Article(id=1321425825522631240, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425746170597545, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.13.012, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1755532800000, acceptedDateStr=2025-08-19, onlineDate=1792982067708, onlineDateStr=2026-10-26, pubDate=1784044800000, pubDateStr=2026-07-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982067708, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982067708, creator=13701087609, updateTime=1792982067708, updator=13701087609, issue=Issue{id=1321425746170597545, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='13', pageStart='1345', pageEnd='1456', issueExtLink='null', onlineDate='null', pubDate='1784044800000', pubDateStr='2026-07-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982048790, creator='13701087609', updateTime=1792982953102, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429539205534609, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425746170597545, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429539205534610, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425746170597545, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1426, endPage=1431, ext={EN=ArticleExt(id=1321425825728152137, articleId=1321425825522631240, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Quality and efficacy evaluation of curcumin-coaxial drug-loaded composite fibrous membranes, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To design a coaxial drug-loaded composite fiber membrane with a core-shell structure. The coaxial drug-loaded fiber membrane was fabricated using electrospinning and electrospraying techniques, achieving satisfactory quality with demonstrated efficacy in promoting wound healing and antibacterial activity.
Methods: Physicochemical characterization, quality control, and in vitro and in vivo efficacy evaluation were conducted on the fabricated composite fiber membrane.
Results: The coaxial nanofibers exhibited a distinct core-shell structure and excellent antibacterial efficacy. H&E staining and VEGF immunohistochemistry confirmed that the coaxial drug-loaded composite fiber membrane promoted collagen synthesis, accelerated neovascularization, and facilitated wound healing.
Conclusion: The prepared coaxial drug-loaded composite fiber membrane meets all the testing requirements and can effectively promote wound healing and inhibit bacteria, providing a new approach for the development of novel wound dressings.
, authors=Yang JI, Ming-xia LIU, Yu-ning WANG, Guang-chao WEI, Hao PAN
*, authorsList=Yang JI, Ming-xia LIU, Yu-ning WANG, Guang-chao WEI, Hao PAN, authorCompany=null, correspAuthors=Hao PAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425826030142026, articleId=1321425825522631240, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=姜黄素同轴载药复合纤维膜的质量及功效评价研究, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的： 设计一种具有核壳结构的同轴载药复合纤维膜。采用静电纺丝和喷雾技术制备获得了同轴载药纤维膜，以实现促进伤口愈合和抑菌的效果。
方法： 对制备的复合纤维膜进行理化性质表征、质量控制以及体内外功效评价。
结果： 观察到同轴纳米纤维具有明显的核壳结构，表现出优异的抑菌效果。通过HE染色、血管内皮生长因子（VEGF）免疫组化证明同轴载药复合纤维膜能够促进胶原合成，加速新生血管生成以及促进伤口愈合。
结论： 所制备的同轴载药复合纤维膜各项测定结果均符合要求，可达到促进伤口愈合并抑制细菌的效果，为新型伤口敷料的研发提供了新的思路。
, authors=季杨, 刘明霞, 王宇宁, 卫广超, 潘昊
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季杨，女，硕士研究生，主要从事静电纺丝制备纳米载药纤维膜及其促伤口愈合性能研究。E-mail: yangj200211@163.com。
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季杨，女，硕士研究生，主要从事静电纺丝制备纳米载药纤维膜及其促伤口愈合性能研究。E-mail: yangj200211@163.com。
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