Article(id=1322631272443269574, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1322631259684192984, articleNumber=null, orderNo=null, doi=10.7501j.issn.0253-2670.2026.19.011, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1775059200000, receivedDateStr=2026-04-02, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793269468650, onlineDateStr=2026-10-29, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793269468650, onlineIssueDateStr=2026-10-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793269468650, creator=13701087609, updateTime=1793269468650, updator=13701087609, issue=Issue{id=1322631259684192984, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='19', pageStart='7501', pageEnd='7928', issueExtLink='null', onlineDate='null', pubDate='1791734400000', pubDateStr='2026-10-12', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1793269465608, creator='13701087609', updateTime=1793269554856, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322631634101326494, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1322631259684192984, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322631634101326495, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1322631259684192984, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=7615, endPage=7630, ext={EN=ArticleExt(id=1322631272770425288, articleId=1322631272443269574, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Study on zirconium ball water-grinding combined with ultrasound-assisted nanonization process of Realgar and its “efficacy-toxicity” relationship, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective To establish an ultrasound-assisted nanonization process for realgar and elucidate the scientific connotation of achieving toxicity reduction and efficacy enhancement within safety thresholds through nanonization. Methods The parameters of zirconium ball water-grinding were optimized using central composite design-response surface methodology (CCD-RSM), and nano-realgar was prepared by combining acid washing with ultrasonic shearing. Four processed products (dry-ground Realgar, traditional water-floating Realgar, SDS-assisted water-floating Realgar and nano-Realgar) were characterized by laser particle size analyzer, scanning electron microscope (SEM), specific surface area and porosity analyzer based on the Brunauer-Emmett-Teller (BET) method, and liquid chromatography-atomic fluorescence spectrometry (LC-AFS). Toxicity was evaluated using a Caenorhabditis elegans model, and efficacy was assessed using a mouse wound model. Results The optimal process parameters of zirconium ball water-grinding were determined as milling for 3.9 h, three cycles of levigation, and the addition of 190 g of zirconia balls (the mass ratio of zirconium balls with diameters of 1, 2, 3, 4 mm is 1∶1∶2∶4); The particle size of Realgar sample can be reduced to 300 nm 30 min of sonication at 250 W. BET analysis showed that nano-realgar had well-developed mesopores. LC-AFS results indicated that, compared with the dry-milled product, all processing methods reduced the As³⁺ content, with nano-Realgar being slightly higher but still below the safety limit. In the C. elegans assay, nano-Realgar exhibited the lowest toxicity (P < 0.001). In the mouse wound model, it achieved the highest healing rate, significantly reducing inflammatory factors and upregulating growth factor expression (P < 0.05). Conclusion The zirconium ball water-grinding combined with ultrasound-assisted nanonization process successfully prepares nano-Realgar, which possesses dual advantages of toxicity reduction and efficacy enhancement within safety thresholds, providing a theoretical basis for upgrading the processing technology of Realgar., authors=KANG Shuang¹, GE Songqi¹, WU Jingzhen¹, XU Tianyi¹, WANG Xinchen¹, WANG Chuying¹, YANG Xinxin¹, YU Peng¹, authorsList=KANG Shuang, GE Songqi, WU Jingzhen, XU Tianyi, WANG Xinchen, WANG Chuying, YANG Xinxin, YU Peng, authorCompany=1 Changchun University of Traditional Chinese Medicine, Changchun 130117, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322631272694927815, articleId=1322631272443269574, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=雄黄锆球水飞-超声辅助纳米化工艺及其“效-毒”关系研究, columnId=1304140189132149234, journalTitle=中草药, columnName=药剂与工艺, runingTitle=null, highlight=null, articleAbstract=目的 建立超声辅助雄黄Realgar纳米化工艺，阐明纳米化改造在雄黄安全阈值内实现“减毒增效”的科学内涵。方法 采用星点设计-响应面法（central composite design-response surface methodology，CCD-RSM）优化雄黄锆球水飞参数，结合酸洗与超声剪切制备纳米化雄黄；通过激光粒度分析仪（laser particle size analyzer）、扫描电子显微镜（scanning electron microscope，SEM）、比表面积及孔隙度分析仪的Brunauer-Emmett-Teller（BET）分析法及液相色谱-原子荧光光谱联用仪（liquid chromatography-atomic fluorescence spectrometry，LC-AFS）对4种炮制品（干法粉碎雄黄、传统水飞雄黄、SDS水飞雄黄、纳米化雄黄）进行表征；利用线虫模型评价各炮制品毒性，小鼠创面模型评价其药效。结果 雄黄锆球水飞最佳工艺为研磨3.9 h、水飞3次、加锆球（直径分别为1、2、3、4 mm锆球质量比为1∶1∶2∶4）190 g；250 W功率下超声30 min可将水飞后雄黄样品粒径降至300 nm。BET分析结果显示，纳米化雄黄介孔发达；LC-AFS检测结果显示，与干法粉碎雄黄样品相比，3种炮制方法均可降低雄黄样品中As³⁺含量，纳米化雄黄样品略高但低于安全限度。线虫实验中，纳米化雄黄样品毒性最低（P＜0.001）；小鼠创面模型中，其创面愈合率最高，显著降低炎症因子并上调生长因子表达（P＜0.05）。结论 锆球水飞-超声辅助工艺可成功制备纳米化雄黄，在安全阈值内兼具减毒与增效双重优势，为雄黄炮制技术升级提供了理论依据。, authors=康爽¹, 葛松奇¹, 吴京臻¹, 徐天艺¹, 王馨晨¹, 王楚盈¹, 杨辛欣¹, 于澎¹, authorsList=康爽, 葛松奇, 吴京臻, 徐天艺, 王馨晨, 王楚盈, 杨辛欣, 于澎, authorCompany=1 长春中医药大学, 吉林 长春 130117, correspAuthors=杨辛欣, authorNote=康爽: 康爽，女，硕士研究生，研究方向为中药炮制关键技术及科学内涵研究。E-mail:1733718286@qq.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=18heI5FroBwOknd11Y+v5A==, pdfFileSize=2215821, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=吉林省自然科学基金资助项目 (YDZJ202501ZYTS271); 长春中医药大学大学生创新训练项目 (S202510199014))}, authors=[Author(id=1324017961303932976, 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