Article(id=1322631315749450110, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1322631259684192984, articleNumber=null, orderNo=null, doi=10.7501j.issn.0253-2670.2026.19.003, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1783958400000, receivedDateStr=2026-07-14, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793269478975, onlineDateStr=2026-10-29, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793269478975, onlineIssueDateStr=2026-10-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793269478975, creator=13701087609, updateTime=1793269478975, updator=13701087609, issue=Issue{id=1322631259684192984, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='19', pageStart='7501', pageEnd='7928', issueExtLink='null', onlineDate='null', pubDate='1791734400000', pubDateStr='2026-10-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1793269465608, creator='13701087609', updateTime=1793269554856, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322631634101326494, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1322631259684192984, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322631634101326495, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1322631259684192984, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=7519, endPage=7531, ext={EN=ArticleExt(id=1322631316068217216, articleId=1322631315749450110, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=C₂₁ steroidal components of Gymnema latifolium and their glucose uptake promoting activity, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To investigate the C₂₁ steroids from Gymnema latifolium and their glucose uptake-promoting activity. Methods The compounds were isolated and purified by various chromatographic techniques including silica gel, ODS, Sephadex LH-20 and semi-preparative HPLC, and their structures were elucidated on the basis of spectroscopic data. The glucose uptake-promoting activity of the isolates was evaluated using a HepG2 cellular glucose uptake model. Results A total of 18 C₂₁ steroids were isolated and identified as gymlatifoside E (1), 20-O-benzoyl-12-O-cinnamoyl-3β,5α,8β,12β,14β,17β,20-heptahydroxy-(20S)-pregn-6-ene (2), gymnepregoside H (3), prosapogenin (4), sylvepregoside E (5), gymnepregoside G (6), penupogenin (7), gymnepregoside I (8), cissasteroid A (9), cynsaccatol L (10), gymnemarsgenin (11), gnetumoside A (12), cynanchin F (13), gagamine (14), 12-O-benzoylsarcostin (15), cissasteroid B (16), 12,20-O-dibenzoylsarcostin (17), hemoside A (18). Among them, compound 1 is a new C₂₁ steroid, and compounds 2—18 were isolated from G. latifolium for the first time. At non-cytotoxic concentrations, treatment with compounds 1—18 resulted in glucose uptake levels ranging from 0.70- to 1.73-fold of the control group in HepG2 cells, among which compounds 4, 8–10, 12–14, 16, and 17 significantly promoted glucose uptake, reaching 1.38- to 1.73-fold of the control group. Conclusion G. latifolium is rich in C₂₁ steroids, and some of these compounds exhibit promising potential anti-diabetic activity, warranting further investigation., authors=LU Yuling¹, LIU Meiyu¹, CHEN Lian¹, ZHAO Qiuhua¹, XIAO Xiwen¹, ZHANG Jinyan^1,2, LU Rumei^1,2, authorsList=LU Yuling, LIU Meiyu, CHEN Lian, ZHAO Qiuhua, XIAO Xiwen, ZHANG Jinyan, LU Rumei, authorCompany=1 College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, China;
2 University Engineering Research Center of Characteristic Traditional Chinese Medicine and Ethnomedicine, Nanning 530200, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322631315988525439, articleId=1322631315749450110, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=宽叶匙羹藤中C₂₁甾体类成分及其促葡萄糖摄取活性研究, columnId=1304140187169214944, journalTitle=中草药, columnName=化学成分, runingTitle=null, highlight=null, articleAbstract=目的 研究宽叶匙羹藤Gymnema latifolium中的C₂₁甾体类成分及其促葡萄糖摄取活性。方法 采用硅胶、ODS、Sephadex-LH 20凝胶及半制备高效液相等技术进行分离纯化，通过波谱数据分析鉴定化合物的结构；采用HepG2细胞葡萄糖摄取模型评价化合物的促葡萄糖摄取活性。结果 从宽叶匙羹藤中分离得到18个C₂₁甾体类化合物，分别鉴定为20-O-benzoyl-12-O-cinnamoyl-3β,5α,8β,12β,14β,17β,20-heptahydroxy-(20S)-pregn-6-ene-3-O-β-D-allopyranosyl(1→4)-β-D-oleandropyra- nosyl(1→4)-β-D-cymaropyranosyl (1→4)-β-D-digitoxopyranoside（1）、20-O-benzoyl-12-O-cinnamoyl-3β,5α,8β,12β,14β,17β,20-heptahydroxy-(20S)-pregn-6-ene（2）、gymnepregoside H（3）、prosapogenin（4）、sylvepregoside E（5）、gymnepregoside G（6）、penupogenin（7）、gymnepregoside I（8）、cissasteroid A（9）、cynsaccatol L（10）、gymnemarsgenin（11）、gnetumoside A（12）、cynanchin F（13）、gagamine（14）、12-O-benzoylsarcostin（15）、cissasteroid B（16）、12,20-O-dibenzoylsarcostin（17）、hemoside A（18）。其中化合物1为新化合物，命名为宽叶匙羹藤苷E；其余均为首次从该植物中分离得到。在无明显细胞毒性条件下，化合物1～18给药组葡萄糖摄取量为对照组的0.70～1.73倍，其中化合物4、8～10、12～14、16和17可显著促进HepG2细胞葡萄糖摄取，摄取量为对照组的1.38～1.73倍。结论 宽叶匙羹藤富含C₂₁甾体类成分，部分化合物显示出良好的潜在抗糖尿病活性，值得进一步深入研究。, authors=卢羽玲¹, 刘美余¹, 陈连¹, 赵秋华¹, 肖昔文¹, 张进燕^1,2, 卢汝梅^1,2, authorsList=卢羽玲, 刘美余, 陈连, 赵秋华, 肖昔文, 张进燕, 卢汝梅, authorCompany=1 广西中医药大学药学院, 广西 南宁 530200;
2 特色中药民族药广西高校工程研究中心, 广西 南宁 530200, correspAuthors=张进燕, authorNote=卢羽玲: 卢羽玲，硕士研究生，研究方向为中药化学。E-mail:15578963767@163.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=EoTS89UOE+D2d2FWV4D0tA==, pdfFileSize=1240720, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家自然科学基金项目 (82360823); 广西自然科学基金项目 (2025GXNSFBA069359); 广西中医药大学博士启动基金 (2023BS012))}, authors=[Author(id=1324017321030857158, tenantId=1146029695717560320, journalId=null, articleId=1322631315749450110, orderNo=null, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=null, authorType=null, 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