Article(id=1321425724846752498, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425686888305517, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.11.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1756137600000, acceptedDateStr=2025-08-26, onlineDate=1792982043706, onlineDateStr=2026-10-26, pubDate=1781452800000, pubDateStr=2026-06-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982043706, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982043706, creator=13701087609, updateTime=1792982043706, updator=13701087609, issue=Issue{id=1321425686888305517, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='11', pageStart='1121', pageEnd='1232', issueExtLink='null', onlineDate='null', pubDate='1781452800000', pubDateStr='2026-06-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982034656, creator='13701087609', updateTime=1792983035368, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429884228977462, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425686888305517, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429884228977463, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425686888305517, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1138, endPage=1144, ext={EN=ArticleExt(id=1321425725006136051, articleId=1321425724846752498, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Radionuclide selection, conjugation strategies, and CMC considerations for quality control differences in radionuclide drug conjugates, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Radionuclide drug conjugates (RDCs) have shown great potential in the field of nuclear medicine due to their precise targeting and radioactive killing capability. This article comprehensively reviews the selection criteria of radionuclides in RDCs and various conjugation strategies between radionuclides and targeting ligands, and provides an in-depth discussion on the differences in quality control for different radionuclides, aiming to provide a reference for the pharmaceutical research and evaluation of RDCs, and help realize their integrated precision diagnosis and treatment in more diseases.

, authors=Yi-fei DAI, Yu-jia XIE, Tao JIANG, Zhi-jun TU, Ming-hong WANG, Feng REN*, authorsList=Yi-fei DAI, Yu-jia XIE, Tao JIANG, Zhi-jun TU, Ming-hong WANG, Feng REN, authorCompany=null, correspAuthors=Feng REN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425725241017076, articleId=1321425724846752498, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=放射性核素偶联药物的核素选择、偶联策略与质控差异的药学考量, columnId=1236331159400018080, journalTitle=中国新药杂志, columnName=新药注册与审评技术, runingTitle=null, highlight=null, articleAbstract=

放射性核素偶联药物(radionuclide drug conjugates, RDC)凭借精准靶向与放射性杀伤能力,在核医学领域中展现出巨大潜力。本文全面综述了RDC中放射性核素的选择依据、放射性核素与靶向配体的多种偶联策略,并深入探讨了不同核素的质控差异,旨在为RDC的药学研究和审评提供参考,助力其在更多疾病中实现精准诊疗一体化。

, authors=戴逸飞, 谢雨佳, 姜涛, 涂志军, 王明宏, 任峰*, authorsList=戴逸飞, 谢雨佳, 姜涛, 涂志军, 王明宏, 任峰, authorCompany=null, correspAuthors=任峰, authorNote=

戴逸飞,男,博士,审评员,主要从事生物制品药学研究。联系电话:(021)22082295,E-mail: 。

, correspAuthorsNote=
* 任峰,男,博士,审评员,主要从事化学药药学研究。联系电话:(021)22082293,E-mail: 。
, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=ixgCycEObwCGoVsGKb2LDA==, magXml=UahLeVLIxnyQN2puqte9+Q==, pdfUrl=null, pdf=OCD1OIJVgh/IIaZPGGm+rw==, pdfFileSize=3475978, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=Vowf/SKVIx92FAwO/O6elw==, mapNumber=null, fund=null)}, authors=[Author(id=1321425727107482361, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=daiyf@ydcdei.org.cn, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425727195562747, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425727107482361, language=EN, stringName=Yi-fei DAI, firstName=Yi-fei, middleName=null, lastName=DAI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425727304614652, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425727107482361, language=CN, stringName=戴逸飞, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=国家药品监督管理局药品审评检查长三角分中心,上海 201210, bio={"content":"

戴逸飞,男,博士,审评员,主要从事生物制品药学研究。联系电话:(021)22082295,E-mail: 。

"}, bioImg=null, bioContent=

戴逸飞,男,博士,审评员,主要从事生物制品药学研究。联系电话:(021)22082295,E-mail: 。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425727023596277, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, xref=null, ext=[AuthorCompanyExt(id=1321425727031984886, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China), AuthorCompanyExt(id=1321425727040373495, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=国家药品监督管理局药品审评检查长三角分中心,上海 201210)])]), Author(id=1321425727388500734, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425727476581120, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425727388500734, language=EN, stringName=Yu-jia XIE, firstName=Yu-jia, middleName=null, lastName=XIE, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425727556272897, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425727388500734, language=CN, stringName=谢雨佳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=国家药品监督管理局药品审评检查长三角分中心,上海 201210, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425727023596277, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, xref=null, ext=[AuthorCompanyExt(id=1321425727031984886, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China), AuthorCompanyExt(id=1321425727040373495, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=国家药品监督管理局药品审评检查长三角分中心,上海 201210)])]), Author(id=1321425727627576067, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425727711462149, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425727627576067, language=EN, stringName=Tao JIANG, firstName=Tao, middleName=null, lastName=JIANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425727778571014, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425727627576067, language=CN, stringName=姜涛, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=国家药品监督管理局药品审评检查长三角分中心,上海 201210, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425727023596277, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, xref=null, ext=[AuthorCompanyExt(id=1321425727031984886, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China), AuthorCompanyExt(id=1321425727040373495, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=国家药品监督管理局药品审评检查长三角分中心,上海 201210)])]), Author(id=1321425727845679880, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425727912788746, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425727845679880, language=EN, stringName=Zhi-jun TU, firstName=Zhi-jun, middleName=null, lastName=TU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425727975703307, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425727845679880, language=CN, stringName=涂志军, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=国家药品监督管理局药品审评检查长三角分中心,上海 201210, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425727023596277, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, xref=null, ext=[AuthorCompanyExt(id=1321425727031984886, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China), AuthorCompanyExt(id=1321425727040373495, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=国家药品监督管理局药品审评检查长三角分中心,上海 201210)])]), Author(id=1321425728047006477, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425728143475471, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425728047006477, language=EN, stringName=Ming-hong WANG, firstName=Ming-hong, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425728227361552, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425728047006477, language=CN, stringName=王明宏, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=国家药品监督管理局药品审评检查长三角分中心,上海 201210, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425727023596277, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, xref=null, ext=[AuthorCompanyExt(id=1321425727031984886, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China), AuthorCompanyExt(id=1321425727040373495, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=国家药品监督管理局药品审评检查长三角分中心,上海 201210)])]), Author(id=1321425728298664722, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=renf@ydcdei.org.cn, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1321425728378356500, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425728298664722, language=EN, stringName=Feng REN, firstName=Feng, middleName=null, lastName=REN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=*, address=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425728458048277, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425728298664722, language=CN, stringName=任峰, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=*, address=国家药品监督管理局药品审评检查长三角分中心,上海 201210, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425727023596277, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, xref=null, ext=[AuthorCompanyExt(id=1321425727031984886, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China), AuthorCompanyExt(id=1321425727040373495, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=国家药品监督管理局药品审评检查长三角分中心,上海 201210)])])], keywords=[Keyword(id=1321425728583877398, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, language=EN, orderNo=1, keyword=radionuclide drug conjugates), Keyword(id=1321425728646791959, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, language=EN, orderNo=2, keyword=conjugation strategy), Keyword(id=1321425728718095128, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, language=EN, orderNo=3, keyword=quality control), Keyword(id=1321425728785203993, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, language=EN, orderNo=4, keyword=pharmaceutical research), Keyword(id=1321425728852312858, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, language=CN, orderNo=1, keyword=放射性核素偶联药物), Keyword(id=1321425728936198939, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, language=CN, orderNo=2, keyword=偶联策略), Keyword(id=1321425729011696412, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, language=CN, orderNo=3, keyword=质量控制), Keyword(id=1321425729095582493, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, language=CN, orderNo=4, keyword=药学研究)], refs=null, funds=[Fund(id=1321425729196245790, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, awardId=24692122700, language=CN, fundingSource=长三角区域药品领域创新与高质量发展监管科学研究资助项目(24692122700), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1321425727023596277, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, xref=null, ext=[AuthorCompanyExt(id=1321425727031984886, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China), AuthorCompanyExt(id=1321425727040373495, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=国家药品监督管理局药品审评检查长三角分中心,上海 201210)])], figs=null, attaches=null, journal=Journal(id=1235980159023624194, delFlag=0, nameCn=中国新药杂志, nameEn=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, issn=1003-3734, eissn=null, cn=11-2850/R, coden=ZXZHA6, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of New Drugs, journalRemark=null, publicationField=null, createdTime=1772610233314, updatedTime=1788948968376, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=ohPEEN//Vz1tDT3ZBNTp4Q==, picEn=f9WK9bvTM4guTmS/iGhOMg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509780974924039, language=CN, name=中国新药杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968404, updatedTime=1788948968404, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304509781025255688, language=EN, name=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968416, updatedTime=1788948968416, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1235980733773295621, websiteList=[Website(id=1235982099191222761, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/CN, language=CN, createTime=1772610695884, createBy=18614031015, updateTime=1772610860397, updateBy=18614031015, name=中国新药杂志-中文, tplId=1146099689490845704, title=中国新药杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983918629966444, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=articleTextType, value=kx, createTime=1772611129672, updateTime=1772611129672, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918604800617, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=banner, value=null, createTime=1772611129666, updateTime=1772611129666, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918655132271, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=grayFlag, value=0, createTime=1772611129678, updateTime=1772611129678, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918596412008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611129664, updateTime=1772611129664, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918667715185, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=minRunFlag, value=0, createTime=1772611129681, updateTime=1772611129681, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918617383531, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic, createTime=1772611129669, updateTime=1772611129669, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918659326576, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=silenceFlag, value=0, createTime=1772611129679, updateTime=1772611129679, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918613189226, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1772611129668, updateTime=1772611129668, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918634160749, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeColor, value=null, createTime=1772611129673, updateTime=1772611129673, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918646743662, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeStyle, value=null, createTime=1772611129676, updateTime=1772611129676, creator=18614031015, updator=18614031015)]), Website(id=1235982099270914542, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/EN, language=EN, createTime=1772610695903, createBy=18614031015, updateTime=1772610875891, updateBy=18614031015, name=中国新药杂志-英文, tplId=1146101810881728533, title=Chinese Journal of New Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983955829248630, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=articleTextType, value=kx, createTime=1772611138541, updateTime=1772611138541, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955804082803, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=banner, value=null, createTime=1772611138535, updateTime=1772611138535, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955854414457, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=grayFlag, value=0, createTime=1772611138547, updateTime=1772611138547, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955795694194, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611138533, updateTime=1772611138533, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955866997371, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=minRunFlag, value=0, createTime=1772611138550, updateTime=1772611138550, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955820860021, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic, createTime=1772611138539, updateTime=1772611138539, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955862803066, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=silenceFlag, value=0, createTime=1772611138549, updateTime=1772611138549, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955812471412, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1772611138537, updateTime=1772611138537, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955837637239, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeColor, value=null, createTime=1772611138543, updateTime=1772611138543, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955846025848, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeStyle, value=null, createTime=1772611138545, updateTime=1772611138545, creator=18614031015, updator=18614031015)])], journalTitle=中国新药杂志, weixinUrl=null, journalUrl=http://www.newdrug.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of New Drugs, journalPhotoCn=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPhotoEn=f9WK9bvTM4guTmS/iGhOMg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/10.20251/j.cnki.1003-3734.2026.11.003, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/10.20251/j.cnki.1003-3734.2026.11.003, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/PDF/10.20251/j.cnki.1003-3734.2026.11.003, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/PDF/10.20251/j.cnki.1003-3734.2026.11.003, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1781452800000, fullTextJson=null, articleText=null, reference=null)
收藏切换
放射性核素偶联药物的核素选择、偶联策略与质控差异的药学考量
收藏切换
PDF下载
戴逸飞 , 谢雨佳 , 姜涛 , 涂志军 , 王明宏 , 任峰 *
中国新药杂志 | 新药注册与审评技术 2026,35(11): 1138-1144
收起
收藏切换
中国新药杂志 |新药注册与审评技术 2026 , 35 (11) : 1138 -1144
放射性核素偶联药物的核素选择、偶联策略与质控差异的药学考量
全屏
[Author(id=1321425727107482361, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=daiyf@ydcdei.org.cn, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425727195562747, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425727107482361, language=EN, stringName=Yi-fei DAI, firstName=Yi-fei, middleName=null, lastName=DAI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425727304614652, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425727107482361, language=CN, stringName=戴逸飞, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=国家药品监督管理局药品审评检查长三角分中心,上海 201210, bio={"content":"

戴逸飞,男,博士,审评员,主要从事生物制品药学研究。联系电话:(021)22082295,E-mail: 。

"}, bioImg=null, bioContent=

戴逸飞,男,博士,审评员,主要从事生物制品药学研究。联系电话:(021)22082295,E-mail: 。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425727023596277, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, xref=null, ext=[AuthorCompanyExt(id=1321425727031984886, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China), AuthorCompanyExt(id=1321425727040373495, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=国家药品监督管理局药品审评检查长三角分中心,上海 201210)])]), Author(id=1321425727388500734, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425727476581120, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425727388500734, language=EN, stringName=Yu-jia XIE, firstName=Yu-jia, middleName=null, lastName=XIE, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425727556272897, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425727388500734, language=CN, stringName=谢雨佳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=国家药品监督管理局药品审评检查长三角分中心,上海 201210, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425727023596277, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, xref=null, ext=[AuthorCompanyExt(id=1321425727031984886, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China), AuthorCompanyExt(id=1321425727040373495, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=国家药品监督管理局药品审评检查长三角分中心,上海 201210)])]), Author(id=1321425727627576067, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425727711462149, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425727627576067, language=EN, stringName=Tao JIANG, firstName=Tao, middleName=null, lastName=JIANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425727778571014, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425727627576067, language=CN, stringName=姜涛, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=国家药品监督管理局药品审评检查长三角分中心,上海 201210, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425727023596277, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, xref=null, ext=[AuthorCompanyExt(id=1321425727031984886, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China), AuthorCompanyExt(id=1321425727040373495, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=国家药品监督管理局药品审评检查长三角分中心,上海 201210)])]), Author(id=1321425727845679880, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425727912788746, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425727845679880, language=EN, stringName=Zhi-jun TU, firstName=Zhi-jun, middleName=null, lastName=TU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425727975703307, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425727845679880, language=CN, stringName=涂志军, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=国家药品监督管理局药品审评检查长三角分中心,上海 201210, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425727023596277, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, xref=null, ext=[AuthorCompanyExt(id=1321425727031984886, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China), AuthorCompanyExt(id=1321425727040373495, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=国家药品监督管理局药品审评检查长三角分中心,上海 201210)])]), Author(id=1321425728047006477, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425728143475471, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425728047006477, language=EN, stringName=Ming-hong WANG, firstName=Ming-hong, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425728227361552, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425728047006477, language=CN, stringName=王明宏, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=国家药品监督管理局药品审评检查长三角分中心,上海 201210, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425727023596277, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, xref=null, ext=[AuthorCompanyExt(id=1321425727031984886, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China), AuthorCompanyExt(id=1321425727040373495, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=国家药品监督管理局药品审评检查长三角分中心,上海 201210)])]), Author(id=1321425728298664722, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=renf@ydcdei.org.cn, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1321425728378356500, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425728298664722, language=EN, stringName=Feng REN, firstName=Feng, middleName=null, lastName=REN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=*, address=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425728458048277, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, authorId=1321425728298664722, language=CN, stringName=任峰, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=*, address=国家药品监督管理局药品审评检查长三角分中心,上海 201210, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425727023596277, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, xref=null, ext=[AuthorCompanyExt(id=1321425727031984886, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China), AuthorCompanyExt(id=1321425727040373495, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425724846752498, companyId=1321425727023596277, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=国家药品监督管理局药品审评检查长三角分中心,上海 201210)])])]
戴逸飞 , 谢雨佳, 姜涛, 涂志军, 王明宏, 任峰*
作者信息
  • 国家药品监督管理局药品审评检查长三角分中心,上海 201210
通讯作者:
* 任峰,男,博士,审评员,主要从事化学药药学研究。联系电话:(021)22082293,E-mail: 。
作者简介:

戴逸飞,男,博士,审评员,主要从事生物制品药学研究。联系电话:(021)22082295,E-mail: 。

Radionuclide selection, conjugation strategies, and CMC considerations for quality control differences in radionuclide drug conjugates
Yi-fei DAI , Yu-jia XIE, Tao JIANG, Zhi-jun TU, Ming-hong WANG, Feng REN*
Affiliations
  • Yangtze River Delta Branch Center for Drug Evaluation and Inspection of the National Medical Products Administration, Shanghai 201210, China
出版时间: 2026-06-15 doi: 10.20251/j.cnki.1003-3734.2026.11.003
文章导航
收藏切换

放射性核素偶联药物(radionuclide drug conjugates, RDC)凭借精准靶向与放射性杀伤能力,在核医学领域中展现出巨大潜力。本文全面综述了RDC中放射性核素的选择依据、放射性核素与靶向配体的多种偶联策略,并深入探讨了不同核素的质控差异,旨在为RDC的药学研究和审评提供参考,助力其在更多疾病中实现精准诊疗一体化。

放射性核素偶联药物  /  偶联策略  /  质量控制  /  药学研究

Radionuclide drug conjugates (RDCs) have shown great potential in the field of nuclear medicine due to their precise targeting and radioactive killing capability. This article comprehensively reviews the selection criteria of radionuclides in RDCs and various conjugation strategies between radionuclides and targeting ligands, and provides an in-depth discussion on the differences in quality control for different radionuclides, aiming to provide a reference for the pharmaceutical research and evaluation of RDCs, and help realize their integrated precision diagnosis and treatment in more diseases.

radionuclide drug conjugates  /  conjugation strategy  /  quality control  /  pharmaceutical research
戴逸飞, 谢雨佳, 姜涛, 涂志军, 王明宏, 任峰. 放射性核素偶联药物的核素选择、偶联策略与质控差异的药学考量. 中国新药杂志, 2026 , 35 (11) : 1138 -1144 . DOI: 10.20251/j.cnki.1003-3734.2026.11.003
Yi-fei DAI, Yu-jia XIE, Tao JIANG, Zhi-jun TU, Ming-hong WANG, Feng REN. Radionuclide selection, conjugation strategies, and CMC considerations for quality control differences in radionuclide drug conjugates[J]. Chinese Journal of New Drugs, 2026 , 35 (11) : 1138 -1144 . DOI: 10.20251/j.cnki.1003-3734.2026.11.003
  • 长三角区域药品领域创新与高质量发展监管科学研究资助项目(24692122700)
参考文献 引证文献
排序方式:
2026年第35卷第11期
PDF下载
27
5
引用本文
BibTeX
文章信息
doi: 10.20251/j.cnki.1003-3734.2026.11.003
  • 首发时间:2026-10-26
  • 出版时间:2026-06-15
补充材料
相关文章
文章信息
作者
出版历史
  • 录用日期:2025-08-26
基金
长三角区域药品领域创新与高质量发展监管科学研究资助项目(24692122700)
作者信息
    国家药品监督管理局药品审评检查长三角分中心,上海 201210

通讯作者:

* 任峰,男,博士,审评员,主要从事化学药药学研究。联系电话:(021)22082293,E-mail: 。
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/zgxyzz/CN/10.20251/j.cnki.1003-3734.2026.11.003
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏