Article(id=1321425850487128930, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425776323449136, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.14.013, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1773072000000, acceptedDateStr=2026-03-10, onlineDate=1792982073661, onlineDateStr=2026-10-26, pubDate=1785340800000, pubDateStr=2026-07-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982073661, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982073661, creator=13701087609, updateTime=1792982073661, updator=13701087609, issue=Issue{id=1321425776323449136, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='14', pageStart='1457', pageEnd='1568', issueExtLink='null', onlineDate='null', pubDate='1785340800000', pubDateStr='2026-07-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982055979, creator='13701087609', updateTime=1792982930455, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429444191966074, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425776323449136, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429444196160379, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425776323449136, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1545, endPage=1552, ext={EN=ArticleExt(id=1321425850659095395, articleId=1321425850487128930, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Clinical comprehensive evaluation of proprotein convertase subtilisin kexin 9 monoclonal antibodies based on the
Quick Guideline for Drug Evaluation and Selection in Chinese Medical Institutions (
the 2nd edition), columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To conduct a comprehensive analysis of proprotein convertase subtilisin kexin 9 (PCSK9) monoclonal antibodies based on a multi-dimensional evaluation method, providing a reference for clinical medication selection and drug selection in medical institutions.
Methods: Referring to the evaluation system in the Quick Guide for Drug Evaluation and Selection in Chinese Medical Institutions (the 2nd edition), with appropriate adjustments to some scoring criteria, a quantitative assessment was conducted on six PCSK9 monoclonal antibodies available in the domestic market from five aspects: pharmaceutical characteristics, efficacy, safety, economy, and other attributes. The recommendation grades were determined based on the scoring results.
Results: The quantitative scoring results, ranked from high to low, were as follows: evolocumab (79.31 points), alirocumab (74.85 points), tolersimab (73.86 points), recaticimab (71.95 points), ongericimab (70.9 points), and ebronucimab (70.88 points).
Conclusion: All six PCSK9 monoclonal antibodies demonstrated good lipid-lowering efficacy. Among them, evolocumab, alirocumab, and tolersimab are strongly recommended, while the others are weakly recommended.
, authors=Juan-juan MA, Jie CHENG, Xiao-yu JU, Jie-wei SUN, Yun-huan WANG
*, authorsList=Juan-juan MA, Jie CHENG, Xiao-yu JU, Jie-wei SUN, Yun-huan WANG, authorCompany=null, correspAuthors=Yun-huan WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425850982056804, articleId=1321425850487128930, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=基于《中国医疗机构药品评价与遴选快速指南（第二版）》的前蛋白转化酶枯草溶菌素9单克隆抗体临床综合评价, columnId=1236331163573342670, journalTitle=中国新药杂志, columnName=药物安全与合理应用, runingTitle=null, highlight=null, articleAbstract=
目的： 基于多维度评估方法，对前蛋白转化酶枯草溶菌素9（proprotein convertase subtilisin kexin 9, PCSK9）单克隆抗体进行全面分析，为临床用药选择及医疗机构药物遴选提供参考依据。
方法： 参考《中国医疗机构药品评价与遴选快速指南（第二版）》评价体系，对部分评分细则进行适当调整，从药学特性、有效性、安全性、经济性及其他属性5个方面，对国内已上市的6种PCSK9单克隆抗体进行量化评估，并根据得分结果确定推荐等级。
结果： 量化评分结果从高到低排序分别为依洛尤单抗（79.31分）、阿利西尤单抗（74.85分）、托莱西单抗（73.86分）、瑞卡西单抗（71.95分）、昂戈瑞西单抗（70.9分）、伊努西单抗（70.88分）。
结论： 6种PCSK9单克隆抗体均表现出良好的降脂疗效，均为强推荐。
, authors=马娟娟, 程杰, 鞠晓宇, 孙杰威, 王云环
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马娟娟，女，硕士研究生，主要从事心血管临床药学研究。E-mail: mjj0619@126.com。
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