Article(id=1322631246140789039, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1322631228000424183, articleNumber=null, orderNo=null, doi=10.7501/j.issn.0253-2670.2026.18.013, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1784563200000, receivedDateStr=2026-07-21, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793269462380, onlineDateStr=2026-10-29, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793269462380, onlineIssueDateStr=2026-10-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793269462380, creator=13701087609, updateTime=1793269462380, updator=13701087609, issue=Issue{id=1322631228000424183, tenantId=1146029695717560320, journalId=1302319053441957962, year='2026', volume='57', issue='18', pageStart='7073', pageEnd='7500', issueExtLink='null', onlineDate='null', pubDate='1790524800000', pubDateStr='2026-09-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793269458054, creator='13701087609', updateTime=1793269548245, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322631606339228314, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1322631228000424183, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322631606339228315, tenantId=1146029695717560320, journalId=1302319053441957962, issueId=1322631228000424183, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=7233, endPage=7240, ext={EN=ArticleExt(id=1322631246711214385, articleId=1322631246140789039, tenantId=1146029695717560320, journalId=1302319053441957962, language=EN, title=Isolation and identification of Diels-Alder adducts from Morus nigra and their PPARγ binding activity, columnId=null, journalTitle=Chinese Traditional and Herbal Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective Novel Diels-Alder-type adducts from the stems and branches of Morus nigra were investigated, and their peroxisome proliferator-activated receptor gamma (PPARγ) binding activity was preliminarily evaluated. Methods Systematic isolation and purification were carried out by multiple chromatographic methods including silica gel, AB-8 macroporous resin, polyamide, Sephadex LH-20 gel and ODS reversed-phase column chromatography. Structures of the isolated compounds were identified by modern spectroscopic techniques including high-resolution electrospray ionization mass spectrometry（HR-ESI-MS）and nuclear magnetic resonance spectroscopy (¹H-NMR, ¹³C-NMR). The in vitro activities of some compounds were evaluated by PPARγ ligand-binding assay. Results Six Diels-Alder adducts were isolated from the ethanol extract of M. nigra twigs and identified as (5aR,10aR,14S)-2-((1S,2R,3S)-2-(2,4-dihydroxybenzoyl)-2',4'-dihydroxy-5-methyl-1,2,3,6-tetrahydro-[1,1'-biphenyl]-3-yl)-1,3,8, 14-tetrahydroxy-13,13- dimethyl-11H-10a,5a-(epoxypropano)benzofuro[3,2-b]chromen-11-one (1), sanggenon O (2), sanggenon C (3), mulberrofuran F (4), cathayanin B (5), and mulberrofuran G (6). Compound 1 exhibited weak PPARγ ligand-binding activity at 10 μmol/L. Compound 3 exhibited moderate ligand-binding activity toward PPARγ at 10 μmol/L, which was obviously weaker than that of its biosynthetic precursor sanggenol F (SGF). Conclusion Compound 1 is a new compound, named nigragenon Q, it is formed by an intermolecular [4+2] cycloaddition between a sanggenone-type dihydroflavone and a chalcone. Oxidation of the C-2 isoprenyl side chain enables its connection to C-3 via an oxygen bridge, furnishing a six-membered ring and constructing a unique [4,4,3] bridged ring system. Compound 3 exhibited moderate PPARγ ligand-binding activity., authors=YU Zhenming^1,2, CHEN Tianhong^1,2, MAO Xudong^1,2, HUANG Chunyue^1,2, HU Xiao^1,2, authorsList=YU Zhenming, CHEN Tianhong, MAO Xudong, HUANG Chunyue, HU Xiao, authorCompany=1 China State Institute of Pharmaceutical Industry Co., Ltd., Shanghai 201203, China;
2 State Key Laboratory of Lead Druggability Research, Shanghai Institute of Pharmaceutical Industry Co., Ltd., Shanghai 201203, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322631246639911216, articleId=1322631246140789039, tenantId=1146029695717560320, journalId=1302319053441957962, language=CN, title=黑桑中Diels-Alder型加合物的分离鉴定及其PPARγ结合活性研究, columnId=1304140187169214944, journalTitle=中草药, columnName=化学成分, runingTitle=null, highlight=null, articleAbstract=目的 研究黑桑Morus nigra茎枝中新颖的Diels-Alder型加合物，并初步评价其过氧化物酶体增殖物激活受体γ（peroxisome proliferator-activated receptor gamma，PPARγ）结合活性。方法 采用硅胶、AB-8大孔吸附树脂、聚酰胺、Sephadex LH-20凝胶及ODS反相柱色谱等多种方法进行系统分离纯化；通过高分辨质谱（HR-ESI-MS）、核磁共振波谱（¹H-NMR、¹³C-NMR）等现代波谱技术对所得单体化合物进行结构鉴定，通过PPARγ配体结合实验对部分化合物进行体外活性考察。结果 从黑桑茎枝乙醇提取物中分离得到6个Diels-Alder型加合物，分别鉴定为 (5aR,10aR,14S)-2-((1S,2R,3S)-2-(2,4-二羟基苯甲酰)-2′,4′-二羟基-5-甲基-1,2,3,6-四氢-[1,1′-联苯基]-3-基)-1,3,8,14-四羟基-13,13-二甲基-11H-10a,5a-(环氧丙基桥)苯并呋喃并[3,2-b]色烯-11-酮（1）、桑根酮O（2）、桑根酮C（3）、桑呋喃F（4）、cathayanin B（5）、桑呋喃G（6）。化合物1在10 μmol/L浓度下对PPARγ显示出微弱的配体结合活性；化合物3在10 μmol/L浓度下对PPARγ具有一定的配体结合活性，但明显弱于其生源前体sanggenol F。结论 化合物1为新的Diels-Alder加合物，命名为黑桑根酮Q，该化合物由1分子桑根酮型二氢黄酮与1分子查耳酮经[4＋2]环加成生成，C-2位异戊烯基侧链氧化后与C-3位通过氧桥形成六元环，最终构建出结构新颖的[4,4,3]桥环体系。化合物3具有一定的PPARγ配体结合活性。, authors=于振铭^1,2, 陈天鸿^1,2, 毛旭东^1,2, 黄春跃^1,2, 胡晓^1,2, authorsList=于振铭, 陈天鸿, 毛旭东, 黄春跃, 胡晓, authorCompany=1 中国医药工业研究总院, 上海 201203;
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