Article(id=1321425880950358043, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425812331549069, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.15.013, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1755792000000, acceptedDateStr=2025-08-22, onlineDate=1792982080924, onlineDateStr=2026-10-26, pubDate=1786723200000, pubDateStr=2026-08-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982080924, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982080924, creator=13701087609, updateTime=1792982080924, updator=13701087609, issue=Issue{id=1321425812331549069, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='15', pageStart='1569', pageEnd='1680', issueExtLink='null', onlineDate='null', pubDate='1786723200000', pubDateStr='2026-08-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982064564, creator='13701087609', updateTime=1792982904202, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429334083097400, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425812331549069, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429334087291705, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425812331549069, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1663, endPage=1674, ext={EN=ArticleExt(id=1321425881139101724, articleId=1321425880950358043, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Systematic review and meta-analysis of the efficacy and safety of argatroban combined with antiplatelet drugs in patients with acute ischemic stroke, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: At present, the anticoagulant therapy for acute ischemic stroke (AIS) has been controversial. Argatroban, as a relatively safe novel anticoagulant, is widely used in the treatment of AIS. This study aims to systematically summarize the clinical efficacy and safety of argatroban combined with antiplatelet drugs for AIS.
Methods: CNKI, WanFang Data, VIP, PubMed, Embase, Web of Science, and the Cochrane Library were searched for randomized controlled trials (RCTs) on argatroban combined with antiplatelet drugs for acute ischemic stroke, with a search period from inception to June 2024. Two researchers independently screened the literature according to inclusion and exclusion criteria, evaluated the quality of the included studies, extracted data. Meta-analysis and subgroup analysis were performed using statistical software.
Results: A total of 40 RCTs involving 3 864 patients were included. Meta-analysis results showed that Argatroban combined with antiplatelet drugs improved clinical efficacy [odds ratio (OR)=3.51, 95% confidence interval (CI) (2.84, 4.32), Z=11.73 (P<0.000 01)], enhanced the ability of daily living [mean difference (MD)=9.81, 95%CI (8.57, 11.05), P<0.000 01], Z=15.54 (P<0.000 01), improved the degree of clinical neurological deficit [MD=-2.55, 95%CI (-2.88, -2.22), Z=15.09 (P<0.000 01)], coagulation parameters showed no significant abnormalities, with activated partial thromboplastin time (APTT) [MD=0.94, 95%CI (-0.29, 2.18), Z=1.50 (P=0.13)], fibrinogen (FIB) [MD=-0.31, 95%CI (-0.92, 0.30), Z=0.99 (P=0.31)], and the risk of adverse reactions was not increased [OR=0.84, 95%CI (0.63, 1.14), Z=1.12 (P=0.26)].
Conclusion: In the current treatment of AIS, the combination of antiplatelet drugs and argatroban can improve the clinical efficacy, enhance daily living ability, restore neurological function, improve prognosis, and potentially reduce disability rate. However, more rigorous and multi-center, large sample and high-quality studies are still needed to provide more objective and systematic evidence regarding the clinical efficacy, bleeding risk, specific dose, and application type of argatroban in stroke.
, authors=An-na WANG
1, Kang-feng WANG
2, Li-juan ZHANG
3, Nuo LU
1, Jia-le WANG
1, Ting-ting LIU
2, *, authorsList=An-na WANG, Kang-feng WANG, Li-juan ZHANG, Nuo LU, Jia-le WANG, Ting-ting LIU, authorCompany=null, correspAuthors=Ting-ting LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425881407537181, articleId=1321425880950358043, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=阿加曲班联合抗血小板药物对急性缺血性脑卒中疗效和安全性的系统评价与Meta分析, columnId=1236331163573342670, journalTitle=中国新药杂志, columnName=药物安全与合理应用, runingTitle=null, highlight=null, articleAbstract=
目的： 目前对急性缺血性脑卒中（acute ischemic stroke, AIS）抗凝治疗一直存在争议，阿加曲班作为较为安全的新型抗凝药物在AIS治疗中应用较为广泛。本研究旨在系统总结阿加曲班联合抗血小板药物对AIS的临床有效率及安全性。
方法： 通过计算机检索中国知网、万方数据库、维普中文期刊服务平台、PubMed、Embase、Web of Science及国际循证医学图书馆中收录的有关阿加曲班联合抗血小板药物对急性缺血性脑卒中疗效和安全性的相关文献，检索时限为各数据库建库至2024年6月。由2名研究者独立严格按照纳排标准进行文献筛选，并对纳入研究进行质量评价和资料提取，采用统计软件进行Meta分析与亚组分析。
结果： 最终纳入40篇随机对照试验文献，共3 864例患者。Meta分析结果显示阿加曲班联合抗血小板药物治疗可以提高临床有效率[OR=3.51，95%可信区间（credibility interval, CI, 2.84, 4.32），Z=11.73（P<0.000 01）]，增强日常生活能力[均数差（mean difference, MD）=9.81，95%CI（8.57, 11.05），Z=15.54（P<0.000 01）]，改善临床神经功能缺损程度[MD=-2.55，95%CI（-2.88, -2.22），Z=15.09（P<0.000 01）]，凝血功能未见异常活化部分凝血活酶时间[MD=0.94，95%CI（-0.29, 2.18），Z=1.50（P=0.13）]，纤维蛋白原[MD=-0.31，95%CI（-0.92, 0.30），Z=0.99（P=0.31）]，不良反应风险未见升高[OR=0.84，95%CI（0.63，1.14），Z=1.12（P=0.26）]。
结论： 在目前AIS治疗中抗血小板药物联合阿加曲班治疗可提高临床有效率，增强日常生活能力，恢复神经功能，改善预后，或可降低致残率。但仍需更多，更规范的多中心、大样本、高质量研究，为阿加曲班对卒中的临床有效率、出血情况、具体剂量及应用类型提供更客观系统的证据。
, authors=王安娜
1, 王康锋
2, 张立娟
3, 卢诺
1, 王家乐
1, 刘婷婷
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