中草药

速效救心丸“奏效迅速以救心”的生物学机制研究进展

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中草药 | 综述 2026,57(19): 7840-7849

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中草药 |综述 2026 , 57 (19) : 7840 -7849

速效救心丸“奏效迅速以救心”的生物学机制研究进展

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宫玉洁¹, 贺欣雨¹, 代薪钰¹, 焦同艳¹, 刘旋¹, 杨珅珅¹, 李遇伯¹

作者信息

通讯作者:

杨珅珅

作者简介:

宫玉洁: 宫玉洁，硕士研究生，研究方向为中药学。E-mail:17568261693@163.com

Research progress on biological mechanism of Suxiao Jiuxin Pill for “rapid onset in relieving heart disorders”

GONG Yujie¹, HE Xinyu¹, DAI Xinyu¹, JIAO Tongyan¹, LIU Xuan¹, YANG Shenshen¹, LI Yubo¹

Affiliations

doi: 10.7501j.issn.0253-2670.2026.19.027

文章导航

摘要

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速效救心丸系收载于《中国药典》的首个纯中药滴丸制剂，以川芎Chuanxiong Rhizoma、冰片（合成龙脑）Borneolum Syntheticum为核心配伍，临床主要用于气滞血瘀型冠心病、心绞痛的治疗，具有疗效确切、起效迅速的突出优势。在冠心病治疗注重辨证论治与个体化用药的背景下，胸痹急症对临床速效药物的需求日益显著。通过系统梳理国内外相关文献，围绕“速效”起效的关键环节及“救心”的作用机制，从物质基础、剂型优势、药动学特征及分子生物学机制多角度出发，挖掘“速效救心”的科学内涵，为其临床精准应用及后续深度机制研究提供新思路与理论参考。

关键词

速效救心丸 / 速效机制 / 冠心病 / 心肌保护 / 气滞血瘀

Abstract

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Suxiao Jiuxin Pill (速效救心丸, SJP) is the first pure traditional Chinese medicine dripping pill officially recorded in the Pharmacopoeia of the People’s Republic of China. It is formulated with Chuanxiong (Chuanxiong Rhizoma) and Bingpian (Borneolum Syntheticum) as core components, and is clinically indicated for coronary heart disease and angina pectoris belonging to the qi stagnation and blood stasis syndrome, characterized by definite efficacy and rapid onset. Against the background that treatment of coronary heart disease emphasizes syndrome differentiation and individualized medication, the clinical demand for rapid-acting medicines for acute chest impediment has become increasingly prominent. This paper systematically reviews relevant domestic and international literatures, focusing on the key links of its “rapid onset” and the mechanism of “saving the heart”. From the perspectives of chemical constituents, formulation advantages, pharmacokinetic characteristics and molecular biological mechanisms, this review aims to explore the unique advantages of SJP and provide new ideas and theoretical references for its precise clinical application and further in-depth mechanistic research.

Key words

Suxiao Jiuxin Pill / rapid-onset mechanism / coronary heart disease / myocardial protection / qi stagnation and blood stasis

引用本文

宫玉洁, 贺欣雨, 代薪钰, 焦同艳, 刘旋, 杨珅珅, 李遇伯. 速效救心丸“奏效迅速以救心”的生物学机制研究进展. 中草药, 2026 , 57 (19) : 7840 -7849 . DOI: 10.7501j.issn.0253-2670.2026.19.027

GONG Yujie, HE Xinyu, DAI Xinyu, JIAO Tongyan, LIU Xuan, YANG Shenshen, LI Yubo. Research progress on biological mechanism of Suxiao Jiuxin Pill for “rapid onset in relieving heart disorders”[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (19) : 7840 -7849 . DOI: 10.7501j.issn.0253-2670.2026.19.027

基金

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天津市自然科学基金项目 (25JCLZJC0022); 现代中药新质生产力科技创新工程专项 (24ZXZKSY00010)

参考文献

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Tsao C W, Aday A W, Almarzooq Z I, et al. Heart disease and stroke statistics-2022 update: A report from the American heart association [J]. Circulation, 2022, 145(8): e153-e639.
Woodruff R C, Tong X, Khan S S, et al. Trends in cardiovascular disease mortality rates and excess deaths, 2010—2022[J]. Am J Prev Med, 2024, 66(4): 582-589.
Chong B, Jayabaskaran J, Jauhari S M, et al. Global burden of cardiovascular diseases: Projections from 2025 to 2050[J]. Eur J Prev Cardiol, 2025, 32(11): 1001-1015.
肖晨韵, 邹峥嵘. 植物精油活性成分在心血管疾病治疗中的抗氧化研究进展[J]. 中草药, 2025, 56(15): 5658-5667.
Severino P, D’Amato A, Pucci M, et al. Ischemic heart disease and heart failure: Role of coronary ion channels [J]. Int J Mol Sci, 2020, 21(9): 3167.
Xiang Q, Yi X, Zhu X H, et al. Regulated cell death in myocardial ischemia-reperfusion injury [J]. Trends Endocrinol Metab, 2024, 35(3): 219-234.
中国医师协会中西医结合医师分会, 中国中西医结合学会心血管病专业委员会, 中国中西医结合学会重症医学专业委员会, 等. 急性心肌梗死中西医结合诊疗指南[J]. 中国中西医结合杂志, 2018, 38(3): 272-284.
Zhang L Y, Yin H Y, Song X Z, et al. Mechanisms of action of traditional Chinese medicine in the treatment of myocardial injury: A comprehensive review [J]. Phytomedicine, 2025, 147: 157195.
葛腾, 齐鸿飞, 姚彬, 等. 中医药靶向调控线粒体质量控制系统治疗心肌缺血再灌注损伤研究进展[J]. 中草药, 2024, 55(15): 5331-5341.
毛静远, 吴永健, 史大卓. 中成药治疗冠心病临床应用指南(2020年) [J]. 中西医结合心脑血管病杂志, 2021, 19(9): 1409-1435.
中国老年医学学会高血压分会, 北京高血压防治协会, 国家老年疾病临床医学研究中心, 等. 中国老年高血压管理指南2023[J]. 中华高血压杂志, 2023, 31(6): 508-538.
吴宗贵, 王肖龙, 张敏州, 等. 速效救心丸治疗冠心病中国专家共识[J]. 中西医结合心脑血管病杂志, 2019, 17(21): 3265-3267.
硝酸酯类药物低反应性或耐药人群的急诊识别与处理中西医专家共识组. 硝酸酯类药物低反应性或耐药人群的急诊识别与处理中西医专家共识[J]. 中华急诊医学杂志, 2022, 31(9): 1174-1181.
林泉, 徐凤芹, 马晓娟, 等. 速效救心丸对比硝酸甘油治疗心绞痛急性发作疗效和安全性的系统评价[J]. 中西医结合心脑血管病杂志, 2021, 19(2): 177-185.
Wang X, Wang J Y, Chen Y S, et al. The aldehyde dehydrogenase 2 rs671 variant enhances amyloid β pathology [J]. Nat Commun, 2024, 15(1): 2594.
郭玫竹, 国欢, 任文硕, 等. 川芎嗪抗缺血性脑卒中药理作用及机制研究进展[J]. 中草药, 2025, 56(24): 9246-9257.
易畅, 黄思琪, 刘晓轩, 等. 冰片对中枢神经系统兴奋与镇静双向调控作用机制研究进展[J]. 中成药, 2025, 47(11): 3685-3690.
Guo Q X, Zhang J, Li Y Q, et al. Study on anti-atherosclerotic effect of Suxiao Jiuxin Pill and its mechanism [J]. Afr J Tradit Complement Altern Med, 2013, 11(1): 97-102.
陈浩然, 刘浩, 谢雁鸣, 等. 基于复杂网络的速效救心丸治疗冠心病心绞痛用药方案分析[J]. 中药药理与临床, 2020, 36(5): 160-166.
Ruan X F, Li Y P, Sun Y L, et al. Efficacy and safety of Suxiao Jiuxin Pill in the treatment of stable angina (qi stagnation and blood stasis syndrome): Study protocol of a randomized, double-blind, placebo-controlled, multi-center clinical trial [J]. Trials, 2021, 22(1): 466.
Liu J, Lei Z W, Wang Z C, et al. Ethnobotanical usages, phytochemistry, pharmacology, and quality control of Chuanxiong Rhizoma: A review [J]. J Ethnopharmacol, 2025, 337(Pt 3): 118902.
Fang X, Ma Q, Zhang K X, et al. Synthesis of phthalide derivatives and evaluation on their antiplatelet aggregation and antioxidant activities [J]. J Asian Nat Prod Res, 2020, 22(12): 1176-1187.
马宁宁, 范姗姗, 李欣, 等. 川芎的抗炎物质筛选及其作用机制分析[J]. 中国实验方剂学杂志, 2018, 24(18): 140-146.
Lin J G, Wang Q Q, Zhou S M, et al. Tetramethylpyrazine: A review on its mechanisms and functions [J]. Biomed Pharmacother, 2022, 150: 113005.
Wang K, Zhou Y, Wen C, et al. Protective effects of tetramethylpyrazine on myocardial ischemia/reperfusion injury involve NLRP3 inflammasome suppression by autophagy activation [J]. Biochem Pharmacol, 2024, 229: 116541.
Zhang X, Feng Z M, Yang Y N, et al. Phenolic acid derivatives from Ligusticum chuanxiong [J]. Phytochem Lett, 2019, 33: 114-118.
Luo C X, Zhang Y H, Guo H, et al. Ferulic acid attenuates hypoxia/reoxygenation injury by suppressing mitophagy through the PINK1/Parkin signaling pathway in H9c2 cells [J]. Front Pharmacol, 2020, 11: 103.
Zhang X, Han B, Feng Z M, et al. Ferulic acid derivatives from Ligusticum chuanxiong [J]. Fitoterapia, 2018, 125: 147-154.
Mahmoud A M, Hussein O E, Abd El-Twab S M, et al. Ferulic acid protects against methotrexate nephrotoxicity via activation of Nrf2/ARE/HO-1 signaling and PPARγ, and suppression of NF-κB/NLRP3 inflammasome axis [J]. Food Funct, 2019, 10(8): 4593-4607.
Wang J, Wang L, Zhou H, et al. The isolation, structural features and biological activities of polysaccharide from Ligusticum chuanxiong: A review [J]. Carbohydr Polym, 2022, 285: 118971.
Guo Y, Zhang B Y, Peng Y F, et al. Mechanism of action of flavonoids of Oxytropis falcata on the alleviation of myocardial ischemia-reperfusion injury [J]. Molecules, 2022, 27(5): 1706.
Mei Y Q, Li L N, Fan L H, et al. The history, stereochemistry, ethnopharmacology and quality assessment of borneol [J]. J Ethnopharmacol, 2023, 300: 115697.
Zheng Q, Chen Z X, Xu M B, et al. Borneol, a messenger agent, improves central nervous system drug delivery through enhancing blood-brain barrier permeability: A preclinical systematic review and Meta-analysis [J]. Drug Deliv, 2018, 25(1): 1617-1633.
Kulkarni M, Sawant N, Kolapkar A, et al. Borneol: A promising monoterpenoid in enhancing drug delivery across various physiological barriers [J]. AAPS PharmSciTech, 2021, 22(4): 145.
胡盛谋, 王灿坚, 林婉晴, 等. 冰片介导的脑部递药系统构建策略及性能研究进展[J]. 中草药, 2026, 57(14): 5709-5722.
Zou L, Zhang Y, Li W, et al. Comparison of chemical profiles, anti-inflammatory activity, and UPLC-Q-TOF/MS-based metabolomics in endotoxic fever rats between synthetic borneol and natural borneol [J]. Molecules, 2017, 22(9): 1446.
Wang J Y, Dong X Y, Yu Z W, et al. Borneol inhibits CD4⁺ T cells proliferation by down-regulating miR-26a and miR-142-3p to attenuate asthma [J]. Int Immunopharmacol, 2021, 90: 107223.
Yao H, Xie Q, He Q M, et al. Pretreatment with panaxatriol saponin attenuates mitochondrial apoptosis and oxidative stress to facilitate treatment of myocardial ischemia-reperfusion injury via the regulation of Keap1/Nrf2 activity [J]. Oxid Med Cell Longev, 2022, 2022: 9626703.
Zhang H, Dong J F, Zhang J W, et al. Effects of borneol on apoptosis of hypoxia/reoxygenation H9c2 cells and myocardial ischemia-reperfusion injury rats [J]. Acta Cir Bras, 2025, 40: e402225.
赵洋洋, 郭玉洪, 黄汕梅, 等. 冰片引经作用的探讨及其分子机制研究进展[J]. 南京中医药大学学报, 2021, 37(1): 150-155.
乔淳, 胡进茹, 章小羽, 等. 基于固体分散体系的中药滴丸剂: 药剂学特性、工艺机制与智能制造发展[J]. 中草药, 2026, 57(5): 1982-1994.
Wu K R, Chuo W H, Huang Y T. Optimization of formulation parameters in preparation of Fructus Ligustri Lucidi dropping pills by solid dispersion using 23 full experimental design [J]. Pharmaceuticals, 2022, 15(11): 1433.
Qiu M F, Jia W, Li S S, et al. A new silymarin preparation based on solid dispersion technique [J]. Adv Ther, 2005, 22(6): 595-600.
Roma J R, Castro Rebollo P, Bastida C. Sublingual and buccal drug administration in medical emergencies [J]. Med Clínica Engl Ed, 2024, 163(12): 619-625.
Patel K, Shah S, Patel J. Solid dispersion technology as a formulation strategy for the fabrication of modified release dosage forms: A comprehensive review [J]. DARU J Pharm Sci, 2022, 30(1): 165-189.
陈超, 周福军, 刘时乔, 等. 固体分散技术在中药制剂中的应用[J]. 药物评价研究, 2011, 34(4): 279-282.
dos Santos K M, de Melo Barbosa R, Meirelles L, et al. Solid dispersion of β-lapachone in PVP K30 and PEG 6000 by spray drying technique [J]. J Therm Anal Calorim, 2021, 146(6): 2523-2532.
Nikam V K, Shete S K, Khapare J P. Most promising solid dispersion technique of oral dispersible tablet [J]. Beni Suef Univ J Basic Appl Sci, 2020, 9(1): 62.
Debe M S, Ahmad Khan S, Ahmed I S, et al. Nasal versus sublingual routes for emergency drug administration [J]. J Pharm Sci, 2025, 114(9): 103903.
谭妍, 庄笑梅, 沈国林, 等. 川芎嗪的肝微粒体代谢动力学及代谢表型研究[J]. 药学学报, 2014, 49(3): 374-379.
Qu Z H, Liu L, Zhang X F, et al. Exploring the scientific rationality of the phenomenon of “different dosage forms of the same prescription” of Chinese proprietary medicine based on biopharmaceutical properties of powder and pill of Chuanxiong Chatiao prescription [J]. Front Pharmacol, 2022, 13: 893552.
Jiang X Y, Li S Y, Wang N, et al. Ligustrazine as a multitarget scaffold in drug design and discovery [J]. Bioorg Med Chem, 2025, 121: 118110.
Guo M, Liu Y, Shi D Z. Cardiovascular actions and therapeutic potential of tetramethylpyrazine (active component isolated from Rhizoma Chuanxiong): Roles and mechanisms [J]. BioMed Res Int, 2016, 2016: 2430329.
Meng D M, Lu H Y, Huang S S, et al. Comparative pharmacokinetics of tetramethylpyrazine phosphate in rat plasma and extracellular fluid of brain after intranasal, intragastric and intravenous administration [J]. Acta Pharm Sin B, 2014, 4(1): 74-78.
朱芙琴, 马佳怡, 张圆圆, 等. 藁本内酯治疗运动系统疾病的作用机制及药代动力学研究进展[J]. 中国中药杂志, 2024, 49(24): 6625-6634.
Yan R, Ko N L, Li S L, et al. Pharmacokinetics and metabolism of ligustilide, a major bioactive component in Rhizoma Chuanxiong, in the rat [J]. Drug Metab Dispos, 2008, 36(2): 400-408.
Shi Y F, He L C, Wang S C. Determination of ligustilide in rat blood and tissues by capillary gas chromatography/mass spectrometry [J]. Biomed Chromatogr, 2006, 20(10): 993-998.
Ding C G, Sheng Y X, Zhang Y H, et al. Identification and comparison of metabolites after oral administration of essential oil of Ligusticum chuanxiong or its major constituent ligustilide in rats [J]. Planta Med, 2008, 74(14): 1684-1692.
Wu Y N, Liao F Y, Liao W G, et al. Effect of ferulic acid on the brain pharmacokinetics of tetramethylpyrazine in conscious rats [J]. Xenobiotica, 2017, 47(11): 973-979.
Liu J Y, Guan Y, Yang L, et al. Ferulic acid as an anti-inflammatory agent: insights into molecular mechanisms, pharmacokinetics and applications [J]. Pharmaceuticals, 2025, 18(6): 912.
潘倩, 李玮, 杨阳, 等. 阿魏酸人体内代谢产物定性分析[J]. 质谱学报, 2025, 46(3): 265-276.
许黎君, 陈为烤, 居文政, 等. 阿魏酸药物动力学研究进展[J]. 山西医药杂志, 2008, 37(10): 911-914.
Shang Y, Ge M L, Zhao P, et al. A pharmacokinetic study on twenty-one compounds in rat plasma by integrating UPLC-QQQ-MS/MS with GC-MS after oral administration of Suxiao Jiuxin pill [J]. Arab J Chem, 2024, 17(1): 105397.
Qiang T T, Li Y P, Wang K Y, et al. Evaluation of potential herb-drug interactions based on the effect of Suxiao Jiuxin Pill on CYP450 enzymes and transporters [J]. J Ethnopharmacol, 2021, 280: 114408.
Wang Y X, Wang A P, Ye Y N, et al. Elevated triglycerides rather than other lipid parameters are associated with increased urinary albumin to creatinine ratio in the general population of China: A report from the REACTION study [J]. Cardiovasc Diabetol, 2019, 18(1): 57.
He R R, Ma C R, He X, et al. Circulating metabolites of Borneolum syntheticum (Bingpian) ameliorate atherosclerosis in ApoE^-/- mice via inhibiting macrophage foam-cell formation [J]. Acta Pharmacol Sin, 2025, 46(3): 759-776.
孟华, 黄熙, 郭军, 等. 冠心病患者含速效救心丸后体内冰片药动学变化[J]. 中成药, 2003, 25(5): 379-382.
Cheng C, Liu X W, Du F F, et al. Sensitive assay for measurement of volatile borneol, isoborneol, and the metabolite camphor in rat pharmacokinetic study of Borneolum (Bingpian) and Borneolum Syntheticum (synthetic Bingpian) [J]. Acta Pharmacol Sin, 2013, 34(10): 1337-1348.
Hou M Z, Chen L L, Chang C, et al. Pharmacokinetic and tissue distribution study of eight volatile constituents in rats orally administrated with the essential oil of Artemisiae Argyi Folium by GC-MS/MS [J]. J Chromatogr B, 2021, 1181: 122904.
Ren J, Hu C L, Zhang Z P, et al. Development and validation an LC-MS/MS method to quantify (+)-borneol in rat plasma: Application to a pharmacokinetic study [J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2019, 1109: 121-127.
Liao W G, Huang X J, Yin Y X, et al. In vivo microdialysis with ultra performance liquid chromatography-mass spectrometry for analysis of tetramethylpyrazine and its interaction with borneol in rat brain and blood [J]. Biomed Chromatogr, 2018, 32(6): e4210.
王洁, 闫孟琳, 张曼, 等. 速效救心丸中冰片“引经”作用机制研究[J]. 药学学报, 2022, 57(3): 700-706.
Lei W, Deng Y F, Hu X Y, et al. Phthalides, senkyunolide A and ligustilide, show immunomodulatory effect in improving atherosclerosis, through inhibiting AP-1 and NF-κB expression [J]. Biomed Pharmacother, 2019, 117: 109074.
Yang Y Y, Wu Z Y, Xia F B, et al. Characterization of thrombin/factor Xa inhibitors in Rhizoma Chuanxiong through UPLC-MS-based multivariate statistical analysis [J]. Chin Med, 2020, 15: 93.
Huang C C, Zhao Y, Huang S Y, et al. Screening of anti-thrombin active components from Ligusticum chuanxiong by affinity-ultrafiltration coupled with HPLC-Q-Orbitrap-MS(n) [J]. Phytochem Anal, 2023, 34(4): 443-452.
Liu S Y, Long Y, Yu S, et al. Borneol in cardio-cerebrovascular diseases: Pharmacological actions, mechanisms, and therapeutics [J]. Pharmacol Res, 2021, 169: 105627.
Shang Y, Zhu Y M, Zhou S T, et al. A UPLC-MS/MS coupled with GC-MS method for quantification of twenty-one chemical ingredients from Suxiao Jiuxin Pill in multiple tissue of rat and its application to tissue distribution study [J]. J Pharm Biomed Anal, 2025, 252: 116461.
Shoshan-Barmatz V, Krelin Y, Chen Q. VDAC1 as a player in mitochondria-mediated apoptosis and target for modulating apoptosis [J]. Curr Med Chem, 2017, 24(40): 4435-4446.
Al Rahim M, Thatipamula S, Hossain M A. Critical role of neuronal pentraxin 1 in mitochondria-mediated hypoxic-ischemic neuronal injury [J]. Neurobiol Dis, 2013, 50: 59-68.
Qiu Y, Chang S, Zeng Y, et al. Advances in mitochondrial dysfunction and its role in cardiovascular diseases [J]. Cells, 2025, 14(20): 1621.
Feng Y Y, Chen Y, Wu X Y, et al. Interplay of energy metabolism and autophagy [J]. Autophagy, 2024, 20(1): 4-14.
Liu Y, Yin H J, Jiang Y R, et al. Correlation between platelet gelsolin and platelet activation level in acute myocardial infarction rats and intervention effect of effective components of Chuanxiong Rhizome and red peony root [J]. Evid Based Complement Alternat Med, 2013, 2013: 985746.
Senaphan K, Kukongviriyapan U, Sangartit W, et al. Ferulic acid alleviates changes in a rat model of metabolic syndrome induced by high-carbohydrate, high-fat diet [J]. Nutrients, 2015, 7(8): 6446-6464.
Lee J H, Parveen A, Do M H, et al. Lespedeza cuneata protects the endothelial dysfunction via eNOS phosphorylation of PI3K/Akt signaling pathway in HUVECs [J]. Phytomedicine, 2018, 48: 1-9.
Festa J, Hussain A, Al-Hareth Z, et al. Phenolic metabolites protocatechuic acid and vanillic acid improve nitric oxide bioavailability via the Akt-eNOS pathway in response to TNF-α induced oxidative stress and inflammation in endothelial cells [J]. Metabolites, 2024, 14(11): 613.
Kang N, Lee J H, Lee W, et al. Gallic acid isolated from Spirogyra sp. improves cardiovascular disease through a vasorelaxant and antihypertensive effect [J]. Environ Toxicol Pharmacol, 2015, 39(2): 764-772.
Yin B Q, Guo Y H, Liu Y, et al. Molecular mechanism of Chuanxiong Rhizoma in treating coronary artery diseases [J]. Chin Herb Med, 2021, 13(3): 396-402.
Li L, Chen H W, Shen A L, et al. Ligustrazine inhibits platelet activation via suppression of the Akt pathway [J]. Int J Mol Med, 2019, 43(1): 575-582.
Chen Z H, Wu J P, Li S J, et al. Inhibition of myocardial cell apoptosis is important mechanism for ginsenoside in the limitation of myocardial ischemia/reperfusion injury [J]. Front Pharmacol, 2022, 13: 806216.
Dong Y, Chen H W, Gao J L, et al. Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease [J]. J Mol Cell Cardiol, 2019, 136: 27-41.
Wu J H, Ye J, Kong W L, et al. Programmed cell death pathways in hearing loss: A review of apoptosis, autophagy and programmed necrosis [J]. Cell Prolif, 2020, 53(11): e12915.
孙晨, 谢晓芳, 熊亮, 等. 川芎不同提取物对异丙肾上腺素致心肌缺血大鼠的影响[J]. 中药药理与临床, 2017, 33(5): 91-94.
Sepe J J, Gardner R T, Blake M R, et al. Therapeutics that promote sympathetic reinnervation modulate the inflammatory response after myocardial infarction [J]. JACC Basic Transl Sci, 2022, 7(9): 915-930.
Ma X C, Godar R J, Liu H Y, et al. Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death [J]. Autophagy, 2012, 8(3): 297-309.
Marchi S, Guilbaud E, Tait S W G, et al. Mitochondrial control of inflammation [J]. Nat Rev Immunol, 2023, 23(3): 159-173.
Hadas Y, Vincek A S, Youssef E, et al. Altering sphingolipid metabolism attenuates cell death and inflammatory response after myocardial infarction [J]. Circulation, 2020, 141(11): 916-930.
Le W Q, Liao J Y, Zhang Y H, et al. Integrated metabolomics and the microbiome reveal the compatibility mechanism of the Suxiao Jiuxin Pill in the treatment of stable coronary artery disease [J]. Chin Med, 2025, 20(1): 140.
Wang Z, Zhang F, Liu W, et al. Impaired tricarboxylic acid cycle flux and mitochondrial aerobic respiration during isoproterenol induced myocardial ischemia is rescued by bilobalide [J]. J Pharm Anal, 2021, 11(6): 764-775.
贾志鑫, 潘明霞, 刘力榕, 等. 基于代谢组学的速效救心丸抗心肌缺血作用机制研究[J]. 中草药, 2022, 53(15): 4719-4729.
Mu J M, Lam S M, Shui G H. Emerging roles and therapeutic potentials of sphingolipids in pathophysiology: Emphasis on fatty acyl heterogeneity [J]. J Genet Genomics, 2024, 51(3): 268-278.
Wilkerson J L, Tatum S M, Holland W L, et al. Ceramides are fuel gauges on the drive to cardiometabolic disease [J]. Physiol Rev, 2024, 104(3): 1061-1119.
Jozefczuk E, Guzik T J, Siedlinski M. Significance of sphingosine-1-phosphate in cardiovascular physiology and pathology [J]. Pharmacol Res, 2020, 156: 104793.
Song N X, Lu D Y, Wu G S, et al. Serum proteomic analysis reveals the cardioprotective effects of Shexiang Baoxin Pill and Suxiao Jiuxin Pill in a rat model of acute myocardial infarction [J]. J Ethnopharmacol, 2022, 293: 115279.

2026年第57卷第19期

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doi: 10.7501j.issn.0253-2670.2026.19.027

接收时间：2026-05-13
首发时间：2026-10-29

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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