首页 期刊 论文 学科刊群 资讯 加盟 关于
EN
image
Article(id=1239238833045295517, tenantId=1146029695717560320, journalId=1205117082300743687, issueId=1239238829719220640, articleNumber=null, orderNo=null, doi=10.14109/j.cnki.xyylc.2024.08.08, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1686499200000, receivedDateStr=2023-06-12, revisedDate=null, revisedDateStr=null, acceptedDate=1711468800000, acceptedDateStr=2024-03-27, onlineDate=1773387161741, onlineDateStr=2026-03-13, pubDate=1724515200000, pubDateStr=2024-08-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1773387161741, onlineIssueDateStr=2026-03-13, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1773387161741, creator=13701087609, updateTime=1773387161741, updator=13701087609, issue=Issue{id=1239238829719220640, tenantId=1146029695717560320, journalId=1205117082300743687, year='2024', volume='43', issue='8', pageStart='561', pageEnd='640', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1773387160949, creator=13701087609, updateTime=1773387216554, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1239239063014789867, tenantId=1146029695717560320, journalId=1205117082300743687, issueId=1239238829719220640, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1239239063014789868, tenantId=1146029695717560320, journalId=1205117082300743687, issueId=1239238829719220640, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=607, endPage=611, ext={EN=ArticleExt(id=1239238834202923427, articleId=1239238833045295517, tenantId=1146029695717560320, journalId=1205117082300743687, language=EN, title=Effects of ciprofol in intracranial aneurysm embolization, columnId=1207314218647392369, journalTitle=Chinese Journal of New Drugs and Clinical Remedies, columnName=Original Article, runingTitle=null, highlight=null, articleAbstract=
AIM

To observe the anesthetic effect of ciprofol in intracranial aneurysm embolization.

METHODS

One hundred and twenty patients undergoing intracranial aneurysm embolization, ASA Ⅰor Ⅱ, were randomly divided into control group and experimental group （n=60, each group）. During anesthesia induction, patients were given with midazolam 0.04 mg·kg-1, sufentanil 0.25 μg·kg-1, ciprofol 0.4 mg·kg-1 （experimental group） or propofol 2.0 mg·kg-1 （control group）, and rocuronium 0.6 mg·kg-1. During anesthesia maintenance, all patients were maintained with remifentanil 1 μg·kg-1·h-1 and cisatracurium 0.1 mg·kg-1·h-1, combined with ciprofol 0.8 mg·kg-1·h-1 （experimental group） or propofol 5 mg·kg-1·h-1 （control group）. The bispectral index （BIS） was maintained between 40 and 60 by adjusting the pumping speed during the operation. The changes of vital signs and BIS were observed. The anesthesia induction time,awakening time, and Ramsay sedation score after extubation were recorded. And the occurrence of adverse reactions was also　observed.

RESULTS

There was no significant difference in systolic blood pressure （SBP）, diastolic blood pressure （DBP）,and heart rate （HR） between the two groups before anesthesia, after anesthesia induction, after tracheal intubation, at the end of operation, and after tracheal extubation. The BIS at the end of operation in the experimental group was lower than that in the control group （P<0.05）. The fluctuation value of SBP, DBP, and HR during anesthesia induction in the control group was significantly greater than that in the experimental group （P<0.05）. The recovery time of the experimental group was slightly longer while the use of sedatives was less than that of the control group （P<0.05）. The incidences of post-induced hypotension, hypertension after intubation, and injection pain in the experimental group were lower than those in the control group （P<0.05）.

CONCLUSION

Ciprofol can be used in intracranial aneurysm embolization with outstanding sedative efficacy. The hemodynamics of patient is more stable, and the incidence of postoperative adverse reaction is low.

, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Feng-mei MEI, Qiong ZENG, Jun LU, Yi-feng RUAN, Shan-shan WU), CN=ArticleExt(id=1239238834936926645, articleId=1239238833045295517, tenantId=1146029695717560320, journalId=1205117082300743687, language=CN, title=环泊酚应用于颅内动脉瘤栓塞术的效果, columnId=1207314219226206329, journalTitle=中国新药与临床杂志, columnName=论著, runingTitle=null, highlight=null, articleAbstract=
目的

观察环泊酚在颅内动脉瘤栓塞术中的麻醉效果。

方法

选择择期行颅内动脉瘤栓塞术的患者120例，ASA分级Ⅰ~Ⅱ级，随机分为对照组和试验组，每组60例。麻醉诱导时采用咪达唑仑0.04 mg·kg-1、舒芬太尼0.25 μg·kg-1、环泊酚0.4 mg·kg-1（试验组）或丙泊酚2.0 mg·kg-1（对照组）及罗库溴铵0.6 mg·kg-1。麻醉维持2组均持续泵注瑞芬太尼1 μg·kg-1·h-1、顺阿曲库铵0.1 mg·kg-1·h-1，试验组加用环泊酚0.8 mg·kg-1·h-1，对照组加用丙泊酚5 mg·kg-1·h-1。术中调整泵注速度使脑电双频指数（BIS）维持在40~60，观察生命体征和BIS的变化，记录麻醉诱导时间、苏醒时间、拔管后Ramsay镇静评分等，观察不良反应发生情况。

结果

2组麻醉前、麻醉诱导后、气管插管后、手术结束时、气管导管拔除后各观察时点收缩压（SBP）、舒张压（DBP）和心率（HR）比较，均无显著差异（P>0.05）,试验组手术结束时的BIS显著低于对照组（P<0.05）。麻醉诱导期间对照组SBP、DBP和HR的波动值显著大于试验组（P<0.05）。试验组苏醒时间长于对照组，镇静药物总用量少于对照组，均有显著差异（P<0.05）。试验组麻醉诱导后低血压、插管后高血压以及注射痛的发生率显著低于对照组（P<0.05）。

结论

环泊酚应用于颅内动脉瘤栓塞术具有良好的镇静效果，患者术中血流动力学波动更趋平稳，术后不良反应发生率低。

, correspAuthors=null, authorNote=null, correspAuthorsNote=
吴姗姗，E-mail:
, copyrightStatement=null, copyrightOwner=《中国新药与临床杂志》编辑部, extLink=null, articleAbsUrl=null, sourceXml=CaTa+GgyMJ1EWFG17YGsUg==, magXml=hVS5NMEwi53F0GtTwwX2CQ==, pdfUrl=null, pdf=TevghokIO7ZsZmji4h4fzg==, pdfFileSize=1047744, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=Ah8yQcok/hCXOc+yOWPyDw==, mapNumber=null, authorCompany=null, fund=null, authors=

梅凤美，女，副主任医师，硕士，主要从事围术期脑保护的研究，Phn: 86-25-8229-6327, E-mail:

, authorsList=梅凤美, 曾琼, 陆军, 阮义峰, 吴姗姗)}, authors=[Author(id=1239238835360551365, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=mfm82@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1239238835490574797, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, authorId=1239238835360551365, language=EN, stringName=Feng-mei MEI, firstName=Feng-mei, middleName=null, lastName=MEI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Anesthesiology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing JIANGSU 210029, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1239238835570266581, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, authorId=1239238835360551365, language=CN, stringName=梅凤美, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=南京医科大学附属脑科医院 麻醉科，江苏 南京 210029, bio={"content":"

梅凤美，女，副主任医师，硕士，主要从事围术期脑保护的研究，Phn: 86-25-8229-6327, E-mail:

"}, bioImg=null, bioContent=

梅凤美，女，副主任医师，硕士，主要从事围术期脑保护的研究，Phn: 86-25-8229-6327, E-mail:

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1239238835238916539, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, xref=null, ext=[AuthorCompanyExt(id=1239238835259888061, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, companyId=1239238835238916539, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Anesthesiology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing JIANGSU 210029, China), AuthorCompanyExt(id=1239238835268276670, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, companyId=1239238835238916539, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=南京医科大学附属脑科医院 麻醉科，江苏 南京 210029)])]), Author(id=1239238835641569754, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1239238835763204580, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, authorId=1239238835641569754, language=EN, stringName=Qiong ZENG, firstName=Qiong, middleName=null, lastName=ZENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Anesthesiology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing JIANGSU 210029, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1239238835851284966, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, authorId=1239238835641569754, language=CN, stringName=曾琼, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=南京医科大学附属脑科医院 麻醉科，江苏 南京 210029, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1239238835238916539, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, xref=null, ext=[AuthorCompanyExt(id=1239238835259888061, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, companyId=1239238835238916539, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Anesthesiology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing JIANGSU 210029, China), AuthorCompanyExt(id=1239238835268276670, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, companyId=1239238835238916539, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=南京医科大学附属脑科医院 麻醉科，江苏 南京 210029)])]), Author(id=1239238835951948271, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1239238836048417269, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, authorId=1239238835951948271, language=EN, stringName=Jun LU, firstName=Jun, middleName=null, lastName=LU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Anesthesiology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing JIANGSU 210029, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1239238836165857786, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, authorId=1239238835951948271, language=CN, stringName=陆军, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=南京医科大学附属脑科医院 麻醉科，江苏 南京 210029, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1239238835238916539, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, xref=null, ext=[AuthorCompanyExt(id=1239238835259888061, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, companyId=1239238835238916539, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Anesthesiology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing JIANGSU 210029, China), AuthorCompanyExt(id=1239238835268276670, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, companyId=1239238835238916539, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=南京医科大学附属脑科医院 麻醉科，江苏 南京 210029)])]), Author(id=1239238836258132481, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1239238836350407178, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, authorId=1239238836258132481, language=EN, stringName=Yi-feng RUAN, firstName=Yi-feng, middleName=null, lastName=RUAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Anesthesiology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing JIANGSU 210029, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1239238836455264783, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, authorId=1239238836258132481, language=CN, stringName=阮义峰, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=南京医科大学附属脑科医院 麻醉科，江苏 南京 210029, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1239238835238916539, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, xref=null, ext=[AuthorCompanyExt(id=1239238835259888061, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, companyId=1239238835238916539, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Anesthesiology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing JIANGSU 210029, China), AuthorCompanyExt(id=1239238835268276670, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, companyId=1239238835238916539, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=南京医科大学附属脑科医院 麻醉科，江苏 南京 210029)])]), Author(id=1239238836534956563, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=11765115@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1239238836610454043, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, authorId=1239238836534956563, language=EN, stringName=Shan-shan WU, firstName=Shan-shan, middleName=null, lastName=WU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Anesthesiology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing JIANGSU 210029, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1239238836719505951, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, authorId=1239238836534956563, language=CN, stringName=吴姗姗, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=南京医科大学附属脑科医院 麻醉科，江苏 南京 210029, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1239238835238916539, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, xref=null, ext=[AuthorCompanyExt(id=1239238835259888061, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, companyId=1239238835238916539, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Anesthesiology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing JIANGSU 210029, China), AuthorCompanyExt(id=1239238835268276670, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, companyId=1239238835238916539, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=南京医科大学附属脑科医院 麻醉科，江苏 南京 210029)])])], keywords=[Keyword(id=1239238836803392035, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, language=EN, orderNo=1, keyword=ciprofol), Keyword(id=1239238836866306601, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, language=EN, orderNo=2, keyword=propofol), Keyword(id=1239238836954386993, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, language=EN, orderNo=3, keyword=intracranial aneurysm), Keyword(id=1239238838414004786, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, language=EN, orderNo=4, keyword=embolization, therapeutic), Keyword(id=1239238838518862392, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, language=CN, orderNo=1, keyword=环泊酚), Keyword(id=1239238838606942778, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, language=CN, orderNo=2, keyword=丙泊酚), Keyword(id=1239238838707606078, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, language=CN, orderNo=3, keyword=颅内动脉瘤), Keyword(id=1239238838804075076, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, language=CN, orderNo=4, keyword=栓塞，治疗性)], refs=[Reference(id=1239238839663907434, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2021, volume=18, issue=8, pageStart=546, pageEnd=574, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=中国医师协会神经介入专业委员会, 中国颅内动脉瘤计划研究组, journalName=中国脑血管病杂志, refType=null, unstructuredReference=中国医师协会神经介入专业委员会，中国颅内动脉瘤计划研究组. 中国颅内破裂动脉瘤诊疗指南2021[J].中国脑血管病杂志，2021, 18（8）: 546-574., articleTitle=中国颅内破裂动脉瘤诊疗指南2021, refAbstract=null), Reference(id=1239238839760376431, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2021, volume=18, issue=8, pageStart=546, pageEnd=574, url=null, language=null, rfNumber=[1], rfOrder=1, authorNames=Chinese Federation of Interventional Clinical Neurosciences, China Intracranial Aneurysm Project Study Group, journalName=Chin J Cerebrovasc Dis, refType=null, unstructuredReference=Chinese Federation of Interventional Clinical Neurosciences, China Intracranial Aneurysm Project Study Group. Chinese guidelines for diagnosis and treatment of ruptured intracranial aneurysm 2021 [J]. Chin J Cerebrovasc Dis, 2021, 18（8）: 546-574., articleTitle=Chinese guidelines for diagnosis and treatment of ruptured intracranial aneurysm 2021, refAbstract=null), Reference(id=1239238839856845430, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2019, volume=35, issue=10, pageStart=941, pageEnd=944, url=null, language=null, rfNumber=[2], rfOrder=2, authorNames=吴姗姗, 李锦汶, 梅凤美, journalName=临床麻醉学杂志, refType=null, unstructuredReference=吴姗姗，李锦汶，梅凤美，等.控制性降压对颅内动脉瘤夹闭术中脑氧饱和度和术后神经认知功能的影响[J]. 临床麻醉学杂志，2019, 35（10）: 941-944., articleTitle=控制性降压对颅内动脉瘤夹闭术中脑氧饱和度和术后神经认知功能的影响, refAbstract=null), Reference(id=1239238839923954295, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2019, volume=35, issue=10, pageStart=941, pageEnd=944, url=null, language=null, rfNumber=[2], rfOrder=3, authorNames=WU SS, LI JW, MEI FM, journalName=J Clin Anesthesiol, refType=null, unstructuredReference=WU SS, LI JW,MEI FM, et al. Effect of controlled hypotension on intraoperative cerebral oxygen saturation and postoperative neural cognitive function in patients with intracranial aneurysm clipping [J]. J Clin Anesthesiol, 2019, 35（10）: 941-944., articleTitle=Effect of controlled hypotension on intraoperative cerebral oxygen saturation and postoperative neural cognitive function in patients with intracranial aneurysm clipping, refAbstract=null), Reference(id=1239238840037200504, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2018, volume=49, issue=4, pageStart=848, pageEnd=855, url=null, language=null, rfNumber=[3], rfOrder=4, authorNames=JABBARLI R, DINGER TF, DARKWAH OM, journalName=Stroke, refType=null, unstructuredReference=JABBARLI R, DINGER TF, DARKWAH OM, et al. Risk factors for and clinical consequences of multiple intracranial aneurysms：a systematic review and meta-analysis[J]. Stroke, 2018, 49（4）:848-855., articleTitle=Risk factors for and clinical consequences of multiple intracranial aneurysms：a systematic review and meta-analysis, refAbstract=null), Reference(id=1239238840125280890, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2021, volume=40, issue=9, pageStart=646, pageEnd=649, url=null, language=null, rfNumber=[4], rfOrder=5, authorNames=张 郃, 龙 超, 张森兵, journalName=中国新药与临床杂志, refType=null, unstructuredReference=张 郃，龙 超，张森兵，等. 瑞马唑仑用于颅内动脉瘤栓塞术的麻醉效果[J].中国新药与临床杂志, 2021, 40 （9）：646-649., articleTitle=瑞马唑仑用于颅内动脉瘤栓塞术的麻醉效果, refAbstract=null), Reference(id=1239238840209166976, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2021, volume=40, issue=9, pageStart=646, pageEnd=649, url=null, language=null, rfNumber=[4], rfOrder=6, authorNames=ZHANG H, LONG C, ZHANG SB, journalName=Chin J New Drugs Clin Rem, refType=null, unstructuredReference=ZHANG H, LONG C, ZHANG SB, et al. Anesthetic effects of remimazolam in intracranial aneurysm embolization surgery[J]. Chin J New Drugs Clin Rem, 2021, 40（9）: 646-649., articleTitle=Anesthetic effects of remimazolam in intracranial aneurysm embolization surgery, refAbstract=null), Reference(id=1239238840297247362, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2021, volume=41, issue=2, pageStart=129, pageEnd=132, url=null, language=null, rfNumber=[5], rfOrder=7, authorNames=刘 进, 米卫东, 姚尚龙, journalName=中华麻醉学杂志, refType=null, unstructuredReference=刘 进，米卫东，姚尚龙，等．环泊酚临床应用指导意见[J].中华麻醉学杂志， 2021, 41（2） : 129-132．, articleTitle=环泊酚临床应用指导意见, refAbstract=null), Reference(id=1239238840502768265, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2021, volume=41, issue=2, pageStart=129, pageEnd=132, url=null, language=null, rfNumber=[5], rfOrder=8, authorNames=LIU J, MI WD, YAO SL, journalName=Clin J Anesthesiol, refType=null, unstructuredReference=LIU J, MI WD, YAO SL, et al. Guidelines on clinical application of ciprofol [J]. Clin J Anesthesiol, 2021, 41（2）: 129-132., articleTitle=Guidelines on clinical application of ciprofol, refAbstract=null), Reference(id=1239238840574071436, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2023, volume=40, issue=6, pageStart=399, pageEnd=406, url=null, language=null, rfNumber=[6], rfOrder=9, authorNames=LIANG P, DAI M, WANG X, journalName=Eur J Anaesthesiol, refType=null, unstructuredReference=LIANG P, DAI M, WANG X, et al. Efficacy and safety of ciprofol vs.propofol for the induction and maintenance of general anaesthesia:a multicentre, single-blind, randomised, parallel-group, phase 3 clinical trial[J]. Eur J Anaesthesiol, 2023, 40（6）: 399-406., articleTitle=Efficacy and safety of ciprofol vs.propofol for the induction and maintenance of general anaesthesia:a multicentre, single-blind, randomised, parallel-group, phase 3 clinical trial, refAbstract=null), Reference(id=1239238840670540432, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2015, volume=25, issue=12, pageStart=1264, pageEnd=1273, url=null, language=null, rfNumber=[7], rfOrder=10, authorNames=SUN T, WEST N, ANSERMINO JM, journalName=Paediatr Anaesth, refType=null, unstructuredReference=SUN T，WEST N，ANSERMINO JM ，et al. A smartphone version of the faces pain scale-revised and the color analog scale for postoperative pain assessment in children[J]. Paediatr Anaesth，2015, 25（12）: 1264-1273., articleTitle=A smartphone version of the faces pain scale-revised and the color analog scale for postoperative pain assessment in children, refAbstract=null), Reference(id=1239238840758620820, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2015, volume=19, issue=7, pageStart=1227, pageEnd=1233, url=null, language=null, rfNumber=[8], rfOrder=11, authorNames=CUI YF, XU H, LIU HT, journalName=Eur Rev Med Pharmacol Sci, refType=null, unstructuredReference=CUI YF，XU H，LIU HT，et al. Clinical application of solitaire AB stents in the embolization of intracranial aneurysms [J]. Eur Rev Med Pharmacol Sci, 2015, 19（7） : 1227-1233．, articleTitle=Clinical application of solitaire AB stents in the embolization of intracranial aneurysms, refAbstract=null), Reference(id=1239238840842506901, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2016, volume=36, issue=6, pageStart=641, pageEnd=649, url=null, language=null, rfNumber=[9], rfOrder=12, authorNames=中华医学会麻醉学分会全凭静脉麻醉专家共识工作小组, journalName=中华麻醉学杂志, refType=null, unstructuredReference=中华医学会麻醉学分会全凭静脉麻醉专家共识工作小组. 全凭静脉麻醉专家共识[J]. 中华麻醉学杂志, 2016, 36（6）:641-649., articleTitle=全凭静脉麻醉专家共识, refAbstract=null), Reference(id=1239238840922198679, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2016, volume=36, issue=6, pageStart=641, pageEnd=649, url=null, language=null, rfNumber=[9], rfOrder=13, authorNames=Chinese Society of Anesthesiology Task Force on Total　Intravenous Anesthesia, journalName=Chin J Anesthesiol, refType=null, unstructuredReference=Chinese Society of Anesthesiology Task Force on Total　Intravenous Anesthesia. Consensus on total intravenous anesthesia[J]. Chin J Anesthesiol, 2016, 36（6）: 641-649., articleTitle=Consensus on total intravenous anesthesia, refAbstract=null), Reference(id=1239238841001890459, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2022, volume=13, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=14, authorNames=LONG YQ, FENG CD, DING YY, journalName=Front Pharmacol, refType=null, unstructuredReference=LONG YQ，FENG CD，DING YY，et al． Esketamine as an adjuvant to ciprofol or propofol sedation for same-day bidirectional endoscopy: protocol for a randomized，double-blind，controlled trial with factorial design[J]. Front Pharmacol, 2022, 13 : 821691., articleTitle=Esketamine as an adjuvant to ciprofol or propofol sedation for same-day bidirectional endoscopy: protocol for a randomized，double-blind，controlled trial with factorial design, refAbstract=null), Reference(id=1239238841085776541, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2021, volume=12, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=15, authorNames=LI X, YANG D, LI Q, journalName=Front Pharmacol, refType=null, unstructuredReference=LI X, YANG D, LI Q, et al. Safety, pharmacokinetics and pharmacodynamics of a single bolus of the γ-aminobutyric acid（GABA） receptor potentiator HSK3486 in healthy Chinese elderly and non-elderly [J]. Front Pharmacol, 2021, 12 : 735700., articleTitle=Safety, pharmacokinetics and pharmacodynamics of a single bolus of the γ-aminobutyric acid（GABA） receptor potentiator HSK3486 in healthy Chinese elderly and non-elderly, refAbstract=null), Reference(id=1239238841190634143, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=1998, volume=45, issue=6, pageStart=242, pageEnd=247, url=null, language=null, rfNumber=[12], rfOrder=16, authorNames=ORTIZ JR, PERCAZ JA, CARRASCOSA F, journalName=Rev Esp Anestesiol Reanim, refType=null, unstructuredReference=ORTIZ JR，PERCAZ JA，CARRASCOSA F. Cisatracurium [J].Rev Esp Anestesiol Reanim, 1998, 45（6）: 242-247., articleTitle=Cisatracurium, refAbstract=null), Reference(id=1239238841287103136, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2004, volume=null, issue=null, pageStart=481, pageEnd=487, url=null, language=null, rfNumber=[13], rfOrder=17, authorNames=庄心良, 曾因明, 陈伯鉴, journalName=现代麻醉学, refType=null, unstructuredReference=庄心良, 曾因明, 陈伯鉴. 现代麻醉学 [M]. 3版. 北京：人民卫生出版社， 2004: 481-487., articleTitle=null, refAbstract=null), Reference(id=1239238841387766435, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2021, volume=38, issue=11, pageStart=5484, pageEnd=5500, url=null, language=null, rfNumber=[14], rfOrder=18, authorNames=HU C, OU X, TENG Y, journalName=Adv Ther, refType=null, unstructuredReference=HU C, OU X, TENG Y, et al. Sedation effects produced by a ciprofol initial infusion or bolus dose followed by continuous maintenance infusion in healthy subjects: a phase 1 trial[J]. Adv Ther, 2021,38（11）: 5484-5500., articleTitle=Sedation effects produced by a ciprofol initial infusion or bolus dose followed by continuous maintenance infusion in healthy subjects: a phase 1 trial, refAbstract=null), Reference(id=1239238841459069607, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2021, volume=87, issue=1, pageStart=93, pageEnd=105, url=null, language=null, rfNumber=[15], rfOrder=19, authorNames=BIAN YC, ZHANG H, MA S, journalName=Br J Clin Pharmacol, refType=null, unstructuredReference=BIAN YC, ZHANG H, MA S, et al. Mass balance, pharmacokinetics and pharmacodynamics of intravenous HSK3486, a novel anaesthetic, administered to healthy subjects[J]. Br J Clin Pharmacol, 2021, 87 （1）: 93-105., articleTitle=Mass balance, pharmacokinetics and pharmacodynamics of intravenous HSK3486, a novel anaesthetic, administered to healthy subjects, refAbstract=null), Reference(id=1239238841526178473, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2021, volume=13, issue=12, pageStart=13791, pageEnd=13802, url=null, language=null, rfNumber=[16], rfOrder=20, authorNames=TENG Y, OU MC, WANG X, journalName=Am J Transl Res, refType=null, unstructuredReference=TENG Y, OU MC, WANG X, et al. Pharmacokinetic and pharmacodynamic properties of ciprofol emulsion in Chinese subjects: a single center, open-label, single-arm dose-escalation phase 1 study[J]. Am J Transl Res, 2021, 13（12）: 13791-13802., articleTitle=Pharmacokinetic and pharmacodynamic properties of ciprofol emulsion in Chinese subjects: a single center, open-label, single-arm dose-escalation phase 1 study, refAbstract=null), Reference(id=1239238842994184874, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2021, volume=164, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=21, authorNames=TENG Y, OU M, WANG X, journalName=Eur J Pharm Sci, refType=null, unstructuredReference=TENG Y, OU M, WANG X, et al. Efficacy and safety of ciprofol for the sedation/anesthesia in patients undergoing colonoscopy: phaseⅡa and Ⅱb multi-center clinical trials[J]. Eur J Pharm Sci,2021, 164 : 105904., articleTitle=Efficacy and safety of ciprofol for the sedation/anesthesia in patients undergoing colonoscopy: phaseⅡa and Ⅱb multi-center clinical trials, refAbstract=null), Reference(id=1239238843094848170, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, doi=null, pmid=null, pmcid=null, year=2022, volume=131, issue=2, pageStart=138, pageEnd=148, url=null, language=null, rfNumber=[18], rfOrder=22, authorNames=LI J, WANG X, LIU J, journalName=Basic Clin Pharmacol Toxicol, refType=null, unstructuredReference=LI J, WANG X, LIU J, et al. Comparison of ciprofol （HSK3486）versus propofol for the induction of deep sedation during gastroscopy and colonoscopy procedures: a multi-centre, non-inferiority, randomized, controlled phase 3 clinical trial [J]. Basic Clin Pharmacol Toxicol, 2022, 131（2）: 138-148., articleTitle=Comparison of ciprofol （HSK3486）versus propofol for the induction of deep sedation during gastroscopy and colonoscopy procedures: a multi-centre, non-inferiority, randomized, controlled phase 3 clinical trial, refAbstract=null)], funds=null, companyList=[AuthorCompany(id=1239238835238916539, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, xref=null, ext=[AuthorCompanyExt(id=1239238835259888061, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, companyId=1239238835238916539, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Anesthesiology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing JIANGSU 210029, China), AuthorCompanyExt(id=1239238835268276670, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, companyId=1239238835238916539, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=南京医科大学附属脑科医院 麻醉科，江苏 南京 210029)])], figs=[ArticleFig(id=1239238838950875719, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
指标对照组试验组
性别/例 男3829
女2231
年龄/岁44.2±9.546.3±9.9
体重/kg66.9±8.063.7±8.6
ASA分级/例 Ⅰ级2432
Ⅱ级3628
麻醉时间/min165.8±25.9174.7±24.1
), ArticleFig(id=1239238839026373194, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, language=CN, label=表1, caption=

一般情况组间比较

, figureFileSmall=null, figureFileBig=null, tableContent=
指标对照组试验组
性别/例 男3829
女2231
年龄/岁44.2±9.546.3±9.9
体重/kg66.9±8.063.7±8.6
ASA分级/例 Ⅰ级2432
Ⅱ级3628
麻醉时间/min165.8±25.9174.7±24.1
), ArticleFig(id=1239238839110259279, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
组别时点SBP/mmHgDBP/mmHgHR/次·min-1BIS
对照麻醉前120.4±16.874.2±11.073.2±8.793.2±6.0
麻醉诱导后107.3±11.0b66.0±8.1b70.2±8.6b56.7±8.9b
气管插管后116.4±11.5a73.5±11.0a73.8±8.4a50.6±7.6b
手术结束时113.5±11.8b68.2±6.0b70.6±7.3b57.2±9.0b
气管导管拔除后126.2±12.5b77.7±7.7b77.8±8.8b90.9±4.2a
试验麻醉前124.6±15.1d71.9±9.6d74.5±9.5d91.7±4.6d
麻醉诱导后116.9±10.6bd66.8±6.9bd72.2±9.0ad54.7±6.9bd
气管插管后120.8±14.9ad70.8±8.0ad72.9±7.3ad48.5±7.4bd
手术结束时116.6±8.5bd69.3±6.0bd70.8±7.9bd49.0±6.2be
气管导管拔除后127.9±9.4bd74.7±6.9ad75.6±7.0ad88.6±4.2ad
), ArticleFig(id=1239238839198339666, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, language=CN, label=表2, caption=

血流动力学及镇静相关指数的比较

, figureFileSmall=null, figureFileBig=null, tableContent=
组别时点SBP/mmHgDBP/mmHgHR/次·min-1BIS
对照麻醉前120.4±16.874.2±11.073.2±8.793.2±6.0
麻醉诱导后107.3±11.0b66.0±8.1b70.2±8.6b56.7±8.9b
气管插管后116.4±11.5a73.5±11.0a73.8±8.4a50.6±7.6b
手术结束时113.5±11.8b68.2±6.0b70.6±7.3b57.2±9.0b
气管导管拔除后126.2±12.5b77.7±7.7b77.8±8.8b90.9±4.2a
试验麻醉前124.6±15.1d71.9±9.6d74.5±9.5d91.7±4.6d
麻醉诱导后116.9±10.6bd66.8±6.9bd72.2±9.0ad54.7±6.9bd
气管插管后120.8±14.9ad70.8±8.0ad72.9±7.3ad48.5±7.4bd
手术结束时116.6±8.5bd69.3±6.0bd70.8±7.9bd49.0±6.2be
气管导管拔除后127.9±9.4bd74.7±6.9ad75.6±7.0ad88.6±4.2ad
), ArticleFig(id=1239238839269642837, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
指标对照组试验组
诱导时间/s43.7±5.347.3±5.8a
苏醒时间/min12.9±4.215.3±2.9b
Ramsay镇静评分2.30±0.662.50±0.65a
瑞芬太尼总用量/mg434.6±72.6394.4±56.9a
镇静药物总用量/mg801.5±124.3181.6±24.2b
), ArticleFig(id=1239238839361917529, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, language=CN, label=表3, caption=

麻醉相关指标组间比较

, figureFileSmall=null, figureFileBig=null, tableContent=
指标对照组试验组
诱导时间/s43.7±5.347.3±5.8a
苏醒时间/min12.9±4.215.3±2.9b
Ramsay镇静评分2.30±0.662.50±0.65a
瑞芬太尼总用量/mg434.6±72.6394.4±56.9a
镇静药物总用量/mg801.5±124.3181.6±24.2b
), ArticleFig(id=1239238839458386526, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=
不良反应对照组试验组
低血压11（18）3（5）b
高血压12（20）4（7）b
心动过缓9（15）7（12）a
心动过速8（13）5（8）a
注射痛12（20）0 b
恶心呕吐3（5）1（2）a
躁动5（8）3（5）a
), ArticleFig(id=1239238839554855524, tenantId=1146029695717560320, journalId=1205117082300743687, articleId=1239238833045295517, language=CN, label=表4, caption=

不良反应发生率组间比较

, figureFileSmall=null, figureFileBig=null, tableContent=
不良反应对照组试验组
低血压11（18）3（5）b
高血压12（20）4（7）b
心动过缓9（15）7（12）a
心动过速8（13）5（8）a
注射痛12（20）0 b
恶心呕吐3（5）1（2）a
躁动5（8）3（5）a
)], attaches=null, journal=Journal(id=1205114437246812164, delFlag=0, nameCn=中国新药与临床杂志, nameEn=Chinese Journal of New Drugs and Clinical Remedies, nameHistory1=null, nameHistory2=null, issn=1007-7669, eissn=, cn=31-1746/R, coden=null, periodic=月刊, language=CN, oaType=1, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=, officePhone=, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=4CRZH/cEJmlFWJuWhAUDig==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of New Drugs and Clinical Remedies, journalRemark=null, publicationField=null, createdTime=1765251271787, updatedTime=1765252216403, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=C, firstLetterEn=C, subjectCode=Life Sciences, subjectName=生命医学, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=4CRZH/cEJmlFWJuWhAUDig==, picEn=N3vp8/tZorUwVBJknBXdng==, jcr=null, cjcr=null, exts=[JournalExt(id=1205118399413203150, language=CN, name=中国新药与临床杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1765252216437, updatedTime=1765252216437, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=http://xyyl.cbpt.cnki.net/index.aspx?t=1, submissionEditorUrl=http://xyyl.cbpt.cnki.net/index.aspx?t=3, submissionReviewUrl=http://xyyl.cbpt.cnki.net/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1205118399467729103, language=EN, name=Chinese Journal of New Drugs and Clinical Remedies, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1765252216450, updatedTime=1765252216450, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=http://xyyl.cbpt.cnki.net/index.aspx?t=1, submissionEditorUrl=http://xyyl.cbpt.cnki.net/index.aspx?t=3, submissionReviewUrl=http://xyyl.cbpt.cnki.net/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1205117082300743687, websiteList=[Website(id=1205118568049389783, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1205117082300743687, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyylczz/CN, language=CN, createTime=1765252256643, createBy=18614031015, updateTime=1765252598399, updateBy=18614031015, name=中国新药与临床杂志-中文, tplId=1146099689490845704, title=中国新药与临床杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1205154564317098673, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568049389783, code=articleTextType, value=kx, createTime=1765260838822, updateTime=1765260838822, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154564300321454, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568049389783, code=banner, value=null, createTime=1765260838818, updateTime=1765260838818, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154564333875892, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568049389783, code=grayFlag, value=0, createTime=1765260838826, updateTime=1765260838826, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154564296127149, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568049389783, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyylczz/CN/file/pic?fileId=EPNvNLzzPrR2hCakA9eyOQ==, createTime=1765260838817, updateTime=1765260838817, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154564354847414, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568049389783, code=minRunFlag, value=0, createTime=1765260838831, updateTime=1765260838831, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154564312904368, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568049389783, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyylczz/CN/file/pic, createTime=1765260838821, updateTime=1765260838821, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154564342264501, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568049389783, code=silenceFlag, value=0, createTime=1765260838828, updateTime=1765260838828, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154564308710063, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568049389783, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1765260838820, updateTime=1765260838820, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154564325487282, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568049389783, code=themeColor, value=null, createTime=1765260838824, updateTime=1765260838824, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154564329681587, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568049389783, code=themeStyle, value=null, createTime=1765260838825, updateTime=1765260838825, creator=18614031015, updator=18614031015)]), Website(id=1205118568124887278, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1205117082300743687, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyylczz/EN, language=EN, createTime=1765252256661, createBy=18614031015, updateTime=1765252618802, updateBy=18614031015, name=中国新药与临床杂志-英文, tplId=1146101810881728533, title=Chinese Journal of New Drugs and Clinical Remedies, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1205154594314756492, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568124887278, code=articleTextType, value=kx, createTime=1765260845974, updateTime=1765260845974, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154594297979273, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568124887278, code=banner, value=null, createTime=1765260845970, updateTime=1765260845970, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154594331533711, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568124887278, code=grayFlag, value=0, createTime=1765260845978, updateTime=1765260845978, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154594289590664, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568124887278, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyylczz/EN/file/pic?fileId=EPNvNLzzPrR2hCakA9eyOQ==, createTime=1765260845968, updateTime=1765260845968, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154594344116625, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568124887278, code=minRunFlag, value=0, createTime=1765260845981, updateTime=1765260845981, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154594310562187, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568124887278, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyylczz/EN/file/pic, createTime=1765260845973, updateTime=1765260845973, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154594335728016, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568124887278, code=silenceFlag, value=0, createTime=1765260845979, updateTime=1765260845979, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154594302173578, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568124887278, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1765260845971, updateTime=1765260845971, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154594323145101, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568124887278, code=themeColor, value=null, createTime=1765260845976, updateTime=1765260845976, creator=18614031015, updator=18614031015), WebsiteProps(id=1205154594327339406, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1205118568124887278, code=themeStyle, value=null, createTime=1765260845977, updateTime=1765260845977, creator=18614031015, updator=18614031015)])], journalTitle=中国新药与临床杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of New Drugs and Clinical Remedies, journalPhotoCn=4CRZH/cEJmlFWJuWhAUDig==, journalPhotoEn=N3vp8/tZorUwVBJknBXdng==, journalFirstLetter=C, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxyylczz/CN/10.14109/j.cnki.xyylc.2024.08.08, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxyylczz/EN/10.14109/j.cnki.xyylc.2024.08.08, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxyylczz/CN/PDF/10.14109/j.cnki.xyylc.2024.08.08, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxyylczz/EN/PDF/10.14109/j.cnki.xyylc.2024.08.08, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)
收藏切换
环泊酚应用于颅内动脉瘤栓塞术的效果
收藏切换
PDF下载
梅凤美 , 曾琼 , 陆军 , 阮义峰 , 吴姗姗
中国新药与临床杂志 | 论著 2024,43(8): 607-611
收起
收藏切换
中国新药与临床杂志 | 论著 2024, 43(8): 607-611
环泊酚应用于颅内动脉瘤栓塞术的效果
全屏
梅凤美 , 曾琼, 陆军, 阮义峰, 吴姗姗
作者信息
  • 南京医科大学附属脑科医院 麻醉科，江苏 南京 210029

    • 梅凤美，女，副主任医师，硕士，主要从事围术期脑保护的研究，Phn: 86-25-8229-6327, E-mail:

通讯作者:

吴姗姗，E-mail:
Effects of ciprofol in intracranial aneurysm embolization
Feng-mei MEI , Qiong ZENG, Jun LU, Yi-feng RUAN, Shan-shan WU
Affiliations
  • Department of Anesthesiology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing JIANGSU 210029, China
出版时间: 2024-08-25 doi: 10.14109/j.cnki.xyylc.2024.08.08
文章导航
收藏切换
摘要
收起
目的

观察环泊酚在颅内动脉瘤栓塞术中的麻醉效果。

方法

选择择期行颅内动脉瘤栓塞术的患者120例，ASA分级Ⅰ~Ⅱ级，随机分为对照组和试验组，每组60例。麻醉诱导时采用咪达唑仑0.04 mg·kg-1、舒芬太尼0.25 μg·kg-1、环泊酚0.4 mg·kg-1（试验组）或丙泊酚2.0 mg·kg-1（对照组）及罗库溴铵0.6 mg·kg-1。麻醉维持2组均持续泵注瑞芬太尼1 μg·kg-1·h-1、顺阿曲库铵0.1 mg·kg-1·h-1，试验组加用环泊酚0.8 mg·kg-1·h-1，对照组加用丙泊酚5 mg·kg-1·h-1。术中调整泵注速度使脑电双频指数（BIS）维持在40~60，观察生命体征和BIS的变化，记录麻醉诱导时间、苏醒时间、拔管后Ramsay镇静评分等，观察不良反应发生情况。

结果

2组麻醉前、麻醉诱导后、气管插管后、手术结束时、气管导管拔除后各观察时点收缩压（SBP）、舒张压（DBP）和心率（HR）比较，均无显著差异（P>0.05）,试验组手术结束时的BIS显著低于对照组（P<0.05）。麻醉诱导期间对照组SBP、DBP和HR的波动值显著大于试验组（P<0.05）。试验组苏醒时间长于对照组，镇静药物总用量少于对照组，均有显著差异（P<0.05）。试验组麻醉诱导后低血压、插管后高血压以及注射痛的发生率显著低于对照组（P<0.05）。

结论

环泊酚应用于颅内动脉瘤栓塞术具有良好的镇静效果，患者术中血流动力学波动更趋平稳，术后不良反应发生率低。

环泊酚  /  丙泊酚  /  颅内动脉瘤  /  栓塞，治疗性
AIM

To observe the anesthetic effect of ciprofol in intracranial aneurysm embolization.

METHODS

One hundred and twenty patients undergoing intracranial aneurysm embolization, ASA Ⅰor Ⅱ, were randomly divided into control group and experimental group （n=60, each group）. During anesthesia induction, patients were given with midazolam 0.04 mg·kg-1, sufentanil 0.25 μg·kg-1, ciprofol 0.4 mg·kg-1 （experimental group） or propofol 2.0 mg·kg-1 （control group）, and rocuronium 0.6 mg·kg-1. During anesthesia maintenance, all patients were maintained with remifentanil 1 μg·kg-1·h-1 and cisatracurium 0.1 mg·kg-1·h-1, combined with ciprofol 0.8 mg·kg-1·h-1 （experimental group） or propofol 5 mg·kg-1·h-1 （control group）. The bispectral index （BIS） was maintained between 40 and 60 by adjusting the pumping speed during the operation. The changes of vital signs and BIS were observed. The anesthesia induction time,awakening time, and Ramsay sedation score after extubation were recorded. And the occurrence of adverse reactions was also　observed.

RESULTS

There was no significant difference in systolic blood pressure （SBP）, diastolic blood pressure （DBP）,and heart rate （HR） between the two groups before anesthesia, after anesthesia induction, after tracheal intubation, at the end of operation, and after tracheal extubation. The BIS at the end of operation in the experimental group was lower than that in the control group （P<0.05）. The fluctuation value of SBP, DBP, and HR during anesthesia induction in the control group was significantly greater than that in the experimental group （P<0.05）. The recovery time of the experimental group was slightly longer while the use of sedatives was less than that of the control group （P<0.05）. The incidences of post-induced hypotension, hypertension after intubation, and injection pain in the experimental group were lower than those in the control group （P<0.05）.

CONCLUSION

Ciprofol can be used in intracranial aneurysm embolization with outstanding sedative efficacy. The hemodynamics of patient is more stable, and the incidence of postoperative adverse reaction is low.

ciprofol  /  propofol  /  intracranial aneurysm  /  embolization, therapeutic
梅凤美, 曾琼, 陆军, 阮义峰, 吴姗姗. 环泊酚应用于颅内动脉瘤栓塞术的效果. 中国新药与临床杂志, 2024 , 43 (8) : 607 -611 . DOI: 10.14109/j.cnki.xyylc.2024.08.08
Feng-mei MEI, Qiong ZENG, Jun LU, Yi-feng RUAN, Shan-shan WU. Effects of ciprofol in intracranial aneurysm embolization[J]. Chinese Journal of New Drugs and Clinical Remedies, 2024 , 43 (8) : 607 -611 . DOI: 10.14109/j.cnki.xyylc.2024.08.08
正文
收起
颅内动脉瘤是动脉壁异常膨出所致的脑血管常见疾病，有破裂的风险，是自发性蛛网膜下腔出血的首要因素和脑血管意外的第三大发病因素［1］。手术治疗主要有开颅夹闭和介入栓塞两种术式，其中开颅夹闭术创伤大、并发症多［2］，而介入栓塞术具有创伤小、安全性高、并发症少、术后恢复快的优点［3］。颅内动脉瘤栓塞术常采用气管内插管全身麻醉（全麻），要求围术期充分制动，避免血流动力学剧烈波动，保证足够脑灌注压而不使动脉瘤破裂。临床常用的镇静药物丙泊酚和瑞马唑仑都可安全有效地用于颅内动脉瘤栓塞术麻醉［4］。环泊酚是在丙泊酚的化学结构上引入环丙基，与γ-氨基丁酸A型（GABAA）受体的亲和力增强，效价约为丙泊酚的4~5倍［5］，在全麻中具有良好的有效性和安全性［6］。本研究观察环泊酚用于颅内动脉瘤栓塞术的麻醉效果。
资料与方法
收起
一般资料
选择2022年1月至2023年5月在本院择期行数字减影血管造影（DSA）下颅内动脉瘤栓塞术的患者，ASA分级Ⅰ~Ⅱ级，年龄18~65岁，体重45~90 kg。排除未控制的严重高血压患者，严重肝肾功能异常者，严重心肺疾病者及既往有麻醉药物过敏史的患者。本研究经医院伦理委员会审核通过（伦理编号2022-KY121-01），术前与家属沟通并签署知情同意书。共纳入患者120例，采用随机数字表法分为对照组 （丙泊酚组）和试验组（环泊酚组），每组60例。
麻醉方法
所有患者术前禁食8 h、禁饮6 h。入室后监测生命体征和脑电双频指数（BIS），开放上肢静脉通道，予乳酸钠林格液静脉滴注。局部麻醉下行桡动脉穿刺测动态血压，待患者平静后于麻醉诱导前记录各项基础数值。麻醉诱导：静脉注射（静注）咪达唑仑0.04 mg·kg-1（15 s），舒芬太尼0.25 μg·kg-1（30 s），2 min后再缓慢静注（至少30 s）丙泊酚2.0 mg·kg-1（对照组）或环泊酚0.4 mg·kg-1（试验组），并对注射疼痛进行评估。当患者睫毛反射消失时给予罗库溴铵0.6 mg·kg-1，肌松药起效完全且BIS<60时行气管插管，插管后行机械通气，调节呼吸参数，维持呼气末二氧化碳分压35~45 mmHg。麻醉维持：对照组给予丙泊酚5 mg·kg-1·h-1静脉泵注，试验组给予环泊酚0.8 mg·kg-1·h-1，2组均持续泵注瑞芬太尼1 μg·kg-1·h-1以及顺阿曲库铵0.1 mg·kg-1·h-1。手术过程中严密监测患者呼吸和循环情况，根据手术刺激强弱和血流动力学变化调整环泊酚或丙泊酚、瑞芬太尼的泵注速度，维持血压波动幅度不超过基础值的20%，心率50~100次min-1，BIS 40~60。必要时给予阿托品、艾司洛尔、麻黄碱、乌拉地尔对症处理。手术结束停用所有泵注药物，患者均送至麻醉后监护室（PACU）。待患者BIS达85以上，呼之能应，自主呼吸恢复，潮气量达300~400 mL，不吸氧条件下脉搏氧饱和度（SpO2）达到95%以上拔除气管导管，Steward评分达到4分及以上送返病房。
观察指标
记录麻醉前、麻醉诱导后、气管插管后、手术结束时、气管导管拔除后各时点患者的收缩压（SBP）、舒张压（DBP）、心率（HR）和BIS的变化，设定麻醉诱导后15 min内指标最大值和最小值的差为麻醉诱导期的波动值。记录麻醉诱导时间（给药至睫毛反射消失的时间）、苏醒时间（停药至呼之能应的时间），评估拔管后Ramsay镇静评分，比较2组麻醉药物使用量。采用脸谱评分法（face pain scale，FPS）［7］评估给药时疼痛反应，评分≥1分判定为有注射痛。观察麻醉后心血管系统不良反应如麻醉诱导后低血压和心动过缓、插管及拔管时高血压和心动过速的发生情况以及苏醒期30 min内有无恶心、呕吐以及躁动发生。
统计学分析
采用SPSS 22.0统计软件进行分析。计量资料以均数±标准差表示，组间比较采用独立样本的t检验，组内比较采用重复测量的方差分析；计数资料比较采用χ2检验。P<0.05为差异有显著意义。本研究样本量参考环泊酚Ⅲ期临床试验［5］结果，在麻醉诱导后30 min内环泊酚和丙泊酚低血压的发生率分别为 63.0%和87.5%，规定检验效能为1-β=0.9，检验水准为α=0.05，使用PASS15.0软件计算得出所需样本量为每组60例，共需120例。
结　果
收起
一般情况
2组患者性别、年龄、体重、ASA分级和麻醉时间等一般情况比较，差异均无显著意义（P>0.05）。见表1 。
血流动力学及镇静情况
与麻醉前比较，2组血压和HR在麻醉诱导后、手术结束时有不同程度的下降（P<0.05）；但各观察时点组间比较，均无显著差异（P>0.05）。麻醉诱导后15 min内，试验组SBP、DBP、HR波动值分别为（7.4±3.8）mmHg、（6.7±6.0）mmHg、（6.5±4.2）次·min-1，对照组分别为（13.5±9.0）mmHg、（8.8±7.8）mmHg、（8.7±7.1）次·min-1，试验组波动值均显著小于对照组（P<0.05）。2组BIS在麻醉诱导后快速下降至最低值后趋平稳，手术结束后逐渐上升至麻醉前水平。手术结束时试验组的BIS显著低于对照组（P<0.05），见表2。BIS>60的患者试验组有2例（3%），对照组有12例（19%） ，试验组BIS>60的患者比例显著低于对照组（P<0.05）。
麻醉质量
试验组苏醒时间较对照组延长，镇静药物总用量减少，差异有显著意义（P<0.05）。2组诱导时间、Ramsay镇静评分、瑞芬太尼总用量比较，差异均无显著意义（P>0.05）。见表3。
不良反应
与对照组比较，试验组麻醉诱导后低血压、插管或拔管后的高血压以及注射痛的发生率显著降低（P<0.05） ；而2组术中心动过缓、心动过速和术后恶心呕吐、躁动等不良反应发生率差异无显著意义（P>0.05）。见表4。
讨　论
收起
颅内动脉瘤介入栓塞术对麻醉深度与麻醉质量有较高的要求，既要充分控制气管内插管引起的心血管反应，又要避免因加深麻醉所致的循环过度抑制，避免血流动力学稳定性下降诱发围术期动脉瘤破裂的危险［8］。本研究中2组HR、SBP、DBP及BIS在麻醉诱导后降低，至手术结束后逐渐恢复至麻醉前水平，表明环泊酚与丙泊酚的镇静作用迅速、可控，并随着药物的代谢患者能快速恢复，苏醒期血压较基础值轻度升高可以提高脑灌注，预防脑血管痉挛。丙泊酚有剂量依赖性的循环抑制作用［9］，本研究中对照组麻醉诱导后血压和HR均较基础值有明显大幅度下降，但尚在可接受的范围之内；试验组在麻醉诱导后15 min内以及插管和拔管期间血压和HR的波动值均较对照组小，可能与环泊酚镇静作用较强而对循环抑制较轻有关［5,10,11］。BIS是评价麻醉镇静程度的可靠指标，BIS<60可确保无术中知晓，本研究中2组BIS随时间变化趋势相似，手术结束时试验组BIS低于对照组，且BIS>60的患者比率显著低于对照组，提示环泊酚术中镇静作用持续强效。拔除气管导管时2组BIS即已恢复至麻醉前水平，且在拔管后Ramsay镇静评分无显著差异，说明2组患者均苏醒完全、质量佳。
本研究持续输注环泊酚或丙泊酚全麻维持，复合瑞芬太尼和顺阿曲库铵。瑞芬太尼作用时间短，半衰期为3~10 min，与给药剂量和持续给药时间无关，长时间输注代谢速度无变化［8］。顺阿曲库铵长时间输注停药后肌松作用亦恢复迅速，恢复指数不受给药方式和给药总量的影响，且不依赖于输注时间［12］。这两种药物长时间输注均不会影响患者术后恢复时间。丙泊酚连续输注时血浆药物浓度稳定，停药后血浆药物浓度迅速降低，患者苏醒迅速［13］。HU等［14］在健康志愿者中发现，长时间持续输注环泊酚的血浆浓度-时间曲线与丙泊酚相似，持续输注4 h停药后环泊酚血浆浓度迅速下降，在10 min内即可下降50%，患者意识恢复。本研究中环泊酚和丙泊酚的等效剂量约为15，环泊酚总用量明显减少，且其清除较快，清除率无剂量依赖性［15］，不影响患者术后快速苏醒。本研究中试验组苏醒时间略长，可能与环泊酚的强效镇静作用［5］或长时间输注结束时其血浆浓度较高［11］有关，但这对临床工作进展并无实质性的影响。此外，环泊酚在较宽剂量范围内可安全耐受［16］，对呼吸的抑制轻于丙泊酚，对循环的影响有优于丙泊酚的趋势［17,18］。本研究中，试验组注射痛发生率及心血管系统不良反应发生率均显著低于对照组，提示环泊酚持续输注安全性较好，可能比丙泊酚更适用于合并有心血管基础疾病患者的麻醉。
综上所述，环泊酚和丙泊酚应用于颅内动脉瘤栓塞术均有良好的镇静效果，环泊酚能够显著减少镇静药物的使用剂量，更好地维持血流动力学的稳定，术后患者恢复状况好，不良反应发生率低。但本研究是一项单中心临床试验，样本量较小，且仅纳入择期手术的ASA分级Ⅰ或Ⅱ级患者，对于急诊手术或伴有较多合并症的患者，环泊酚和丙泊酚的效果是否有差异尚需进一步研究。
文献
收起
参考文献 引证文献
排序方式：
[1]
中国医师协会神经介入专业委员会，中国颅内动脉瘤计划研究组. 中国颅内破裂动脉瘤诊疗指南2021[J].中国脑血管病杂志，2021, 18（8）: 546-574.
Chinese Federation of Interventional Clinical Neurosciences, China Intracranial Aneurysm Project Study Group. Chinese guidelines for diagnosis and treatment of ruptured intracranial aneurysm 2021 [J]. Chin J Cerebrovasc Dis, 2021, 18（8）: 546-574.
[2]
吴姗姗，李锦汶，梅凤美，等.控制性降压对颅内动脉瘤夹闭术中脑氧饱和度和术后神经认知功能的影响[J]. 临床麻醉学杂志，2019, 35（10）: 941-944.
WU SS, LI JW,MEI FM, et al. Effect of controlled hypotension on intraoperative cerebral oxygen saturation and postoperative neural cognitive function in patients with intracranial aneurysm clipping [J]. J Clin Anesthesiol, 2019, 35（10）: 941-944.
[3]
JABBARLI R, DINGER TF, DARKWAH OM, et al. Risk factors for and clinical consequences of multiple intracranial aneurysms：a systematic review and meta-analysis[J]. Stroke, 2018, 49（4）:848-855.
[4]
张 郃，龙 超，张森兵，等. 瑞马唑仑用于颅内动脉瘤栓塞术的麻醉效果[J].中国新药与临床杂志, 2021, 40 （9）：646-649.
ZHANG H, LONG C, ZHANG SB, et al. Anesthetic effects of remimazolam in intracranial aneurysm embolization surgery[J]. Chin J New Drugs Clin Rem, 2021, 40（9）: 646-649.
[5]
刘 进，米卫东，姚尚龙，等．环泊酚临床应用指导意见[J].中华麻醉学杂志， 2021, 41（2） : 129-132．
LIU J, MI WD, YAO SL, et al. Guidelines on clinical application of ciprofol [J]. Clin J Anesthesiol, 2021, 41（2）: 129-132.
[6]
LIANG P, DAI M, WANG X, et al. Efficacy and safety of ciprofol vs.propofol for the induction and maintenance of general anaesthesia:a multicentre, single-blind, randomised, parallel-group, phase 3 clinical trial[J]. Eur J Anaesthesiol, 2023, 40（6）: 399-406.
[7]
SUN T，WEST N，ANSERMINO JM ，et al. A smartphone version of the faces pain scale-revised and the color analog scale for postoperative pain assessment in children[J]. Paediatr Anaesth，2015, 25（12）: 1264-1273.
[8]
CUI YF，XU H，LIU HT，et al. Clinical application of solitaire AB stents in the embolization of intracranial aneurysms [J]. Eur Rev Med Pharmacol Sci, 2015, 19（7） : 1227-1233．
[9]
中华医学会麻醉学分会全凭静脉麻醉专家共识工作小组. 全凭静脉麻醉专家共识[J]. 中华麻醉学杂志, 2016, 36（6）:641-649.
Chinese Society of Anesthesiology Task Force on Total　Intravenous Anesthesia. Consensus on total intravenous anesthesia[J]. Chin J Anesthesiol, 2016, 36（6）: 641-649.
[10]
LONG YQ，FENG CD，DING YY，et al． Esketamine as an adjuvant to ciprofol or propofol sedation for same-day bidirectional endoscopy: protocol for a randomized，double-blind，controlled trial with factorial design[J]. Front Pharmacol, 2022, 13 : 821691.
[11]
LI X, YANG D, LI Q, et al. Safety, pharmacokinetics and pharmacodynamics of a single bolus of the γ-aminobutyric acid（GABA） receptor potentiator HSK3486 in healthy Chinese elderly and non-elderly [J]. Front Pharmacol, 2021, 12 : 735700.
[12]
ORTIZ JR，PERCAZ JA，CARRASCOSA F. Cisatracurium [J].Rev Esp Anestesiol Reanim, 1998, 45（6）: 242-247.
[13]
庄心良, 曾因明, 陈伯鉴. 现代麻醉学 [M]. 3版. 北京：人民卫生出版社， 2004: 481-487.
[14]
HU C, OU X, TENG Y, et al. Sedation effects produced by a ciprofol initial infusion or bolus dose followed by continuous maintenance infusion in healthy subjects: a phase 1 trial[J]. Adv Ther, 2021,38（11）: 5484-5500.
[15]
BIAN YC, ZHANG H, MA S, et al. Mass balance, pharmacokinetics and pharmacodynamics of intravenous HSK3486, a novel anaesthetic, administered to healthy subjects[J]. Br J Clin Pharmacol, 2021, 87 （1）: 93-105.
[16]
TENG Y, OU MC, WANG X, et al. Pharmacokinetic and pharmacodynamic properties of ciprofol emulsion in Chinese subjects: a single center, open-label, single-arm dose-escalation phase 1 study[J]. Am J Transl Res, 2021, 13（12）: 13791-13802.
[17]
TENG Y, OU M, WANG X, et al. Efficacy and safety of ciprofol for the sedation/anesthesia in patients undergoing colonoscopy: phaseⅡa and Ⅱb multi-center clinical trials[J]. Eur J Pharm Sci,2021, 164 : 105904.
[18]
LI J, WANG X, LIU J, et al. Comparison of ciprofol （HSK3486）versus propofol for the induction of deep sedation during gastroscopy and colonoscopy procedures: a multi-centre, non-inferiority, randomized, controlled phase 3 clinical trial [J]. Basic Clin Pharmacol Toxicol, 2022, 131（2）: 138-148.
2024年第43卷第8期
PDF下载
57
23
引用本文
BibTeX
文章信息
doi: 10.14109/j.cnki.xyylc.2024.08.08
  • 接收时间：2023-06-12
  • 首发时间：2026-03-13
  • 出版时间：2024-08-25
补充材料
相关文章
文章信息
作者
出版历史
  • 收稿日期：2023-06-12
  • 录用日期：2024-03-27
基金
作者信息
    南京医科大学附属脑科医院 麻醉科，江苏 南京 210029

通讯作者:

吴姗姗，E-mail:
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/zgxyylczz/CN/10.14109/j.cnki.xyylc.2024.08.08
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
相关链接
论文
最新文章
热读文章
热点专题
内参
蓝皮书
产业发展报告
传播力报告
期刊分级目录
资讯
学术新闻
行业新闻
学术会议
行业会议
关于
关于我们
联系我们
北京市海淀区学院南路86号
100081
010-62199257
qkjq@cast.org.cn

中国科学技术协会版权所有 京ICP 备10216604号-4 海淀分局备案 1101084647
科技导报社主办 中国科协信息中心技术支持