Article(id=1321425680533930419, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425625915707977, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.09.013, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1747152000000, acceptedDateStr=2025-05-14, onlineDate=1792982033141, onlineDateStr=2026-10-26, pubDate=1778774400000, pubDateStr=2026-05-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982033141, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982033141, creator=13701087609, updateTime=1792982033141, updator=13701087609, issue=Issue{id=1321425625915707977, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='9', pageStart='897', pageEnd='1008', issueExtLink='null', onlineDate='null', pubDate='1778774400000', pubDateStr='2026-05-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982020119, creator='13701087609', updateTime=1792983090252, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321430114441745406, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425625915707977, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321430114441745407, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425625915707977, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=994, endPage=1001, ext={EN=ArticleExt(id=1321425682169708980, articleId=1321425680533930419, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Pharmacoeconomic study and drug pricing of imipenem/cilastatin/relebactam in the treatment of ventilator-associated pneumonia and hospital-acquired pneumonia, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To evaluate the cost-effectiveness of imipenem/cilastatin/relebactam (IMI/REL) in patients with hospital-acquired bacterial pneumonia (HABP) and ventilator-associated pneumonia (VAP), using piperacillin/tazobactam (PIP/TAZ) as a comparator, and to assess its economic viability within the Chinese healthcare system.
Methods: From the perspective of the Chinese healthcare system, a hybrid decision tree-Markov model was constructed to simulate the long-term health outcomes of IMI/REL and PIP/TAZ from the mean age of disease onset until death. Efficacy and safety data were derived from a Phase Ⅲ clinical trial (NCT03583333), while cost and utility parameters were obtained based on literature reviews and expert interviews. Cost-utility analysis was performed, and one-way and probabilistic sensitivity analyses were conducted to validate the robustness of the results. The unit price of IMI/REL was set at 1 240 yuan per vial based on publicly available sales prices, and which both base-case and scenario analyses were conducted.
Results: The base-case analysis showed that the total treatment cost in the IMI/REL group was 164 275.71 yuan with a quality-adjusted life year (QALY) of 4.32, while the total cost in the PIP/TAZ group was 143 946 yuan with a QALY of 4.13. The incremental cost-utility ratio (ICER) was 104 991.37 yuan per QALY, which was lower than the threshold of three times China's per capita gross domestic product (GDP). The scenario analysis indicated that under the assumption of partial survival among uncured patients, the cost-effectiveness conclusion of IMI/REL remained robust.
Conclusion: Under the currently available price setting, IMI/REL demonstrates favorable cost-effectiveness compared with PIP/TAZ, providing a reference for optimizing treatment strategies and informing medical insurance payment policies for HABP/VAP in China.
, authors=Yu-xi ZHANG
1, Ran-ran ZHANG
1, Jing ZHANG
2, Sheng-nan GAO
3, Ning GAO
1, Bing FENG
1, Ran LIU
1, Guo-qiang LIU
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目的： 评估亚胺培南/西司他丁/瑞来巴坦（imipenem/cilastatin/relebactam, IMI/REL）在医院获得性细菌性肺炎（hospital-acquired bacterial pneumonia, HABP）和呼吸机相关肺炎（ventilator-associated pneumonia, VAP）患者中的成本效益，并以哌拉西林/他唑巴坦（PIP/TAZ）为对照，评估其在中国医疗体系下的经济性。
方法： 基于中国卫生体系视角，构建决策树-马尔科夫模型，模拟IMI/REL与PIP/TAZ从平均发病年龄至死亡的长期健康结局。疗效和安全性数据来源于一项Ⅲ期临床试验（NCT03583333），成本与效用参数则基于文献回顾与专家访谈确定。采用成本-效用分析方法，同时开展单因素和概率敏感性分析以验证结果稳健性。参考公开渠道可获取的销售价格（1 240元·瓶-1）设定IMI/REL单价，进行基础与情景分析。
结果： 基础分析显示，IMI/REL组总治疗成本为164 275.71元，质量调整生命年（QALY）为4.32；PIP/TAZ组总成本为143 946元，QALY为4.13，增量成本-效益比（ICER）为104 991.37元·QALY-1，低于我国3倍人均GDP阈值。情景分析结果表明，在未治愈患者部分存活的假设下，IMI/REL的经济性结论依然稳健。
结论： 在当前可得价格设定下，IMI/REL相较于PIP/TAZ具有良好的成本效益，为我国HABP/VAP治疗策略优化与医保支付政策制定提供了参考依据。
, authors=张羽曦
1, 张冉冉
1, 张菁
2, 高胜男
3, 高宁
1, 冯冰
1, 刘冉
1, 刘国强
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