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Calcitonin gene-related peptide (CGRP) is a neuropeptide with potent vasodilatory effect, closely associated with migraine attacks. CGRP and its receptor (CGRP-R) are currently the most promising targets for the treatment and prevention of migraine. The migraine treatment drugs for CGRP mainly include CGRP-R antagonists and CGRP monoclonal antibodies. By blocking the binding of CGRP to its receptor, CGRP-R antagonists can have a similar effect on migraine as triptans, with a lower incidence of adverse reactions. They are more effective and safe new drugs for treating migraine. The author used the incoPat database to search and count the patent applications of small molecule CGRP/CGRP-R antagonists, analyzed the overall trend of patent applications, geographical distribution, applications of important applicants, the distribution of technical fields of patent applications, and the core patents of key varieties, and tried to reflect the patent application status of small molecule CGRP/CGRP-R antagonists, reveal their development trend, and give relevant suggestions. It provides a reference for domestic pharmaceutical companies and research institutions.

, authors=Peng-cheng KANG, Ya-nan WU, authorsList=Peng-cheng KANG, Ya-nan WU, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425625437552658, articleId=1321425625001345040, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=小分子CGRP/CGRP-R拮抗剂的专利分析, columnId=1236331162679955859, journalTitle=中国新药杂志, columnName=新药述评与论坛, runingTitle=null, highlight=null, articleAbstract=

降钙素基因相关肽（CGRP）是一种具有强效扩血管作用的神经肽，与偏头痛的发作有密切的联系。CGRP及其受体（CGRP-R）是目前治疗和预防偏头痛最有前途的靶点，针对CGRP的偏头痛治疗药物主要包括CGRP-R拮抗剂以及CGRP单克隆抗体两大类药物。CGRP-R拮抗剂通过阻滞CGRP与其受体结合，可起到与曲坦类药物相似的治疗偏头痛的效果，且不良反应的发生率更低，是一种有效且安全的治疗偏头痛的新型药物。笔者利用incoPat数据库对小分子CGRP/CGRP-R拮抗剂的专利申请进行检索、统计，分析了专利申请量总体趋势、地域分布、重要申请人的申请情况、专利申请的技术领域分布、重点品种的核心专利，力求反映小分子CGRP/CGRP-R拮抗剂的专利申请现状，揭示小分子CGRP/CGRP-R拮抗剂的发展趋势，并给出相关建议，为国内制药企业和研究机构提供参考。

, authors=康鹏程, 吴亚男, authorsList=康鹏程, 吴亚男, authorCompany=null, correspAuthors=null, authorNote=, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=Ge/JEBwAdZBbk+J4fFztog==, magXml=XI4BGNnC4r2jxIe0nKkjnw==, pdfUrl=null, pdf=MnjMpqkLBXsi7Rc+Oha8eQ==, pdfFileSize=1439463, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=7S5OLMptDKhjpyiDdil+RQ==, mapNumber=null, fund=null)}, authors=[Author(id=1321425625844400151, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425625001345040, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=550577915@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425625945063449, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425625001345040, authorId=1321425625844400151, language=EN, stringName=Peng-cheng KANG, firstName=Peng-cheng, middleName=null, lastName=KANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Patent Examination Cooperation Beijing Center of the Patent Office, CNIPA, Beijing 100160, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425626028949530, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425625001345040, authorId=1321425625844400151, language=CN, stringName=康鹏程, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=国家知识产权局专利局专利审查协作北京中心，北京 100160, bio={"content":"

康鹏程，男，硕士，主要从事药物领域专利审查工作。E-mail: 550577915@qq.com。

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康鹏程，男，硕士，主要从事药物领域专利审查工作。E-mail: 550577915@qq.com。

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