Article(id=1321425697889960457, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425656810951355, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.10.009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1773072000000, acceptedDateStr=2026-03-10, onlineDate=1792982037278, onlineDateStr=2026-10-26, pubDate=1780070400000, pubDateStr=2026-05-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982037278, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982037278, creator=13701087609, updateTime=1792982037278, updator=13701087609, issue=Issue{id=1321425656810951355, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='10', pageStart='1009', pageEnd='1120', issueExtLink='null', onlineDate='null', pubDate='1780070400000', pubDateStr='2026-05-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982027485, creator='13701087609', updateTime=1792983064574, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321430006727820106, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425656810951355, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321430006727820107, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425656810951355, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1072, endPage=1081, ext={EN=ArticleExt(id=1321425698078704138, articleId=1321425697889960457, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Study on biological properties, antibacterial and analgesic activities of ibuprofen-loaded photocrosslinked hydrogel wound dressing, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To develop multifunctional hydrogels with excellent antibacterial properties and biocompatibility for the treatment of bacterial infection wounds, which can rapidly heal wounds and relieve pain.

Methods:

A three-dimensional porous composite hydrogel was prepared by using methacrylated gelatin and polyacrylamide as raw materials and loading copper sulfide particles and ibuprofen through photo-crosslinking. The hydrogel has good biocompatibility and antibacterial properties. The morphology and structure of the hydrogel were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffractometer (XRD), etc. The swelling and degradation properties, mechanical properties and rheological properties of the drug-loaded PAAM/GelMA composite hydrogel were analyzed. Meanwhile, in vitro biological experiments were conducted to verify its excellent biocompatibility and explore its antibacterial properties.

Results:

The PG-CuS@Ib hydrogel displayed a high swelling performance (100%±5%), which can effectively absorb exudate. The antibacterial tests against Escherichia coli and Staphylococcus aureus showed that the inhibition rates were both over 99%. In the biocompatibility test, the survival rate of MC3T1-E1 cells was high, the cell morphology was spread out, and there was no obvious hemolysis (<5%).

Conclusion:

The PG-CuS@Ib multifunctional composite hydrogel can meet the key requirements for wound healing. In general, the PG-CuS@Ib hydrogel has promising prospects as a wound dressing.

, authors=Yu-chen ZHOU, Liang-liang ZHANG, Yang LIU*, authorsList=Yu-chen ZHOU, Liang-liang ZHANG, Yang LIU, authorCompany=null, correspAuthors=Yang LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425698481357323, articleId=1321425697889960457, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=负载布洛芬光交联水凝胶敷料的生物性能及抑菌镇痛性能研究, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的:

开发具有良好抑菌性能和生物相容性的多功能水凝胶,用于治疗细菌感染创面,起到快速愈合伤口和止痛的作用。

方法:

本文以甲基丙烯酰化明胶和聚丙烯酰胺为原料,搭载硫化铜粒子和布洛芬,采用光交联的方式制备三维多孔结构的复合水凝胶,具有良好的生物相容性和抗菌性能。通过扫描电子显微镜(SEM)、红外光谱仪(FT-IR)、X射线衍射仪(XRD)等仪器对其形貌和结构进行表征,分析聚丙烯酰胺/甲基丙烯酰化明胶载药复合水凝胶的溶胀降解性、力学性能和流变性,同时进行生物体外实验,验证其优异的生物相容性,并探究其抗菌性能。

结果:

PG-CuS@Ib水凝胶具有高溶胀性能(100%±5%),能有效吸收渗出液;对大肠埃希菌和金黄色葡萄球菌的抗菌测试显示,抑菌率均超过99%;生物相容性测试显示,MC3T1-E1细胞存活率较高,细胞形态舒展,且无明显的溶血现象(<5%)。

结论:

PG-CuS@Ib多功能复合水凝胶能够满足伤口愈合的关键要求。总体而言,PG-CuS@Ib水凝胶作为伤口敷料具有一定应用前景。

, authors=周昱辰, 张亮亮, 刘阳*, authorsList=周昱辰, 张亮亮, 刘阳, authorCompany=null, correspAuthors=刘阳, authorNote=

周昱辰,男,硕士研究生,研究方向:水凝胶组分设计。E-mail: 。

, correspAuthorsNote=
* 刘阳,男,副主任医师,研究方向:镇痛水凝胶设计。E-mail: 。
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周昱辰,男,硕士研究生,研究方向:水凝胶组分设计。E-mail: 。

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周昱辰,男,硕士研究生,研究方向:水凝胶组分设计。E-mail: 。

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负载布洛芬光交联水凝胶敷料的生物性能及抑菌镇痛性能研究
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周昱辰 , 张亮亮 , 刘阳 *
中国新药杂志 | 实验研究 2026,35(10): 1072-1081
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中国新药杂志 |实验研究 2026 , 35 (10) : 1072 -1081
负载布洛芬光交联水凝胶敷料的生物性能及抑菌镇痛性能研究
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周昱辰,男,硕士研究生,研究方向:水凝胶组分设计。E-mail: 。

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周昱辰 , 张亮亮, 刘阳*
作者信息
  • 首都医科大学附属北京世纪坛医院,北京 100038
通讯作者:
* 刘阳,男,副主任医师,研究方向:镇痛水凝胶设计。E-mail: 。
作者简介:

周昱辰,男,硕士研究生,研究方向:水凝胶组分设计。E-mail: 。

Study on biological properties, antibacterial and analgesic activities of ibuprofen-loaded photocrosslinked hydrogel wound dressing
Yu-chen ZHOU , Liang-liang ZHANG, Yang LIU*
Affiliations
  • Beijing Shijitan Hospital, Beijing 100038, China
出版时间: 2026-05-30 doi: 10.20251/j.cnki.1003-3734.2026.10.009
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目的:

开发具有良好抑菌性能和生物相容性的多功能水凝胶,用于治疗细菌感染创面,起到快速愈合伤口和止痛的作用。

方法:

本文以甲基丙烯酰化明胶和聚丙烯酰胺为原料,搭载硫化铜粒子和布洛芬,采用光交联的方式制备三维多孔结构的复合水凝胶,具有良好的生物相容性和抗菌性能。通过扫描电子显微镜(SEM)、红外光谱仪(FT-IR)、X射线衍射仪(XRD)等仪器对其形貌和结构进行表征,分析聚丙烯酰胺/甲基丙烯酰化明胶载药复合水凝胶的溶胀降解性、力学性能和流变性,同时进行生物体外实验,验证其优异的生物相容性,并探究其抗菌性能。

结果:

PG-CuS@Ib水凝胶具有高溶胀性能(100%±5%),能有效吸收渗出液;对大肠埃希菌和金黄色葡萄球菌的抗菌测试显示,抑菌率均超过99%;生物相容性测试显示,MC3T1-E1细胞存活率较高,细胞形态舒展,且无明显的溶血现象(<5%)。

结论:

PG-CuS@Ib多功能复合水凝胶能够满足伤口愈合的关键要求。总体而言,PG-CuS@Ib水凝胶作为伤口敷料具有一定应用前景。

硫化铜纳米粒子  /  布洛芬  /  抑菌性  /  镇痛  /  水凝胶
Objective:

To develop multifunctional hydrogels with excellent antibacterial properties and biocompatibility for the treatment of bacterial infection wounds, which can rapidly heal wounds and relieve pain.

Methods:

A three-dimensional porous composite hydrogel was prepared by using methacrylated gelatin and polyacrylamide as raw materials and loading copper sulfide particles and ibuprofen through photo-crosslinking. The hydrogel has good biocompatibility and antibacterial properties. The morphology and structure of the hydrogel were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffractometer (XRD), etc. The swelling and degradation properties, mechanical properties and rheological properties of the drug-loaded PAAM/GelMA composite hydrogel were analyzed. Meanwhile, in vitro biological experiments were conducted to verify its excellent biocompatibility and explore its antibacterial properties.

Results:

The PG-CuS@Ib hydrogel displayed a high swelling performance (100%±5%), which can effectively absorb exudate. The antibacterial tests against Escherichia coli and Staphylococcus aureus showed that the inhibition rates were both over 99%. In the biocompatibility test, the survival rate of MC3T1-E1 cells was high, the cell morphology was spread out, and there was no obvious hemolysis (<5%).

Conclusion:

The PG-CuS@Ib multifunctional composite hydrogel can meet the key requirements for wound healing. In general, the PG-CuS@Ib hydrogel has promising prospects as a wound dressing.

copper sulfide nanoparticles  /  ibuprofen  /  antibacterial activity  /  relieve pain  /  hydrogel
周昱辰, 张亮亮, 刘阳. 负载布洛芬光交联水凝胶敷料的生物性能及抑菌镇痛性能研究. 中国新药杂志, 2026 , 35 (10) : 1072 -1081 . DOI: 10.20251/j.cnki.1003-3734.2026.10.009
Yu-chen ZHOU, Liang-liang ZHANG, Yang LIU. Study on biological properties, antibacterial and analgesic activities of ibuprofen-loaded photocrosslinked hydrogel wound dressing[J]. Chinese Journal of New Drugs, 2026 , 35 (10) : 1072 -1081 . DOI: 10.20251/j.cnki.1003-3734.2026.10.009

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doi: 10.20251/j.cnki.1003-3734.2026.10.009
  • 首发时间:2026-10-26
  • 出版时间:2026-05-30
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  • 录用日期:2026-03-10
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    首都医科大学附属北京世纪坛医院,北京 100038

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* 刘阳,男,副主任医师,研究方向:镇痛水凝胶设计。E-mail: 。
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2种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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