1 , Jin-ping YUAN2, Xing-hua GAO1, Yan WU1
Affiliations
  • 1Department of Dermatology, First Affiliated Hospital of China Medical University, Shenyang 110000, China
  • 2Department of Dermatology, Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China
出版时间: 2023-10-15
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白癜风是一种难治性色素脱失性皮肤病,严重影响患者的容貌与心理。目前白癜风的发病机制包括遗传、氧化应激、自身免疫、环境因素等,其治疗手段包括系统应用糖皮质激素、局部应用糖皮质激素或钙调磷酸酶抑制剂、光疗、黑素细胞移植手术等。在此,本文回顾了既往白癜风常用的治疗药物并总结白癜风治疗药物新进展,新的小分子靶向药物的出现如Janus活化激酶(JAK)抑制剂巴瑞替尼等给白癜风的治疗带来新希望。

白癜风  /  新药研发  /  Janus活化激酶抑制剂

Vitiligo is a kind of refractory depigmentation skin disease, which seriously affects the appearance and psychology of patients. At present, the pathogenesis of vitiligo includes heredity, oxidative stress, autoimmunity and environmental factors. The treatment includes systematic application of glucocorticoid, local application of glucocorticoid or calcineurin inhibitor, phototherapy and melanocyte transplantation. In this article, we reviewed the commonly used therapeutic drugs for vitiligo in the past and summarized the new progress of therapeutic drugs for the treatment of vitiligo. The emergence of new small-molecule targeted drugs, such as Janus kinase inhibitor baricitinib, has brought hope for vitiligo.

vitiligo  /  new drugs development  /  Janus kinase inhibitor
马枞, 苑金平, 高兴华, 吴严. 白癜风新药研发的挑战与展望. 中国新药杂志, 2023 , 32 (19) : 1972 -1978 .
Cong MA, Jin-ping YUAN, Xing-hua GAO, Yan WU. Research and development of new vitiligo drugs: challenges and prospects[J]. Chinese Journal of New Drugs, 2023 , 32 (19) : 1972 -1978 .
2023年第32卷第19期
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  • 首发时间:2026-03-05
  • 出版时间:2023-10-15
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  • 录用日期:2023-07-03
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    1中国医科大学附属第一医院皮肤科,沈阳 110000
    2哈尔滨医科大学附属第二医院皮肤科,哈尔滨 150000

通讯作者:

吴严,女,博士,教授,主任医师,主要从事激光美容相关研究。E-mail:
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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