中草药

直肠给药抗溃疡性结肠炎的制剂创新与临床研究进展

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中草药 | 综述 2026,57(19): 7861-7876

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中草药 |综述 2026 , 57 (19) : 7861 -7876

直肠给药抗溃疡性结肠炎的制剂创新与临床研究进展

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作者信息

通讯作者:

张文锍

作者简介:

雷晓萌: 雷晓萌，博士研究生，研究方向为中药新剂型与新技术。E-mail:577649625@qq.com

Research progress on formulation innovation and clinical research of rectal drug delivery for treatment of ulcerative colitis

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doi: 10.7501j.issn.0253-2670.2026.19.029

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摘要

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溃疡性结肠炎（ulcerative colitis，UC）是累及结肠黏膜的慢性复发性炎症性疾病，临床以腹痛、腹泻、黏液脓血便为主要表现。直肠给药凭借直达病所、局部浓度高、规避首过效应等优势，成为UC治疗的重要途径。近年来，中药、化学药及多种直肠制剂不断发展，使其在滞留性和控释性等方面取得重要进展。通过系统综述直肠给药的国内外发展历程、生物学基础及UC发病机制，并重点分析了近5年制剂创新与临床研究在直肠给药抗UC中的进展，为UC个体化治疗策略提供参考。

关键词

直肠给药 / 溃疡性结肠炎 / 单一疗法 / 联合疗法 / 制剂创新 / 临床研究

Abstract

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Ulcerative colitis (UC) is a chronic relapsing inflammatory disease involving the colonic mucosa, clinically characterized by abdominal pain, diarrhea, and mucopurulent bloody stools. Rectal drug delivery has emerged as an important approach for UC treatment due to its advantages such as direct access to the lesion site, high local drug concentration, and avoidance of the first-pass effect. In recent years, the continuous development of traditional Chinese medicines, chemical drugs, and various rectal formulations have significantly improved the retention and controlled-release performance of rectal drug delivery systems. This review systematically summarizes the domestic and international development history, biological basis of rectal drug delivery, and the pathogenesis of UC, with a focus on analyzing the progress of formulation innovations and clinical studies in rectal drug delivery for UC treatment over the past five years, aiming to provide a reference for the individualized treatment strategies of UC.

Key words

rectal administration / ulcerative colitis / monotherapy / combination therapy / formulation innovation / clinical research

引用本文

雷晓萌, 许茹欣, 苏裕, 刘贞妍, 潘萍, 张文锍, 张国松. 直肠给药抗溃疡性结肠炎的制剂创新与临床研究进展. 中草药, 2026 , 57 (19) : 7861 -7876 . DOI: 10.7501j.issn.0253-2670.2026.19.029

LEI Xiaomeng, XU Ruxin, SU Yu, LIU Zhenyan, PAN Ping, ZHANG Wenliu, ZHANG Guosong. Research progress on formulation innovation and clinical research of rectal drug delivery for treatment of ulcerative colitis[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (19) : 7861 -7876 . DOI: 10.7501j.issn.0253-2670.2026.19.029

基金

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全国重点实验室自主部署重点研发计划项目 (20243BCC31008)

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2026年第57卷第19期

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doi: 10.7501j.issn.0253-2670.2026.19.029

接收时间：2026-03-30
首发时间：2026-10-29

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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