首页 期刊 论文 学科刊群 资讯 加盟 关于
EN
image
Article(id=1241022580828722016, tenantId=1146029695717560320, journalId=1205117082300743687, issueId=1241022576185634950, articleNumber=null, orderNo=null, doi=10.14109/j.cnki.xyylc.2024.09.10, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1693324800000, receivedDateStr=2023-08-30, revisedDate=null, revisedDateStr=null, acceptedDate=1722960000000, acceptedDateStr=2024-08-07, onlineDate=1773812440354, onlineDateStr=2026-03-18, pubDate=1727193600000, pubDateStr=2024-09-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1773812440354, onlineIssueDateStr=2026-03-18, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1773812440354, creator=13701087609, updateTime=1773812440354, updator=13701087609, issue=Issue{id=1241022576185634950, tenantId=1146029695717560320, journalId=1205117082300743687, year='2024', volume='43', issue='9', pageStart='641', pageEnd='720', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1773812439247, creator=13701087609, updateTime=1773813972032, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1241029005206417725, tenantId=1146029695717560320, journalId=1205117082300743687, issueId=1241022576185634950, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1241029005206417726, tenantId=1146029695717560320, journalId=1205117082300743687, issueId=1241022576185634950, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=686, endPage=690, ext={EN=ArticleExt(id=1241022581181043571, articleId=1241022580828722016, tenantId=1146029695717560320, journalId=1205117082300743687, language=EN, title=Risk factors analysis on drug-induced liver injury in acquired immunodeficiency syndrome patients treated with compound sulfamethoxazole, columnId=1207314218647392369, journalTitle=Chinese Journal of New Drugs and Clinical Remedies, columnName=Original Article, runingTitle=null, highlight=null, articleAbstract=

AIM To explore the risk factors of drug-induced liver injury (DILI) of compound sulfamethoxazole (sulfamethoxazole-trimethoprim, SMZ-TMP) in acquired immunodeficiency syndrome (AIDS) patients and provide reference for clinical pharmacovigilance and rational drug use. METHODS The data of AIDS patients treated with SMZ-TMP in our hospital from December 2020 to December 2022 were collected retrospectively. The general information of patients with DILI after taking SMZ-TMP was compared with that of patients without DILI, and binary logistic regression equation was constructed to screen out the risk factors of DILI in AIDS patients induced by SMZ-TMP. RESULTS Totally 271 AIDS patients were involved, and 29 patients had DILI, all of whom were male. Among them, 27 patients were of hepatocellular injury pattern and 2 patients were of cholestatic injury pattern. All DILI patients were cured or improved after symptomatic treatment. Relevant factor analysis showed that, allergy history (OR=15.334，95%CI: 3.147 to 74.710), no receiving antiviral treatment or tenofovir+lamivudine+lopinavir/ritonavir (TDF+3TC+LPV/r) regimen (OR=56.123, 95% CI: 10.797 to 291.719), daily dose of SMZ-TMP ≥ 12 tablets (OR=52.809, 95% CI: 9.894 to 281.868), alanine transaminase (ALT) ≥ 23 U·L-1 (OR=18.514, 95% CI: 3.993 to 85.843), CD4+ T cell ≤110·µL-1 (OR=40.586，95%CI：6.625 to 248.634), and CD8+ T cell ≤ 920·µL-1 (OR=135.978，95%CI：11.190 to 1 652.303) can increase the risk of SMZ-TMP related DILI in AIDS patients (P<0.05). CONCLUSION The incidence of SMZ-TMP related DILI is relatively high in AIDS patients. Allergy history, selection of antiviral treatment regimens, dose of SMZ-TMP, ALT level, and CD4+ and CD8+ T lymphocyte counts are the independent risk factors for SMZ-TMP related DILI in AIDS patients. Monitoring of high-risk population should be strengthened and early intervention measures should be taken.

, correspAuthors=Wei LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Xin-ye QIU, Yue YIN, Wei LIU), CN=ArticleExt(id=1241022581722108814, articleId=1241022580828722016, tenantId=1146029695717560320, journalId=1205117082300743687, language=CN, title=获得性免疫缺陷综合征患者应用复方磺胺甲噁唑致药物性肝损伤危险因素分析, columnId=1207314219226206329, journalTitle=中国新药与临床杂志, columnName=论著, runingTitle=null, highlight=null, articleAbstract=

目的 研究复方磺胺甲噁唑（SMZ-TMP）致获得性免疫缺陷综合征（AIDS）患者药物性肝损伤（DILI）的危险因素，为临床药物警戒及合理用药提供参考。方法 回顾性收集2020年12月至2022年12月在本院住院并服用SMZ-TMP治疗的AIDS患者的病例资料，将服用SMZ-TMP后发生DILI患者与未发生DILI患者的一般资料进行比较，并构建二分类logistic回归方程，筛选出AIDS患者应用SMZ-TMP致药物性肝损伤的危险因素。结果 271例服用SMZ-TMP治疗的AIDS患者中，共有29例发生DILI，均为男性，其中27例为肝细胞损伤型，2例为胆汁淤积型，经对症治疗后全部患者临床症状均好转或痊愈。相关因素分析显示，患者合并过敏史（OR=15.334，95%CI：3.147~74.710）、未进行抗病毒治疗或使用替诺福韦+拉米夫定+洛匹那韦/利托那韦（TDF+3TC+LPV/r）方案（OR=56.123，95%CI：10.797~291.719）、SMZ-TMP日剂量≥12片（OR=52.809，95%CI：9.894~281.868）、丙氨酸转氨酶（ALT）≥23 U·L-1（OR=18.514，95%CI：3.993~85.843）、CD4+ T淋巴细胞数≤110个·µL-1（OR=40.586，95%CI：6.625~248.634）及CD8+ T淋巴细胞数≤920个·µL-1（OR=135.978，95%CI：11.190~1 652.303），均可增加AIDS患者SMZ-TMP相关DILI的发生风险（P<0.05）。结论 AIDS患者SMZ-TMP相关DILI发生率较高，过敏史、抗病毒治疗方案的选择、SMZ-TMP剂量、ALT水平、CD4+及CD8+ T淋巴细胞数为AIDS患者发生SMZ-TMP相关DILI的独立危险因素，应加强高风险人群监测，并及早采取干预措施。

, correspAuthors=刘炜, authorNote=null, correspAuthorsNote=
刘炜，
尹月
, copyrightStatement=null, copyrightOwner=《中国新药与临床杂志》编辑部, extLink=null, articleAbsUrl=null, sourceXml=NO/bqzlx0fFqY9vvQJ5+7w==, magXml=KK/Y13jKymsV+XXGpmWmdw==, pdfUrl=null, pdf=SwQU5fnr8EPoXFdQ/bI6Sw==, pdfFileSize=1785007, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=9wQPj3+QWFWhQdFAkCdEpw==, mapNumber=null, authorCompany=null, fund=null, authors=

邱新野，男，副主任药师，硕士，主要从事临床药学工作，E-mail：

尹月，女，主管药师，硕士，主要从事临床药学工作，E-mail：

刘炜，男，主任药师，硕士生导师，硕士，主要从事临床药学工作，E-mail：

, authorsList=邱新野, 尹月, 刘炜)}, authors=[Author(id=1241029119492813171, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=qiuxinye@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1241029119622836602, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, authorId=1241029119492813171, language=EN, stringName=Xin-ye QIU, firstName=Xin-ye, middleName=null, lastName=QIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Department of Pharmacy, Beijing Youan Hospital, Capital Medical University, BEIJING 100069, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1241029119727694208, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, authorId=1241029119492813171, language=CN, stringName=邱新野, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.首都医科大学附属北京佑安医院 药学部，北京　100069, bio={"content":"

邱新野，男，副主任药师，硕士，主要从事临床药学工作，E-mail：

"}, bioImg=null, bioContent=

邱新野，男，副主任药师，硕士，主要从事临床药学工作，E-mail：

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1241029119283097954, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, xref=1., ext=[AuthorCompanyExt(id=1241029119291486563, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, companyId=1241029119283097954, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Department of Pharmacy, Beijing Youan Hospital, Capital Medical University, BEIJING 100069, China), AuthorCompanyExt(id=1241029119299875172, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, companyId=1241029119283097954, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.首都医科大学附属北京佑安医院 药学部，北京　100069)])]), Author(id=1241029119811580295, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=yinyue_1108@sina.com.cn, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1241029119916437902, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, authorId=1241029119811580295, language=EN, stringName=Yue YIN, firstName=Yue, middleName=null, lastName=YIN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pharmacy, Peking University Cancer Hospital & Institute, BEIJING 100142, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1241029119991935379, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, authorId=1241029119811580295, language=CN, stringName=尹月, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.北京大学肿瘤医院暨北京市肿瘤防治研究所 药剂科，恶性肿瘤发病机制及转化研究教育部重点实验室，北京　100142, bio={"content":"

尹月，女，主管药师，硕士，主要从事临床药学工作，E-mail：

"}, bioImg=null, bioContent=

尹月，女，主管药师，硕士，主要从事临床药学工作，E-mail：

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1241029119366984039, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, xref=2., ext=[AuthorCompanyExt(id=1241029119400538474, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, companyId=1241029119366984039, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pharmacy, Peking University Cancer Hospital & Institute, BEIJING 100142, China), AuthorCompanyExt(id=1241029119413121389, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, companyId=1241029119366984039, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.北京大学肿瘤医院暨北京市肿瘤防治研究所 药剂科，恶性肿瘤发病机制及转化研究教育部重点实验室，北京　100142)])]), Author(id=1241029120071627158, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=liuwei8090@126.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1241029120180679068, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, authorId=1241029120071627158, language=EN, stringName=Wei LIU, firstName=Wei, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 刘炜, address=1.Department of Pharmacy, Beijing Youan Hospital, Capital Medical University, BEIJING 100069, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1241029120293925280, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, authorId=1241029120071627158, language=CN, stringName=刘炜, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 刘炜, address=1.首都医科大学附属北京佑安医院 药学部，北京　100069, bio={"content":"

刘炜，男，主任药师，硕士生导师，硕士，主要从事临床药学工作，E-mail：

"}, bioImg=null, bioContent=

刘炜，男，主任药师，硕士生导师，硕士，主要从事临床药学工作，E-mail：

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1241029119283097954, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, xref=1., ext=[AuthorCompanyExt(id=1241029119291486563, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, companyId=1241029119283097954, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Department of Pharmacy, Beijing Youan Hospital, Capital Medical University, BEIJING 100069, China), AuthorCompanyExt(id=1241029119299875172, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, companyId=1241029119283097954, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.首都医科大学附属北京佑安医院 药学部，北京　100069)])])], keywords=[Keyword(id=1241029120482668968, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, language=EN, orderNo=1, keyword=compound sulfamethoxazole), Keyword(id=1241029120600109488, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, language=EN, orderNo=2, keyword=acquired immunodeficiency syndrome), Keyword(id=1241029120667218360, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, language=EN, orderNo=3, keyword=drug-induced liver injury), Keyword(id=1241029120742715836, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, language=EN, orderNo=4, keyword=risk factor), Keyword(id=1241029122231693765, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, language=CN, orderNo=1, keyword=复方磺胺甲噁唑), Keyword(id=1241029122332357065, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, language=CN, orderNo=2, keyword=获得性免疫缺陷综合征), Keyword(id=1241029122420437457, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, language=CN, orderNo=3, keyword=药物性肝损伤), Keyword(id=1241029122516906455, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, language=CN, orderNo=4, keyword=危险因素)], refs=[Reference(id=1241029123657757204, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2021, volume=27, issue=11, pageStart=1182, pageEnd=1200, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=中华医学会感染病学分会艾滋病丙型肝炎学组, 中国疾病预防控制中心, journalName=中国艾滋病性病, refType=null, unstructuredReference=中华医学会感染病学分会艾滋病丙型肝炎学组，中国疾病预防控制中心. 中国艾滋病诊疗指南（2021版）[J].中国艾滋病性病, 2021, 27（11）: 1182-1200., articleTitle=中国艾滋病诊疗指南（2021版）, refAbstract=null), Reference(id=1241029123779392025, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2007, volume=null, issue=null, pageStart=154, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=ARONOFF GR, BENNETT WM, BERNS JS, journalName=Drug prescribing in renal failure, refType=null, unstructuredReference=ARONOFF GR, BENNETT WM, BERNS JS, et al. Drug prescribing in renal failure[M]. 5th ed. Portland, OR: American College of Physicians, 2007 : 154., articleTitle=null, refAbstract=null), Reference(id=1241029123863278109, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2003, volume=163, issue=4, pageStart=402, pageEnd=410, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=MASTERS PA, O'BRYAN TA, ZURLO J, journalName=Arch Intern Med, refType=null, unstructuredReference=MASTERS PA, O'BRYAN TA, ZURLO J, et al. Trimethoprim-sulfamethoxazole revisited[J]. Arch Intern Med, 2003, 163（4）:402-410., articleTitle=Trimethoprim-sulfamethoxazole revisited, refAbstract=null), Reference(id=1241029123980718626, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2019, volume=19, issue=6, pageStart=647, pageEnd=655, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=曹明雪, 朱丽丽, 蔡华丹, journalName=中国医院用药评价与分析, refType=null, unstructuredReference=曹明雪, 朱丽丽, 蔡华丹. 复方磺胺甲噁唑片在人类免疫缺陷病毒感染者中的不良反应分析[J]. 中国医院用药评价与分析, 2019, 19（6）: 647-655., articleTitle=复方磺胺甲噁唑片在人类免疫缺陷病毒感染者中的不良反应分析, refAbstract=null), Reference(id=1241029124060410408, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2019, volume=19, issue=6, pageStart=647, pageEnd=655, url=null, language=null, rfNumber=[4], rfOrder=4, authorNames=CAO MX, ZHU LL, CAI HD, journalName=Eval Anal Drug-Use Hosp China, refType=null, unstructuredReference=CAO MX, ZHU LL, CAI HD. Analysis of adverse drug reactions of compound sulfamethoxazole tablets in human immunodeficiency virus infected patients[J]. Eval Anal Drug-Use Hosp China, 2019, 19（6）: 647-655., articleTitle=Analysis of adverse drug reactions of compound sulfamethoxazole tablets in human immunodeficiency virus infected patients, refAbstract=null), Reference(id=1241029124148490795, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2023, volume=28, issue=7, pageStart=397, pageEnd=431, url=null, language=null, rfNumber=[5], rfOrder=5, authorNames=中国医药生物技术协会药物性肝损伤防治技术专业委员会, 中华医学会肝病学分会药物性肝病学组, journalName=胃肠病学, refType=null, unstructuredReference=中国医药生物技术协会药物性肝损伤防治技术专业委员会,中华医学会肝病学分会药物性肝病学组.中国药物性肝损伤诊治指南（2023年版）[J].胃肠病学, 2023, 28（7）: 397-431., articleTitle=中国药物性肝损伤诊治指南（2023年版）, refAbstract=null), Reference(id=1241029124253348398, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2019, volume=70, issue=6, pageStart=1222, pageEnd=1261, url=null, language=null, rfNumber=[6], rfOrder=6, authorNames=European Association for the Study of the Liver, journalName=J Hepatol, refType=null, unstructuredReference=European Association for the Study of the Liver. EASL clinical practice guidelines: drug-induced liver injury[J]. J Hepatol,2019, 70（6）: 1222-1261., articleTitle=EASL clinical practice guidelines: drug-induced liver injury, refAbstract=null), Reference(id=1241029124337234483, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2014, volume=4, issue=1, pageStart=54, pageEnd=67, url=null, language=null, rfNumber=[7], rfOrder=7, authorNames=EVY Y, ALVINA W, HARJONO KT, journalName=Asia Pacific Allergy, refType=null, unstructuredReference=EVY Y, ALVINA W, HARJONO KT. Drug hypersensitivity in human immunodeficiency virus-infected patient: challenging diagnosis and management[J]. Asia Pacific Allergy, 2014, 4（1）:54-67., articleTitle=Drug hypersensitivity in human immunodeficiency virus-infected patient: challenging diagnosis and management, refAbstract=null), Reference(id=1241029124425314871, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2021, volume=34, issue=1, pageStart=71, pageEnd=74, url=null, language=null, rfNumber=[8], rfOrder=8, authorNames=孙 娜, 郜桂菊, 梁洪远, journalName=传染病信息, refType=null, unstructuredReference=孙 娜,郜桂菊,梁洪远,等. AIDS患者肝功能异常的原因及预后分析[J]. 传染病信息, 2021, 34（1） : 71-74., articleTitle=AIDS患者肝功能异常的原因及预后分析, refAbstract=null), Reference(id=1241029124530172475, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2021, volume=34, issue=1, pageStart=71, pageEnd=74, url=null, language=null, rfNumber=[8], rfOrder=9, authorNames=SUN N, GAO GJ, LIANG HY, journalName=Infect Dis Inf, refType=null, unstructuredReference=SUN N, GAO GJ, LIANG HY, et al. Analysis of causes and prognosis of abnormal liver function in AIDS patients[J]. Infect Dis Inf, 2021,34（1）: 71-74., articleTitle=Analysis of causes and prognosis of abnormal liver function in AIDS patients, refAbstract=null), Reference(id=1241029124635030081, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2015, volume=187, issue=4, pageStart=E138, pageEnd=E143, url=null, language=null, rfNumber=[9], rfOrder=10, authorNames=ANTONIOU T, HOLLANDS S, MACDONALD EM, journalName=CMAJ, refType=null, unstructuredReference=ANTONIOU T, HOLLANDS S, MACDONALD EM, et al. Trimethoprim-sulfamethoxazole and risk of sudden death among patients taking spironolactone[J]. CMAJ, 2015, 187（4）:E138-E143., articleTitle=Trimethoprim-sulfamethoxazole and risk of sudden death among patients taking spironolactone, refAbstract=null), Reference(id=1241029124739887686, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2017, volume=33, issue=8, pageStart=1537, pageEnd=1542, url=null, language=null, rfNumber=[10], rfOrder=11, authorNames=杨君洋, 齐唐凯, 张仁芳, journalName=临床肝胆病杂志, refType=null, unstructuredReference=杨君洋, 齐唐凯, 张仁芳，等. 119例艾滋病患者并发药物性肝损伤的临床特点及预后分析[J]. 临床肝胆病杂志,2017, 33（8）: 1537-1542., articleTitle=119例艾滋病患者并发药物性肝损伤的临床特点及预后分析, refAbstract=null), Reference(id=1241029124857328200, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2017, volume=33, issue=8, pageStart=1537, pageEnd=1542, url=null, language=null, rfNumber=[10], rfOrder=12, authorNames=YANG JY, QI TK, ZHANG RF, journalName=J Clin Hepatol, refType=null, unstructuredReference=YANG JY, QI TK, ZHANG RF, et al. Clinical features and prognosis of AIDS complicated by drug-induced liver injury: an analysis of 119 cases[J]. J Clin Hepatol,2017, 33（8）: 1537-1542., articleTitle=Clinical features and prognosis of AIDS complicated by drug-induced liver injury: an analysis of 119 cases, refAbstract=null), Reference(id=1241029124941214283, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2020, volume=18, issue=9, pageStart=77, pageEnd=78, url=null, language=null, rfNumber=[11], rfOrder=13, authorNames=刘 维, 张 雯, 赵红心, journalName=中国处方药, refType=null, unstructuredReference=刘 维, 张 雯, 赵红心.复方新诺明在AIDS/PCP患者中引起肝损伤的相关因素分析[J].中国处方药, 2020, 18（9）:77-78., articleTitle=复方新诺明在AIDS/PCP患者中引起肝损伤的相关因素分析, refAbstract=null), Reference(id=1241029125058654800, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2010, volume=125, issue=2, pageStart=S126, pageEnd=S137, url=null, language=null, rfNumber=[12], rfOrder=14, authorNames=KHAN DA, SOLENSKY R, journalName=J Allergy Clin Immunol, refType=null, unstructuredReference=KHAN DA, SOLENSKY R. Drug allergy[J]. J Allergy Clin Immunol, 2010, 125（2 Suppl 2）: S126-S137．, articleTitle=Drug allergy, refAbstract=null), Reference(id=1241029125163512404, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=15, authorNames=China CDC Weekly, journalName=null, refType=null, unstructuredReference=China CDC Weekly. Preplanned studies: trends in mortality and prevalence of reported HIV/AIDS cases—China, 2002 - 2021 [EB/OL].（2023-10-20） [2024-07-04]. https://weekly.chinacdc.cn/en/article/doi/10.46234/ccdcw2023.177., articleTitle=Preplanned studies: trends in mortality and prevalence of reported HIV/AIDS cases—China, 2002 - 2021, refAbstract=null), Reference(id=1241029125247398488, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2015, volume=37, issue=2, pageStart=95, pageEnd=96, url=null, language=null, rfNumber=[14], rfOrder=16, authorNames=毛 霖, 汪习成, 杨欣平, journalName=皮肤病与性病, refType=null, unstructuredReference=毛 霖,汪习成,杨欣平,等.AIDS患者药物性肝损伤98例临床分析[J].皮肤病与性病, 2015, 37（2）: 95-96., articleTitle=AIDS患者药物性肝损伤98例临床分析, refAbstract=null), Reference(id=1241029126723793499, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2023, volume=118, issue=9, pageStart=1566, pageEnd=1575, url=null, language=null, rfNumber=[15], rfOrder=17, authorNames=FONTANA RJ, KLEINER DE, CHALASANI N, journalName=Am J Gastroenterol, refType=null, unstructuredReference=FONTANA RJ, KLEINER DE, CHALASANI N, et al. The impact of patient age and corticosteroids in patients with sulfonamide hepatotoxicity[J]. Am J Gastroenterol, 2023, 118（9）: 1566-1575., articleTitle=The impact of patient age and corticosteroids in patients with sulfonamide hepatotoxicity, refAbstract=null), Reference(id=1241029126845428320, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2008, volume=121, issue=4, pageStart=826, pageEnd=832, url=null, language=null, rfNumber=[16], rfOrder=18, authorNames=DAVIS CM, SHEARER WT, journalName=J Allergy Clin Immunol, refType=null, unstructuredReference=DAVIS CM, SHEARER WT. Diagnosis and management of HIV drug hypersensitivity[J]. J Allergy Clin Immunol, 2008, 121（4） :826-832．, articleTitle=Diagnosis and management of HIV drug hypersensitivity, refAbstract=null), Reference(id=1241029126958674529, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2016, volume=38, issue=3, pageStart=319, pageEnd=326, url=null, language=null, rfNumber=[17], rfOrder=19, authorNames=ICE LL, BARRETO JN, DAO BD, journalName=Ther Drug Monit, refType=null, unstructuredReference=ICE LL, BARRETO JN, DAO BD, et al. Relationship of sulfamethoxazole therapeutic drug monitoring to clinical efficacy and toxicity: a retrospective cohort study[J]. Ther Drug Monit,2016, 38（3）: 319-326., articleTitle=Relationship of sulfamethoxazole therapeutic drug monitoring to clinical efficacy and toxicity: a retrospective cohort study, refAbstract=null), Reference(id=1241029127042560614, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2023, volume=43, issue=2, pageStart=207, pageEnd=210, url=null, language=null, rfNumber=[18], rfOrder=20, authorNames=卢张阳, 梁 培, 祁 慧, journalName=中国医院药学杂志, refType=null, unstructuredReference=卢张阳, 梁 培, 祁 慧, 等. 重症患者复方磺胺甲噁唑血药峰浓度与不良反应的相关性研究[J]. 中国医院药学杂志, 2023, 43（2）: 207-210., articleTitle=重症患者复方磺胺甲噁唑血药峰浓度与不良反应的相关性研究, refAbstract=null), Reference(id=1241029127134835307, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2023, volume=43, issue=2, pageStart=207, pageEnd=210, url=null, language=null, rfNumber=[18], rfOrder=21, authorNames=LU ZY, LIANG P, QI H, journalName=Chin J Hosp Pharm, refType=null, unstructuredReference=LU ZY, LIANG P, QI H, et al. The relationships of peak plasma concentration with toxicity of trimethoprim-sulfamethoxazole in ICU patients[J]. Chin J Hosp Pharm, 2023, 43（2）: 207-210., articleTitle=The relationships of peak plasma concentration with toxicity of trimethoprim-sulfamethoxazole in ICU patients, refAbstract=null), Reference(id=1241029127206138478, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2021, volume=35, issue=9, pageStart=1007, pageEnd=1011, url=null, language=null, rfNumber=[19], rfOrder=22, authorNames=辅海平, 孙 强, journalName=中国皮肤性病学杂志, refType=null, unstructuredReference=辅海平, 孙 强. 浙江省桐乡市2005—2019年HIV/AIDS患者CD4+ T淋巴细胞检测情况分析 [J]. 中国皮肤性病学杂志, 2021, 35（9）: 1007-1011., articleTitle=浙江省桐乡市2005—2019年HIV/AIDS患者CD4+ T淋巴细胞检测情况分析, refAbstract=null), Reference(id=1241029127306801778, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, doi=null, pmid=null, pmcid=null, year=2021, volume=35, issue=9, pageStart=1007, pageEnd=1011, url=null, language=null, rfNumber=[19], rfOrder=23, authorNames=FU HP, SUN Q, journalName=Chin J Dermatovenereol, refType=null, unstructuredReference=FU HP, SUN Q. Analysis of CD4+ T lymphocyte test in patients with HIV/AIDS in the Tongxiang city of Zhejiang province from 2005 to 2019 [J]. Chin J Dermatovenereol,2021, 35（9）: 1007-1011., articleTitle=Analysis of CD4+ T lymphocyte test in patients with HIV/AIDS in the Tongxiang city of Zhejiang province from 2005 to 2019, refAbstract=null)], funds=[Fund(id=1241029123452236296, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, awardId=YNKTGL2021002, language=CN, fundingSource=首都医科大学附属北京佑安医院2021年度中青年人才孵育项目(YNKTGL2021002), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1241029119283097954, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, xref=1., ext=[AuthorCompanyExt(id=1241029119291486563, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, companyId=1241029119283097954, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Department of Pharmacy, Beijing Youan Hospital, Capital Medical University, BEIJING 100069, China), AuthorCompanyExt(id=1241029119299875172, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, companyId=1241029119283097954, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.首都医科大学附属北京佑安医院 药学部，北京　100069)]), AuthorCompany(id=1241029119366984039, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, xref=2., ext=[AuthorCompanyExt(id=1241029119400538474, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, companyId=1241029119366984039, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pharmacy, Peking University Cancer Hospital & Institute, BEIJING 100142, China), AuthorCompanyExt(id=1241029119413121389, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, companyId=1241029119366984039, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.北京大学肿瘤医院暨北京市肿瘤防治研究所 药剂科，恶性肿瘤发病机制及转化研究教育部重点实验室，北京　100142)])], figs=[ArticleFig(id=1241029122714038751, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
项目肝损伤组（n=29）未肝损伤组（n=242）统计量P值
性别/例χ2=1.7800.182
男29220
女022
年龄/岁32（29, 47）32（31, 47）Z=1.6140.107
过敏史/例χ2=22.8490.000
有911
无20231
基础疾病/例χ2=13.6880.000
有（白血病、CMV、梅毒）1022
无19220
HAART方案/例χ2=83.9610.000
未治疗80
TDF+3TC+LPV/r1622a
TAF/FTC/EVG/c2110be
TDF+3TC+EFV344be
TDF+3TC+DTG066be
复方磺胺甲噁唑日剂量/片12（12, 12）2（2, 6）Z=8.2550.000
实验室检查
丙氨酸转氨酶/U·L-135（24, 46）23（16, 27）Z=5.4320.000
天冬氨酸转氨酶/U·L-131（27, 34）26（19, 29）Z=4.7130.000
碱性磷酸酶/U·L-175（61, 110）70（49, 93）Z=1.6050.109
总胆红素/µmol·L-18（5.0, 8.4）7.4（3.3, 9.9）Z=0.0280.978
红细胞沉降率/mm·h-171（56, 81）38（21, 67）Z=5.0900.000
CD4+ T淋巴细胞数/个·µL-126（11, 39）110（86, 314）Z=5.5050.000
CD8+ T淋巴细胞数/个·µL-1270（209, 440）921（468, 1101）Z=6.3340.000
HIV病毒载量/copies·mL-1800 000（709 000, 950 000）500（0, 126 800）Z=8.0190.000
), ArticleFig(id=1241029122810507748, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, language=CN, label=表1, caption=

2组服用复方磺胺甲噁唑的AIDS患者一般资料比较

, figureFileSmall=null, figureFileBig=null, tableContent=
项目肝损伤组（n=29）未肝损伤组（n=242）统计量P值
性别/例χ2=1.7800.182
男29220
女022
年龄/岁32（29, 47）32（31, 47）Z=1.6140.107
过敏史/例χ2=22.8490.000
有911
无20231
基础疾病/例χ2=13.6880.000
有（白血病、CMV、梅毒）1022
无19220
HAART方案/例χ2=83.9610.000
未治疗80
TDF+3TC+LPV/r1622a
TAF/FTC/EVG/c2110be
TDF+3TC+EFV344be
TDF+3TC+DTG066be
复方磺胺甲噁唑日剂量/片12（12, 12）2（2, 6）Z=8.2550.000
实验室检查
丙氨酸转氨酶/U·L-135（24, 46）23（16, 27）Z=5.4320.000
天冬氨酸转氨酶/U·L-131（27, 34）26（19, 29）Z=4.7130.000
碱性磷酸酶/U·L-175（61, 110）70（49, 93）Z=1.6050.109
总胆红素/µmol·L-18（5.0, 8.4）7.4（3.3, 9.9）Z=0.0280.978
红细胞沉降率/mm·h-171（56, 81）38（21, 67）Z=5.0900.000
CD4+ T淋巴细胞数/个·µL-126（11, 39）110（86, 314）Z=5.5050.000
CD8+ T淋巴细胞数/个·µL-1270（209, 440）921（468, 1101）Z=6.3340.000
HIV病毒载量/copies·mL-1800 000（709 000, 950 000）500（0, 126 800）Z=8.0190.000
), ArticleFig(id=1241029122898588139, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
因素BSEWaldOR（95%CI）P
合并过敏史2.7300.80811.41815.334（3.147~74.710）0.001
合并基础疾病（白血病、CMV感染、梅毒）1.7541.4521.4595.780（0.335~99.571）0.227
未抗病毒治疗或使用TDF+3TC+LPV/r方案4.0280.84122.93756.123（10.797~291.719）0.000
复方磺胺甲噁唑日剂量≥12片3.9670.85421.55052.809（9.894~281.868）0.000
), ArticleFig(id=1241029123011834355, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, language=CN, label=表2, caption=

复方磺胺甲噁唑致AIDS患者药物性肝损伤的二分类logistic回归分析（基本情况）

, figureFileSmall=null, figureFileBig=null, tableContent=
因素BSEWaldOR（95%CI）P
合并过敏史2.7300.80811.41815.334（3.147~74.710）0.001
合并基础疾病（白血病、CMV感染、梅毒）1.7541.4521.4595.780（0.335~99.571）0.227
未抗病毒治疗或使用TDF+3TC+LPV/r方案4.0280.84122.93756.123（10.797~291.719）0.000
复方磺胺甲噁唑日剂量≥12片3.9670.85421.55052.809（9.894~281.868）0.000
), ArticleFig(id=1241029123125080571, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
因素BSEWaldOR（95%CI）P
丙氨酸转氨酶≥23 U·L-12.9190.78313.90618.514（3.993~85.843）0.000
天冬氨酸转氨酶≥26 U·L-1-1.9941.0333.7220.136（0.018~1.032）0.054
红细胞沉降率≥38 mm·h-117.0872 343.3370.00026 348 260.750.994
CD4+ T淋巴细胞数≤110个·µL-13.7030.92516.03740.586（6.625~248.634）0.000
CD8+ T淋巴细胞数≤920个·µL-14.9121.27414.863135.978（11.190~1 652.303）0.000
HIV病毒载量≥500 copies·mL-110.4652 343.3370.00035 064.8770.996
), ArticleFig(id=1241029123255104001, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1241022580828722016, language=CN, label=表3, caption=

复方磺胺甲噁唑致AIDS患者药物性肝损伤的二分类logistic回归分析（实验室检查）

, figureFileSmall=null, figureFileBig=null, tableContent=
因素BSEWaldOR（95%CI）P
丙氨酸转氨酶≥23 U·L-12.9190.78313.90618.514（3.993~85.843）0.000
天冬氨酸转氨酶≥26 U·L-1-1.9941.0333.7220.136（0.018~1.032）0.054
红细胞沉降率≥38 mm·h-117.0872 343.3370.00026 348 260.750.994
CD4+ T淋巴细胞数≤110个·µL-13.7030.92516.03740.586（6.625~248.634）0.000
CD8+ T淋巴细胞数≤920个·µL-14.9121.27414.863135.978（11.190~1 652.303）0.000
HIV病毒载量≥500 copies·mL-110.4652 343.3370.00035 064.8770.996
)], attaches=null, journal=Journal(id=1205114437246812164, delFlag=0, nameCn=中国新药与临床杂志, nameEn=Chinese Journal of New Drugs and Clinical Remedies, nameHistory1=null, nameHistory2=null, issn=1007-7669, eissn=, cn=31-1746/R, coden=null, periodic=月刊, language=CN, oaType=1, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=, officePhone=, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=4CRZH/cEJmlFWJuWhAUDig==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of New Drugs and Clinical Remedies, journalRemark=null, publicationField=null, createdTime=1765251271787, updatedTime=1765252216403, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=C, firstLetterEn=C, subjectCode=Life Sciences, subjectName=生命医学, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=4CRZH/cEJmlFWJuWhAUDig==, picEn=N3vp8/tZorUwVBJknBXdng==, jcr=null, cjcr=null, exts=[JournalExt(id=1205118399413203150, language=CN, name=中国新药与临床杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1765252216437, updatedTime=1765252216437, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=http://xyyl.cbpt.cnki.net/index.aspx?t=1, submissionEditorUrl=http://xyyl.cbpt.cnki.net/index.aspx?t=3, submissionReviewUrl=http://xyyl.cbpt.cnki.net/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1205118399467729103, language=EN, name=Chinese Journal of New Drugs and Clinical Remedies, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1765252216450, updatedTime=1765252216450, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=http://xyyl.cbpt.cnki.net/index.aspx?t=1, submissionEditorUrl=http://xyyl.cbpt.cnki.net/index.aspx?t=3, submissionReviewUrl=http://xyyl.cbpt.cnki.net/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1205117082300743687, websiteList=[Website(id=1205118568049389783, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1205117082300743687, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyylczz/CN, language=CN, createTime=1765252256643, createBy=18614031015, updateTime=1765252598399, updateBy=18614031015, name=中国新药与临床杂志-中文, tplId=1146099689490845704, title=中国新药与临床杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1205154564317098673, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568049389783, code=articleTextType, value=kx, createTime=1765260838822, updateTime=1765260838822, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154564300321454, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568049389783, code=banner, value=null, createTime=1765260838818, updateTime=1765260838818, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154564333875892, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568049389783, code=grayFlag, value=0, createTime=1765260838826, updateTime=1765260838826, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154564296127149, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568049389783, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyylczz/CN/file/pic?fileId=EPNvNLzzPrR2hCakA9eyOQ==, createTime=1765260838817, updateTime=1765260838817, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154564354847414, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568049389783, code=minRunFlag, value=0, createTime=1765260838831, updateTime=1765260838831, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154564312904368, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568049389783, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyylczz/CN/file/pic, createTime=1765260838821, updateTime=1765260838821, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154564342264501, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568049389783, code=silenceFlag, value=0, createTime=1765260838828, updateTime=1765260838828, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154564308710063, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568049389783, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1765260838820, updateTime=1765260838820, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154564325487282, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568049389783, code=themeColor, value=null, createTime=1765260838824, updateTime=1765260838824, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154564329681587, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568049389783, code=themeStyle, value=null, createTime=1765260838825, updateTime=1765260838825, creator=18614031015, updator=18614031015)]), Website(id=1205118568124887278, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1205117082300743687, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyylczz/EN, language=EN, createTime=1765252256661, createBy=18614031015, updateTime=1765252618802, updateBy=18614031015, name=中国新药与临床杂志-英文, tplId=1146101810881728533, title=Chinese Journal of New Drugs and Clinical Remedies, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1205154594314756492, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568124887278, code=articleTextType, value=kx, createTime=1765260845974, updateTime=1765260845974, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154594297979273, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568124887278, code=banner, value=null, createTime=1765260845970, updateTime=1765260845970, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154594331533711, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568124887278, code=grayFlag, value=0, createTime=1765260845978, updateTime=1765260845978, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154594289590664, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568124887278, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyylczz/EN/file/pic?fileId=EPNvNLzzPrR2hCakA9eyOQ==, createTime=1765260845968, updateTime=1765260845968, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154594344116625, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568124887278, code=minRunFlag, value=0, createTime=1765260845981, updateTime=1765260845981, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154594310562187, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568124887278, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyylczz/EN/file/pic, createTime=1765260845973, updateTime=1765260845973, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154594335728016, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568124887278, code=silenceFlag, value=0, createTime=1765260845979, updateTime=1765260845979, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154594302173578, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568124887278, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1765260845971, updateTime=1765260845971, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154594323145101, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568124887278, code=themeColor, value=null, createTime=1765260845976, updateTime=1765260845976, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154594327339406, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568124887278, code=themeStyle, value=null, createTime=1765260845977, updateTime=1765260845977, creator=18614031015, updator=18614031015)])], journalTitle=中国新药与临床杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of New Drugs and Clinical Remedies, journalPhotoCn=4CRZH/cEJmlFWJuWhAUDig==, journalPhotoEn=N3vp8/tZorUwVBJknBXdng==, journalFirstLetter=C, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxyylczz/CN/10.14109/j.cnki.xyylc.2024.09.10, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxyylczz/EN/10.14109/j.cnki.xyylc.2024.09.10, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxyylczz/CN/PDF/10.14109/j.cnki.xyylc.2024.09.10, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxyylczz/EN/PDF/10.14109/j.cnki.xyylc.2024.09.10, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)
收藏切换
获得性免疫缺陷综合征患者应用复方磺胺甲噁唑致药物性肝损伤危险因素分析
收藏切换
PDF下载
邱新野 1 , 尹月 2 , 刘炜 1, 刘炜
中国新药与临床杂志 | 论著 2024,43(9): 686-690
收起
收藏切换
中国新药与临床杂志 | 论著 2024, 43(9): 686-690
获得性免疫缺陷综合征患者应用复方磺胺甲噁唑致药物性肝损伤危险因素分析
全屏
邱新野1 , 尹月2 , 刘炜1, 刘炜
作者信息
  • 1.首都医科大学附属北京佑安医院 药学部，北京　100069
  • 2.北京大学肿瘤医院暨北京市肿瘤防治研究所 药剂科，恶性肿瘤发病机制及转化研究教育部重点实验室，北京　100142

    • 邱新野，男，副主任药师，硕士，主要从事临床药学工作，E-mail：

    尹月，女，主管药师，硕士，主要从事临床药学工作，E-mail：

    刘炜，男，主任药师，硕士生导师，硕士，主要从事临床药学工作，E-mail：

通讯作者:

刘炜，
尹月
Risk factors analysis on drug-induced liver injury in acquired immunodeficiency syndrome patients treated with compound sulfamethoxazole
Xin-ye QIU1 , Yue YIN2 , Wei LIU1, 刘炜
Affiliations
  • 1.Department of Pharmacy, Beijing Youan Hospital, Capital Medical University, BEIJING 100069, China
  • 2.Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pharmacy, Peking University Cancer Hospital & Institute, BEIJING 100142, China
出版时间: 2024-09-25 doi: 10.14109/j.cnki.xyylc.2024.09.10
文章导航
收藏切换
摘要
收起

目的 研究复方磺胺甲噁唑（SMZ-TMP）致获得性免疫缺陷综合征（AIDS）患者药物性肝损伤（DILI）的危险因素，为临床药物警戒及合理用药提供参考。方法 回顾性收集2020年12月至2022年12月在本院住院并服用SMZ-TMP治疗的AIDS患者的病例资料，将服用SMZ-TMP后发生DILI患者与未发生DILI患者的一般资料进行比较，并构建二分类logistic回归方程，筛选出AIDS患者应用SMZ-TMP致药物性肝损伤的危险因素。结果 271例服用SMZ-TMP治疗的AIDS患者中，共有29例发生DILI，均为男性，其中27例为肝细胞损伤型，2例为胆汁淤积型，经对症治疗后全部患者临床症状均好转或痊愈。相关因素分析显示，患者合并过敏史（OR=15.334，95%CI：3.147~74.710）、未进行抗病毒治疗或使用替诺福韦+拉米夫定+洛匹那韦/利托那韦（TDF+3TC+LPV/r）方案（OR=56.123，95%CI：10.797~291.719）、SMZ-TMP日剂量≥12片（OR=52.809，95%CI：9.894~281.868）、丙氨酸转氨酶（ALT）≥23 U·L-1（OR=18.514，95%CI：3.993~85.843）、CD4+ T淋巴细胞数≤110个·µL-1（OR=40.586，95%CI：6.625~248.634）及CD8+ T淋巴细胞数≤920个·µL-1（OR=135.978，95%CI：11.190~1 652.303），均可增加AIDS患者SMZ-TMP相关DILI的发生风险（P<0.05）。结论 AIDS患者SMZ-TMP相关DILI发生率较高，过敏史、抗病毒治疗方案的选择、SMZ-TMP剂量、ALT水平、CD4+及CD8+ T淋巴细胞数为AIDS患者发生SMZ-TMP相关DILI的独立危险因素，应加强高风险人群监测，并及早采取干预措施。

复方磺胺甲噁唑  /  获得性免疫缺陷综合征  /  药物性肝损伤  /  危险因素

AIM To explore the risk factors of drug-induced liver injury (DILI) of compound sulfamethoxazole (sulfamethoxazole-trimethoprim, SMZ-TMP) in acquired immunodeficiency syndrome (AIDS) patients and provide reference for clinical pharmacovigilance and rational drug use. METHODS The data of AIDS patients treated with SMZ-TMP in our hospital from December 2020 to December 2022 were collected retrospectively. The general information of patients with DILI after taking SMZ-TMP was compared with that of patients without DILI, and binary logistic regression equation was constructed to screen out the risk factors of DILI in AIDS patients induced by SMZ-TMP. RESULTS Totally 271 AIDS patients were involved, and 29 patients had DILI, all of whom were male. Among them, 27 patients were of hepatocellular injury pattern and 2 patients were of cholestatic injury pattern. All DILI patients were cured or improved after symptomatic treatment. Relevant factor analysis showed that, allergy history (OR=15.334，95%CI: 3.147 to 74.710), no receiving antiviral treatment or tenofovir+lamivudine+lopinavir/ritonavir (TDF+3TC+LPV/r) regimen (OR=56.123, 95% CI: 10.797 to 291.719), daily dose of SMZ-TMP ≥ 12 tablets (OR=52.809, 95% CI: 9.894 to 281.868), alanine transaminase (ALT) ≥ 23 U·L-1 (OR=18.514, 95% CI: 3.993 to 85.843), CD4+ T cell ≤110·µL-1 (OR=40.586，95%CI：6.625 to 248.634), and CD8+ T cell ≤ 920·µL-1 (OR=135.978，95%CI：11.190 to 1 652.303) can increase the risk of SMZ-TMP related DILI in AIDS patients (P<0.05). CONCLUSION The incidence of SMZ-TMP related DILI is relatively high in AIDS patients. Allergy history, selection of antiviral treatment regimens, dose of SMZ-TMP, ALT level, and CD4+ and CD8+ T lymphocyte counts are the independent risk factors for SMZ-TMP related DILI in AIDS patients. Monitoring of high-risk population should be strengthened and early intervention measures should be taken.

compound sulfamethoxazole  /  acquired immunodeficiency syndrome  /  drug-induced liver injury  /  risk factor
邱新野, 尹月, 刘炜. 获得性免疫缺陷综合征患者应用复方磺胺甲噁唑致药物性肝损伤危险因素分析. 中国新药与临床杂志, 2024 , 43 (9) : 686 -690 . DOI: 10.14109/j.cnki.xyylc.2024.09.10
Xin-ye QIU, Yue YIN, Wei LIU. Risk factors analysis on drug-induced liver injury in acquired immunodeficiency syndrome patients treated with compound sulfamethoxazole[J]. Chinese Journal of New Drugs and Clinical Remedies, 2024 , 43 (9) : 686 -690 . DOI: 10.14109/j.cnki.xyylc.2024.09.10
正文
收起
获得性免疫缺陷综合征（acquired immunodeficiency syndrome，AIDS）即艾滋病，已成为严重威胁我国公众健康的重要公共卫生问题之一[1]。AIDS患者由于免疫功能异常，导致卡氏肺孢子菌肺炎等机会性感染发生率增加。磺胺甲恶唑（sulfamethoxazole, SMZ）与甲氧苄啶（trimethoprim, TMP）的复方制剂，复方磺胺甲噁唑（SMZ-TMP），是治疗和预防AIDS患者卡氏肺孢子菌肺炎的重要药物，然而，与非AIDS患者使用该药6%~8%的不良反应发生率[2]相比，该药在AIDS患者中不良反应发生率高达65%，且多为严重不良反应，甚至约50%的AIDS患者因为药物不良反应而停用该药治疗[3,4]。SMZ-TMP引起的药物性肝损伤（drug-induced liver injury，DILI）发生率较高，SMZ-TMP的剂量、疗程以及药物相互作用可影响DILI的潜伏期、临床表型、病程及结局[5,6]，甚至会影响高效抗逆转录病毒治疗（highly active antiretroviral therapy, HAART）的使用，延误患者的整体治疗[7-9]。本研究回顾性分析应用SMZ-TMP治疗的AIDS患者的临床资料，分析该药所致DILI的危险因素，以期为临床提供合理、科学的用药建议，降低患者治疗风险。
资料与方法
收起
病例来源
统计2020年12月至2022年12月在首都医科大学附属北京佑安医院住院且服用SMZ-TMP治疗的AIDS患者的临床资料。排除标准：（1）临床资料不全患者；（2）基础肝功能异常患者。
资料收集
通过医院电子病历系统收集整理患者资料。（1）基本信息：姓名、病历号、性别、年龄、既往史、过敏史及HAART方案。（2）SMZ-TMP用药情况：剂量、频次及疗程。（3）合并用药情况。（4）SMZ-TMP治疗前实验室检查：丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、总胆红素（TBIL）、碱性磷酸酶（ALP）、红细胞沉降率（ESR）、CD4+ T淋巴细胞计数、CD8+ T淋巴细胞计数及人类免疫缺陷病毒（HIV）载量。（5）SMZ-TMP治疗结束后实验室检查：ALT、AST、TBIL、ALP。
DILI诊断及关联性评价
DILI诊断及分型标准参考《药物性肝损伤诊治指南（2023年）》[4]。诊断标准：（1）有可疑药物应用史。（2）除外其他肝损伤病因。（3）Roussel Uclaf因果关系评估法（RUCAM）评分≥3分（药物与肝损伤的因果相关性分为5个等级：>8分为极可能，6~8分为很可能，3~5分为可能，1~2分为不太可能，≤0分为可排除）。DILI病理分型：（1）肝细胞损伤型——ALT≥3倍正常值上限（ULN），且R≥5；（2）胆汁淤积型——ALP≥2ULN，且R≤2；（3）混合型——ALT≥3ULN，ALP≥2ULN，且2< R <5。R=（ALT实测值/ALT ULN）/（ALP实测值/ALP ULN）。
SMZ-TMP致DILI关联性评价参考我国《药品不良反应报告和监测管理办法》及《药物性肝损伤诊治指南（2023年）》：（1）DILI与使用SMZ-TMP存在明确时间相关性；（2）减量或停用SMZ-TMP，或经对症治疗后，临床症状缓解或消失；（3）DILI与其他合并用药时间相关性较差（DILI发生在其他合并用药停药后15 d，或合并用药为患者长期使用且未发生任何药物不良反应）；（4）停用其他合并用药，且经对症治疗后，临床症状未缓解；（5）除外疾病因素导致的肝脏损伤。
统计学方法
运用SPSS 26.0软件进行数据分析。符合正态分布计量资料采用均数±标准差（）表示，非正态分布计量资料采用中位数和四分位数［M（Q1，Q3）］表示。计量资料正态分布组间比较采用t检验，非正态分布采用Mann-Whitney U检验。计数资料采用Pearson χ2检验/Yate校正χ2检验/Fisher确切概率法进行组间比较。将单因素分析差异有统计学意义的指标进行二分类logistic回归分析，计算比值比（OR），分析独立危险因素。P<0.05为差异有显著意义。
结果
收起
一般资料
共纳入服用SMZ-TMP的AIDS患者271例，其中有29例发生DILI，发生率为10.7%，一般资料见表1。发生DILI的患者全部为男性，年龄27~57岁，既往均无肝脏基础疾病。
DILI分型及RUCAM评分
29例SMZ-TMP致DILI患者中，27例为肝细胞损伤型，2例为胆汁淤积型，无混合型。RUCAM评分显示，药物与肝损伤的因果相关性为极可能有5例，很可能22例，可能2例。
DILI转归
29例SMZ-TMP致DILI患者中，经抗炎保肝治疗，25例患者临床症状及实验室检查恢复正常，痊愈；4例患者临床症状及实验室检查较治疗前好转。
DILI相关因素分析
将服用SMZ-TMP后发生DILI患者与未发生DILI患者进行单因素比较，在基本情况方面，2组患者过敏史、基础疾病、HAART方案及SMZ-TMP日剂量比较，差异有显著意义（P<0.05）；实验室检查方面，2组患者ALT、AST、红细胞沉降率、CD4+ T淋巴细胞数、CD8+ T淋巴细胞数及HIV病毒载量比较，差异有显著意义（P<0.05），见表1。
对基本情况中的危险因素构建二分类logistic回归方程，结果显示，合并过敏史（OR=15.334，95%CI：3.147~74.710）、未进行抗病毒治疗或使用替诺福韦+拉米夫定+洛匹那韦/利托那韦（TDF+3TC+LPV/r）方案（OR = 56.123，95%CI：10.797~291.719）及SMZ-TMP日剂量≥12片（OR = 52.809，95%CI：9.894~281.868），均增加患者发生DILI风险，差异有显著意义（P<0.05），见表2。对实验室检查中的危险因素构建二分类logistic回归方程，结果显示，ALT≥23 U·L-1（OR =18.514，95%CI：3.993~85.843）、CD4+ T淋巴细胞数≤110个·µL-1（OR = 40.586，95%CI：6.625~248.634）及CD8+ T淋巴细胞数≤920个·µL-1（OR = 135.978，95%CI：11.190~1 652.303）也可增加患者发生DILI风险，差异有显著意义（P<0.05），见表3。
讨论
收起
研究认为，SMZ-TMP是引起AIDS患者DILI的最常见因素[8,10]。本研究中SMZ-TMP致AIDS患者DILI发生率为10.7%，低于其他研究数据[11]，这可能与本研究所纳入患者合并其他疾病较少、用药简单相关。部分研究认为[12]，男性性别与SMZ-TMP诱发的不良反应存在一定相关性，这可能与我国男性AIDS患者相关报告率和流行率的峰值分别是女性的4.0倍和2.86倍[13]相关。本研究与刘维等[11]的研究均认为，虽然男性DILI发生率高于女性，但两者间无统计学差异。本研究中DILI病理类型主要为肝细胞损伤型，少量为胆汁淤积型，一般认为肝脏中经过代谢的药物具有细胞杀伤作用，可直接激活细胞凋亡途径，进而诱发免疫应答，且药物本身或其代谢产物影响肝细胞代谢和胆汁分泌的某些环节，从而会引起肝细胞损伤或胆汁淤积相关的DILI[14]。从DILI的年龄结构分析，由于AIDS在老年人群中流行率低，本研究入组患者均为中青年，无法进行比较；但对非AIDS患者的研究发现，青年患者使用SMZ-TMP导致DILI发生率显著高于老年患者[15]。在转归和预后方面，本研究中大多数患者肝功能完全恢复正常，符合相关指南[5,6]对急性DILI预后的判断。
本研究发现，患者合并过敏史、未进行抗病毒治疗或使用TDF+3TC+LPV/r方案、SMZ-TMP日剂量≥12片、ALT≥23 U·L-1、CD4+ T淋巴细胞数≤110个·µL-1及CD8+ T淋巴细胞数≤920个·µL-1，均是增加SMZ-TMP相关DILI风险的独立危险因素。过敏与遗传因素相关，药物代谢酶、药物转运蛋白和人类白细胞抗原系统等遗传因素与DILI的发生也存在一定相关性。药物经过肝脏代谢，多种药物联用加重肝脏负担，几乎所有的HAART药物均有潜在肝毒性，在治疗AIDS患者并发症的基础上应用HAART可在一定程度上增加DILI的风险[8,10]，这与本研究中TDF+3TC+LPV/r方案是AIDS患者使用SMZ-TMP治疗发生DILI的危险因素相一致。指南[5]指出，无论是固有型还是特异质型DILI，均与药物剂量相关，SMZ-TMP日剂量≥12片为DILI的高风险因素与此相符。研究认为，SMZ-TMP的血清浓度与不良反应的发生密切相关[16]。血液系统毒性、肾毒性及高血钾的发生与SMZ-TMP剂量无相关性[17]；肝功能异常与SMZ-TMP剂量存在一定相关[3,18]，且在AIDS患者中更为显著，这与本研究结果一致。低CD4+ T淋巴细胞及CD8+ T淋巴细胞计数，通常提示AIDS患者进入感染最终阶段，各器官功能均明显异常，药物吸收、分布、代谢、排泄等均发生变化[19]，导致此类患者SMZ-TMP相关不良反应发生率显著增加。另外，刘维等[11]认为，AIDS患者合并巨细胞病毒感染，会增加SMZ-TMP相关DILI的风险，主要与联合使用药物相关，但本研究未发现相关性，这可能由于本研究入组患者合并巨细胞病毒感染较少，且并未进行针对性治疗相关。
合理用药是对SMZ-TMP导致AIDS患者DILI最有效的干预措施。医务人员处方该药时应充分评估和识别潜在高风险人群，避免联合使用肝毒性较强的药物，并对高风险人群密切监测肝功能等相关指标。临床药师也应加入决策团队，避免SMZ-TMP与其他药物的相互作用而导致血药浓度增加[5]。由于SMZ-TMP导致的DILI为剂量相关性，高风险人群使用SMZ-TMP应从低剂量开始。患者教育也至关重要，应避免错误的服药习惯，如使用茶、饮料等送服药物。
综上所述，AIDS患者SMZ-TMP相关DILI发生率较高，过敏史、抗病毒治疗方案的选择、SMZ-TMP剂量、ALT水平、CD4+及CD8+ T淋巴细胞数为此类患者发生SMZ-TMP相关DILI的独立危险因素，对于合并高危因素的患者，应给予警惕并采取适当的干预措施。本研究也存在一定局限性，如未纳入门诊患者、相关实验室检查时间不完全一致等，后续会通过扩大样本数量，加强随访，对研究结论进行验证。
基金
收起
  • 首都医科大学附属北京佑安医院2021年度中青年人才孵育项目(YNKTGL2021002)
文献
收起
参考文献 引证文献
排序方式：
[1]
中华医学会感染病学分会艾滋病丙型肝炎学组，中国疾病预防控制中心. 中国艾滋病诊疗指南（2021版）[J].中国艾滋病性病, 2021, 27（11）: 1182-1200.
[2]
ARONOFF GR, BENNETT WM, BERNS JS, et al. Drug prescribing in renal failure[M]. 5th ed. Portland, OR: American College of Physicians, 2007 : 154.
[3]
MASTERS PA, O'BRYAN TA, ZURLO J, et al. Trimethoprim-sulfamethoxazole revisited[J]. Arch Intern Med, 2003, 163（4）:402-410.
[4]
曹明雪, 朱丽丽, 蔡华丹. 复方磺胺甲噁唑片在人类免疫缺陷病毒感染者中的不良反应分析[J]. 中国医院用药评价与分析, 2019, 19（6）: 647-655.
CAO MX, ZHU LL, CAI HD. Analysis of adverse drug reactions of compound sulfamethoxazole tablets in human immunodeficiency virus infected patients[J]. Eval Anal Drug-Use Hosp China, 2019, 19（6）: 647-655.
[5]
中国医药生物技术协会药物性肝损伤防治技术专业委员会,中华医学会肝病学分会药物性肝病学组.中国药物性肝损伤诊治指南（2023年版）[J].胃肠病学, 2023, 28（7）: 397-431.
[6]
European Association for the Study of the Liver. EASL clinical practice guidelines: drug-induced liver injury[J]. J Hepatol,2019, 70（6）: 1222-1261.
[7]
EVY Y, ALVINA W, HARJONO KT. Drug hypersensitivity in human immunodeficiency virus-infected patient: challenging diagnosis and management[J]. Asia Pacific Allergy, 2014, 4（1）:54-67.
[8]
孙 娜,郜桂菊,梁洪远,等. AIDS患者肝功能异常的原因及预后分析[J]. 传染病信息, 2021, 34（1） : 71-74.
SUN N, GAO GJ, LIANG HY, et al. Analysis of causes and prognosis of abnormal liver function in AIDS patients[J]. Infect Dis Inf, 2021,34（1）: 71-74.
[9]
ANTONIOU T, HOLLANDS S, MACDONALD EM, et al. Trimethoprim-sulfamethoxazole and risk of sudden death among patients taking spironolactone[J]. CMAJ, 2015, 187（4）:E138-E143.
[10]
杨君洋, 齐唐凯, 张仁芳，等. 119例艾滋病患者并发药物性肝损伤的临床特点及预后分析[J]. 临床肝胆病杂志,2017, 33（8）: 1537-1542.
YANG JY, QI TK, ZHANG RF, et al. Clinical features and prognosis of AIDS complicated by drug-induced liver injury: an analysis of 119 cases[J]. J Clin Hepatol,2017, 33（8）: 1537-1542.
[11]
刘 维, 张 雯, 赵红心.复方新诺明在AIDS/PCP患者中引起肝损伤的相关因素分析[J].中国处方药, 2020, 18（9）:77-78.
[12]
KHAN DA, SOLENSKY R. Drug allergy[J]. J Allergy Clin Immunol, 2010, 125（2 Suppl 2）: S126-S137．
[13]
China CDC Weekly. Preplanned studies: trends in mortality and prevalence of reported HIV/AIDS cases—China, 2002 - 2021 [EB/OL].（2023-10-20） [2024-07-04]. https://weekly.chinacdc.cn/en/article/doi/10.46234/ccdcw2023.177.
[14]
毛 霖,汪习成,杨欣平,等.AIDS患者药物性肝损伤98例临床分析[J].皮肤病与性病, 2015, 37（2）: 95-96.
[15]
FONTANA RJ, KLEINER DE, CHALASANI N, et al. The impact of patient age and corticosteroids in patients with sulfonamide hepatotoxicity[J]. Am J Gastroenterol, 2023, 118（9）: 1566-1575.
[16]
DAVIS CM, SHEARER WT. Diagnosis and management of HIV drug hypersensitivity[J]. J Allergy Clin Immunol, 2008, 121（4） :826-832．
[17]
ICE LL, BARRETO JN, DAO BD, et al. Relationship of sulfamethoxazole therapeutic drug monitoring to clinical efficacy and toxicity: a retrospective cohort study[J]. Ther Drug Monit,2016, 38（3）: 319-326.
[18]
卢张阳, 梁 培, 祁 慧, 等. 重症患者复方磺胺甲噁唑血药峰浓度与不良反应的相关性研究[J]. 中国医院药学杂志, 2023, 43（2）: 207-210.
LU ZY, LIANG P, QI H, et al. The relationships of peak plasma concentration with toxicity of trimethoprim-sulfamethoxazole in ICU patients[J]. Chin J Hosp Pharm, 2023, 43（2）: 207-210.
[19]
辅海平, 孙 强. 浙江省桐乡市2005—2019年HIV/AIDS患者CD4+ T淋巴细胞检测情况分析 [J]. 中国皮肤性病学杂志, 2021, 35（9）: 1007-1011.
FU HP, SUN Q. Analysis of CD4+ T lymphocyte test in patients with HIV/AIDS in the Tongxiang city of Zhejiang province from 2005 to 2019 [J]. Chin J Dermatovenereol,2021, 35（9）: 1007-1011.
2024年第43卷第9期
PDF下载
81
36
引用本文
BibTeX
文章信息
doi: 10.14109/j.cnki.xyylc.2024.09.10
  • 接收时间：2023-08-30
  • 首发时间：2026-03-18
  • 出版时间：2024-09-25
补充材料
相关文章
文章信息
作者
出版历史
  • 收稿日期：2023-08-30
  • 录用日期：2024-08-07
基金
首都医科大学附属北京佑安医院2021年度中青年人才孵育项目(YNKTGL2021002)
作者信息
    1.首都医科大学附属北京佑安医院 药学部，北京　100069
    2.北京大学肿瘤医院暨北京市肿瘤防治研究所 药剂科，恶性肿瘤发病机制及转化研究教育部重点实验室，北京　100142

通讯作者:

刘炜，
尹月
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/zgxyylczz/CN/10.14109/j.cnki.xyylc.2024.09.10
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
相关链接
论文
最新文章
热读文章
热点专题
内参
蓝皮书
产业发展报告
传播力报告
期刊分级目录
资讯
学术新闻
行业新闻
学术会议
行业会议
关于
关于我们
联系我们
北京市海淀区学院南路86号
100081
010-62199257
qkjq@cast.org.cn

中国科学技术协会版权所有 京ICP 备10216604号-4 海淀分局备案 1101084647
科技导报社主办 中国科协信息中心技术支持