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Autoimmune skin diseases are a kind of diseases caused by the immune response to self-antigens, resulting in damages to skin with or without to other tissues and organs. The traditional immunosuppressants exert their curative effect, but accompanied by a wide range of adverse reactions. In-depth understanding of pathogenesis facilitated the development of various cytokine-based therapies or drugs targeting the signaling pathways, which has significantly improved the patient's condition. However, these therapies often require long-term maintenance treatment, and the targeting pathways of many autoimmune skin diseases are still not quite clear. Therefore, emerging therapeutic strategies and innovative drugs are still in need to balance the homeostasis of the immune system and induce the long-term remission of the disease, providing new hope for the treatment of autoimmune skin diseases. This review discusses the development of drugs treating autoimmune skin diseases according to different mechanisms of action and targets.

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自身免疫性皮肤病是由于免疫系统对自身抗原发生免疫反应导致免疫失衡，从而引起皮肤损伤伴有或不伴有其他组织器官损伤的一类疾病。传统免疫抑制剂发挥疗效的同时伴随着广泛的不良反应。对发病机制的深入了解促进了各种基于靶向细胞因子或信号通路药物的研发。这些药物的应用显著改善了患者的病情，但往往需要长期维持治疗，且仍有许多自身免疫性皮肤病缺乏明确的靶标。因此仍需要更多新兴治疗策略和创新药物以重新平衡免疫系统的稳态，诱导疾病的长期缓解，为治疗自身免疫性皮肤病提供新的希望。本研究将根据不同的作用机制及靶点，讨论治疗自身免疫性皮肤病的药物研发进展。

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³Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing 210042, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236330556456227142, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236330555193741557, authorId=1236330556259094836, language=CN, stringName=史丽晴, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2, 3}, address=¹中国医学科学院北京协和医学院皮肤病医院，南京 210042
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³江苏省皮肤病与性病分子生物学重点实验室，南京 210042, bio={"content":"

史丽晴，女，博士，主要从事系统性红斑狼疮机制和治疗研究。E-mail: 824868762@qq.com。

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史丽晴，女，博士，主要从事系统性红斑狼疮机制和治疗研究。E-mail: 824868762@qq.com。

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