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This study used "microneedles" as the keyword to search for relevant literature in CNKI and PubMed databases from 2017 to 2022. This article reviews the research progress of the carriers of microneedles based on structures, preparation methods, pharmacodynamics and clinical applications. A total of 1 040 valid kinds of literature were retrieved from the two databases. The structure of microneedles can be divided into solid microneedles, coated microneedles, dissolve microneedles, hydrogel microneedles, and hollow microneedles. The microneedles preparation methods involve microcasting, drawing lithography, and 3D printing methods. Some microneedle carrier pharmacodynamics studies include the treatment of skin, metabolic diseases, immune system diseases, and eye diseases. The microneedles' clinical application researches include vaccine, radiofrequency therapy and biological diagnosis. The main direction of future microneedle research is to develop a new transdermal microneedle drug delivery system, which is combined with the new pharmaceutical preparation technology. This study provides reference for further development of microneedle transdermal delivery formulations. The authors expect to provide a reference for the related research on microneedles.

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本研究以“微针”和“microneedles”为关键词，检索2017—2022年中国知网（CNKI）和PubMed数据库中的相关文献，从微针载体的结构研究、制备方法、药效学研究及临床应用研究四方面进行综述。在两大数据库中共检索得到有效文献1 040篇。其中，微针结构的研究包含固体微针、涂层微针、可溶性微针、水凝胶微针及中空微针；微针的制备方法包括微模塑法、拉延光刻法及3D打印法；微针载体的药效学研究涵盖对皮肤类、代谢类、免疫类及眼部疾病的治疗；微针的临床应用研究包括疫苗、射频疗法及生物诊断研究等。结合药物制剂新技术，开发新的经皮微针给药系统是微针未来研究的主要方向，本研究为进一步开发微针透皮给药制剂提供参考，以期为微针相关研究提供参考和借鉴。

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平洋，女，医学博士，硕士生导师，讲师，研究方向：中药制剂新剂型。E-mail: 18245482328@163.com。

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平洋，女，医学博士，硕士生导师，讲师，研究方向：中药制剂新剂型。E-mail: 18245482328@163.com。

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