Article(id=1321425772963804087, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425746170597545, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.13.013, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1761494400000, acceptedDateStr=2025-10-27, onlineDate=1792982055178, onlineDateStr=2026-10-26, pubDate=1784044800000, pubDateStr=2026-07-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982055178, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982055178, creator=13701087609, updateTime=1792982055178, updator=13701087609, issue=Issue{id=1321425746170597545, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='13', pageStart='1345', pageEnd='1456', issueExtLink='null', onlineDate='null', pubDate='1784044800000', pubDateStr='2026-07-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982048790, creator='13701087609', updateTime=1792982953102, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429539205534609, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425746170597545, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429539205534610, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425746170597545, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1432, endPage=1439, ext={EN=ArticleExt(id=1321425773127381944, articleId=1321425772963804087, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=
In vitro release study of benzoyl peroxide gel, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To investigate the in vitro release behavior of benzoyl peroxide gel using a diffusion cell method, and to obtain release profiles with subsequent kinetic model fitting.
Methods: The method was established with Franz diffusion cell. The PEG400-ethanol-water (25∶25∶50) is selected as receiving medium. The nylon membrane with 0.45 μm is used as the artificial membrane. The release amount was determined by high performance liquid chromatography (HPLC). The release data were fitted to zero-order, first-order, Korsmeyer-Peppas, and Higuchi models to identify the optimal release model.
Results: An in vitro release testing method for benzoyl peroxide gel was successfully established. The release data of benzoyl peroxide were best fitted by the zero-order kinetic model, whereas the release data of benzoic acid were best described by the Higuchi model.
Conclusion: The established in vitro release method is suitable for evaluating the release characteristics of benzoyl peroxide gel and provides a useful reference for the quality assessment of topical formulations containing poorly soluble drugs.
, authors=Yi-xin CUI
1, 2, 3, Xiao-xia YE
2, 3, *, Jian LE
2, 3, *, authorsList=Yi-xin CUI, Xiao-xia YE, Jian LE, authorCompany=null, correspAuthors=Xiao-xia YE, Jian LE, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425773429371833, articleId=1321425772963804087, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=过氧苯甲酰凝胶体外释放研究, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的： 采用扩散池法对过氧苯甲酰凝胶的体外释放度进行研究，测定释放曲线并对释放数据进行模型拟合。
方法： 采用Franz扩散池，以PEG400-无水乙醇-水（25∶25∶50）为释放介质，以孔径0.45 μm的尼龙膜为人工膜，采用高效液相色谱法（HPLC）测定释放量，采用零级模型、一级模型、Korsmeyer-Peppas模型和Higuchi模型拟合释放曲线，确定最优释放模型。
结果： 建立了过氧苯甲酰凝胶的体外释放测定方法，过氧苯甲酰零级模型拟合最优，苯甲酸Higuchi模型拟合最优。
结论： 本研究建立的体外释放方法可用于过氧苯甲酰凝胶的释放度测定，并为类似难溶性药物制剂的质量研究提供参考。
, authors=崔潆心
1, 2, 3, 叶晓霞
2, 3, *, 乐健
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1School of Pharmacy, Fudan University, Shanghai 201203, China
2Shanghai Institute of Food and Drug Inspection, Shanghai 201203, China
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2上海市食品药品检验研究院，上海 201203
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崔潆心，女，硕士研究生，主要从事药物分析及质量控制。E-mail: 23211030058@m.fudan.edu.cn。
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崔潆心，女，硕士研究生，主要从事药物分析及质量控制。E-mail: 23211030058@m.fudan.edu.cn。
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