Article(id=1322631317309731211, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1322631259684192984, articleNumber=null, orderNo=null, doi=10.7501j.issn.0253-2670.2026.19.002, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1784476800000, receivedDateStr=2026-07-20, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793269479347, onlineDateStr=2026-10-29, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793269479347, onlineIssueDateStr=2026-10-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793269479347, creator=13701087609, updateTime=1793269479347, updator=13701087609, issue=Issue{id=1322631259684192984, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='19', pageStart='7501', pageEnd='7928', issueExtLink='null', onlineDate='null', pubDate='1791734400000', pubDateStr='2026-10-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1793269465608, creator='13701087609', updateTime=1793269554856, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322631634101326494, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1322631259684192984, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322631634101326495, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1322631259684192984, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=7512, endPage=7518, ext={EN=ArticleExt(id=1322631319192973710, articleId=1322631317309731211, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=A new antiatherosclerotic meroterpenoid from Ganoderma cochlear, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To discover anti-atherosclerotic compounds from Ganoderma cochlear. Methods Silica gel column chromatography, reversed-phase C₁₈ column chromatography, and semi-preparative HPLC were used for isolation and purification, and the structures of the isolates were elucidated by various spectroscopic techniques (1D and 2D NMR). The in vitro anti-atherosclerotic activity of compound was evaluated using an ox-LDL-induced macrophage lipid deposition model, and the expression of phenotype-related protein was detected by Western blotting. Results A previously undescribed meroterpenoid, designated as cochlemeroid A (1), was isolated and identified from G. cochlear. BODIPY and Oil Red O staining showed that compound 1 significantly inhibited ox-LDL-induced macrophage lipid deposition in a dose-dependent manner, accompanied by reduced TC and TG levels. Furthermore, Western blotting results demonstrated that compound 1 downregulated the expression of cluster of differentiation 36 (CD36) and class A scavenger receptor (SR-A), while upregulating the expression of the ATP-binding cassette transporter A1 (ABCA1). Conclusion In this study, a new meroterpenoid was successfully isolated from G. cochlear. The bioactivity results indicated that compound 1 possessed significant antiatherosclerotic potential., authors=SU Haiguo¹, CHU Tianjiao¹, XIONG Liang^1,2, authorsList=SU Haiguo, CHU Tianjiao, XIONG Liang, authorCompany=1 Key Laboratory of Standardization of Chinese Medicine (Ministry of Education), School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;
2 College of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322631317544612236, articleId=1322631317309731211, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=反柄紫芝中1个具有抗动脉粥样硬化潜力的新颖杂萜, columnId=1304140187169214944, journalTitle=中草药, columnName=化学成分, runingTitle=null, highlight=null, articleAbstract=目的 从反柄紫芝Ganoderma cochlear中寻找具有抗动脉粥样硬化潜力的活性分子。方法 采用硅胶柱色谱、反相C₁₈柱色谱及半制备高效液相色谱等技术进行分离纯化，并通过多种谱学技术（1D、2D NMR）鉴定化合物结构；采用氧化低密度脂蛋白（oxidized low-density lipoprotein，ox-LDL）诱导的巨噬细胞脂质沉积模型评估化合物体外抗动脉粥样硬化潜力，通过Western blotting技术检测相关表型蛋白的变化。结果 从反柄紫芝中分离鉴定了1个新的杂萜化合物2′,5′-二羟基-6-(2-羟基丙-2-基)-[1,1′-联苯]-3-羧酸甲酯，命名为反柄紫芝杂萜A（1）。BODIPY和油红O染色结果表明，化合物1能够显著抑制ox-LDL诱导的巨噬细胞脂质沉积，降低三酰甘油（triglycerides，TG）、降低总胆固醇（total cholesterol，TC）水平，且具有剂量相关性。同时，Western blotting结果表明化合物1能够下调白细胞分化抗原36（cluster of differentiation 36，CD36）和清道夫受体A（class A scavenger receptor，SR-A）的表达、同时上调ATP结合盒转运体A1（ATP-binding cassette transporter A1，ABCA1）的表达。结论 从反柄紫芝中分离了1个结构新颖的杂萜化合物，且化合物1具有显著的抗动脉粥样硬化潜力。, authors=苏海国¹, 褚天骄¹, 熊亮^1,2, authorsList=苏海国, 褚天骄, 熊亮, authorCompany=1 成都中医药大学药学院, 中药材标准化教育部重点实验室, 四川 成都 611137;
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Targeting epsins to inhibit fibroblast growth factor signaling while potentiating transforming growth factor-β signaling constrains endothelial-to-mesenchymal transition in atherosclerosis [J]. Circulation, 2023, 147(8): 669-685.
Kong P, Cui Z Y, Huang X F, et al. Inflammation and atherosclerosis: Signaling pathways and therapeutic intervention [J]. Signal Transduct Target Ther, 2022, 7: 131.
Malekmohammad K, Bezsonov E E, Rafieian-Kopaei M. Role of lipid accumulation and inflammation in atherosclerosis: Focus on molecular and cellular mechanisms [J]. Front Cardiovasc Med, 2021, 8: 707529.
Brophy M L, Dong Y Z, Tao H, et al. Myeloid-specific deletion of epsins 1 and 2 reduces atherosclerosis by preventing LRP-1 downregulation [J]. Circ Res, 2019, 124(4): E6-E19.
Ajoolabady A, Pratico D, Lin L, et al. Inflammation in atherosclerosis: Pathophysiology and mechanisms [J]. Cell Death Dis, 2024, 15(11): 817.
Alonso R, Cuevas A, Cafferata A. Diagnosis and management of statin intolerance [J]. J Atheroscler Thromb, 2019, 26(3): 207-215.
彭杨芷, 苏悦, 芦光亮, 等. 灵芝主要功效现代研究进展[J]. 亚太传统医药, 2016, 12(18): 71.
Zheng G B, Zhao Y, Li Z H, et al. GLSP and GLSP-derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis [J]. Theranostics, 2023, 13(4): 1325-1341.
Cheng Y F, Zheng G B, Huang H M, et al. GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation [J]. Theranostics, 2025, 15(10): 4345-4367.
彭惺蓉, 刘接卿, 夏建军, 等. 反柄紫芝中2个新三萜类化合物[J]. 中草药, 2012, 43(6): 1045-1049.
叶家文, 褚天骄, 熊利, 等. 反柄紫芝化学成分及其生物活性研究[J]. 中草药, 2026, 57(6): 2009-2015.
Ye J W, Shi D W, Xiong L, et al. Lanostane triterpenoids from medicinal fungi Ganoderma cochlear and their antiatherosclerotic activity [J]. J Mol Struct, 2026, 1352: 144558.
Peng X R, Qiu M H. Meroterpenoids from Ganoderma species: A review of last five years [J]. Nat Prod Bioprospect, 2018, 8(3): 137-149.
Zhang J J, Qin F Y, Cheng Y X. Insights into Ganoderma fungi meroterpenoids opening a new era of racemic natural products in mushrooms [J]. Med Res Rev, 2024, 44(3): 1221-1266.
Peng X R, Unsicker S B, Gershenzon J, et al. Structural diversity, hypothetical biosynthesis, chemical synthesis, and biological activity of Ganoderma meroterpenoids [J]. Nat Prod Rep, 2023, 40(8): 1354-1392.
Li L, Li H, Peng X R, et al. (±)-ganoapplanin, a pair of polycyclic meroterpenoid enantiomers from Ganoderma applanatum [J]. Org Lett, 2016, 18(23): 6078-6081.
Zhou F J, Nian Y, Yan Y M, et al. Two new classes of T-type calcium channel inhibitors with new chemical scaffolds from Ganoderma cochlear [J]. Org Lett, 2015, 17(12): 3082-3085.
Yan Y M, Ai J, Zhou L L, et al. Lingzhiols, unprecedented rotary door-shaped meroterpenoids as potent and selective inhibitors of p-Smad3 from Ganoderma lucidum [J]. Org Lett, 2013, 15(21): 5488-5491.
Luo Q, Tian L, Di L, et al. (±)-Sinensilactam A, a pair of rare hybrid metabolites with Smad3 phosphorylation inhibition from Ganoderma sinensis [J]. Org Lett, 2015, 17(6): 1565-1568.
Wang K, Bao L, Ma K, et al. A novel class of α-glucosidase and HMG-CoA reductase inhibitors from Ganoderma leucocontextum and the anti-diabetic properties of ganomycin I in KK-Ay mice [J]. Eur J Med Chem, 2017, 127: 1035-1046.
Quan Y Z, Ma A, Ren C Q, et al. Ganoderic acids alleviate atherosclerosis by inhibiting macrophage M1 polarization via TLR4/MyD88/NF-κB signaling pathway [J]. Atherosclerosis, 2024, 391: 117478.
Hsu P L, Lin Y C, Ni H, et al. Ganoderma triterpenoids exert antiatherogenic effects in mice by alleviating disturbed flow-induced oxidative stress and inflammation [J]. Oxid Med Cell Longev, 2018, 2018(1): 3491703.
Ma Y Z, Han J B, Wang K F, et al. Research progress of Ganoderma lucidum polysaccharide in prevention and treatment of atherosclerosis [J]. Heliyon, 2024, 10(12): e33307.
Wang K, Bao L, Zhou N, et al. Structural modification of natural product ganomycin I leading to discovery of a α-glucosidase and HMG-CoA reductase dual inhibitor improving obesity and metabolic dysfunction in vivo [J]. J Med Chem, 2018, 61(8): 3609-3625.
Qiao S, Liu C, Sun L, et al. Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism [J]. Nat Metab, 2022, 4(10): 1271-1286.)