Article(id=1321425786591101253, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425717926154257, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.12.012, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1773849600000, acceptedDateStr=2026-03-19, onlineDate=1792982058426, onlineDateStr=2026-10-26, pubDate=1782748800000, pubDateStr=2026-06-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982058426, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982058426, creator=13701087609, updateTime=1792982058426, updator=13701087609, issue=Issue{id=1321425717926154257, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='12', pageStart='1233', pageEnd='1344', issueExtLink='null', onlineDate='null', pubDate='1782748800000', pubDateStr='2026-06-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982042056, creator='13701087609', updateTime=1792982988069, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429686186529703, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425717926154257, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429686186529704, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425717926154257, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1324, endPage=1334, ext={EN=ArticleExt(id=1321425786796622150, articleId=1321425786591101253, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Efficacy and safety of injectable non-steroidal anti-inflammatory drugs for postoperative analgesia: a systematic review and Meta-analysis, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To systematically evaluate the efficacy and safety of injectable non-steroidal anti-inflammatory drugs (NSAIDs) for postoperative analgesia.

Methods:

A comprehensive literature search was conducted across databases including CNKI, WanFang, VIP, SinoMed, PubMed, Embase, Web of Science, and the Cochrane Library, supplemented by clinical trial registries, from inception to September 2025. The Cochrane Risk of Bias tool was utilized to assess the methodological quality of the included studies. Data synthesis and Meta-analysis were performed using RevMan 5.4 and Stata software.

Results:

A total of 58 studies involving nine injectable NSAIDs were included. Compared with placebo, all evaluated NSAIDs significantly reduced cumulative opioid consumption at 24 hours postoperatively (all P<0.05). Notably, binaprofen exhibited the most substantial opioid-sparing effect (pooled reduction rate: 36.8%, 95% CI: 32.0% to 40.0%). Furthermore, binaprofen significantly decreased the requirement for patient-controlled analgesia (PCA) rescue [RR=0.42, 95%CI(0.30, 0.58), P<0.001] and the number of effective PCA demands at 24 h. Regarding analgesic efficacy, both parecoxib and ibuprofen significantly lowered pain scores at 24 h postoperatively (both P<0.001). In terms of safety, parecoxib significantly reduced the risk of overall adverse events [RR=0.61, 95%CI (0.51, 0.73)] and gastrointestinal events [RR=0.67, 95%CI (0.54, 0.85)]. Binaprofen also demonstrated a favorable safety profile.

Conclusion:

Injectable NSAIDs effectively alleviate postoperative pain and exert a significant opioid-sparing effect, with parecoxib and binaprofen demonstrating favorable safety profiles. Future well-designed studies should focus on the dose-response relationship and long-term safety in specific patient populations.

, authors=Xiao-zhou ZOU1, Yong-tao YANG2, Sai-ying WANG1, *, authorsList=Xiao-zhou ZOU, Yong-tao YANG, Sai-ying WANG, authorCompany=null, correspAuthors=Sai-ying WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425787052474695, articleId=1321425786591101253, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=非甾体抗炎药注射剂用于术后镇痛的疗效与安全性系统评价和Meta分析, columnId=1236331163573342670, journalTitle=中国新药杂志, columnName=药物安全与合理应用, runingTitle=null, highlight=null, articleAbstract=
目的:

系统评价多种非甾体抗炎药(non-steroidal anti-inflammatory drugs, NSAIDs)注射剂用于术后镇痛的有效性和安全性。

方法:

计算机检索CNKI、WanFang、VIP、SinoMed、PubMed、Embase、Web of Science及Cochrane Library数据库,并补充检索临床试验注册平台,检索时限均从建库至2025年9月。采用Cochrane偏倚风险评估工具评价纳入研究质量,采用RevMan 5.4和Stata软件进行数据合并。

结果:

共纳入58项研究,涉及9种NSAIDs药物。与安慰剂相比,所有NSAIDs均能减少术后24 h阿片类药物用量(P<0.05),其中苯胺洛芬降幅最显著(合并减少率36.8%,95%CI:32.0%~40.0%),并能降低术后24 h患者自控镇痛的补救需求[RR=0.42,95%CI(0.30, 0.58),P<0.001]及有效按压次数。在镇痛效果方面,帕瑞昔布和布洛芬可降低术后24 h疼痛评分(均P<0.001);安全性方面,帕瑞昔布组显著降低了总体不良事件发生风险[RR=0.61,95%CI(0.51, 0.73)]和胃肠道事件发生风险[RR=0.67,95%CI(0.54, 0.85)],苯胺洛芬亦显示出良好的安全性趋势。

结论:

NSAIDs注射剂可有效降低术后疼痛评分并减少阿片类药物消耗量,帕瑞昔布和苯胺洛芬安全性良好。未来研究应关注特定患者人群的剂量-反应关系和长期安全性。

, authors=邹小舟1, 杨永涛2, 汪赛赢1, *, authorsList=邹小舟, 杨永涛, 汪赛赢, authorCompany=null, correspAuthors=汪赛赢, authorNote=

邹小舟,男,硕士,医师,主要从事围术期镇痛研究。E-mail: 。

, correspAuthorsNote=
* 汪赛赢,女,博士,主任医师,主要从事麻醉药理研究。E-mail: 。
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邹小舟,男,硕士,医师,主要从事围术期镇痛研究。E-mail: 。

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非甾体抗炎药注射剂用于术后镇痛的疗效与安全性系统评价和Meta分析
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邹小舟 1 , 杨永涛 2 , 汪赛赢 1, *
中国新药杂志 | 药物安全与合理应用 2026,35(12): 1324-1334
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中国新药杂志 |药物安全与合理应用 2026 , 35 (12) : 1324 -1334
非甾体抗炎药注射剂用于术后镇痛的疗效与安全性系统评价和Meta分析
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邹小舟1 , 杨永涛2, 汪赛赢1, *
作者信息
  • 1中南大学湘雅三医院麻醉科,长沙 410013
  • 2石家庄以岭药业股份有限公司,石家庄 050035
通讯作者:
* 汪赛赢,女,博士,主任医师,主要从事麻醉药理研究。E-mail: 。
作者简介:

邹小舟,男,硕士,医师,主要从事围术期镇痛研究。E-mail: 。

Efficacy and safety of injectable non-steroidal anti-inflammatory drugs for postoperative analgesia: a systematic review and Meta-analysis
Xiao-zhou ZOU1 , Yong-tao YANG2, Sai-ying WANG1, *
Affiliations
  • 1Department of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha 410013, China
  • 2Shijiazhuang Yiling Pharmaceutical Co., Ltd., Shijiazhuang 050035, China
出版时间: 2026-06-30 doi: 10.20251/j.cnki.1003-3734.2026.12.012
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目的:

系统评价多种非甾体抗炎药(non-steroidal anti-inflammatory drugs, NSAIDs)注射剂用于术后镇痛的有效性和安全性。

方法:

计算机检索CNKI、WanFang、VIP、SinoMed、PubMed、Embase、Web of Science及Cochrane Library数据库,并补充检索临床试验注册平台,检索时限均从建库至2025年9月。采用Cochrane偏倚风险评估工具评价纳入研究质量,采用RevMan 5.4和Stata软件进行数据合并。

结果:

共纳入58项研究,涉及9种NSAIDs药物。与安慰剂相比,所有NSAIDs均能减少术后24 h阿片类药物用量(P<0.05),其中苯胺洛芬降幅最显著(合并减少率36.8%,95%CI:32.0%~40.0%),并能降低术后24 h患者自控镇痛的补救需求[RR=0.42,95%CI(0.30, 0.58),P<0.001]及有效按压次数。在镇痛效果方面,帕瑞昔布和布洛芬可降低术后24 h疼痛评分(均P<0.001);安全性方面,帕瑞昔布组显著降低了总体不良事件发生风险[RR=0.61,95%CI(0.51, 0.73)]和胃肠道事件发生风险[RR=0.67,95%CI(0.54, 0.85)],苯胺洛芬亦显示出良好的安全性趋势。

结论:

NSAIDs注射剂可有效降低术后疼痛评分并减少阿片类药物消耗量,帕瑞昔布和苯胺洛芬安全性良好。未来研究应关注特定患者人群的剂量-反应关系和长期安全性。

非甾体抗炎药  /  注射剂  /  术后镇痛  /  阿片类药物节约效应  /  Meta分析
Objective:

To systematically evaluate the efficacy and safety of injectable non-steroidal anti-inflammatory drugs (NSAIDs) for postoperative analgesia.

Methods:

A comprehensive literature search was conducted across databases including CNKI, WanFang, VIP, SinoMed, PubMed, Embase, Web of Science, and the Cochrane Library, supplemented by clinical trial registries, from inception to September 2025. The Cochrane Risk of Bias tool was utilized to assess the methodological quality of the included studies. Data synthesis and Meta-analysis were performed using RevMan 5.4 and Stata software.

Results:

A total of 58 studies involving nine injectable NSAIDs were included. Compared with placebo, all evaluated NSAIDs significantly reduced cumulative opioid consumption at 24 hours postoperatively (all P<0.05). Notably, binaprofen exhibited the most substantial opioid-sparing effect (pooled reduction rate: 36.8%, 95% CI: 32.0% to 40.0%). Furthermore, binaprofen significantly decreased the requirement for patient-controlled analgesia (PCA) rescue [RR=0.42, 95%CI(0.30, 0.58), P<0.001] and the number of effective PCA demands at 24 h. Regarding analgesic efficacy, both parecoxib and ibuprofen significantly lowered pain scores at 24 h postoperatively (both P<0.001). In terms of safety, parecoxib significantly reduced the risk of overall adverse events [RR=0.61, 95%CI (0.51, 0.73)] and gastrointestinal events [RR=0.67, 95%CI (0.54, 0.85)]. Binaprofen also demonstrated a favorable safety profile.

Conclusion:

Injectable NSAIDs effectively alleviate postoperative pain and exert a significant opioid-sparing effect, with parecoxib and binaprofen demonstrating favorable safety profiles. Future well-designed studies should focus on the dose-response relationship and long-term safety in specific patient populations.

non-steroidal anti-inflammatory drugs  /  injections  /  postoperative analgesia  /  opioid-sparing effect  /  Meta-analysis
邹小舟, 杨永涛, 汪赛赢. 非甾体抗炎药注射剂用于术后镇痛的疗效与安全性系统评价和Meta分析. 中国新药杂志, 2026 , 35 (12) : 1324 -1334 . DOI: 10.20251/j.cnki.1003-3734.2026.12.012
Xiao-zhou ZOU, Yong-tao YANG, Sai-ying WANG. Efficacy and safety of injectable non-steroidal anti-inflammatory drugs for postoperative analgesia: a systematic review and Meta-analysis[J]. Chinese Journal of New Drugs, 2026 , 35 (12) : 1324 -1334 . DOI: 10.20251/j.cnki.1003-3734.2026.12.012

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doi: 10.20251/j.cnki.1003-3734.2026.12.012
  • 首发时间:2026-10-26
  • 出版时间:2026-06-30
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  • 录用日期:2026-03-19
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    1中南大学湘雅三医院麻醉科,长沙 410013
    2石家庄以岭药业股份有限公司,石家庄 050035

通讯作者:

* 汪赛赢,女,博士,主任医师,主要从事麻醉药理研究。E-mail: 。
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2种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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