Article(id=1321425648183263427, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425625915707977, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.09.007, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1764000000000, acceptedDateStr=2025-11-25, onlineDate=1792982025427, onlineDateStr=2026-10-26, pubDate=1778774400000, pubDateStr=2026-05-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982025427, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982025427, creator=13701087609, updateTime=1792982025427, updator=13701087609, issue=Issue{id=1321425625915707977, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='9', pageStart='897', pageEnd='1008', issueExtLink='null', onlineDate='null', pubDate='1778774400000', pubDateStr='2026-05-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982020119, creator='13701087609', updateTime=1792983090252, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321430114441745406, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425625915707977, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321430114441745407, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425625915707977, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=942, endPage=950, ext={EN=ArticleExt(id=1321425648560750788, articleId=1321425648183263427, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Application of ion chromatography in pharmaceutical analysis, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Ion chromatography, an important branch of liquid chromatography, has been widely used in the field of analytical chemistry due to its advantages including rapidity, sensitivity, good selectivity, and the ability to simultaneously determine multiple components. This paper comprehensively summarizes the technical principles, development history, detection methods and pretreatment techniques of ion chromatography (IC), with emphasis on its application in pharmaceutical analysis, particularly in the quality control of aminoglycoside antibiotics, with the aim of providing a comprehensive summary for future research and application.

, authors=Yong-xiang LIU1, 2, 3, Xiao YE2, 3, Bin LI1, 2, 3, Yun-li ZHAO1, *, Ye TIAN2, 3, *, authorsList=Yong-xiang LIU, Xiao YE, Bin LI, Yun-li ZHAO, Ye TIAN, authorCompany=null, correspAuthors=Yun-li ZHAO, Ye TIAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425649064067269, articleId=1321425648183263427, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=离子色谱技术在药物分析中的应用, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

离子色谱(ion chromatography, IC)作为液相色谱的重要分支,凭借其快速、灵敏、选择性好且能同时测定多组分等优点,在分析化学领域得到了广泛应用。本文全面总结了离子色谱的技术原理、发展历程、检测方法、前处理技术,重点综述了其在药品分析中的应用,尤其是在氨基糖苷类抗生素的质量控制中的应用,旨在为后续研究和应用提供全面参考。

, authors=刘永祥1, 2, 3, 叶潇2, 3, 李彬1, 2, 3, 赵云丽1, *, 田冶2, 3, *, authorsList=刘永祥, 叶潇, 李彬, 赵云丽, 田冶, authorCompany=null, correspAuthors=赵云丽, 田冶, authorNote=

叶潇,女,博士,助理研究员,主要从事药动学研究。E-mail: 。

刘永祥,男,硕士研究生,主要从事药物分析与质量控制。E-mail: 。

, correspAuthorsNote=
* 赵云丽,女,教授,主要从事药品质量控制与药动学研究。联系电话:(024)43520578,E-mail: 。
* 田冶,男,研究员,主要从事药品质量控制研究。联系电话:(010)53851533,E-mail: 。
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离子色谱技术在药物分析中的应用
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刘永祥 1, 2, 3 , 叶潇 2, 3 , 李彬 1, 2, 3 , 赵云丽 1, * , 田冶 2, 3, *
中国新药杂志 | 综述 2026,35(9): 942-950
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中国新药杂志 |综述 2026 , 35 (9) : 942 -950
离子色谱技术在药物分析中的应用
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刘永祥,男,硕士研究生,主要从事药物分析与质量控制。E-mail: 。

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刘永祥,男,硕士研究生,主要从事药物分析与质量控制。E-mail: 。

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刘永祥1, 2, 3 , 叶潇2, 3 , 李彬1, 2, 3, 赵云丽1, * , 田冶2, 3, *
作者信息
  • 1沈阳药科大学,沈阳 110016
  • 2中国食品药品检定研究院安全评价研究所,北京 100176
  • 3药品监管科学全国重点实验室,北京 102629
通讯作者:
* 赵云丽,女,教授,主要从事药品质量控制与药动学研究。联系电话:(024)43520578,E-mail: 。
* 田冶,男,研究员,主要从事药品质量控制研究。联系电话:(010)53851533,E-mail: 。
作者简介:

叶潇,女,博士,助理研究员,主要从事药动学研究。E-mail: 。

刘永祥,男,硕士研究生,主要从事药物分析与质量控制。E-mail: 。

Application of ion chromatography in pharmaceutical analysis
Yong-xiang LIU1, 2, 3 , Xiao YE2, 3 , Bin LI1, 2, 3, Yun-li ZHAO1, * , Ye TIAN2, 3, *
Affiliations
  • 1Shenyang Pharmaceutical University, Shenyang 110016, China
  • 2Institute of Safety Evaluation, National Institutes for Food and Drug Control, Beijing 100176, China
  • 3State Key Laboratory of Drug Regulatory Science, Beijing 102629, China
出版时间: 2026-05-15 doi: 10.20251/j.cnki.1003-3734.2026.09.007
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离子色谱(ion chromatography, IC)作为液相色谱的重要分支,凭借其快速、灵敏、选择性好且能同时测定多组分等优点,在分析化学领域得到了广泛应用。本文全面总结了离子色谱的技术原理、发展历程、检测方法、前处理技术,重点综述了其在药品分析中的应用,尤其是在氨基糖苷类抗生素的质量控制中的应用,旨在为后续研究和应用提供全面参考。

离子色谱  /  安培检测器  /  电导检测器  /  氨基糖苷类抗生素  /  药物分析

Ion chromatography, an important branch of liquid chromatography, has been widely used in the field of analytical chemistry due to its advantages including rapidity, sensitivity, good selectivity, and the ability to simultaneously determine multiple components. This paper comprehensively summarizes the technical principles, development history, detection methods and pretreatment techniques of ion chromatography (IC), with emphasis on its application in pharmaceutical analysis, particularly in the quality control of aminoglycoside antibiotics, with the aim of providing a comprehensive summary for future research and application.

ion chromatography  /  amperometry detector  /  conductance detector  /  aminoglycosides  /  pharmaceutical analysis
刘永祥, 叶潇, 李彬, 赵云丽, 田冶. 离子色谱技术在药物分析中的应用. 中国新药杂志, 2026 , 35 (9) : 942 -950 . DOI: 10.20251/j.cnki.1003-3734.2026.09.007
Yong-xiang LIU, Xiao YE, Bin LI, Yun-li ZHAO, Ye TIAN. Application of ion chromatography in pharmaceutical analysis[J]. Chinese Journal of New Drugs, 2026 , 35 (9) : 942 -950 . DOI: 10.20251/j.cnki.1003-3734.2026.09.007
  • 国家药典委员会标准制修订研究课题资助项目(2023Y04)
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2026年第35卷第9期
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doi: 10.20251/j.cnki.1003-3734.2026.09.007
  • 首发时间:2026-10-26
  • 出版时间:2026-05-15
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  • 录用日期:2025-11-25
基金
国家药典委员会标准制修订研究课题资助项目(2023Y04)
作者信息
    1沈阳药科大学,沈阳 110016
    2中国食品药品检定研究院安全评价研究所,北京 100176
    3药品监管科学全国重点实验室,北京 102629

通讯作者:

* 赵云丽,女,教授,主要从事药品质量控制与药动学研究。联系电话:(024)43520578,E-mail: 。
* 田冶,男,研究员,主要从事药品质量控制研究。联系电话:(010)53851533,E-mail: 。
参考文献
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https://castjournals.cast.org.cn/joweb/zgxyzz/CN/10.20251/j.cnki.1003-3734.2026.09.007
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2种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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