中草药

中药通过抑制细胞衰老抗肺纤维化的研究进展

PDF下载

宋子玉, 李晓雯, 卢雪茹, 王佳然, 王靖宇, 张浩洋, 臧凝子, 庞立健, 吕晓东, 刘勇明

中草药 | 中药防治器官纤维化研究 2026,57(18): 7097-7109

收起

中草药 |中药防治器官纤维化研究 2026 , 57 (18) : 7097 -7109

中药通过抑制细胞衰老抗肺纤维化的研究进展

全屏

宋子玉, 李晓雯, 卢雪茹, 王佳然, 王靖宇, 张浩洋, 臧凝子, 庞立健, 吕晓东, 刘勇明

作者信息

通讯作者:

吕晓东

作者简介:

宋子玉: 宋子玉，硕士研究生，研究方向为中医药防治肺系疾病。E-mail:songziyu0203@163.com

Research progress on traditional Chinese medicine on anti-pulmonary fibrosis by inhibiting cell senescence

SONG Ziyu, LI Xiaowen, LU Xueru, WANG Jiaran, WANG Jingyu, ZHANG Haoyang, ZANG Ningzi, PANG Lijian, LYU Xiaodong, LIU Yongming

Affiliations

doi: 10.7501/j.issn.0253-2670.2026.18.003

文章导航

摘要

收起

肺纤维化是多种间质性肺疾病的终末期表现，病理特征表现在于肺泡结构和功能性肺泡单位渐进性破坏、持续性肺组织纤维化，预后极差，严重影响患者生存质量。肺纤维化病理过程中存在端粒缩短、细胞凋亡抵抗、衰老相关分泌表型等典型“衰老特征”，细胞衰老作为肺纤维化的发病机制之一，在肺纤维化发生发展中发挥重要作用。研究表明，中药活性成分、单味药和复方制剂能够通过直接或间接抑制细胞衰老，进而达到延缓肺纤维化疾病进展的治疗作用。因此，通过阐述细胞衰老与肺纤维化的联系，归纳总结近年来关于中药通过抑制细胞衰老治疗肺纤维化的研究现状，为临床肺纤维化治疗提供参考。

关键词

肺纤维化 / 细胞衰老 / 衰老相关分泌表型 / 中药 / 间质性肺疾病

Abstract

收起

Pulmonary fibrosis (PF) is the terminal manifestation of various interstitial lung diseases. It is pathologically characterized by progressive destruction of alveolar structure and functional alveolar units, as well as persistent fibrosis of lung tissue. The prognosis is extremely poor, seriously affecting the quality of life of patients. In the pathological process of PF, there are typical “senescence-associated features” such as telomere shortening, resistance to apoptosis, and senescence-associated secretory phenotype. Cellular senescence, as one of the pathogenic mechanisms, plays an important role in the occurrence and development of PF. Studies have shown that the active ingredients of traditional Chinese medicine (TCM), single medicinal herbs and compound preparations of TCM can achieve the therapeutic effect of delaying the progression of PF by directly or indirectly inhibiting cellular senescence. Therefore, this article elaborates on the connection between cellular senescence and PF, summarizes the current research status of TCM in treating PF by inhibiting cellular senescence in recent years, and provides a reference for the clinical treatment of PF.

Key words

pulmonary fibrosis / cellular senescence / senescence-associated secretory phenotype / traditional Chinese medicine / interstitial lung disease

引用本文

宋子玉, 李晓雯, 卢雪茹, 王佳然, 王靖宇, 张浩洋, 臧凝子, 庞立健, 吕晓东, 刘勇明. 中药通过抑制细胞衰老抗肺纤维化的研究进展. 中草药, 2026 , 57 (18) : 7097 -7109 . DOI: 10.7501/j.issn.0253-2670.2026.18.003

SONG Ziyu, LI Xiaowen, LU Xueru, WANG Jiaran, WANG Jingyu, ZHANG Haoyang, ZANG Ningzi, PANG Lijian, LYU Xiaodong, LIU Yongming. Research progress on traditional Chinese medicine on anti-pulmonary fibrosis by inhibiting cell senescence[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (18) : 7097 -7109 . DOI: 10.7501/j.issn.0253-2670.2026.18.003

基金

收起

国家自然科学基金区域联合基金项目 (U24A20777); 国家自然科学基金资助项目 (82274440); 国家自然科学基金资助项目 (82204993); 国家自然科学基金资助项目 (82305157); 国家自然科学基金资助项目 (82505490); 辽宁中医药大学中医脏象理论及应用教育部重点实验室开放基金资助项目 (zyzx2503,zyzx2502); 辽宁省科技厅博士启动项目 (2025-BS-0721); 辽宁省教育厅高校基本科研项目 (LJ222510162023)

参考文献

收起

文献

收起

参考文献引证文献

排序方式：

Koudstaal T, Funke-Chambour M, Kreuter M, et al.Pulmonary fibrosis:From pathogenesis to clinical decision-making[J]. Trends Mol Med, 2023, 29(12):1076-1087.
Herberts M B, Teague T T, Thao V, et al. Idiopathic pulmonary fibrosis in the United States:Time to diagnosis and treatment[J]. BMC Pulm Med, 2023, 23(1):281.
Kim H J, Snyder L D, Adegunsoye A, et al.Hospitalizations in patients with idiopathic pulmonary fibrosis[J]. Respir Res, 2021, 22(1):257.
Raghu G, Remy-Jardin M, Richeldi L, et al. Idiopathic pulmonary fibrosis(an update)and progressive pulmonary fibrosis in adults:An official ATS/ERS/JRS/ALAT clinical practice guideline[J]. Am J Respir Crit Care Med, 2022,205(9):e18-e47.
Lucas V, Cavadas C, Aveleira C A. Cellular senescence:From mechanisms to current biomarkers and senotherapies[J]. Pharmacol Rev, 2023, 75(4):675-713.
任正肖,张颖颖,车萍,等.细胞衰老与特发性肺纤维化药物治疗研究进展[J]. 中国药理学通报, 2024,40(4):601-605.
Mebratu Y A, Soni S, Rosas L, et al. The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype[J]. Am J Physiol Cell Physiol, 2023,325(3):C565-C579.
Lancaster L, Cottin V, Ramaswamy M, et al. Bexotegrast in patients with idiopathic pulmonary fibrosis:The INTEGRIS-IPF clinical trial[J]. Am J Respir Crit Care Med, 2024, 210(4):424-434.
Raghu G, Richeldi L, Fernández Pérez E R, et al.Pamrevlumab for idiopathic pulmonary fibrosis:The ZEPHYRUS-1 randomized clinical trial[J]. JAMA, 2024,332(5):380-389.
Romero Ortiz A D, Jiménez-Rodríguez B M, LópezRamírez C, et al. Antifibrotic treatment adherence,efficacy and outcomes for patients with idiopathic pulmonary fibrosis in Spain:A real-world evidence study[J]. BMJ Open Respir Res, 2024, 11(1):e001687.
Richeldi L, Azuma A, Cottin V, et al. Nerandomilast in patients with idiopathic pulmonary fibrosis[J]. N Engl J Med, 2025, 392(22):2193-2202.
Wang B S, Han J, Elisseeff J H, et al. The senescenceassociated secretory phenotype and its physiological and pathological implications[J]. Nat Rev Mol Cell Biol, 2024,25(12):958-978.
Yao C F, Guan X R, Carraro G, et al. Senescence of alveolar type 2 cells drives progressive pulmonary fibrosis[J]. Am J Respir Crit Care Med, 2021, 203(6):707-717.
Parimon T, Chen P, Stripp B R, et al. Senescence of alveolar epithelial progenitor cells:A critical driver of lung fibrosis[J]. Am J Physiol Cell Physiol, 2023, 325(2):C483-C495.
Parimon T, Hohmann M S, Yao C F. Cellular senescence:Pathogenic mechanisms in lung fibrosis[J]. Int J Mol Sci,2021, 22(12):6214.
Torres-Machorro A L, García-VicenteÁ, Espina-Ordoñez M, et al. Update of aging hallmarks in idiopathic pulmonary fibrosis[J]. Cells, 2025, 14(3):222.
Wang S H, Wang R R, He Q Y, et al. Cellular senescence:A pathogenic driver for pulmonary fibrosis[J]. Front Biosci, 2025, 30(7):37811.
Schafer M J, White T A, Iijima K, et al. Cellular senescence mediates fibrotic pulmonary disease[J]. Nat Commun, 2017, 8:14532.
吴迪,高笑宇,杨宏新.特发性肺纤维化患者发生Ⅱ型肺泡上皮细胞衰老的机制及其抗衰疗法研究进展[J]. 实用心脑肺血管病杂志, 2025, 33(8):119-123.
Adams T S, Schupp J C, Poli S, et al. Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis[J]. Sci Adv, 2020, 6(28):eaba1983.
Su L L, Dong Y P, Wang Y Y, et al. Potential role of senescent macrophages in radiation-induced pulmonary fibrosis[J]. Cell Death Dis, 2021, 12:527.
Zheng C M, Zhan X, Yang Y H, et al. A rare missense variant in telomerase reverse transcriptase is associated with idiopathic pulmonary fibrosis in a Chinese Han family[J]. Chin Med J, 2018, 131(18):2205-2209.
Habiel D M, Hohmann M S, Espindola M S, et al. DNAPKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis[J]. BMC Pulm Med, 2019, 19(1):165.
Lee J S, La J, Aziz S, et al. Molecular markers of telomere dysfunction and senescence are common findings in the usual interstitial pneumonia pattern of lung fibrosis[J]. Histopathology, 2021, 79(1):67-76.
Qi Z Y, Yang W Q, Xue B B, et al. ROS-mediated lysosomal membrane permeabilization and autophagy inhibition regulate bleomycin-induced cellular senescence[J]. Autophagy, 2024, 20(9):2000-2016.
Feng J K, Liu H, Jiang K W, et al. Enhanced oxidative stress aggravates BLM-induced pulmonary fibrosis by promoting cellular senescence through enhancing NLRP3activation[J]. Life Sci, 2024, 358:123128.
Bale L K, Schafer M J, Atkinson E J, et al. Pregnancyassociated plasma protein-A(PAPP-A)is a key component of an interactive cellular mechanism promoting pulmonary fibrosis[J]. J Cell Physiol, 2022, 237(4):2220-2229.
Selvaggio P, Taci E, Barassi A, et al. Exploring the uncharted role of cell senescence in rare diseases[J]. Orphanet J Rare Dis, 2025, 20(1):465.
Miwa S, Kashyap S, Chini E, et al. Mitochondrial dysfunction in cell senescence and aging[J]. J Clin Invest,2022, 132(13):e158447.
Adlimoghaddam A. Mitochondrial dysfunction in aging and age-related disorders[J]. Aging Dis, 2025, 16(5):2495-2497.
Chen X Y, Wang D M, Zhou Y, et al. The critical role of mitophagy in cell senescence-mediated pulmonary fibrosis and potential therapeutic strategies[J]. Mol Biol Rep,2025, 52(1):565.
Liu S Q, Xi Q, Li X N, et al. Mitochondrial dysfunction and alveolar type II epithelial cell senescence:The destroyer and rescuer of idiopathic pulmonary fibrosis[J]. Front Cell Dev Biol, 2025, 13:1535601.
Basilicata M G, Sommella E, Scisciola L, et al. Multiomics strategies to decode the molecular landscape of cellular senescence[J]. Ageing Res Rev, 2025, 111:102824.
Bhardwaj S, Gautam R K, Kushwaha S. From senescence to scarring:Exploring TGF-β signaling in cellular aging,fibrotic remodeling, and pulmonary fibrosis[J]. Cytokine Growth Factor Rev, 2025, 86:29-39.
Bhatt J, Ghigo A, Hirsch E. PI3K/Akt in IPF:Untangling fibrosis and charting therapies[J]. Front Immunol, 2025,16:1549277.
罗成,叶远航,柯佳.中药基于PI3K/Akt信号通路治疗肺纤维化的研究进展[J]. 沈阳药科大学学报, 2025,42(4):311-321.
Ma X Y, Jiang M N, Ji W Q, et al. The role and regulation of SIRT1 in pulmonary fibrosis[J]. Mol Biol Rep, 2024,51(1):338.
Wang X Z, Zhu Y Y, Liu H L, et al. Nitazoxanide alleviates experimental pulmonary fibrosis by inhibiting the development of cellular senescence[J]. Life Sci, 2025,361:123302.
Ren Y J, Sun T Q, Lu Y, et al. rhCC16 suppresses cellular senescence and ameliorates COPD-like symptoms by activating the AMPK/Sirt1-PGC-1-α-TFAM pathway to promote mitochondrial function[J]. J Cell Mol Med, 2025,29(8):e70566.
Cheng Y, Jiao Y, Wei W, et al. FBR2 modulates ferroptosis via the SIRT3/p53 pathway to ameliorate pulmonary fibrosis[J]. Front Pharmacol, 2025, 16:1509665.
Jing X Y, Sun W, Yang X Y, et al. CCAAT/enhancerbinding protein(C/EBP)homologous protein promotes alveolar epithelial cell senescence via the nuclear factorkappa B pathway in pulmonary fibrosis[J]. Int J Biochem Cell Biol, 2022, 143:106142.
Gao A Y, Diaz Espinosa A M, GianìF, et al. Pim-1 kinase is a positive feedback regulator of the senescent lung fibroblast inflammatory secretome[J]. Am J Physiol Lung Cell Mol Physiol, 2022, 323(6):L685-L697.
Liu D, Guan Y. Mechanism of action of miR-15a-5p and miR-152-3p in paraquat-induced pulmonary fibrosis through Wnt/β-catenin signaling mediation[J]. PeerJ,2024, 12:e17662.
Liu J L, Wang J Y, Xiong A Y, et al. Mitochondrial quality control in lung diseases:Current research and future directions[J]. Front Physiol, 2023, 14:1236651.
Wang X F, Lu W Z, Xia X Y, et al. Selenomethionine mitigate PM2.5-induced cellular senescence in the lung via attenuating inflammatory response mediated by cGAS/STING/NF-κB pathway[J]. Ecotoxicol Environ Saf, 2022,247:114266.
Zhang C Y, Zhong W J, Liu Y B, et al. EETs alleviate alveolar epithelial cell senescence by inhibiting endoplasmic reticulum stress through the Trim25/Keap1/Nrf2 axis[J]. Redox Biol, 2023, 63:102765.
Hu M, Guan X H, Wang L F, et al. Endothelial CD38-induced endothelial-to-mesenchymal transition is a pivotal driver in pulmonary fibrosis[J]. Cell Mol Life Sci, 2024,82(1):30.
梁元钰,吕晓东,庞立健,等.肺痹、肺痿思辨[J]. 中华中医药杂志, 2025, 40(5):2091-2095.
冯嘉文,彭渊,孙鑫,等.肺纤维化的中医药治疗研究进展[J]. 世界中医药, 2025, 20(12):2184-2188.
曾梓苑,陈生,黄俊浩,等.国医大师晁恩祥运用养阴益气法治疗肺痿经验[J]. 陕西中医, 2022, 43(10):1442-1444.
王三凤,陈炜.国医大师韩明向基于“金水相生,培土生金”理论论治间质性肺疾病[J]. 山西中医药大学学报, 2024, 25(2):169-173.
弓雪峰,崔红生,陈秋仪,等.国医大师王琦院士“象数形神气”中医原创思维在肺间质纤维化诊治中的应用[J]. 中医学报, 2023, 38(1):1-6.
邓祥丽,陈丽娟,杨梅,等.基于国医大师颜德馨教授“衡法”理论管窥肺痿发病机制及治疗[J]. 四川中医,2024, 42(2):6-9.
孙明月,王志英,黄瑞欧.国医大师周仲瑛教授辨治间质性肺疾病经验初探[J]. 中华中医药杂志, 2017,32(11):4949-4951.
纪娟,王浩,刘丹丽,等.张念志教授治疗特发性肺纤维化经验[J]. 中医学报, 2017, 32(4):517-519.
叶燕燕,黄依晴,卢峰,等.严桂珍教授论治间质性肺病经验[J]. 福建中医药, 2023, 54(4):47-48.
刘琪,田春燕.李竹英教授从虚痰瘀郁辨治特发性肺纤维化经验总结[J]. 现代中西医结合杂志, 2023,32(3):392-395.
吴金鹏,张紫丹,杨宏志.王鹏从肺络病理论谈通络药在特发性肺纤维化中的应用[J]. 湖北中医杂志, 2023,45(5):20-24.
肖庆龄,谌晓莉,孙航成,等.朱启勇教授治疗肺纤维化经验探析[J]. 中国民族民间医药, 2019, 28(19):61-63.
莫丽莎,肖晨晓,朱卫娜,等.刘良徛“全程温法治疗肺纤维化”思想在系统性硬化症相关间质性肺病中的应用[J]. 江西中医药大学学报, 2024, 36(2):21-25.
徐嘉,庞立健,刘创,等.基于络病理论浅谈特发性肺纤维化[J]. 辽宁中医杂志, 2019, 46(2):277-279.
怀宝赓,姚鹏宇,梁景乾,等.刘德山教授基于“疏散通络”法治疗特发性肺纤维化经验[J]. 现代中西医结合杂志, 2022, 31(6):825-829.
孟丽红,薛晓明,张晓梅.从状态论治特发性肺纤维化[J]. 中华中医药杂志, 2023, 38(4):1576-1579.
王域辰,焦扬,李智鹏,等.名中医周平安以益气解毒法治疗特发性肺纤维化经验撷英[J]. 世界中西医结合杂志, 2023, 18(7):1315-1318.
施侠威,沈悦倩,邵婧怡,等.徐志瑛从《难经》“肺熟”理论辨治特发性肺纤维化思路探析[J]. 中华中医药杂志, 2021, 36(8):4714-4717.
张玉萱,王鹏程,贾立军.基于“阳杀阴藏,清衰散结”理论探析靶向衰老的中医抗肿瘤治疗[J]. 上海中医药杂志, 2025, 59(9):32-36.
孟丽红,关炜,薛晓明.中药靶向肺泡上皮细胞衰老治疗肺纤维化的研究进展[J]. 中国现代医生, 2025,63(26):84-87.
Wu W J, Wu X H, Qiu L X, et al. Quercetin influences intestinal dysbacteriosis and delays alveolar epithelial cell senescence by regulating PTEN/PI3K/Akt signaling in pulmonary fibrosis[J]. Naunyn Schmiedebergs Arch Pharmacol, 2024, 397(7):4809-4822.
Hohmann M S, Habiel D M, Coelho A L, et al. Quercetin enhances ligand-induced apoptosis in senescent idiopathic pulmonary fibrosis fibroblasts and reduces lung fibrosis in vivo[J]. Am J Respir Cell Mol Biol, 2019,60(1):28-40.
Geng F, Xu M Y, Zhao L, et al. Quercetin alleviates pulmonary fibrosis in mice exposed to silica by inhibiting macrophage senescence[J]. Front Pharmacol, 2022, 13:912029.
Wang L B, Lin F, Liu Y L, et al. Wogonin protects against bleomycin-induced mouse pulmonary fibrosis via the inhibition of CDK9/p53-mediated cell senescence[J]. Front Pharmacol, 2024, 15:1407891.
Li T Y, Wang J, Bai L, et al. Nobiletin’s role in idiopathic pulmonary fibrosis via the PI3K/Akt/MDM2/p53signaling pathway[J]. Naunyn Schmiedeberg's Arch Pharmacol, 2026, 399(1):225-242.
Lin Q, Fan W J, Chen Z Y, et al. Hesperetin alleviates bleomycin-induced pulmonary fibrosis by modulating cellular senescence and promoting impaired autophagy in a CISD2-dependent manner[J]. FASEB J, 2025, 39(19):e71083.
Han D, Gong H Y, Wei Y, et al. Hesperidin inhibits lung fibroblast senescence via IL-6/STAT3 signaling pathway to suppress pulmonary fibrosis[J]. Phytomedicine, 2023,112:154680.
Xie W X, Deng L, Zhang X H, et al. Myricetin alleviates silica-mediated lung fibrosis via PPARγ-PGC-1α loop and suppressing mitochondrial senescence in epithelial cells[J]. J Agric Food Chem, 2024, 72(50):27737-27749.
Zhang L, Tong X, Huang J Z, et al. Fisetin alleviated bleomycin-induced pulmonary fibrosis partly by rescuing alveolar epithelial cells from senescence[J]. Front Pharmacol, 2020, 11:553690.
刘颖,李慧星,邵琦,等.豆蔻明通过m TOR-ROS轴抑制肺成纤维细胞衰老的机制[J]. 中国药科大学学报, 2025, 56(5):592-600.
Yuan S, Zuo B, Zhou S C, et al. Integrating network pharmacology and experimental validation to explore the pharmacological mechanism of astragaloside IV in treating bleomycin-induced pulmonary fibrosis[J]. Drug Des Dev Ther, 2023, 17:1289-1302.
Zheng Q, Lei F P, Hui S, et al. Ginsenoside Rb1 relieves cellular senescence and pulmonary fibrosis by promoting Nrf2/QKI/Smad7 axis[J]. Am J Chin Med, 2024, 52(8):2491-2509.
Zhang W X, Li K, Li W L, et al. Ginsenoside Rh2ameliorates pulmonary fibrosis via HSP70-dependent autophagic flux regulation and senescence arrest[J]. J Ethnopharmacol, 2025, 353:120448.
Zeng Q, Luo Y Y, Sang X X, et al. Senegenin attenuates pulmonary fibrosis by inhibiting oxidative-stress-induced epithelial cell senescence through activation of the Sirt1/PGC-1α signaling pathway[J]. Antioxidants, 2024, 13(6):675.
Zhou Q, Yi G, Chang M Y, et al. Activation of Sirtuin3 by honokiol ameliorates alveolar epithelial cell senescence in experimental silicosis via the cGAS-STING pathway[J]. Redox Biol, 2024, 74:103224.
Xiong D, Gao F, Shao J B, et al. Arctiin-encapsulated DSPE-PEG bubble-like nanoparticles inhibit alveolar epithelial type 2 cell senescence to alleviate pulmonary fibrosis via the p38/p53/p21 pathway[J]. Front Pharmacol, 2023, 14:1141800.
Chu L H, Zhuo J Z, Huang H H, et al. Tetrandrine alleviates pulmonary fibrosis by inhibiting alveolar epithelial cell senescence through PINK1/Parkin-mediated mitophagy[J]. Eur J Pharmacol, 2024, 969:176459.
Guo H C, Chen J J, Yu H X, et al. Activation of Nrf2/ARE pathway by Anisodamine(654-2)for Inhibition of cellular aging and alleviation of Radiation-Induced lung injury[J]. Int Immunopharmacol, 2023, 124:110864.
Zhao X X, Zhou S X, Sheng Z Y, et al. Parishin alleviates pulmonary fibrosis by reducing CD38 levels in naturally aging mice[J]. Rejuvenation Res, 2025, 28(1):25-32.
陈宏,宋倩男,齐鑫,等.基于化学蛋白质组学技术揭示雷公藤甲素抑制肺周细胞衰老的作用机制[J]. 辽宁中医药大学学报, 2026, 28(5):1-6.
Ding C C, Guo Z Z, Liao Q, et al. Network pharmacology and machine learning reveal salidroside’s mechanisms in idiopathic pulmonary fibrosis treatment[J]. J Inflamm Res,2024, 17:9453-9467.
Chen S W, Yuan A, Fan S W, et al. Isorhapontigenin alleviates pulmonary fibrosis by inhibiting oxidative stress-induced senescence via STAT3/PRDX2 signals in alveolar epithelial cells[J]. Int Immunopharmacol, 2025,163:115287.
Li Y J, Chen R Y, Wu J Z, et al. Salvianolic acid B protects against pulmonary fibrosis by attenuating stimulating protein 1-mediated macrophage and alveolar type 2 cell senescence[J]. Phytother Res, 2024, 38(2):620-635.
张会哲.基于自噬和衰老探讨白藜芦醇缓解肺纤维化的作用及机制研究[D]. 南京:南京中医药大学, 2024.
Feng F C, Wang Z C, Li R F, et al. Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2[J]. Biomed Pharmacother, 2019, 112:108669.
王璇,徐泳,罗子宸,等.基于网络药理学探索桔梗治疗肺纤维化的作用机制[J]. 药学学报, 2021, 56(11):2957-2967.
范卫锋.冬虫夏草繁育品抗肺纤维化作用与机制研究[D]. 广州:广州中医药大学, 2022.
商丹丹,周鸿,黄蔓如,等.华山参通过TGF-β1/Smad3通路对体外纤维化的调节作用[J]. 天津中医药大学学报, 2024, 43(6):523-530.
Pu X Y, Li X D, Liu B H, et al. An AMPK-centric strategy:Foenumoside B coordinates PINK1/Parkin-mediated mitophagy with Nrf2/HO-1 antioxidant signaling to resolve oxidative stress in radiation-induced lung injury[J]. FASEB J, 2025, 39(22):e71225.
Zhou X Q, Tan F, Zhang S X, et al. Deciphering the underlying mechanisms of Sanleng-Ezhu for the treatment of idiopathic pulmonary fibrosis based on network pharmacology and single-cell RNA sequencing data[J]. Curr Comput Aided Drug Des, 2024, 20(6):888-910.
Zhou Y H, Su W, Xu M Z, et al. Maimendong Decoction modulates the PINK1/Parkin signaling pathway alleviates type 2 alveolar epithelial cells senescence and enhances mitochondrial autophagy to offer potential therapeutic effects for idiopathic pulmonary fibrosis[J]. J Ethnopharmacol, 2025, 345:119568.
李洋,周禹,张振豪,等.补阳还五汤防治特发性肺纤维化机制研究[J]. 国医论坛, 2023, 38(5):68-72.
罗朝磊,渠景连.基于博来霉素诱导的A549细胞衰老探讨补阳还五汤改善特发性肺纤维化的作用机制[J]. 中国实验方剂学杂志, 2026, 32(5):11-20.
闫亚男,梁玉磊,王杰鹏,等.升陷汤调节Wnt3a/β-catenin信号途径介导的细胞衰老改善特发性肺纤维化大鼠肺功能[J]. 中国实验方剂学杂志, 2024, 30(12):31-38.
Wang J, Zhao Y, Wei Y, et al. Mai-Wei-Yang-Fei Decoction protects against pulmonary fibrosis by reducing telomere shortening and inhibiting AECII senescence via FBW7/TPP1 regulation[J]. Phytomedicine, 2025, 141:156682.
王单,徐泳,黄同杏,等.麦味养肺汤通过调控p53/p21信号通路抑制Ⅱ型肺泡上皮细胞衰老抗肺纤维化的作用机制研究[J]. 中药新药与临床药理, 2023,34(6):754-763.
徐泳.麦味养肺汤通过p53抑制肺成纤维细胞衰老抗肺纤维化的机制研究[D]. 南京:南京中医药大学,2022.
孙玉洁,刘一凡,吕文亮,等.清燥救肺汤对肺纤维化小鼠细胞衰老和NLRP3/IL-1β信号通路的影响[J]. 时珍国医国药, 2025, 36(13):2467-2473.
Zhou S Y, Peng L, Wang Y, et al. Bazibushen attenuates fibroblast senescence in silica-induced pulmonary fibrosis via FoxO1/PINK1/Parkin axis[J]. Phytomedicine, 2025,141:156714.
Zuo B, Zuo L, Du X Q, et al. Yiqi Huayu Decoction alleviates bleomycin-induced pulmonary fibrosis in rats by inhibiting senescence[J]. Front Pharmacol, 2022, 13:1033919.
Du K, Wen X J, Zhu J, et al. Yi-Fei-Tong-Bi Decoction alleviates bleomycin induced pulmonary fibrosis in mice[J]. Drug Des Dev Ther, 2025, 19:3983-3995.
蔡宇,王宇,沈俊岭,等.金水缓纤方调控CD38/NAD+-SIRT1轴延缓AEC2s细胞衰老抗肺纤维化的机制研究[J]. 海南医科大学学报, 2025, 31(15):1153-1162.
王宇,游梦月,余本嫚,等.金水缓纤方通过p53-KRT8信号通路减轻HPAEPICS细胞衰老和分化障碍改善肺纤维化的作用机制[J]. 海南医科大学学报,2026, 32(4):258-268.
哈希睿.参龙煎剂调控c GAS-STING信号通路改善细胞衰老防治IPF的分子机制[D]. 沈阳:辽宁中医药大学, 2025.
冯家腾,马先,李轩年,等.通过血清药物化学和网络药理学探索益肺通络方治疗特发性肺纤维化的活性成分和作用机制[J]. 中药材, 2025, 48(1):119-128.
张伟洲,徐泳,韩迪,等.党参平肺活血汤治疗肺纤维化作用机制的网络药理学和分子对接研究[J]. 中国药理学通报, 2023, 39(6):1165-1173.
Han X R, Zhang A J, Meng Z Q, et al. Bioinformatics analysis based on extracted ingredients combined with network pharmacology, molecular docking and molecular dynamics simulation to explore the mechanism of Jinbei Oral Liquid in the therapy of idiopathic pulmonary fibrosis[J]. Heliyon, 2024, 10(18):e38173.
Sun X J, Zhao J W, Ma Y T, et al. Combatting pulmonary fibrosis with Astragalus membranaceus:A review of active components and multifaceted mechanisms[J]. Chin Herb Med, 2026, 18(3):541-554.

2026年第57卷第18期

PDF下载

引用本文

BibTeX

文章信息

doi: 10.7501/j.issn.0253-2670.2026.18.003

接收时间：2026-01-30
首发时间：2026-10-29

补充材料

相关文章

文章信息

作者

出版历史

收稿日期：2026-01-30

基金

作者信息

参考文献

分享链接

https://castjournals.cast.org.cn/joweb/zcy/CN/10.7501/j.issn.0253-2670.2026.18.003

分享至

全文二维码

扫描看全文

引用本文

BibTeX

本文的引用情况

2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

关闭全屏

BibTeX
EndNote
RefWorks
TxT